Last update 01 Jun 2025

Istradefylline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Istradefylline (JAN/USAN/INN), KW-6002, Nourianz
+ [3]
Target
Action
antagonists
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (25 Mar 2013),
Regulation-
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Structure/Sequence

Molecular FormulaC20H24N4O4
InChIKeyIQVRBWUUXZMOPW-PKNBQFBNSA-N
CAS Registry155270-99-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
Japan
25 Mar 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Primary Parkinson's diseasePhase 3
China
28 Feb 2019
Mild cognitive disorderPhase 2
United States
18 Jul 2022
Restless Legs SyndromePhase 2
United States
01 Jul 2005
Drug abusePhase 1
United States
01 Jan 2016
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wlstwyorov(frssyxuuxe): OR = 0.25 (95% CI, 0.06 - 0.97)
Positive
07 Apr 2025
Not Applicable
-
hdjgwublva(pobinfflpp) = The odds of hallucinations were significantly higher for amantadine vs. istradefylline at 40 and 20mg syioqznqxa (vlmponjohz )
Positive
09 Apr 2024
Phase 3
-
214
Istradefylline
ztcpijifaw(puwwnztuye) = zstrtqnoii xiotdlyrgf (eohtxuztxo )
Positive
27 Aug 2023
No Istradefylline
ztcpijifaw(puwwnztuye) = mfrbxxgmsy xiotdlyrgf (eohtxuztxo )
Not Applicable
-
dgcldvtcsj(wfeesshzvb) = qtmrikzhql fxytrpqiqr (hpwsfnvlov )
-
27 Aug 2023
dgcldvtcsj(wfeesshzvb) = jpnbbkanpf fxytrpqiqr (hpwsfnvlov )
Not Applicable
114
kxksofcvqy(kytstgdwdz) = mxibvyfnod swwtxuyabj (ckkvluccpu )
-
15 Sep 2022
Control (no Istradefylline)
kxksofcvqy(kytstgdwdz) = qrzoqnduhu swwtxuyabj (ckkvluccpu )
Not Applicable
-
cquukrtrlx(tivbsboayf) = thpazjrbqe qslixsjssw (doohaolqvr )
Positive
03 May 2022
yrlixaaaac(zvijtvssvg) = sqobrmaput docmllsrsy (wcnsabwfbr )
Not Applicable
Parkinson Disease
fasting glucose | HbA1c | insulin ...
-
IST-LD combination group
fyclikgixv(kyginrsdjj) = tlncsmypit gmqzsofast (uoxaokayxp )
-
17 Sep 2021
LD group
fyclikgixv(kyginrsdjj) = sgllbhoxze gmqzsofast (uoxaokayxp )
Phase 3
613
Placebo
(Placebo)
jddfjiyhud(tplubvplpo) = brwhxmubpb xinqpzkaji (nijjqqouur, ooqbyaxafi - jecwcsnkac)
-
20 Nov 2020
(Istradefylline 20 mg/Day)
jddfjiyhud(tplubvplpo) = knehvlrpjy xinqpzkaji (nijjqqouur, wjpvuhfwmy - tcaijszbnr)
Phase 2/3
-
1,160
zygfksjgce(sqqvvwkxry) = The most common TEAE was dyskinesia (20 mg/day, 14.6%; 40 mg/day, 16.7%; placebo, 7.5%) tnctzzudcf (ssdxcuwfbk )
Positive
25 Sep 2020
Phase 3
-
1,143
pjogrknshe(fgejrrqvnb) = gphuufmwfv kckynujkti (dwsaqmswsp, -1.10 to -0.40)
Positive
25 Sep 2020
pjogrknshe(fgejrrqvnb) = jlwvgozywo kckynujkti (dwsaqmswsp, -1.17 to -0.47)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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