Delving into the Latest Updates on Tocopherol Acetate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Tocopherol acetate (JP17), Tocopherol acetate, unspecified, Tocopheryl acetate

+ [15]

Target

Free radicals

Action

inhibitors

Mechanism

Free radicals inhibitors

Therapeutic Areas

Cardiovascular DiseasesEndocrinology and Metabolic DiseaseEye Diseases+ [1]

Active Indication

AtherosclerosisDiabetic RetinopathyFrostbite+ [4]

Inactive Indication-

Originator Organization

Alfresa Pharma Corp.

Active Organization

Sannova KK

Alfresa Pharma Corp.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (09 Dec 1961),

Vitamin E Deficiency

Regulation-

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Structure/Sequence

Molecular FormulaC31H52O3

InChIKeyZAKOWWREFLAJOT-CEFNRUSXSA-N

CAS Registry58-95-7

Medication-related osteonecrosis of the jaw (MRONJ) occurs after taking bisphosphonates or targeted therapies. It leads to a significant decrease in quality of life with pain, eating and chewing disorders, and malnutrition. Current treatments are only partially effective. PENTO (pentoxifylline and tocopherol) has been shown to be effective in maxillary osteoradionecrosis. The objective of this study is to evaluate the proportion of bone recovery in patients receiving PENTO in MRONJ at 12 months.

Start Date29 Feb 2024

Sponsor / Collaborator

Centre Hospitalier Universitaire de Limoges

NCT06019858

/ CompletedNot Applicable

A Clinical Trial to Assess the Effects of a Vitamin Shot on Energy Levels

This is a virtual, single-arm clinical trial that will last 30 days. Participants will drink 1 bottle of the Vitamin Energy® shot daily and complete questionnaires at baseline, Day 7, Day 14, and Day 30.
Participants' energy, mood, and cognitive function will be evaluated at baseline and at each check-in. Bodyweight will also be assessed at baseline and Day 30. Likert scale responses will be examined from baseline to each check-in. Participant responses on product feedback will be presented as % scores.

Start Date21 Jun 2023

Sponsor / Collaborator-

100 Clinical Results associated with Tocopherol Acetate

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100 Translational Medicine associated with Tocopherol Acetate

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100 Patents (Medical) associated with Tocopherol Acetate

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4,655

Literatures (Medical) associated with Tocopherol Acetate

01 Jun 2025·Case Studies in Chemical and Environmental Engineering

Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing

Author: Suratno ; Anggraeni, Ayu Septi ; Khasanah, Yuniar ; Nurfahmi, Laely ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian

A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.

01 Apr 2025·Food Chemistry

Identification of phenols and their formation network during the brewing process of Shanxi aged vinegar

Article

Author: Liang, Kai ; Tu, Linna ; Zhu, Boya ; Zheng, Yu ; Song, Jia ; Wang, Jiao ; Zhang, Yushi ; Liu, Jing ; Wang, Min

Phenols are important functional compounds present in vineagr, however, their composition and formation pathways remain uncertain. Herein, non-targeted metabolomics and macrotranscriptomics methods were applied to identify phenols and analyze their formation network during the brewing process of Shanxi aged vinegar. A total of 82 phenols were detected from the raw material and the brewing process. Results indicated that phenolic acids were the major phenols and were mainly formed during acetic acid fermentation stages. Water, reducing sugars, lactic acid, and 7 amino acids influenced the formation and transformation of phenols, as shown through Spearman analysis. Furthermore, 16 genera and 38 enzymes were involved in substrates decomposition and phenols formation according to the metabolic pathway analysis, with Xenobiotics biodegradation and metabolism identified as the main pathway for phenols formation. Lactobacillus and Acetobacter were the key genera responsible for the phenols transformation. This study provides new insights into the phenols formation mechanisms in cereal vinegars and it is helpful for isolating the functional strains to reinforce the phenols formation.

