Single-Dose HPV Vaccination Among Young Adult Women in Costa Rica: the PRISMA-ESCUDDO Trial (PRevencIón Del Cáncer Cervical Con Una Sola Dosis de Vacuna Contra VPH en Mujeres Adultas Jóvenes)

This phase IV trial tests whether a single dose of the human papillomavirus (HPV) vaccine works in preventing cervical cancer in young women in Costa Rica. Human papilloma viruses, called HPV, are a group of viruses that very frequently cause infection in both men and women, mainly in the genital organs. There are many types of HPV, and some can cause cancer. The World Health Organization recommends a two-dose schedule for adolescents 9-14 and three doses for individuals 15 years old or older. This study examines whether a single dose of HPV vaccine can reduce the frequency with which women between ages 18-30 become infected with HPV.

Start Date01 Mar 2022

Sponsor / Collaborator

National Cancer Institute

NCT04301154

/ Active, not recruitingPhase 1IIT

Phase I, Proof of Concept, Open-Label, Randomized Clinical Trial to Evaluate the Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens With or Without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth

Phase I, Proof of Concept, Open-Label, Randomized Clinical Trial to Evaluate the Safety and Effects of Using Prime-boost HIVIS DNA and MVA-CMDR Vaccine Regimens with or without Toll-like Receptor 4 Agonist on HIV Reservoirs in Perinatally HIV Infected Children and Youth

Start Date18 Feb 2022

Sponsor / Collaborator

The Henry M. Jackson Foundation

[+11]

CTR20210535

/ CompletedPhase 4

一项监测葛兰素史克生物制品公司(GSK)希瑞适疫苗上市前后根据当地处方信息(PI)接种希瑞适疫苗的9至45岁中国女性宫颈癌相关终点的观察性数据库研究。

[Translation] An observational database study monitoring cervical cancer-related endpoints in Chinese women aged 9 to 45 years who received GlaxoSmithKline Biologicals (GSK) Cervarix vaccine according to local prescribing information (PI) before and after its launch.

第一步：评估数据库监测宫颈癌相关终点能力（次要目的）第二步：基线分析（次要目的）第三步：主要分析（主要目的）描述上市前后9-70岁女性宫颈癌相关终点(有/无HPV分型)患病率，按总体、疫苗接种状态、年龄组、每日历年描述。描述上市前后参与当地宫颈筛查实践9-70岁女性宫颈癌相关终点(有/无HPV分型)患病率，按总体、疫苗接种状态、年龄组、每日历年描述。第四步：条件分析（次要目的）

[Translation]

Step 1: Evaluate the database's ability to monitor cervical cancer-related endpoints (secondary objective) Step 2: Baseline analysis (secondary objective) Step 3: Primary analysis (primary objective) Describe the prevalence of cervical cancer-related endpoints (with/without HPV typing) in women aged 9-70 years before and after marketing, by overall, vaccination status, age group, and calendar year. Describe the prevalence of cervical cancer-related endpoints (with/without HPV typing) in women aged 9-70 years who participated in local cervical screening practices before and after marketing, by overall, vaccination status, age group, and calendar year. Step 4: Conditional analysis (secondary objective)

Start Date10 Sep 2021

Sponsor / Collaborator

GlaxoSmithKline (China) Investment Co., Ltd.

[+1]

100 Clinical Results associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

100 Translational Medicine associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

100 Patents (Medical) associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

461

Literatures (Medical) associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

31 Dec 2024·Osong public health and research perspectives

Safety of the bivalent COVID-19 mRNA booster vaccination among persons aged over 18 years in the Republic of Korea

Article

Author: Lee, Yeonkyeong ; Choi, Seok-Kyoung ; Bahng, Eunok ; Heo, Yeseul ; Ko, Mijeong ; Jang, Juyeon ; Kim, Tae Eun ; Kim, Seontae

