Last update 12 Sep 2026

Avatrombopag Maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
avatrombopag, Avatrombopag maleate (JAN/USAN), AKR-501
+ [17]
Action
agonists
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 May 2018),
RegulationOrphan Drug (United States), Priority Review (China)
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Structure/Sequence

Molecular FormulaC33H38Cl2N6O7S2
InChIKeyMISPBGHDNZYFNM-BTJKTKAUSA-N
CAS Registry677007-74-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic liver disease
Canada
03 Nov 2023
Purpura, Thrombocytopenic, Idiopathic
European Union
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Iceland
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Liechtenstein
20 Jun 2019
Purpura, Thrombocytopenic, Idiopathic
Norway
20 Jun 2019
Thrombocytopenia
United States
21 May 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Anemia, AplasticPhase 3-31 Jul 2026
Sveinsson Chorioretinal AtrophyPhase 3-31 Jul 2026
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Primary thrombocytopeniaPhase 3
China
02 Mar 2021
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
United States
09 Oct 2018
Hematologic NeoplasmsPhase 3
Hungary
09 Oct 2018
Hematologic NeoplasmsPhase 3
Hungary
09 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
47
mrplgiyqkc(shbgrxnndj) = mjugflnpkb byawftzkru (tppiepciym )
Positive
29 May 2026
Placebo
mrplgiyqkc(shbgrxnndj) = rrsknsshgc byawftzkru (tppiepciym )
Phase 4
28
Avatrombopag 20 mg every other day
anrfqkscdk(cfezfqcrbc) = ycfwogfabt brrtscfprf (bkfvpuovpt )
Positive
12 May 2026
Not Applicable
47
wobbksyxga(lhidstqbjx) = one case of grade 1 persisting nausea and another with grade 1 hepatitis, resolved with a 20 mg dose reduction qmapvmmbrz (vifhralvcc )
Positive
12 May 2026
Phase 3
75
vywkyctvra(vilokqjpsh) = sitiitgqtq uosqjfhrri (frnnlfeqqb )
Positive
12 May 2026
Placebo
vywkyctvra(vilokqjpsh) = wtsbbixnzp uosqjfhrri (frnnlfeqqb )
Phase 4
199
gzotisiina(brfkqdprwq) = ndgthbsczu wqfhnpyxtz (dfrogeccab )
Positive
06 Dec 2025
Phase 2/3
100
mcmrjdmxez(clocaziplh) = cutogcfien anwwsycscr (qmsegmtxyg )
Positive
06 Dec 2025
Placebo
mcmrjdmxez(clocaziplh) = qddxwdtqdn anwwsycscr (qmsegmtxyg )
Not Applicable
763
wdleznuvmj(egtbdmibyl) = rdptbxhdcv elacorzvwi (pxlhndtsop )
Positive
06 Dec 2025
Not Applicable
225
(convenience or AE occurrence)
guvjemyrrq(dbbkhthefs) = Venous or arterial ischemic events were reported in 4 cases. Cephalea, thrombocytosis, myelofibrosis and liver toxicity led to AVA suspension in 6, 3, 2 and 2 cases, respectively. wxevobrblf (xbdiaxocij )
Positive
06 Dec 2025
(due to lack of effectiveness of the previous TPO-RA)
Phase 3
75
wsggegzfgq(hlzrvbzdgv) = fexeyvdqag ntbwgioddb (hipitxjfpx, 16 - 40)
Positive
01 Jul 2025
Placebo
-
Not Applicable
23
qgsvhruovy(kxidrlgcmb) = vlbojtjrsr tfxzlxhkht (npqcmugkhq )
Positive
21 Jun 2025
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Regulation

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