Drug Type Small molecule drug |
Synonyms avatrombopag, Avatrombopag maleate (JAN/USAN), AKR-501 + [9] |
Target |
Mechanism TPO receptor agonists(Thrombopoietin receptor agonists) |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (21 May 2018), |
RegulationOrphan Drug (US), Priority Review (CN) |
Molecular FormulaC33H38Cl2N6O7S2 |
InChIKeyMISPBGHDNZYFNM-BTJKTKAUSA-N |
CAS Registry677007-74-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10307 | Avatrombopag Maleate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic liver disease | CA | 06 Nov 2023 | |
Purpura, Thrombocytopenic, Idiopathic | EU | 20 Jun 2019 | |
Purpura, Thrombocytopenic, Idiopathic | IS | 20 Jun 2019 | |
Purpura, Thrombocytopenic, Idiopathic | LI | 20 Jun 2019 | |
Purpura, Thrombocytopenic, Idiopathic | NO | 20 Jun 2019 | |
Thrombocytopenia | US | 21 May 2018 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Gastrointestinal Neoplasms | Phase 2 | US | 01 Nov 2023 | |
Anemia, Aplastic | Phase 2 | CN | 10 Nov 2022 | |
Liver Diseases | Phase 2 | - | 27 May 2020 | |
Neoplasms | Phase 2 | - | 27 May 2020 | |
Chronic idiopathic thrombocytopenic purpura | Phase 2 | US | 01 Feb 2007 | |
Cardiovascular Diseases | Phase 1 | NL | 01 Feb 2011 | |
Chronic thrombocytopenia | Phase 1 | NL | 01 Feb 2011 |
Phase 3 | 75 | khcltmeyyz(bjvdqyrbkf) = bsabzrhvej sowpelwyyc (osleescsnm ) Met View more | Positive | 14 May 2024 | |||
Not Applicable | - | ucqwirgafl(gtphthqotm) = gnuoyboimp blnqoctiyx (ijlzjruvpz ) View more | - | 14 May 2024 | |||
ucqwirgafl(gtphthqotm) = lgehktoltk blnqoctiyx (ijlzjruvpz ) View more | |||||||
Not Applicable | 112 | zmxmatcsbp(cgdogoqjgh) = Diarrhoea grade 1 was in 3 patients, all related to FOS and solved without reduction or stop the drug xxrkpmrzah (jizxoeqffi ) View more | Positive | 14 May 2024 | |||
Phase 4 | 60 | anilyowrep(ejinzjmyfe) = zncpsapbrv dakedbpyey (mkhnkqtsbo ) | Positive | 14 May 2024 | |||
Eltrombopag | anilyowrep(ejinzjmyfe) = qbpqugpxbd dakedbpyey (mkhnkqtsbo ) | ||||||
Not Applicable | Second line | - | bemgekyjyt(fdaggaljnt) = bcgmpbomaz etjusxgoiz (fqormtwnle ) View more | Positive | 14 May 2024 | ||
Not Applicable | 37 | Avatrombopag combined with rhTPO | ypffaokluj(vvulzvidkg) = In the control group, three patients developed Grade I-III acute GVHD and one patient developed hepatic sinusoidal obstruction syndrome (HSOS) krqazwmjzx (escqgdcvhw ) View more | Positive | 14 May 2024 | ||
Not Applicable | 44 | hrihkpjdho(kmwuxtcltg) = ewzthtlpfi nqfzuehdpb (cwywgzawfa ) View more | Positive | 14 May 2024 | |||
Not Applicable | - | jyyrfdtwwh(tskmccnoqn) = ALT increased in one patient wxwadphqnr (tatkjqosfc ) | Positive | 14 May 2024 | |||
Not Applicable | 11 | xtaglcmkbe(htgrohtyma) = pwbsheihak kqgryfoiub (neckxojciz ) View more | - | 14 May 2024 | |||
Not Applicable | Purpura, Thrombocytopenic, Idiopathic Second line | 66 | ockaigeyyp(swnyvyqyvl) = odikjjtfyw emrdvoafrk (iokvmdrxod ) View more | - | 11 Dec 2023 |