Objectives: The aim of this study was to disseminate information about the safety of bivalent coronavirus disease 2019 (COVID-19) mRNA booster vaccines administered to adults in the Republic of Korea.Methods: Two databases were used to assess the safety of COVID-19 booster doses of Pfizer BA.1, Pfizer BA.4/5, Moderna BA.1, and Moderna BA.4/5 vaccines for adults aged 18 years and older. Adverse events (AEs) were analyzed using data reported to the web-based COVID-19 vaccination management system (CVMS) and a self-reported text-message survey.Results: Between October 11, 2022 and March 30, 2023, the CVMS received reports of 2,369 (93.7%) non-serious AEs from vaccinated adults, along with 158 (6.3%) serious AEs, which included 5 cases of anaphylaxis and 33 deaths. From October 11, 2022 to January 27, 2023, 40,022 people aged 18 and older responded to a survey conducted via text message. The booster doses were associated with fewer local and systemic AEs compared to the original vaccines. After receiving the bivalent vaccine, the most commonly reported AEs were pain at the injection site, headache, fatigue, and myalgia.Conclusion: Overall, bivalent vaccines exhibited fewer AEs compared to the original vaccines. The majority of AEs were non-serious, and serious AEs were rare among adults aged 18 years and older following vaccination with the Pfizer and Moderna bivalent vaccines.

31 Dec 2024·Virulence

Evaluation of the immune responses of biological adjuvant bivalent vaccine with three different insertion modes for ND and IBD

Article

Author: Li, Huimin ; Xue, Zhiqiang ; Sun, Wenying ; Guo, Yunpeng ; Qin, Ruihan ; Niu, Dun ; Liu, Jinmiao ; Liu, Yijia ; Li, Shuang ; Jiang, Xinghao ; Guo, Xiaochen ; Ren, Guiping ; Yin, Jiechao

Infectious bursal disease (IBD) is a widespread problem in the poultry industry, and vaccination is the primary preventive method. However, moderately virulent vaccines may damage the bursa, necessitating the development of a safe and effective vaccine. The Newcastle disease virus (NDV) has been explored as a vector for vaccine development. In this study, reverse genetic technology was used to obtain three recombinant viruses, namely, rClone30-VP2L (P/M)-chGM-CSF (NP), rClone30-chGM-CSF (P/M)-VP2L (NP), and rClone30-VP2L-chGM-CSF (P/M). Animal experiments showed that the three biological adjuvant bivalent vaccines effectively increased anti-NDV and anti-infectious bursal disease virus (IBDV) titres, enhancing both humoral and cellular immune responses in chickens without leading to any harm. Amongst the three biological adjuvant bivalent vaccines, the rClone30-chGM-CSF (P/M)-VP2L (NP) group had higher levels of anti-NDV antibodies at 14 days after the first immunization and stimulated a greater humoral immune response in 7-10 days. While, the rClone30-VP2L (P/M)-chGM-CSF (NP) group was the most effective in producing a higher level of IBDV antibody response. In conclusion, these three vaccines can induce immune responses more rapidly and effectively, streamline production processes, be cost-effective, and provide a new avenue for the development of Newcastle disease (ND) and IBD bivalent vaccines.

10 Nov 2024·West African journal of medicine

KNOWLEDGE AND PERCEPTION OF HUMAN PAPILLOMAVIRUS VACCINE AMONG ADOLESCENTS AND CAREGIVERS IN JOS METROPOLIS, PLATEAU STATE, NIGERIA.

Article

Author: Tony-Okeke, T O ; Aule, S K ; Mathew, M ; Odoh, A F ; Zoakah, J H ; Nnorom, O C ; Envuladu, E A

Introduction:

HPV infection is well-recognized as a cause of nearly all cases of cervical cancer. There are currently three prophylactic HPV vaccines; a bivalent (Cervarix), a quadrivalent (Gardasil), and a nonavalent vaccine (Gardasil- 9). With the recent rollout of HPV vaccines in Nigeria, it is imperative to understand potential barriers and facilitators to its uptake.

Objectives:

The objectives of this study were to evaluate the awareness, perception, and willingness to accept HPV vaccine and explore enablers and barriers to HPV vaccine uptake among adolescents and caregivers.

