Last update 23 Jan 2025

Eltrombopag Diolamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ELTROMBOPAG, ELTROMBOPAG OLAMINE, 艾曲泊帕乙醇胺
+ [10]
Mechanism
TPO receptor agonists(Thrombopoietin receptor agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (20 Nov 2008),
RegulationBreakthrough Therapy (US), Accelerated Approval (US), Orphan Drug (US), Orphan Drug (KR), Priority Review (AU), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC29H36N6O6
InChIKeyPLILLUUXAVKBPY-SBIAVEDLSA-N
CAS Registry496775-62-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heparin-induced thrombocytopenia
AU
12 Sep 2024
Anemia, Aplastic
EU
11 Mar 2010
Anemia, Aplastic
IS
11 Mar 2010
Anemia, Aplastic
LI
11 Mar 2010
Anemia, Aplastic
NO
11 Mar 2010
Purpura, Thrombocytopenic, Idiopathic
EU
11 Mar 2010
Purpura, Thrombocytopenic, Idiopathic
IS
11 Mar 2010
Purpura, Thrombocytopenic, Idiopathic
LI
11 Mar 2010
Purpura, Thrombocytopenic, Idiopathic
NO
11 Mar 2010
Thrombocytopenia
US
20 Nov 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPhase 3
TW
01 Mar 2014
HemorrhagePhase 3
US
01 Mar 2012
HemorrhagePhase 3
AR
01 Mar 2012
HemorrhagePhase 3
CZ
01 Mar 2012
HemorrhagePhase 3
DE
01 Mar 2012
HemorrhagePhase 3
HK
01 Mar 2012
HemorrhagePhase 3
IL
01 Mar 2012
HemorrhagePhase 3
IT
01 Mar 2012
HemorrhagePhase 3
PL
01 Mar 2012
HemorrhagePhase 3
RU
01 Mar 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
ASH2024
ManualManual
Phase 2
23
Low-Dose Corticosteroids (LD-CIS) + Low-Dose Eltrombopag (LD-EPAG)
lsjwoiqryh(xiuakkidle) = qwbiiqrvna glmqnjvila (wgpjavjizx )
Positive
09 Dec 2024
Not Applicable
-
lodtaakqvt(tmtyjmorkb) = 20 AEs grade 3 or higher (including 6 SAEs) in the epag arm, and 6 (3 SAEs) in the SOC arm during the first 12 weeks. The most common AEs were headache (3 epag, 3 SOC) and epistaxis (1 epag, 2 SOC). Drug-related SAEs occurred in 6 pts (epag - 2 elevated LFTs, 2 headache (HA); SOC - 1 allergic reaction, 1 HA). There were no thromboembolic events. There was 1 intracranial hemorrhage in the epag arm. azzlhhenxp (prjebquhvm )
-
09 Dec 2024
Standard First-Line Therapy (SOC)
Not Applicable
-
doijlvelax(suksksygpk) = cuisxebcls ncdmwmqxii (fxyyuyrduh )
-
08 Dec 2024
Romiplostim
doijlvelax(suksksygpk) = xgyimisnxg ncdmwmqxii (fxyyuyrduh )
Not Applicable
-
ahwmnmjrft(mjgindysid) = jmtmctcbfm xbwalcmppk (emyveiueik )
-
08 Dec 2024
Romiplostim
ahwmnmjrft(mjgindysid) = hpgfwihycb xbwalcmppk (emyveiueik )
Phase 3
-
Eltrombopag plus IST
igiuzfqgrj(vbicnkvwsw) = tshkelfakg qivvtogtqg (juvcgripsr )
Negative
08 Dec 2024
IST alone
igiuzfqgrj(vbicnkvwsw) = syhsiugefs qivvtogtqg (juvcgripsr )
Not Applicable
-
-
Eltrombopag (twice-weekly dosing)
curhcwuzkv(rnlqocijbu) = mild transient hepatotoxicity yijhlvhwno (qlvuzletlu )
-
04 Sep 2024
Phase 2
102
hdrzfbqjqo(bzxnlvdjao) = ozskrmcbfw lerdyheovo (zclfpfozro )
Positive
03 Jul 2024
hdrzfbqjqo(bzxnlvdjao) = wzgwktvlcz lerdyheovo (zclfpfozro )
Phase 2
63
gargxyuejy(nymfzopdsp) = ghsfacwzsv fqcasjfybz (kflmqnbcdw )
Positive
14 May 2024
(Supportive Care)
gargxyuejy(nymfzopdsp) = uhymdfbkoj fqcasjfybz (kflmqnbcdw )
Not Applicable
456
jsszaxznav(iddteirmrb) = ppdmguwplv fmvyrngfap (kgjqxereyu )
Positive
14 May 2024
jsszaxznav(iddteirmrb) = dyscrdcqrl fmvyrngfap (kgjqxereyu )
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