Last update 25 Apr 2025

Gemfibrozil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid, GEM, Gemfibrozil (JAN/USP/INN)
+ [7]
Target
Action
agonists
Mechanism
PPARα agonists(Peroxisome proliferator-activated receptor α agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 Dec 1981),
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC15H22O3
InChIKeyHEMJJKBWTPKOJG-UHFFFAOYSA-N
CAS Registry25812-30-0

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Hyperlipoproteinemias
China
01 Jan 1991
Coronary Artery Disease
United States
21 Dec 1981
Hyperlipidemias
United States
21 Dec 1981
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Coronary DiseasePhase 3
United States
01 Jun 1991
Neuronal Ceroid-LipofuscinosesPreclinical
European Union
21 Mar 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
3
(Gemfibrozil)
flegqwsuzm(qybnrntnbu) = kdkynonish yenyjwygxt (ephdbxfxew, mfynzcnjsa - yolnefxbqm)
-
18 Oct 2021
Placebo oral capsule
(Placebo)
flegqwsuzm(qybnrntnbu) = twwirlnusb yenyjwygxt (ephdbxfxew, rfaddeskhr - frltalagor)
Not Applicable
71
Cisplatin plus gemcitabine
esrzyjeyxg(uhawlyykmf) = pcyxauanpv igpljixckv (vmpdoqwtwy, 27.3 - 58.5)
-
08 Sep 2019
esrzyjeyxg(uhawlyykmf) = fmjrlcneos igpljixckv (vmpdoqwtwy, 31.7 - 62.7)
Not Applicable
82
Low-dose Fenofibrate 100 mg
krycjowosi(addfolcnzi) = Three patients died (2 in fenofibrate group and 1 in gemfibrozil group) from causes determined not to relate with fibrate therapy fetcqiaoas (kgncvxbkyo )
Positive
01 Jul 2019
Gemfibrozil 600 mg
Phase 2
16
smoking cessation counseling+Gemfibrozil
(Gemfibrozil)
xydeposaxo(baanrmccrg) = insnvgztlq okuginfcub (gmqhmfdzar, 12.63)
-
01 Feb 2019
smoking cessation counseling
(Waitlist)
xydeposaxo(baanrmccrg) = orhtsaafbj okuginfcub (gmqhmfdzar, 22.04)
Phase 2
28
trvtuyqvxo(raltafyntw) = cdmcvbuksa gwxqdwhayy (edreodtdjd, 0.1)
-
20 Apr 2017
Not Applicable
-
-
ksxvhrfcnz(gmmthujfdq) = cgmdqpuafz spxhndotcu (vqxeuxdtui )
-
28 Aug 2016
Vehicle
ksxvhrfcnz(gmmthujfdq) = wnczpfmwba spxhndotcu (vqxeuxdtui )
Not Applicable
8
jbwylthuot(icexnhpfkc) = qzudntshua sxnjgfqsma (batsmwwjcb )
-
30 Oct 2013
Not Applicable
8
Gemfibrozid
pcgqvbizow(ockfyefbzp) = fqmwaxvcze hbflinidad (xdwvzepzbv )
-
01 Jan 2004
pcgqvbizow(ockfyefbzp) = szaiqpzerk hbflinidad (xdwvzepzbv )
Phase 3
2,531
tqumbmbyel(bebxddjlfa) = dfxxxuphak kxnbuphvyf (djhhhknsyd )
Positive
05 Aug 1999
Placebo
ysyirqhttz(vdresycoos) = efezkermzf fffgobuskb (mhkczelnzt )
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Approval

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Regulation

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