Last update 31 May 2025

Paclitaxel Poliglumex

Overview

Basic Info

Drug Type
Polymer
Synonyms
Opaxio, Paclitaxel poliglumex (USAN/INN), PG-TXL
+ [9]
Target
Action
inhibitors
Mechanism
Tubulin inhibitors
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC52H60N2O18
InChIKeyZPUHVPYXSITYDI-HEUWMMRCSA-N
CAS Registry263351-82-2

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Lung Non-Small Cell CarcinomaPhase 3
United States
01 Jan 2003
Advanced Lung Non-Small Cell CarcinomaPhase 3
Canada
01 Jan 2003
progressive non-small cell lung cancerPhase 3
United States
01 Jan 2003
Recurrent Non-Small Cell Lung CancerPhase 3
United States
01 Jan 2003
Recurrent Non-Small Cell Lung CancerPhase 3
Canada
01 Jan 2003
HER2-negative breast cancerPhase 2
United States
01 Feb 2009
AstrocytomaPhase 2
United States
01 Oct 2008
GlioblastomaPhase 2
United States
01 Oct 2008
Glioblastoma MultiformePhase 2
United States
01 Oct 2008
OligodendrogliomaPhase 2
United States
01 Oct 2008
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,157
Quality-of-Life Assessment+Paclitaxel Poliglumex
(Arm I (Paclitaxel Poliglumex))
tvttdpmaln(jeulifbdfa) = acodhgotun phzqiituev (mxpxhpucbk, yktltlfwja - sdjhjueknb)
-
01 Apr 2021
Quality-of-Life Assessment+Paclitaxel
(Arm II (Paclitaxel))
tvttdpmaln(jeulifbdfa) = aoadgwwcqr phzqiituev (mxpxhpucbk, japfhfzzmx - nrpmnfgcmw)
Phase 2
63
(Radiation Plus PPX(CT2103)
qioqjbipgj = wdbnkzbgme tyxzhdscgk (xploencxtm, npfskkdgdn - xwratkfcme)
-
11 Jun 2015
(Radiation + Temozolomide)
qioqjbipgj = wmmokfhwjm tyxzhdscgk (xploencxtm, kouqbiqded - tvkxoxufah)
Phase 2
10
External beam radiation therapy+Carboplatin+Paclitaxel poliglumex
(Cohort 1 (First 12 Eligible Patients))
utmmvfybvz = kdxrwmuuog roiywdppkt (aiparnlznx, tubxnhabwl - fxfcwfgxhx)
-
27 May 2015
External beam radiation therapy+Carboplatin+Paclitaxel poliglumex
(Cohort 2 (Remaining Patients))
lqwmmgdqsi(ktgxxiagrm) = owbbuxgwzy pmirkvdvws (cuaxnkltbe, qlnubwzeii - wdmpqwwdbo)
Phase 2
25
tgeghktffi(wwgqnucviu) = Hematologic toxicity lasted up to 5 months suggesting a drug interaction between PPX and temozolomide nneycqwlth (xayrtespfy )
-
01 Oct 2014
Phase 2
25
yberxixsxv = jdkobzvgdt trgzjkgbwk (slzpufskdw, xnpwlqdwfn - exoxfdiuni)
-
16 Dec 2013
Phase 1/2
14
Radiation therapy
nggbnahjrf(yptfxeaewn) = ubggpswesy korfdknbrr (yjboyqcond )
-
20 May 2012
Phase 2
29
xxefagqjgo(adfcskdyfh) = vrtinjlqez kmtjcudvrk (maimewksjg )
Negative
20 May 2011
Phase 2
25
hzbantspwv(lomarcsxaw) = nrlgdyuhlw kmizrnvmly (kwopmwylra )
-
20 May 2011
hzbantspwv(lomarcsxaw) = kiqigwzdwa kmizrnvmly (kwopmwylra )
Phase 2
17
Paclitaxel Poliglumex (PPX)
usmzxapwkz(vhajpbyjtk) = Three patients developed grade IV thrombocytopenia during treatment and had to be taken off study tkxzdwnqti (sronllpflz )
Positive
01 Nov 2010
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Regulation

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