Methods:

Four focus group discussions were conducted with adolescents from public and private secondary schools in Plateau, 4 with the parents of adolescents, and one IDI with the head of ANCOPSS. Each FGD had between 8-12 participants. Interviews were recorded and notes were taken. The interviews were transcribed, codes were generated and analysis was conducted using a thematic framework approach with NVIVO version 11 software.

Results:

Most participants demonstrated inadequate knowledge and poor perception of HPV and the vaccine. Girls were willing to accept the vaccine, while boys saw it as a female problem. Parents had limited knowledge but expressed willingness to allow their children to be vaccinated. The fear of side effects, poor vaccine quality, and lack of parental approval were major barriers expressed by the girls while myths and misconceptions regarding the vaccine interference with fertility and as a means of population control were significant barriers on the parts of the parents.

Conclusion:

Low awareness and poor perception of HPV vaccine exist among adolescents and caregivers. Long-term individual and community-level interventions are needed to provide accurate information address knowledge gaps and promote inclusive access.

News (Medical) associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

18 Mar 2025

·www.globenewswire.com

Curevo Raises $110 Million to Advance Amezosvatein Shingles Vaccine

-- Amezosvatein has shown excellent immunogenicity and improved tolerability in Phase 2 study -- Medicxi leads round, joined by new investors OrbiMed, HBM Healthcare Investments, and Sanofi Ventures -- Former Chair of GSK’s vaccine business and Chief Scientific Advisor to Operation Warp Speed, Moncef Slaoui, to join Curevo as Board Chair March 17, 2025 -- Curevo Vaccine (Curevo), a privately-held clinical-stage biotechnology company dedicated to developing varicella zoster virus (VZV) vaccines with improved tolerability, today announces the closing of a $110 million Series B round to advance development of amezosvatein, its vaccine for shingles. Leading the round is new investor Medicxi, a European biotech-focused investment firm with significant experience investing in vaccine companies such as Vaxcyte and ViceBio. Joining Medicxi is an international group of investment funds including OrbiMed, HBM Healthcare Investments, and Sanofi Ventures plus existing investors RA Capital Management, Janus Henderson Investors, Adjuvant Capital, and founding investor GC Biopharma. “This Series B round will fund the extension of our successful Phase 2 program into an additional 640 participants, including the key population of adults over age 70, to finalize dose selection ahead of the Phase 3 program,” said Curevo’s CEO, George Simeon, MBA/MPH. “Designed based upon feedback from regulators and other stakeholders, this short extension trial will begin mid-2025 and serve to set the company for clinical, strategic, and regulatory success.” Concurrent with the round, Moncef Slaoui, PhD, will join Curevo as Board Chair. Dr. Slaoui was most recently the Chief Scientific Advisor to Operation Warp Speed during the COVID-19 pandemic, helping deliver vaccines against the SARS-CoV-2 virus. He spent nearly 30 years at GlaxoSmithKline, during which he helped shape its vaccine business by contributing to the creation of numerous new vaccines including Shingrix® (shingles), Cervarix® (HPV-induced cervical cancer), Mosquirix® (malaria), Rotarix® (rotavirus gastroenteritis), and Synflorix® (pneumococcal disease). “I have been collaborating with the Curevo team for several weeks now,” stated Dr. Slaoui. “I’m very excited to work with them to help perfect shingles vaccination, adding good tolerability to the exceptional efficacy achieved by the current vaccine. The data so far show Curevo’s adjuvant technology has the attributes to succeed in this endeavor.” Also joining Curevo’s Board of Directors will be Giovanni Mariggi, PhD, co-founder and Partner at Medicxi, an experienced infectious disease investor and board member. “Patients, doctors, and payors are very clear a new shingles vaccine like amezosvatein would be welcome in the global marketplace. Amezosvatein’s activity and improved tolerability profile could allow it to be a significant product in the shingles vaccines market. We are excited to support Curevo’s plan with a streamlined path to approval,” stated Dr. Mariggi. Tal Zaks, MD/PhD, will be joining Curevo’s Board of Directors on behalf of OrbiMed. Dr. Zaks is the former Chief Medical Officer of Moderna, where he led development of their mRNA vaccine against the SARS-CoV-2 virus. He previously held senior leadership positions in drug development at GSK and Sanofi. “OrbiMed has a long history of investing in biotech companies like Curevo seeking to improve healthcare outcomes while creating long-term shareholder value,” said Dr. Zaks. “The fact amezosvatein contains an optimized version of the TLR4 agonist with a known mechanism of action reduces biological risk while providing the competitive advantage of potentially improved tolerability, which should position it as the first choice for people who want to be protected from shingles.” ‘Amezosvatein’ is the assigned non-proprietary name for CRV-101, a non-mRNA adjuvanted subunit vaccine under investigation by Curevo. Like Shingrix, amezosvatein uses a subunit protein antigen called glycoprotein ‘E’ (gE). Targeting the gE antigen is proven to elicit a long-term, protective immune response to prevent shingles. Amezosvatein’s adjuvant contains an optimized version of the TLR4 agonist proven by Shingrix to be biologically active in shingles vaccination. Amezosvatein was engineered to maintain exceptional efficacy and have a best-in-class tolerability profile. The SLA-SE adjuvant formulation was developed at Seattle-based Access to Advanced Health Institute (AAHI) and amezosvatein was licensed from the Mogam Institute for Biomedical Research, a research institute funded by South Korea’s GC Biopharma. Curevo is