Last update 01 Nov 2024

Cervical Adenocarcinoma In Situ

Last update 01 Nov 2024

Basic Info

Synonyms

AIS - Adenocarcinoma in situ of cervix, Adenocarcinoma in situ of Cervix, Adenocarcinoma in situ of Cervix Uteri

+ [19]

Introduction

Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no longer includes stage 0. (AJCC 7th ed.)

Drugs associated with Cervical Adenocarcinoma In Situ

Human papillomavirus vaccine recombinant bivalent (Zerun Biotechnology)

Target-

Mechanism

Immunostimulants

Active Org.

Yuxi Zerun Biotechnology Co., Ltd.

Originator Org.

Walvax Biotechnology Co., Ltd. [+1]

Active Indication

Human Papillomavirus-Related Cervical Adenocarcinoma In Situ [+2]

Inactive Indication

Human Papillomavirus Infection

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date24 Mar 2022

Human papillomavirus vaccine [types 16, 18](GlaxoSmithKline Plc)

Target-

Mechanism

Immunostimulants

Active Org.

GlaxoSmithKline Biologicals SA [+2]

Originator Org.

GSK Plc

Active Indication

Uterine Cervical Dysplasia [+4]

Inactive Indication

Adenocarcinoma in Situ [+7]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

EU [+3]

First Approval Date20 Sep 2007

Human papillomavirus quadrivalent (types 6, 11, 16, 18) vaccine, recombinant(Emmanuel College, University of Queensland)

Target-

Mechanism-

Active Org.

Merck Sharp & Dohme BV [+3]

Originator Org.

Emmanuel College, University of Queensland

Active Indication

Anal Precancerous Condition [+11]

Inactive Indication

Acute Ischemic Stroke [+8]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date08 Jun 2006

Clinical Trials associated with Cervical Adenocarcinoma In Situ

ChiCTR2400088167 / RecruitingEarly Phase 1IIT

The value of human ASTN1, DLX1, ITGA4, RXFP3, SOX17, and ZNF671 gene methylation assays for the diagnosis and risk assessment of recurrence or progression of cervical ductal carcinoma in situ (AIS) and cervical adenocarcinoma: a multicenter, prospective, observational clinical study

Start Date16 Dec 2024

Sponsor / Collaborator-

ChiCTR2400079901 / SuspendedPhase 2IIT

The safety and effectiveness of primidone in the treatment of Acute Cerebral Ischemic Stroke

Start Date20 Feb 2024

Sponsor / Collaborator-

NCT06196190 / RecruitingNot ApplicableIIT

The Prognostic Value of Conization and Negative HPV Typing After Conization Prior to Surgical Intervention in Adenocarcinoma in Situ and Early Stage Cervical Cancer

In women with cervical cancer -Squamous cell carcinoma, Adeno carcinoma,
Adeno-squamous carcinoma or AIS we want to examine prospectively:
Examine if negative HR-HPV after conization to the HR-HPV the women had before conization has a high prognostic value for no residual tumor in the final pathology.
To examine if conization in women with cervical tumor up to Stage I B 2 (FIGO 2018) is corelated with better prognosis.

Start Date26 Jul 2023

Sponsor / Collaborator

Rambam Health Care Campus

100 Clinical Results associated with Cervical Adenocarcinoma In Situ

100 Translational Medicine associated with Cervical Adenocarcinoma In Situ

0 Patents (Medical) associated with Cervical Adenocarcinoma In Situ

147

Literatures (Medical) associated with Cervical Adenocarcinoma In Situ

01 Apr 2024·Data in Brief

CAISHI: A benchmark histopathological H&E image dataset for cervical adenocarcinoma in situ identification, retrieval and few-shot learning evaluation

Article

Author: He, Ruilin ; Li, Chen ; Grzegorzek, Marcin ; Liu, Chang ; Yang, Jinzhu ; Li, Xiaohan ; Yang, Xinyi ; Jiang, Tao ; Sun, Hongzan

A benchmark histopathological Hematoxylin and Eosin (H&E) image dataset for Cervical Adenocarcinoma in Situ (CAISHI), containing 2240 histopathological images of Cervical Adenocarcinoma in Situ (AIS), is established to fill the current data gap, of which 1010 are images of normal cervical glands and another 1230 are images of cervical AIS. The sampling method is endoscope biopsy. Pathological sections are obtained by H&E staining from Shengjing Hospital, China Medical University. These images have a magnification of 100 and are captured by the Axio Scope. A1 microscope. The size of the image is 3840 × 2160 pixels, and the format is ".png". The collection of CAISHI is subject to an ethical review by China Medical University with approval number 2022PS841K. These images are analyzed at multiple levels, including classification tasks and image retrieval tasks. A variety of computer vision and machine learning methods are used to evaluate the performance of the data. For classification tasks, a variety of classical machine learning classifiers such as k-means, support vector machines (SVM), and random forests (RF), as well as convolutional neural network classifiers such as Residual Network 50 (ResNet50), Vision Transformer (ViT), Inception version 3 (Inception-V3), and Visual Geometry Group Network 16 (VGG-16), are used. In addition, the Siamese network is used to evaluate few-shot learning tasks. In terms of image retrieval functions, color features, texture features, and deep learning features are extracted, and their performances are tested. CAISHI can help with the early diagnosis and screening of cervical cancer. Researchers can use this dataset to develop new computer-aided diagnostic tools that could improve the accuracy and efficiency of cervical cancer screening and advance the development of automated diagnostic algorithms.

