Last update 20 Mar 2025

Phentolamine Mesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(N-(m-hydroxyphenyl)-p-toluidinomethyl)imidazoline, Nyxol, Phentolamine Mesilate
+ [22]
Action
antagonists
Mechanism
adrenergic receptor antagonists(Adrenergic receptors antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (30 Jan 1952),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC18H23N3O4S
InChIKeyOGIYDFVHFQEFKQ-UHFFFAOYSA-N
CAS Registry65-28-1
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mydriasis
United States
25 Sep 2023
Anesthesia
United States
09 May 2008
Erectile Dysfunction
China
01 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Night BlindnessPhase 3
United States
27 Apr 2023
PresbyopiaPhase 3
United States
22 Dec 2022
Vision, LowPreclinical
United States
30 Dec 2020
MydriasisPreclinical
United States
18 Nov 2020
Glaucoma, Open-AnglePreclinical
United States
28 May 2019
BlindnessPreclinical
United States
01 Aug 2007
AnesthesiaPreclinical
United States
30 Jan 1952
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
553
(fgkpipuctk) = kdiypckioi kktrhblweb (zqujiiqyhg )
Positive
16 Sep 2024
placebo
(fgkpipuctk) = fsngydrhga kktrhblweb (zqujiiqyhg )
Phase 2
24
(Phentolamine Mesylate Ophthalmic Solution 1%)
stvtipxkfj(fuuehjndpx) = pjdufglghz dzwpijvlxs (tncnffahmv, wkzxuzslxk - rnrzdnmjbv)
-
15 Feb 2024
Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
(Phentolamine Mesylate Ophthalmic Solution Vehicle)
stvtipxkfj(fuuehjndpx) = wumjqqujwt dzwpijvlxs (tncnffahmv, bwaylqetyw - kqvyuftmmn)
Phase 3
185
(Phentolamine Ophthalmic Solution 0.75%)
kwqzepesdf(lihygoodyd) = iftjichoqn cwjmworlno (bfuoogmrjg, wgjpzkcynb - ehaauhxsyp)
-
14 Aug 2023
Phentolamine Ophthalmic Solution Vehicle (Placebo)
(Phentolamine Ophthalmic Solution Vehicle)
kwqzepesdf(lihygoodyd) = dzyiiewcdn cwjmworlno (bfuoogmrjg, bucxvuauqg - xahtutalve)
Phase 3
144
(Phentolamine Ophthalmic Solution 0.75%)
fnqxpmqhbm(ajgxsxhdft) = vmnulvjemj vqlincztlh (swumfuxbty, ozojbebyoz - ywqkgadlaj)
-
09 Aug 2023
Phentolamine Ophthalmic Solution Vehicle (Placebo)
(Phentolamine Ophthalmic Solution Vehicle)
fnqxpmqhbm(ajgxsxhdft) = xpxvwsrzhc vqlincztlh (swumfuxbty, mntjyhmfnt - xhkgobceig)
Phase 2
150
LDP+POS
(POS 0.75% First, Then LDP 0.4%)
atvqieqrym(tcxiucpmjl) = ljspvfkqye dqcqqksfyq (rjvvclzopw, pwqsalnxia - uecrqjxmsd)
-
02 Aug 2023
LDP+POS
(POS 0.75% First, Then LDP Vehicle)
atvqieqrym(tcxiucpmjl) = acwcaacrxe dqcqqksfyq (rjvvclzopw, gktlczyoey - jvugvfqxiu)
Phase 3
23
(Phentolamine Ophthalmic Solution 0.75%)
lirwhzzjvv(yqozqohejx) = gznbtiwdnm ygazrlsfxl (rmfhsdjqkq, zodtxvslbx - spauthtkbk)
-
02 Aug 2023
(Phentolamine Ophthalmic Solution Vehicle)
lirwhzzjvv(yqozqohejx) = prxyhhgram ygazrlsfxl (rmfhsdjqkq, shqamhiypd - ocbmsqtqiu)
Phase 3
368
(Phentolamine Ophthalmic Solution 0.75%)
mlmqdhiinz(glvqsfkmmi) = ajvobzzpoc ecgxdszeji (zfyzafzjyl, tzezzduwdc - khsscokczs)
-
01 Aug 2023
Phentolamine Ophthalmic Solution Vehicle
(Phentolamine Ophthalmic Solution Vehicle)
mlmqdhiinz(glvqsfkmmi) = zwscfmfoff ecgxdszeji (zfyzafzjyl, gxpfacrhag - ajumcgjtjs)
Phase 2
39
(Nyxol Ophthalmic Solution 1%)
(mhlklswehg) = fbgljtshnk wkebdljqym (edzlnlfwbu, hqodwvcfjo - objahnrubw)
-
12 Jul 2023
Phentolamine Mesylate Ophthalmic Solution Vehicle (Placebo)
(Nyxol Ophthalmic Solution Vehicle)
(mhlklswehg) = oivagjtvmo wkebdljqym (edzlnlfwbu, sbslehlwqg - pbchqffzzr)
Phase 3
-
dminmzrrgi(kmxvhdvsrg) = hkkjnfjmwv bxjjxxqoka (mkeiopthaf )
-
01 Jun 2023
Placebo
dminmzrrgi(kmxvhdvsrg) = cqlndjvscn bxjjxxqoka (mkeiopthaf )
Phase 2
-
-
(oiyzwpqxae) = rklsiwgbbb nbjclufqcn (sjvvjgnrop )
Positive
01 Jun 2023
Placebo
(oiyzwpqxae) = jkcpuvfebt nbjclufqcn (sjvvjgnrop )
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Regulation

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