a privately held, clinical-stage biotechnology company based near Seattle dedicated to reducing the burden of infectious disease by developing vaccines with improved tolerability and accessibility. Curevo’s lead product is amezosvatein, a non-mRNA adjuvanted sub-unit vaccine to prevent shingles, a serious medical condition involving a painful, blistering skin rash where 10-18% of people also develop serious, long-lasting nerve pain. The current $4+ billion shingles vaccine market is characterized by accessibility issues and vaccine hesitancy/dose avoidance related to vaccine tolerability. For more information visit https://curevovaccine.com/. Medicxi is a healthcare-focused investment firm with the mission to create and invest in companies across the full drug development continuum. Leveraging deep expertise in drug development and company creation spanning over two decades, Medicxi invests in early and late-stage therapeutics with a product vision that can fulfill a clear unmet medical need. For more information, please visit: https://www.medicxi.com. OrbiMed is a leading global healthcare investment firm with approximately $17 billion in assets under management. OrbiMed invests globally across the healthcare industry, from start-ups to large multinational corporations, via private equity funds, public equity funds, and royalty/credit funds. OrbiMed seeks to be a capital provider of choice, providing tailored financing solutions and extensive global team resources to help build world-class healthcare companies. OrbiMed’s team of over 100 professionals is based in New York City, London, San Francisco, Shanghai, Hong Kong, Mumbai, Herzliya, and other key global markets. For more information, please visit www.orbimed.com. Switzerland-based HBM Healthcare Investments focuses on the healthcare sector, holding and managing an international portfolio of promising companies in the human medicine, biotechnology, medical technology, diagnostics, and related areas. Many of these companies have their lead products already available on the market or are at an advanced stage of development. The portfolio companies are closely tracked and actively guided in their strategic direction. This is what makes HBM Healthcare Investments an interesting alternative to investments in big pharma and biotechnology companies. HBM Healthcare Investments has an international shareholder base and is listed on SIX Swiss Exchange (SIX:HBMN). Sanofi Ventures is the corporate venture capital arm of Sanofi, focused on investing in promising early-stage healthcare companies. The firm supports pioneering innovations in biotechnology, digital health, and life sciences aligning with Sanofi’s mission to bring life-changing treatments to patients worldwide. For more information, please visit www.sanofiventures.com. Founded in 2004, RA Capital Management is a multi-stage investment manager dedicated to evidence-based investing in public and private healthcare, life sciences, and planetary health companies. RA Capital creates and funds innovative companies, from private seed rounds to public follow-on financings, allowing management teams to drive value creation from inception through commercialization and beyond. RA Capital's knowledge engine is guided by its TechAtlas internal research division, and Raven, RA Capital's healthcare incubator, offers entrepreneurs and innovators a collaborative and comprehensive platform to explore the novel and the re-imagined. RA Capital has more than 150 employees and over $10 billion in assets under management. Janus Henderson Investors exists to help clients achieve their long-term financial goals. Its active management offers clients the opportunity to outperform passive portfolios over the course of market cycles. With more than 360 investment professionals, Janus Henderson Investors provides access to some of the industry’s most talented and innovative thinkers, spanning equities, fixed income, multi-asset, and alternatives, globally. Its investment teams blend insight, originality, and precision with rigorous analysis, structured processes, and robust risk management. Janus Henderson Investors builds client partnerships on openness and trust, channeling expertise from across the business and communicating the views of its experts in a timely and relevant way. https://www.janushenderson.com/ Headquartered in New York, with offices in Zürich, Adjuvant is a global life science investment fund built to accelerate the development of new technologies for the world's most pressing public health challenges. Backed by prominent healthcare and emerging market investors, Adjuvant draws upon its network of scientists, public health experts, biopharmaceutical industry veterans, and development finance professionals to identify new investment opportunities. Adjuvant invests in companies developing promising new vaccines, therapeutics, diagnostics, and medical devices targeting high-burden infectious diseases, maternal and child health, antimicrobial resistance, and malnutrition, with a commitment to make these interventions accessible globally. For more information, visit http://www.adjuvantcapital.com Founding investor GC Biopharma (formerly known as Green Cross Corporation) is a biopharmaceutical company headquartered in Yongin, South Korea. The company has over half a century of experience in the development and manufacturing of plasma derivatives and vaccines and expanded its global presence with the successful USA market entry of ALYGLO™ (intravenous immunoglobulin G) in 2024. In line with its mission to meet the demands of future healthcare, GC Biopharma continues to drive innovation by leveraging its core R&D capabilities in engineering of proteins, mRNAs, and lipid nanoparticle (LNP) drug delivery platforms to develop therapeutics for the field of rare disease as well as I&I (Immunology & Inflammation). To learn more about the company, visit https://www.gcbiopharma.com/eng/ The content above comes from the network. if any infringement, please contact us to modify.

