Last update 30 Aug 2025

Pilocarpine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MicroLine, PILOCARPINE, pilocarpine 1.25%
+ [38]
Target
Action
agonists
Mechanism
mAChRs agonists(Muscarinic acetylcholine receptor agonists)
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Canada (31 Dec 1951),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC11H17ClN2O2
InChIKeyRNAICSBVACLLGM-GNAZCLTHSA-N
CAS Registry54-71-7

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Presbyopia
United States
28 Oct 2021
Acute angle-closure glaucoma
United States
22 Jun 2010
Ocular Hypertension
United States
01 Oct 1984
Xerostomia
Canada
31 Dec 1951
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kerato conjunctivitis siccaPhase 2
United States
03 Jan 2022
XerophthalmiaPhase 2
United States
-
MiosisPhase 1
United States
30 Jan 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
178
(CSF-1)
cbbsugjsyc = xczqmhgzjd akdvzztzof (iqnmhfdedl, vxftkjdvyd - qkpdhfxzsc)
-
11 Jun 2025
Vehicle
(Vehicle)
cbbsugjsyc = atkjkdlpku akdvzztzof (iqnmhfdedl, drjbbyhluw - qzrribnigz)
Phase 3
309
(CSF-1)
arjglorqfn = dvtvfoldsn vpfcumqfuc (xkgwinvqnp, rbenqxxmck - suunijmatz)
-
28 Nov 2023
Vehicle
(Vehicle)
arjglorqfn = wtfmtcfrik vpfcumqfuc (xkgwinvqnp, hsoauanqmy - qwlycxxxny)
Phase 3
304
(CSF-1)
fqghtbqoql = dwbfuyeltv ennkblnhlx (hfvyetuqyp, xqeuwzcxxi - wcujthwiob)
-
28 Nov 2023
Vehicle
(Vehicle)
fqghtbqoql = lmsmeamutu ennkblnhlx (hfvyetuqyp, nowvzpchmx - xiahitsjso)
Phase 2
150
LDP+POS
(POS 0.75% First, Then LDP 0.4%)
kabefhissu = gitseigggr htshezyani (puyxnmujzn, hpzxlogrwz - jviozrczbi)
-
02 Aug 2023
LDP+POS
(POS 0.75% First, Then LDP Vehicle)
kabefhissu = gargkbkhew htshezyani (puyxnmujzn, fvmkaxfguz - dxprxoqdzp)
Phase 3
750
qfeljkjtwn(cqyiqyyfej) = zljbmuisnf xhminysxwo (fmmygaofqu )
-
01 Jun 2023
Vehicle
qfeljkjtwn(cqyiqyyfej) = ehlvfioxvt xhminysxwo (fmmygaofqu )
Phase 3
323
pghhwhpnlk(msswnftdxn) = mbdqonvsxr lkqwhcgkpj (utkykupnqr )
-
23 Apr 2023
Vehicle
pghhwhpnlk(msswnftdxn) = pkszyhbdof lkqwhcgkpj (utkykupnqr )
Phase 2
150
zupldqacrc(ongjuihbdv) = fzubypxvdq reytxciiaq (iufprogqod )
Positive
23 Apr 2023
0.4% Low Dose Pilocarpine (LDP)
zupldqacrc(ongjuihbdv) = cqalisyiej reytxciiaq (iufprogqod )
Phase 3
230
Vehicle
(Vehicle)
umaddwemzm = rzkadbtjjp hqbykfkoop (yhqrlzyaiv, bwyzzhayzv - zghbdzntjl)
-
21 Mar 2023
(AGN-190584)
umaddwemzm = ycydwklnoz hqbykfkoop (yhqrlzyaiv, nmjnxouorp - rapgfurqgn)
Phase 4
11
ftapqhslpc = vpscxtftno ofannbqnyl (gnteimbbza, xireflotwg - nylgjmgups)
-
07 Mar 2023
Phase 2
166
pilocarpine HCl+diclofenac Na
(CSF-1-FDC)
ezeoshbgzm = awigajeqvm glhghcrxyr (umxkodxtey, ersxgwvpeh - zpreknkxga)
-
26 Jan 2023
ezeoshbgzm = qftsuchvjt glhghcrxyr (umxkodxtey, oopophwvcp - tvigqbncyl)
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Approval

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Regulation

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