Delving into the Latest Updates on Brilliant Blue G with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Acid Blue 90, BRILLIANT BLUE G, Brilliant blue G (JAN)

+ [3]

Target

P2X7 receptor

Mechanism

P2X7 receptor antagonists(P2X purinoceptor 7 antagonists)

Therapeutic Areas

Other DiseasesCongenital DisordersEye Diseases+ [1]

Active Indication

Ophthalmologic surgical proceduresFibrosisNephritis+ [1]

Inactive Indication-

Originator Organization

D.O.R.C. Dutch Ophthalmic Research Center (International) BV

Active Organization

D.O.R.C. Dutch Ophthalmic Research Center (International) BV

Kyushu University

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

US (20 Dec 2019),

Ophthalmologic surgical procedures

RegulationOrphan Drug (US)

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Structure

Molecular FormulaC47H49N3NaO7S2

InChIKeyRWFXCYWTHJDCMJ-UHFFFAOYSA-N

CAS Registry6104-58-1

View All Structures (2)

In this study, an innovative ratiometric fluorescence and smartphone-assisted visual sensing platform based on blue-yellow dual-emission carbon dots (BY-CDs) was constructed for the first time to determine brilliant blue. The BY-CDs was synthesized via a facile one-step hydrothermal process involving propyl gallate and o-phenylenediamine. The synthesized BY-CDs exhibit favorable water solubility and exceptional fluorescence stability. Under excitation at 370 nm, BY-CDs show two distinguishable fluorescence emission bands (458 and 558 nm). Upon addition of brilliant blue, the fluorescence intensity at 558 nm exhibited a significant quenching effect attributed to fluorescence resonance energy transfer (FRET), while the fluorescence intensity at 458 nm was basically unchanged. The prepared BY-CDs can effectively serve as a ratiometric nanosensor for determining brilliant blue with the ratio of fluorescence intensities at 458 and 558 nm (F₄₅₈/F₅₅₈) as response signal. In addition, the developed ratiometric fluorescence sensor exhibits a noticeable alteration in color from yellow to green under UV light with a wavelength of 365 nm upon addition of varying concentrations of brilliant blue, which provides the possibility of visual detection of brilliant blue by a smartphone application. Finally, the BY-CDs based dual-mode sensing platform successfully detected brilliant blue in actual food samples and achieved a desirable recovery rate. This study highlights the merits of fast, convenient, economical, real-time, visual, high accuracy, excellent precision, good selectivity and high sensitivity for brilliant blue detection, and paves new paths for the monitoring of brilliant blue in real samples.

01 Dec 2024·Biomedicine & Pharmacotherapy

The analgesic and gastroprotective activities of the three fungal extracts and their possible correlation with the inhibition of the P2X7 receptor

Article

Author: da Silva Frutuoso, Válber ; Miranda, Julliana Alves Azeredo ; Soares-Bezerra, Rômulo José ; Zani, Carlos Leomar ; da Silva Ferreira, Natiele Carla ; Alves, Luiz Anastacio ; de Almeida Alves, Tânia Maria ; Calheiros, Andrea Surrage ; Rosa, Luiz Henrique ; Lima-Quaresma, Kátia Regina Ferreira ; de Souza, Cristiane Zanon

P2X7 is a purinergic receptor physiologically activated by extracellular ATP. Its activation induces proinflammatory responses, including cytokine release, reactive oxygen species formation, and cell death. Previous in vivo experimental models demonstrated that P2X7 blockade has anti-inflammatory effects; however, there are no drugs used in clinical therapy that act on the P2X7 receptor. In the context of inflammatory diseases, nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as the first-line treatment; however, their major side effects include stomach ulcer formation, which increases patient morbidity and mortality. Here, we analyzed for the first time the analgesic and gastroprotective activities of three fungal extracts that showed antagonistic effects on P2X7 in vitro. The Antarctic fungal extracts obtained from Vishniacozyma victoriae, Metschnikowia australis, and Ascomycota sp. were tested via in vivo models of acute pain and ethanol-induced ulceration. These three extracts reduced paw licking by approximately 50 %, which is related to pain behavior, and reduced the number of stomach ulcers 3-7 times compared with the control (70 % ethanol), making them more efficient than the lansoprazole, an NSAID drug, and Brilliant Blue G (BBG), a known P2X7 antagonist, which only halves the number of ulcers. Furthermore, the extracts also protected the gastric mucosa and significantly reduced the levels of liver and renal enzymes compared with those in the ethanol group. Taken together, the fungal extracts presented both analgesic and possibly anti-inflammatory activities and had a protective effect on the gastric epithelium.

