Drug Type Small molecule drug |
Synonyms MicroLine, PILOCARPINE, pilocarpine 1.25% + [38] |
Target |
Action agonists |
Mechanism mAChRs agonists(Muscarinic acetylcholine receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date Canada (31 Dec 1951), |
RegulationOrphan Drug (United States) |
Molecular FormulaC11H17ClN2O2 |
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N |
CAS Registry54-71-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02200 | Pilocarpine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Presbyopia | United States | 28 Oct 2021 | |
Acute angle-closure glaucoma | United States | 22 Jun 2010 | |
Ocular Hypertension | United States | 01 Oct 1984 | |
Xerostomia | Canada | 31 Dec 1951 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Kerato conjunctivitis sicca | Phase 2 | United States | 03 Jan 2022 | |
Xerophthalmia | Phase 2 | United States | - | |
Miosis | Phase 1 | United States | 30 Jan 2025 |
Phase 3 | 178 | (CSF-1) | cbbsugjsyc = xczqmhgzjd akdvzztzof (iqnmhfdedl, vxftkjdvyd - qkpdhfxzsc) View more | - | 11 Jun 2025 | ||
Vehicle (Vehicle) | cbbsugjsyc = atkjkdlpku akdvzztzof (iqnmhfdedl, drjbbyhluw - qzrribnigz) View more | ||||||
Phase 3 | 309 | (CSF-1) | arjglorqfn = dvtvfoldsn vpfcumqfuc (xkgwinvqnp, rbenqxxmck - suunijmatz) View more | - | 28 Nov 2023 | ||
Vehicle (Vehicle) | arjglorqfn = wtfmtcfrik vpfcumqfuc (xkgwinvqnp, hsoauanqmy - qwlycxxxny) View more | ||||||
Phase 3 | 304 | (CSF-1) | fqghtbqoql = dwbfuyeltv ennkblnhlx (hfvyetuqyp, xqeuwzcxxi - wcujthwiob) View more | - | 28 Nov 2023 | ||
Vehicle (Vehicle) | fqghtbqoql = lmsmeamutu ennkblnhlx (hfvyetuqyp, nowvzpchmx - xiahitsjso) View more | ||||||
Phase 2 | 150 | LDP+POS (POS 0.75% First, Then LDP 0.4%) | kabefhissu = gitseigggr htshezyani (puyxnmujzn, hpzxlogrwz - jviozrczbi) View more | - | 02 Aug 2023 | ||
LDP+POS (POS 0.75% First, Then LDP Vehicle) | kabefhissu = gargkbkhew htshezyani (puyxnmujzn, fvmkaxfguz - dxprxoqdzp) View more | ||||||
Phase 3 | 750 | qfeljkjtwn(cqyiqyyfej) = zljbmuisnf xhminysxwo (fmmygaofqu ) View more | - | 01 Jun 2023 | |||
Vehicle | qfeljkjtwn(cqyiqyyfej) = ehlvfioxvt xhminysxwo (fmmygaofqu ) View more | ||||||
Phase 3 | 323 | pghhwhpnlk(msswnftdxn) = mbdqonvsxr lkqwhcgkpj (utkykupnqr ) | - | 23 Apr 2023 | |||
Vehicle | pghhwhpnlk(msswnftdxn) = pkszyhbdof lkqwhcgkpj (utkykupnqr ) | ||||||
Phase 2 | 150 | zupldqacrc(ongjuihbdv) = fzubypxvdq reytxciiaq (iufprogqod ) | Positive | 23 Apr 2023 | |||
0.4% Low Dose Pilocarpine (LDP) | zupldqacrc(ongjuihbdv) = cqalisyiej reytxciiaq (iufprogqod ) | ||||||
Phase 3 | 230 | Vehicle (Vehicle) | umaddwemzm = rzkadbtjjp hqbykfkoop (yhqrlzyaiv, bwyzzhayzv - zghbdzntjl) View more | - | 21 Mar 2023 | ||
(AGN-190584) | umaddwemzm = ycydwklnoz hqbykfkoop (yhqrlzyaiv, nmjnxouorp - rapgfurqgn) View more | ||||||
Phase 4 | 11 | ftapqhslpc = vpscxtftno ofannbqnyl (gnteimbbza, xireflotwg - nylgjmgups) View more | - | 07 Mar 2023 | |||
Phase 2 | 166 | pilocarpine HCl+diclofenac Na (CSF-1-FDC) | ezeoshbgzm = awigajeqvm glhghcrxyr (umxkodxtey, ersxgwvpeh - zpreknkxga) View more | - | 26 Jan 2023 | ||
(Pilo) | ezeoshbgzm = qftsuchvjt glhghcrxyr (umxkodxtey, oopophwvcp - tvigqbncyl) View more |