Vaccine

04 Feb 2025

·ir.arcturusrx.com

Arcturus Therapeutics Announces Appointment of Moncef Slaoui, Ph.D., as Chair Designate

SAN DIEGO --(BUSINESS WIRE)--Feb. 4, 2025-- Arcturus Therapeutics Holdings Inc. (the “Company”, “Arcturus”, Nasdaq: ARCT), a commercial messenger RNA medicines company focused on the development of infectious disease vaccines and opportunities within liver and respiratory rare diseases, today announced the appointment of Moncef Slaoui , Ph.D., as Chair Designate. Dr. Slaoui has been serving on the Company’s Board of Directors since June 2024 . “Dr. Moncef Slaoui has a long-proven track record in the pharmaceutical and biotechnology industry, and we are delighted to have him as our Chair Designate,” said Joseph Payne , President & Chief Executive Officer of Arcturus. “We look forward to working with him as we enter a transformative year of advancing our pipeline of therapeutics and vaccines.” “Arcturus has deep expertise in mRNA delivery for therapeutics and a validated commercial stage vaccines platform,” said Dr. Moncef Slaoui . “I am excited to work with the company during this potentially transformational time with multiple key data readouts across its pipeline.” About Dr. Moncef Slaoui Dr. Moncef Slaoui was most recently the Chief Scientific Advisor to Operation Warp Speed. Under his leadership the operation enabled the fastest ever development, manufacturing, and approval of multiple COVID-19 vaccines in less than 11 months after the virus genetic sequence was described. Dr. Slaoui has sat on several biotechnology company boards, including Moderna, Inc. and Lonza Group AG , and he chaired the boards of Galvani, and Vaxcyte, a vaccine development platform company. Dr. Slaoui spent nearly 30 years at GlaxoSmithKline (GSK) holding leadership positions including as member of the Board of Directors of GSK PLC; Chairman of Pharmaceutical R&D; Chairman Global R&D, Vaccines & Oncology; and Chairman, Global Vaccines. As Chairman of Pharmaceutical R&D, Dr. Slaoui led a redesign of GSK’s R&D structure and culture to improve focus on innovation and productivity. As Chairman of Global Vaccines, Dr. Slaoui was directly involved in GSK's vaccine pipeline, leading to the creation of 14 new vaccines, including Shingrix®, to prevent shingles; Cervarix®, to prevent cervical cancer; Mosquirix, to prevent malaria; Rotarix®, to prevent rotavirus gastroenteritis; and Synflorix, to prevent pneumococcal disease. In 2016, Dr. Slaoui was recognized as one of Fortune's 50 Greatest World Leaders for his work in under-researched diseases common in the developing world. He served on the Advisory Committee to the Director of the NIH from 2011 to 2016 and has advised the U.S. President's Council of Advisors on Science and Technology . Dr. Slaoui holds a Ph.D. in Molecular Biology and Immunology from the Université Libre de Bruxelles , completed postdoctoral studies at Harvard Medical School and Tufts University School of Medicine , and was a Professor of Immunology at the University of Mons , Belgium . He received an accelerated Master of Business Administration from IMD, Switzerland in 1998. About Arcturus Founded in 2013 and based in San Diego, California , Arcturus Therapeutics Holdings Inc. (Nasdaq: ARCT) is a commercial mRNA medicines and vaccines company with enabling technologies: (i) LUNAR® lipid-mediated delivery, (ii) STARR® mRNA Technology (sa-mRNA) and (iii) mRNA drug substance along with drug product manufacturing expertise. Arcturus developed KOSTAIVE®, the first self-amplifying messenger RNA (sa-mRNA) COVID vaccine in the world to be approved. Arcturus has an ongoing global collaboration for innovative mRNA vaccines with CSL Seqirus, and a joint venture in Japan , ARCALIS , focused on the manufacture of mRNA vaccines and