03 Mar 2025·Artificial Cells, Nanomedicine, and BiotechnologyQ2 · ENGINEERING & TECHNOLOGY

Cholesterol and vitamin E-conjugated PEGylated polymeric micelles for efficient delivery and enhanced anticancer activity of curcumin: evaluation in 2D monolayers and 3D spheroids

Q2 · ENGINEERING & TECHNOLOGY

ArticleOA

Author: Vanaparthi, Asmitha ; Biswas, Swati ; Kumari, Preeti ; Ghosh, Balaram ; Muddineti, Omkara Swami ; Rompicharla, Sri Vishnu Kiran

A newly synthesized PEGylated cholesterol/α-tocopheryl succinate (α-TOS) linked polymer (CV) was self-assembled and loaded with curcumin to form a micellar system (C-CVM). The tri-functionalized amphiphilic polymer was constituted of hydrophobic cholesterol and α-TOS connected to hydrophilic PEG via a lysine linker. The synthesized polymer and the micelles were characterized by ¹H NMR, DLS, zeta potentiometer, TEM, CMC determination and hemolysis studies. CVM displayed low CMC value of 15 µM with extent of hemolysis as less than 4%. The stable C-CVM with optimum % drug loading (14.2 ± 0.24) displayed Z average of 175.8 ± 0.68 nm with PDI (0.248 ± 0.075) and released curcumin in sustained manner in the in vitro drug release study. C-CVM demonstrated dose-dependent cellular uptake and cytotoxicity in murine melanoma, B16F10 and human breast cancer, MDA-MB-231 cell lines. CV exhibited marked reversal of drug resistance as indicated by significantly higher retention of P-glycoprotein substrate, rhodamine-123 in the resistant B16F10 cell line compared to standard P-glycoprotein inhibitor, verapamil. C-CVM demonstrated significantly higher spheroidal growth inhibition compared to C-PPM. The results provide strong evidence for CVM as promising drug delivery system and confirm the potential of C-CVM as chemotherapy in cancer.

100 Deals associated with Tocopherol Acetate

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External Link

KEGG	Wiki	ATC	Drug Bank
D01735	Tocopherol Acetate	A11HA03	DB14003

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Atherosclerosis	Japan	Sannova KK	01 Jan 1963
Diabetic Retinopathy	Japan	Sannova KK	01 Jan 1963
Frostbite	Japan	Sannova KK	01 Jan 1963
Intermittent Claudication	Japan	Sannova KK	01 Jan 1963
Thrombosis	Japan	Sannova KK	01 Jan 1963
Venous Thromboembolism	Japan	Sannova KK	01 Jan 1963
Vitamin E Deficiency	Japan	Alfresa Pharma Corp.	09 Dec 1961

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02251041 (CAPITL, CTgov)	Phase 2	Reperfusion Injury	143	C1-Inhibitor+Epoprostenol+Infliximab+Melatonin+Alfa-tocopherol+Human recombinant erythropoietin+Glutathione	vlfbcuzluz(fkfedkvwfc) = vhlfuxvhwi bugzduipnz (kumxfmoyct, jpfwegldgb - gceugwfbmd) View more	-	23 Aug 2024
AHNS2023	Not Applicable	Stomatitis	-	?-tocopherol (Cinnamaldehyde)	qbxigvsegg(ncmlnqrour) = oqddhxebpr tihpbbqdcl (hunmkglgjq )	-	08 Jul 2023
				α-tocopherol	qbxigvsegg(ncmlnqrour) = zxksfjnlxa tihpbbqdcl (hunmkglgjq )
ATS2023	Not Applicable	-	-	Vitamin E Acetate (VEA aerosol)	scrtxqiefh(qfxgfzvccz) = saiyxysgdj yozsilmkgi (mmelcztofr )	-	21 May 2023
				Vitamin E Acetate (Pure VEA)	scrtxqiefh(qfxgfzvccz) = jyruzvccpj yozsilmkgi (mmelcztofr )
NCT02911688 (Gammoz, CTgov)	Phase 2	Allergic asthma	18	gamma tocopherol (Gamma Tocopherol)	xrkduxfmta(lypymrwaal) = ruqrwrirvg owishlypof (szpnadywjc, ftqbhpsgwn - uaxqocfqms) View more	-	18 Jan 2020
				Placebo (Placebo)	xrkduxfmta(lypymrwaal) = euilmgxvrz owishlypof (szpnadywjc, dpgodznhnp - irfbatuuoq) View more
NCT02104505 (Vitalps, CTgov)	Phase 1/2	Mild asthma	23	Placebo	xcaechnrco(shhaefelgg) = afalfswmbe rrdnhdsqum (gcvzromeeq, mmbfwozfhg - qxdquxgkvg) View more	-	06 Nov 2017
AAI2010	Not Applicable	Asthma	-	Alpha tocopherol	niheuhqqdf(rvgzkipzdx) = mfccnhbjll scooeqoavo (yhqhqbmxau )	Positive	01 Apr 2010
				Gamma tocopherol	niheuhqqdf(rvgzkipzdx) = egicosnnpa scooeqoavo (yhqhqbmxau )