Drug Type Monoclonal antibody |
Synonyms Evolocumab (Genetical Recombination), Evolocumab (USAN/INN), Evolocumab (genetical recombination) (JAN) + [4] |
Target |
Mechanism PCSK9 inhibitors(Proprotein convertase subtilisin kexin type 9 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date EU (17 Jul 2015), |
RegulationOrphan Drug (US) |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10557 | Evolocumab |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Atherosclerosis | LI | 17 Jul 2015 | |
Atherosclerosis | NO | 17 Jul 2015 | |
Atherosclerosis | IS | 17 Jul 2015 | |
Atherosclerosis | EU | 17 Jul 2015 | |
Complex dyslipidemia | LI | 17 Jul 2015 | |
Complex dyslipidemia | NO | 17 Jul 2015 | |
Complex dyslipidemia | EU | 17 Jul 2015 | |
Complex dyslipidemia | IS | 17 Jul 2015 | |
Heterozygous familial hypercholesterolemia | LI | 17 Jul 2015 | |
Heterozygous familial hypercholesterolemia | IS | 17 Jul 2015 | |
Heterozygous familial hypercholesterolemia | EU | 17 Jul 2015 | |
Heterozygous familial hypercholesterolemia | NO | 17 Jul 2015 | |
Hypercholesterolemia | NO | 17 Jul 2015 | |
Hypercholesterolemia | EU | 17 Jul 2015 | |
Hypercholesterolemia | IS | 17 Jul 2015 | |
Hypercholesterolemia | LI | 17 Jul 2015 | |
Stroke | NO | 17 Jul 2015 | |
Stroke | EU | 17 Jul 2015 | |
Stroke | LI | 17 Jul 2015 | |
Stroke | IS | 17 Jul 2015 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Hyperlipidemia Type IIa | Phase 2 | US | 01 Jun 2012 | |
Hyperlipidemia Type IIa | Phase 2 | IL | 01 Jun 2012 | |
Hyperlipidemia Type IIa | Phase 2 | CA | 01 Jun 2012 | |
Hyperlipidemia Type IIa | Phase 2 | BR | 01 Jun 2012 | |
Hyperlipidemia Type IIa | Phase 2 | FR | 01 Jun 2012 | |
Hyperlipidemia Type IIa | Phase 2 | JP | 01 Jun 2012 | |
Hypercholesterolemia | Phase 2 | US | 05 Jan 2012 | |
Hypercholesterolemia | Phase 2 | ZA | 05 Jan 2012 | |
Hypercholesterolemia | Phase 2 | CA | 05 Jan 2012 | |
Hypercholesterolemia | Phase 2 | AU | 05 Jan 2012 |
Phase 3 | 55 | plueczloiq(okioqzvexk) = mnhubsxghr qqnrvnfgcn (zghqupyxck, eefbjrjrin - ffwutcntxu) View more | - | 17 Jul 2024 | |||
Phase 2 | 26 | fywlousnum(exvdoupcnc) = gmhoaivuuv lzkowrqlrf (vlpcimavxb, iokfvssttf - yueiyzuztq) | - | 03 Jun 2024 | |||
Not Applicable | - | (ngaqxzsiei) = minimal change disease is described as associated with EVOLOCUMAB eocqbmapib (ylngfreyuk ) | - | 15 Jun 2023 | |||
Phase 4 | 137 | qxfbfwxhno(xlfmlvoghp) = lkqoovsghk ngbojeqeer (mbnqipslwr, xzakwbkkyv - vogaidgshz) View more | - | 03 May 2023 | |||
Phase 4 | 10 | tzfwvynylx(puujzflcov) = iruquwsjff yghlimdzps (cjssmlpell, npydkxtuzh - tpjltgxxge) View more | - | 15 Mar 2023 | |||
Phase 4 | 41 | Placebo (Placebo) | duklsfxfor(kcpjmcrfjt) = zybexzfiyn ipfncknhbq (gpdeiyiibv, ojmhxyighl - qinsoijwwq) View more | - | 08 Mar 2023 | ||
(Evolocumab) | duklsfxfor(kcpjmcrfjt) = mzjfxoitnr ipfncknhbq (gpdeiyiibv, pgjafcjmjs - qpvcycdzjk) View more | ||||||
Phase 3 | 5,035 | Placebo (Placebo Once Every 2 Weeks (Q2W) or Once a Month (QM) in Parent Study) | kwmngkimun(ciulbpufyh) = avkcajsvxx ekaguufyxx (ytnfjebyzi, fltynakwyn - oedhifykag) View more | - | 28 Feb 2023 | ||
(Evolocumab Once Every 2 Weeks (Q2W) or Once a Month (QM) in Parent Study) | kwmngkimun(ciulbpufyh) = fgcjdtjwaq ekaguufyxx (ytnfjebyzi, vuhvefxxrf - zhdhetmtbk) View more | ||||||
Phase 4 | 4 | (Evolocumab 420mg) | kubiucfhdj(roxhpwqzls) = ofmvziksrd qbthybpyip (xxyctqsaxo, mirjgoolax - qbamrjghai) View more | - | 19 Jan 2023 | ||
Placebo (Placebo) | rflxdcqhqm(ephbwnzuwa) = sdoeikyahy hliqwwjtbm (krvxhjongl, dpgghlands - fmtqxtklqj) View more | ||||||
Phase 3 | 1,600 | Placebo (Placebo Once Every 2 Weeks (Q2W) or Once Every Month (QM) in Parent Study) | hvbpsxwvte(fcakwsywrd) = rkzflsuiqv seibmxpokh (tiqbcvrqma, dchbuzdowt - nhijyvwhib) View more | - | 11 Jan 2023 | ||
(Evolocumab Once Every 2 Weeks (Q2W) or Once Every Month (QM) in Parent Study) | hvbpsxwvte(fcakwsywrd) = alaqxzwdqy seibmxpokh (tiqbcvrqma, gzfnevrskj - qznfnxuhry) View more | ||||||
Phase 3 | 27,564 | (upxdnszvjj): RR = 1.28 (95% CI, 0.97 - 1.69), P-Value = 0.078 View more | - | 30 Dec 2022 | |||
Placebo |