therapeutics. Arcturus’ pipeline includes RNA therapeutic candidates to potentially treat ornithine transcarbamylase (OTC) deficiency and cystic fibrosis (CF), along with its partnered mRNA vaccine programs for SARS-CoV-2 (COVID-19) and influenza. Arcturus’ versatile RNA therapeutics platforms can be applied toward multiple types of nucleic acid medicines including messenger RNA, small interfering RNA, circular RNA, antisense RNA, self-amplifying RNA, DNA, and gene editing therapeutics. Arcturus' technologies are covered by its extensive patent portfolio (over 400 patents and patent applications in the U.S. , Europe , Japan , China , and other countries). For more information, visit www.ArcturusRx.com. In addition, please connect with us on Twitter and LinkedIn. View source version on businesswire.com: https://www.businesswire.com/news/home/20250204663825/en/ Arcturus Therapeutics Public Relations & Investor Relations Neda Safarzadeh VP, Head of IR/PR/Marketing (858) 900-2682 IR@ArcturusRx.com Source: Arcturus Therapeutics Holdings Inc.

VaccineExecutive ChangemRNA

02 Dec 2024

·www.drugs.com

Cervical Cancer Deaths Fell Dramatically After Advent of HPV Vaccine

MONDAY, Dec. 2, 2024 -- A new study provides good evidence that the human papillomavirus (HPV) vaccine may be achieving its goal of slashing rates of cervical cancer. “We observed a … 62% drop in cervical cancer deaths over the last decade, likely due to HPV vaccination,” said study senior author Ashish Deshmukh . “We cannot think of any other reason that would have contributed to such a marked decline.” Deshmukh is co-leader of the Cancer Prevention and Control Research Program at the Medical University of South Carolina's Hollings Cancer Center. HPV, a common sexually transmitted infection, is thought to cause the vast majority of cervical cancer cases. First introduced and approved in the United States in 2006, HPV vaccines such as Gardasi l and Cervarix have revolutionized cervical cancer prevention and care. It takes time to see vaccination translated into real world outcomes, such as a decline in cancer deaths. But studies focused on earlier markers -- HPV infection, precancer and new cases of cervical cancer -- had suggested that widespread vaccination among adolescents and young women might be having an impact. The new study tracked U.S. deaths among women under the age of 25 from the beginning of the 1990s through 2021. Such deaths at a very young age are rare, but Deshmukh and colleagues said that tracking them is a good indicator of whether vaccines might be working. They pointed out that in 2021, women who were 25 would have been 10 years old in 2006, when the vaccine was first introduced. The U.S. Centers for Disease Control and Prevention recommends that HPV vaccines be given to adolescents at ages 11 to 12, before the typical start of sexual activity. The team found that between 50 and 60 women under the age of 25 died of cervical cancer during every three-year block of time throughout the 1990s. However, between 2019 and 2021, that rate had fallen by nearly two-thirds, to 13 deaths over those three years. Of course, girls and women can only be protected by the HPV vaccine if they are immunized, Deshmukh said. The CDC has set a goal of an 80% vaccination rate, but its data for 2024 show that only about 60% of 13-to -15-year-olds have received the recommended doses. “There has been a decline in HPV vaccination post COVID-19 in the most recent generation of U.S. adolescent," Deshmukh said in a university news release. "This is troubling, as a decline in vaccination uptake would potentially lead to smaller gains [against cervical cancer]." The findings were published Nov. 27 in the Journal of the American Medical Association. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

