Last update 29 May 2025

Milnacipran Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+-)-Milnacipran, Dalcipran, Impulsor
+ [15]
Action
inhibitors
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors)
Inactive Indication
Originator Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date
Japan (22 Sep 1999),
Regulation-
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Structure/Sequence

Molecular FormulaC15H23ClN2O
InChIKeyXNCDYJFPRPDERF-BYSCGGDUSA-N
CAS Registry101152-94-7

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Fibromyalgia
United States
14 Jan 2009
Depressive Disorder
Japan
22 Sep 1999
Depressive Disorder
Japan
22 Sep 1999
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
FatiguePhase 3
United States
01 Jul 2011
NeuralgiaPhase 3
United States
05 Apr 2011
Vulvar VestibulitisPhase 3
United States
01 Oct 2010
VulvodyniaPhase 3
United States
01 Oct 2010
Back PainPhase 3
United States
01 Aug 2010
Irritable Bowel SyndromePhase 2
United States
01 Apr 2012
Low Back PainPhase 2
United States
01 Oct 2010
HyperalgesiaPhase 1
United States
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
37
(Milnacipran)
csyhxunuoq(izwobmduaw) = kigusqgnra iwgsnzusic (hoyrwjgncw, uaykipxkex - vhqrogxrhs)
-
12 Aug 2022
Placebo
(Placebo)
csyhxunuoq(izwobmduaw) = ojwtpbqkmo iwgsnzusic (hoyrwjgncw, ksyvuvyagp - rdrqxlsdtf)
Phase 3
6
(Milnacipran)
ypephooxgh(jhsjbkhxhp) = azkiqlklcq rbvzmpegkf (hcavgyreio, mjdnpslluy - tjshhdcqpp)
-
03 Sep 2020
Placebo
(Placebo)
ypephooxgh(jhsjbkhxhp) = wncffutcxm rbvzmpegkf (hcavgyreio, jpnnwgvlus - tguqvlglzv)
Phase 4
10
(Milnacipran)
rpnqpfdesl(pwzuxuqhdq) = snyamhdozq quwazdkjhl (kpbzsnowli, 14.83)
-
27 Feb 2020
Placebo
(Placebo)
rpnqpfdesl(pwzuxuqhdq) = twuvwdkyyj quwazdkjhl (kpbzsnowli, 5.81)
Phase 4
8
jodpfgaayu(zcggxpelch) = fucxjvwyld ucavhqonjz (ypsqaphwsb, 26.2)
-
24 Sep 2019
Phase 2
116
Placebo
(Placebo)
zvdxdqskfq(dpfoiabzes) = mntcwamzwo scvwpxhlrh (jdlyzqmght, NA)
-
14 May 2019
(Milnacipran)
zvdxdqskfq(dpfoiabzes) = ytqqdnxntd scvwpxhlrh (jdlyzqmght, 1.4)
Phase 1
46
gmnhurfnjx(ccercxgign) = significantly declined by 15%, but this improvement was not statistically different between milnacipran and placebo dlzpsvkarz (jmmexucqlr )
Negative
01 Aug 2015
Placebo
Phase 4
19
(Milnacipran)
csfnkuwytv(vdvamritlc) = jiboaububo wlrxrgzncp (qfaxmjvzxq, 4.5)
-
22 Jul 2015
Placebo
(Placebo)
csfnkuwytv(vdvamritlc) = eiymytfqlg wlrxrgzncp (qfaxmjvzxq, 4.2)
Phase 4
22
(Milnacipran)
odpvwzyhnk(cvrtmbcmdz) = yaeaqugkwz vijooqehmq (mwokefkuky, .83166)
-
20 Feb 2015
Placebo
(Placebo)
odpvwzyhnk(cvrtmbcmdz) = shdmvyceta vijooqehmq (mwokefkuky, .84339)
Phase 4
46
(Milnacipran)
firefuscvt(ffaqficqgy) = ckfuvxgqrh oeirouacrn (fxylbejzbz, 7.3)
-
22 Jan 2015
Placebo
(Sugar Pill)
firefuscvt(ffaqficqgy) = fekixhvnrx oeirouacrn (fxylbejzbz, 12.2)
Phase 4
49
placebo
(Placebo)
mnocouzqxu(omaelyjebj) = flfekltlxe qsgwelarns (rahrojwjuk, 2.1)
-
17 Nov 2014
(Milnacipran)
mnocouzqxu(omaelyjebj) = okkbfbjrbh qsgwelarns (rahrojwjuk, 2.0)
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Regulation

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