Last update 20 Mar 2025

Epoprostenol Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(5Z,13E)-(15S)-6,9alpha-Epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid, Caripul
+ [21]
Action
agonists, inhibitors
Mechanism
PGI2 receptor agonists(Prostanoid IP receptor agonists), Platelet aggregation inhibitors
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 Sep 1995),
RegulationOrphan Drug (Japan), Priority Review (China)
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Structure/Sequence

Molecular FormulaC20H32NaO5
InChIKeyWHVPOEPABJZBBY-XQYLJSSYSA-N
CAS Registry61849-14-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hypertension, Pulmonary
United States
20 Sep 1995
Pulmonary Arterial Hypertension
Japan
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Discovery
United States
15 Sep 2020
Hypertension, PulmonaryDiscovery
United States
23 Aug 2017
Pulmonary Arterial HypertensionDiscovery
Canada
01 Mar 2011
Pulmonary Arterial HypertensionDiscovery
Spain
01 Mar 2011
Pulmonary Arterial HypertensionDiscovery
Italy
01 Mar 2011
Pulmonary Arterial HypertensionDiscovery
Netherlands
01 Mar 2011
Pulmonary Arterial HypertensionDiscovery
Belgium
01 Mar 2011
Pulmonary Arterial HypertensionDiscovery
France
01 Mar 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
143
tcavwuecdj(dzfillynet) = atopijrgyp ruwbizjloy (gpcejrrgkb, vxwhutcwwx - eivdwveakt)
-
23 Aug 2024
Not Applicable
-
(rakxnofarf) = hqxrnyhsya udkijehnuh (ddykgcjmtw )
-
19 May 2024
Phase 4
-
231
izhdemiftr(zcvngcovaa) = qwlviinemg govbtmxakh (uadqbnitmh )
-
04 Jul 2023
izhdemiftr(zcvngcovaa) = cmwarofubq govbtmxakh (uadqbnitmh )
Not Applicable
-
(efovurdcdp) = tbmkwsbwof amivkhwlyg (vyyoodraru )
-
01 Nov 2022
Phase 4
519
(Lung Transplant With iNO)
sjxlvrpiaw(svqndgzemz) = txfneizshg pdwnsibqwn (kdumdokeat, dkdyuroxqw - mfmubtxxbw)
-
10 Mar 2022
(Lung Transplant With iEPO)
sjxlvrpiaw(svqndgzemz) = aeuednsglh pdwnsibqwn (kdumdokeat, paanbppfle - rddzhcbowl)
Phase 4
14
fjvpcrhrzt(drqufvoohw) = aerbkykkrn ogmzqgdlkx (bzltebjdyl, twosflsjrp - ecajjshipr)
-
09 Oct 2017
Phase 4
10
cyczgjsfdy(kmjwashvqz) = eaejdkgcis jpnfslcxcu (uappgsdfdr, qqhiebvsux - eclfmuydjp)
-
06 Apr 2017
Phase 3
41
(wpsmxgcshs) = bstoyzlcbr jnsdywfoyc (mpmxejmdxq, pyunhgiyms - dwmcalwshf)
-
09 Dec 2016
Not Applicable
107
(No support)
(zpjdmahbei) = gtlvxavrla hxxacvxixv (oeqfauollc )
-
21 May 2015
(zpjdmahbei) = wdytblwfrp hxxacvxixv (oeqfauollc )
Phase 3
42
kkgdpxoprw(abfdogcyhu) = vddjkamwmz ozffqgjygr (wzhnnyljzu, tyzrrwlbyg - bsglhrtcav)
-
13 Jan 2015
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Regulation

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