VaccineDrug Approval

100 Deals associated with Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	J07BM02	-

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Cervical Adenocarcinoma In Situ	United States	GlaxoSmithKline LLC	16 Oct 2009
Uterine Cervical Cancer	United States	GlaxoSmithKline LLC	16 Oct 2009
Uterine Cervical Cancer	Japan	GlaxoSmithKline KK	16 Oct 2009
Uterine Cervical Dysplasia	United States	GlaxoSmithKline LLC	16 Oct 2009
Anus Neoplasms	European Union	GlaxoSmithKline Biologicals SA	20 Sep 2007
Anus Neoplasms	Iceland	GlaxoSmithKline Biologicals SA	20 Sep 2007
Anus Neoplasms	Liechtenstein	GlaxoSmithKline Biologicals SA	20 Sep 2007
Anus Neoplasms	Norway	GlaxoSmithKline Biologicals SA	20 Sep 2007
Human Papillomavirus Infection	Australia	GlaxoSmithKline Australia Pty Ltd.	18 May 2007
Human Papillomavirus-Related Cervical Carcinoma	Australia	GlaxoSmithKline Australia Pty Ltd.	18 May 2007

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Adenocarcinoma in Situ	Phase 3	China	GlaxoSmithKline (China) Investment Co., Ltd.	28 Feb 2018
Adenocarcinoma in Situ	Phase 3	China	GlaxoSmithKline Biologicals SA	28 Feb 2018
Meningococcal Infections	Phase 3	Dominican Republic	GSK Plc	11 Jan 2013
Meningococcal Infections	Phase 3	Estonia	GSK Plc	11 Jan 2013
Meningococcal Infections	Phase 3	Thailand	GSK Plc	11 Jan 2013
Chronic human papillomavirus (HPV) infection	Phase 3	Senegal	GSK Plc	01 Oct 2007
Chronic human papillomavirus (HPV) infection	Phase 3	Tanzania	GSK Plc	01 Oct 2007
Cervical Intraepithelial Neoplasia	Phase 3	United States	GSK Plc	06 May 2004
Cervical Intraepithelial Neoplasia	Phase 3	Australia	GSK Plc	06 May 2004
Cervical Intraepithelial Neoplasia	Phase 3	Belgium	GSK Plc	06 May 2004

