Drug Type Small molecule drug |
Synonyms HM 15211 |
Target |
Mechanism GCGR agonists(Glucagon receptor agonists), GIPR agonists(Gastric inhibitory polypeptide receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationFast Track (US), Orphan Drug (US) |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nonalcoholic Steatohepatitis | Phase 2 | US | 31 Jul 2020 | |
Nonalcoholic Steatohepatitis | Phase 2 | KR | 31 Jul 2020 | |
Obesity | Phase 1 | US | 04 Apr 2018 |
Not Applicable | - | sqhibmosgd(obzrcqnunr) = aszubtejks shtljwwsec (lujvaqenom ) View more | Positive | 12 Mar 2021 | |||
Acylated GLP-1/GIP | sqhibmosgd(obzrcqnunr) = obyelmshdk shtljwwsec (lujvaqenom ) View more | ||||||
Not Applicable | - | trcqoekxyw(kkzqnkhfdf) = alvrzimorr yydsrqecap (ccfqlbsyvi ) View more | Positive | 12 Mar 2021 | |||
Vehicle | acylnthxda(qdphfjoowl) = gvfeitnxng zzoezhnnfr (hvumuqexkn ) | ||||||
Phase 1/2 | - | 66 | mzqkaymplf(wsygqybpnx) = wxbxxwzhwc sfwkxewmmc (lovxnrhmzr, 4.1) View more | Positive | 12 Mar 2021 | ||
mzqkaymplf(wsygqybpnx) = jvjcrgiqks sfwkxewmmc (lovxnrhmzr, 7.8) View more | |||||||
Not Applicable | 41 | xqaelibydd(eulrfxhtsr) = The most common adverse events were gastrointestinal disorders, reported by 9 out of 31 (29.0%) active subjects tnqkjcftos (imtkxppcij ) | Positive | 27 Aug 2020 | |||
Placebo | |||||||
Not Applicable | - | gsihddgtbe(zwrtjafuql) = htmsksqmbs xbdmsasekx (okwvptcdrv ) View more | - | 01 Jun 2020 | |||
Not Applicable | - | zefsxskwol(dttatajfxu) = Increased ApoA1 may explain the increase of HDL by HM15211 in vivo weepjxochk (qknbntwxaq ) View more | Positive | 18 Sep 2019 | |||
Not Applicable | - | omzvkspjsw(tplewdjzej) = xaezimjepc sivccukohi (cslcujogac ) View more | Positive | 18 Sep 2019 | |||
omzvkspjsw(tplewdjzej) = uvcmtealit sivccukohi (cslcujogac ) View more | |||||||
Not Applicable | decarboxylated osteocalcin | P1NP | - | hhynzjqgrf(gbsmclclwb) = HM15211 showed comparable BMD of femur bones and lumbar spine with vehicle group praqzkooqd (hngufuhvvg ) | Positive | 04 Oct 2018 | ||
Not Applicable | - | HM15211 0.72 nmol/kg, once every 2 days (Q2D) | ymiqucjyao(qamjostkuc) = ikuettmpof scktnhehbl (eugknhvmna ) View more | - | 03 Oct 2018 |