01 Sep 2023·International journal of radiation oncology, biology, physics

The Updated World Health Organization Classification Better Predicts Survival in Patients With Endocervical Adenocarcinoma (KROG 20-07).

Article

Author: Yoon, Meesun ; Choi, Jin Hwa ; Kim, Yeon Joo ; Park, Won ; Kim, Kyu-Rae ; Kim, Young Seok ; Cho, Won Kyung ; Kim, Hyun-Soo ; Kwon, Sun Young ; Kang, Jun ; Kim, Yong Bae ; Kim, Nah Ihm ; Kim, Yeon-Sil ; Kim, Jin Hee

PURPOSEThe 2020 World Health Organization classification divided endocervical adenocarcinoma (ADC) into human papillomavirus-associated (HPVA) and human papillomavirus-independent (HPVI) ADCs. This multi-institutional study aimed to investigate the clinical features and prognosis of patients with endocervical ADC based on the updated World Health Organization classification.METHODS AND MATERIALSWe retrospectively reviewed the 365 patients with endocervical ADC who underwent radical hysterectomy from 7 institutions. Tumor characteristics, patterns of failure, and survival outcomes were compared between HPVA and HPVI ADCs.RESULTSTwo hundred seventy-five (75.3%) and 90 (24.7%) patients had HPVA and HPVI ADC diagnoses, respectively. In all cases, the 5-year disease-free survival (DFS) and overall survival (OS) rates were 58.2% and 71.3%, respectively. HPVI ADC showed higher rates of local recurrence (25.6% vs 10.9%) and distant metastasis (33.3% vs 17.5%) than HPVA ADC. Multivariate survival analysis revealed that HPVI ADC showed significantly worse DFS (hazard ratio [HR], 1.919; 95% confidence interval [CI], 1.324-2.781; P < .001), distant metastasis-free survival (HR, 2.100; 95% CI, 1.397-3.156; P < .001), and OS (HR, 2.481; 95% CI, 1.586-3.881; P < .001) than HPVA ADC. Patients with gastric- and serous-type HPVI ADC had significantly worse OS than those with other HPVI ADCs (P = .020). Similarly, invasive stratified mucin-producing-type HPVA ADC showed significantly worse OS than other HPVA ADCs (P < .001).CONCLUSIONSWe demonstrated that HPVI ADC exhibited inferior DFS and OS and higher rates of local and distant recurrence compared with HPVA ADC. Gastric- and serous-type HPVI ADCs and invasive stratified mucin-producing-type HPVA ADC showed worse OS than other types of HPVI and HPVA ADCs, respectively. Our observation of significant differences in prognoses according to the histologic types needs to be validated in larger cohorts of patients with endocervical ADC.

01 Sep 2023·Journal of Gynecology Obstetrics and Human Reproduction

Impact of cervical excisional dimensions on endocervical margins status in adenocarcinoma in situ of the uterine cervix: A multicenter study from the FRANCOGYN group

Article

Author: Delangle, Romain ; Carcopino, Xavier ; Bolze, Pierre-Adrien ; Canlorbe, Geoffroy ; Uzan, Catherine ; Lecointre, Lise ; Azaïs, Henri ; Castela, Mathieu ; Raimond, Emilie ; Bartin, Raphael ; Philip, Charles-Andre ; Mergui, Jean-Luc ; Kerbage, Yohan

OBJECTIVEExcisional procedures have a central role in the management of adenocarcinoma in situ of the cervix (AIS). We aimed to evaluate the relationship between the excisional specimen dimensions and the endocervical margin status.METHODSWe conducted a multicentric retrospective study in seven French centers. All cases with proven AIS on a colposcopic biopsy and undergoing an excisional procedure afterwards were included in the analysis. We evaluated the impact of excision length, along with the lateral and anteroposterior diameters on the endocervical margin status. An additional subgroup analysis of the impact of maternal age on endocervical margin status was also conducted.RESULTSOf the 101 cases of AIS diagnosed on initial biopsy, 95 underwent a primary excisional procedure, among which 80% (n = 76/95) had uninvolved endocervical margins and 20% (n = 19/95) had positive endocervical margins. The excisional specimen length was not significantly related to the endocervical margin status. Conversely, both lateral and antero-posterior diameters were significantly correlated with the negative endocervical margins status: OR = 1,19, 95% CI [1.03, 1.40], p = 0.025, for the lateral diameter and OR = 1.34, 95% CI [1.14, 1.64], p = 0.001 for the antero-posterior diameter. The median lateral diameter was 20 mm, IQR (18, 24) in case of endocervical negative margins vs. 18 mm IQR (15, 24) in case of positive endocervical margins (p = 0.039), and the median anteroposterior diameter was 17 mm IQR (15, 20) in case of negative endocervical margins vs 14 mm IQR (11, 15) in case of positive endocervical margins (p = 0.004), respectively. Additionally, in patients over 45 years old, endocervical margin were more likely to be positive despite similar excisional dimensions (7/17 (41%) of positive endocercival margins before 45 years old vs 12/78 (15%) after, p = 0.039) CONCLUSIONS: Endocervical margin statues were significantly related to the transverse diameters (lateral and anteroposterior diameters), but not to the excision specimen length. Reducing the excised length may lead to fewer post-procedure complications but would still allow to obtain a large proportion of negative endocervical margins.

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