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03629886 (HPV-092, CTgov)	Phase 4	Cervical Intraepithelial Neoplasia	6,051	HPV (Types 16, 18) Vaccine, Adsorbed (Vacc-092 Group)	qmdkixkijl = hstctugubb vtqhynxhab (hpnxrvonzm, xhrwyzpxgl - ftcdoroyca) View more	-	19 Dec 2020
				HPV vaccine (Vacc-039 Group)	cxqacwifqe = zhyvaqwmwk dfvabfonsz (svsgqlvlcm, qnajuppmeb - zhdeohfkzv) View more
NCT00231413 (CTgov)	Phase 2	Human Papillomavirus Infection	383	HPV 16/18 L1 AS04 (HPV-16/18 Group)	dmworqxnjg = upzoemkvzi kvxqgnmonk (pdthcterog, ghsdzfvrtx - bicclsnrwn) View more	-	12 Dec 2019
				HPV-16/18/31/45 L1 AS04 Formulation 1 (HPV-TETRA A Group)	dmworqxnjg = jyusxgyipg kvxqgnmonk (pdthcterog, qgcossxirw - obmkcslgig) View more
NCT01031069 (CTgov)	Phase 4	Human Papillomavirus Infection \| HIV Infections	873	GSK Biologicals' HPV vaccine 580299 (HIV+/Cervarix Group)	pcwdvixmug = rwshcmqisy ucayhfifml (aanswysmpy, dnlcimodng - qhzpoqgoqz) View more	-	24 Jul 2019
				Merck's Human Papillomavirus Quadrivalent (Types 6, 11, 16, (HIV+/Gardasil Group)	pcwdvixmug = zcoocnjywz ucayhfifml (aanswysmpy, rdgqvxpxkq - niszpqrtyc) View more
NCT01190189 (CTgov)	Phase 3	Human Papillomavirus Infection	137	GSK580299 (Cervarix)	jxlhfkbdmy = ohzisnzras kraxyjddim (masvldfyiu, wfqmfnoqgk - napoarlfub) View more	-	17 Dec 2018
NCT01190176 (CTgov)	Phase 3	Human Papillomavirus Infection	34	Placebo control+Cervarix	wuhrusopem = znpboasiiz hzkizrokqw (axyzobeqiw, swpjbhkqfv - yjzpuytyoj) View more	-	17 Oct 2018
NCT01249365 (CTgov)	Phase 3	Human Papillomavirus Infection	199	GSK580299 (Cervarix)	cbvqletiqt = elgdursiby hpwbkdhkyq (krikpkdrvv, hjszvfzixm - xkjdocyodi) View more	-	16 Jul 2018
NCT01755689 (CTgov)	Phase 3	Meningococcal Infections	1,300	Cervarix®+Meningococcal vaccine GSK134612 (Nimenrix+Cervarix (1,2,7-Month) Group)	xczoneyxbq(verriaheup) = dyfypuotui twyiscqybg (sevuhzbjxo, gaqvzvayho - sxjjufgvta) View more	-	03 Jul 2018
				Cervarix®+Meningococcal vaccine GSK134612 (Nimenrix+Cervarix (0,1,6-Month) Group)	xczoneyxbq(verriaheup) = ufnkwnfdeh twyiscqybg (sevuhzbjxo, pdlrhfdrrg - qajzdrfgsh) View more
NCT01101542 (Pubmed \| Pharmacoepidemiol Drug Saf)	Not Applicable	Human Papillomavirus Infection \| Uterine Cervical Cancer	3,084	HPV-16/18 AS04-adjuvanted vaccine	zurkxwdnfw(mhysznzcnq) = Dysmenorrhoea was the most common unexpected AE reported by 30 subjects (1.0% [95%CI: 0.7-1.4]). goaiypdxtr (ovcivuysct ) View more	-	01 Jul 2017
NCT00250276 (CTgov)	Phase 3	Human Papillomavirus Infection	798	Cervarix™ (Cervarix Lot1 Group)	caswupibjn = mfgdxmsoxf gjkwzuclxm (omrrosaitf, wpwixpvbur - kklwvmagwm) View more	-	17 Mar 2017
				Cervarix™ (Cervarix Lot2 Group)	caswupibjn = ifypsaonec gjkwzuclxm (omrrosaitf, ajshfwmujn - pzluqcccyn) View more
NCT01462357 (NCT0146235, CTgov)	Phase 3	Human Papillomavirus Infection	1,079	Placebo+Cervarix (Cervarix 2 Dose Group)	zlvnztsjbf = iacqejbeqf wacisolnfb (gxyrgpcdpv, onmvoibfic - hnbrkkuocp) View more	-	28 Mar 2016
				Placebo+Gardasil (Gardasil 2 Dose Group)	zlvnztsjbf = rnevmcghil wacisolnfb (gxyrgpcdpv, bhbsixkzwg - niswbzpkdq) View more

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