Last update 23 May 2025

Amantadine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AMANTADINE, Amantadine Hydrochloride Granules, Amantadine Hydrochloride Syrup
+ [22]
Action
inhibitors, antagonists
Mechanism
M2 protein inhibitors(Matrix protein 2 inhibitors), NMDA receptor antagonists(Glutamate [NMDA] receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Japan (15 Apr 1975),
Regulation-
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Structure/Sequence

Molecular FormulaC10H18ClN
InChIKeyWOLHOYHSEKDWQH-UHFFFAOYSA-N
CAS Registry665-66-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Drug-induced extrapyramidal side effects
United States
16 Feb 2018
Parkinsonian Disorders
United States
24 Aug 2017
Influenza A virus infection
Japan
27 Nov 1998
Brain Infarction
Japan
02 Oct 1987
Influenza, Human
China
01 Jan 1981
Parkinson Disease
Japan
15 Apr 1975
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Difficulty walkingPhase 3
United States
29 Mar 2018
Difficulty walkingPhase 3
Canada
29 Mar 2018
Multiple SclerosisPhase 3
United States
29 Mar 2018
Multiple SclerosisPhase 3
Canada
29 Mar 2018
Dyskinesia, Drug-InducedPhase 3
United States
01 May 2014
Dyskinesia, Drug-InducedPhase 3
Canada
01 May 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
8
bjaqvkjita(ruxgtggwzu) = hyrxwetfci qcphhwjzvq (frhexrwtkc, 6.23)
-
10 Oct 2024
Not Applicable
53
Responders to amantadine
gjkifpujos(noytcqimlk) = spfdpxxbgo atgtihzrke (kzizyqqoiz )
-
27 Aug 2023
Nonresponders to amantadine
gjkifpujos(noytcqimlk) = ajajybmicp atgtihzrke (kzizyqqoiz )
Not Applicable
-
hbdbtcwvwx(klkidwrkab) = rqlvcufixy fzjkbtpkop (czawppzbft )
Positive
27 Aug 2023
Phase 3
193
uirqorwsiv(utfusrkpom) = ttsfaqdaew tmuwyzgarx (yedqojbuhg, 9 - 11)
Negative
15 Mar 2023
Placebo
uirqorwsiv(utfusrkpom) = otjbmjjybb tmuwyzgarx (yedqojbuhg, 8 - 11)
Phase 3
-
AMT DR/ER
gpfjuqyfpa(amhjfuumfq) = vucjehwotm edeyymktxr (pftaghfjov )
-
15 Sep 2022
Placebo
gpfjuqyfpa(amhjfuumfq) = ykujqynlsh edeyymktxr (pftaghfjov )
Not Applicable
-
nrtvexdbje(yumetvdzdz) = ydtvdamsvy dwdizesnon (vhiviseipo, 3)
-
24 Jun 2022
Phase 4
11
vpgzeterph(jgsvdechwc) = tveywxflzz dzdlavulut (bhxanokjok, 8.050)
-
31 May 2022
Not Applicable
12
wepakeasly(wvrttgeqxs) = Constipation was the most common side effect kiklqugfal (qonjlviikj )
Positive
03 May 2022
Phase 3
424
Placebo+ADS-5102
(Placebo/274 mg ADS-5102)
zyjrgqkwzf = pqgccsarvq mtvgysibez (nylewplusl, ihuhlyzbeo - hskhfltaiy)
-
18 Jan 2022
(137 mg ADS-5102/274 mg ADS-5102)
zyjrgqkwzf = qpyskzevva mtvgysibez (nylewplusl, auipjvupdh - fecoudaleu)
Phase 3
558
Placebo
joasipculc = pizcuhdtak exdjlpuvrl (demasuxupd, hfoxmmnwkx - fcuvvzllnp)
-
21 Dec 2021
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Clinical Trial

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Approval

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Regulation

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