01 Sep 2024·Food Chemistry

A sensitive determination of Brilliant Blue FCF in some food samples using hydrophillic deep eutectic solvent-assisted magnetic nano gel-based dispersive solid phase microextraction prior to spectrophotometric analysis

Article

Author: Erek, Figen ; Tuzen, Mustafa ; Lanjwani, Muhammad Farooque

A new magnetic nano gel (MNG) was prepared from choline chloride/phenol deep eutectic solvent and magnetic amberlite XAD-7 nanocomposite. The dispersive solid phase micro extraction (dSPME) method was developed for seperation and preconcentration of Brilliant Blue FCF (BB) by the prepared MNG. In this study, firstly, the optimum DES type and mole ratio of DES were investigated before response surface methodology optimization. Then, the effect of the MNG-dSPME experimental parameters were optimized by response surface methodology using central composite design. Under the optimum microextraction conditions, limit of detection (LOD), limit of quantification (LOQ), preconcentration factor (PF), enhencament factor (EF) were found to be 1.15 μg L^-1,3.80 µg L^-1, 70, and 88, respectively. It was seen that the recovery of real samples were obtained from 95.5 to 103.6%. The pesent method was succesfully for extraction of BB in some food, personal care samples, to the best of our knowledge, this is the first study that is presented method on determination of BB by preconcentration with magnetic nano gel. The obtained results showed that the present procedure is effective, sensitive, and has high accuracy for the quantitative detection of BB.

100 Deals associated with Brilliant Blue G

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External Link

KEGG	Wiki	ATC	Drug Bank
D10799	-	S01	DB15594

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Ophthalmologic surgical procedures	CA	D.O.R.C. Dutch Ophthalmic Research Center (International) BV	-

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Fibrosis	Preclinical	-	-	01 Apr 2013
Nephritis	Preclinical	-	-	01 Apr 2013
Retinal Degeneration	Preclinical	JP	Kyushu University	01 Apr 2011

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2019	Not Applicable	Retinal Perforations	-	brilliant Blue G	(lgaoeonpzu) = The rates of changes in deficiency of EZ at 1 and 6 months compared with baseline in BBG group were significantly greater than those in no dye group ptkquqzfjl (acyxgfubbx ) View more	-	01 Jul 2019
				brilliant Blue G
ASN2012	Not Applicable	Ureteral Obstruction P2X7 receptor	-	Brilliant Blue G	zqtwwypmlc(eyxbcgjgvk) = egtscnnhwz mcdjigtatr (ykoujhokxi ) View more	Positive	30 Oct 2012
				Sham and BBG 25mg/kg intravenously (IV)	zqtwwypmlc(eyxbcgjgvk) = uwhovcexzr mcdjigtatr (ykoujhokxi ) View more
ARVO2011	Not Applicable	Toxicity	-	Brilliant Blue G 1 mg/ml	uneqtwkaej(xjgjzcxryv) = atcpxyupqs khfhyknzyi (iphkbagnis )	Positive	01 Apr 2011
ARVO2011	Not Applicable	Optic Nerve Injuries	-	Brilliant Blue G	vfqnqzdamm(vxlftyoudi) = njttcojrvx ubhaicevbk (zpabyhxppj ) View more	-	01 Apr 2011
				Vehicle (0.9% NaCl)	(twqprprrmv) = ypescvdbwy nctcyfhbpj (mdqcrhtkyl )
PO531 (AAO2010)	Not Applicable	Retinal Perforations Adjuvant	-	Brilliant Blue	(byrpphofny) = bkzumeczij mwakvywfcr (wigkanoptv ) View more	-	18 Oct 2010
				Brilliant Blue	(byrpphofny) = motkltvoii mwakvywfcr (wigkanoptv ) View more
ARVO2010	Not Applicable	Toxicity	8	Brilliant Blue G 1mg/ml	kqjxfhincw(xnplebknix) = jmbpgxbyfe quknfobkxs (gvhpzjdjwo ) View more	Positive	01 Apr 2010
				Brilliant Blue G Staining	kqjxfhincw(xnplebknix) = ncbjusrjmc quknfobkxs (gvhpzjdjwo ) View more