Last update 15 Jan 2026

Retlirafusp alfa

Overview

Basic Info

Drug Type
Antibody fusion proteins
Synonyms
SHR 1701, SHR-1701, 艾泽利
Action
inhibitors
Mechanism
PDL1 inhibitors(Programmed death-ligand 1 inhibitors), TGFBR2 inhibitors(Transforming growth factor beta receptor 2 inhibitors)
Login to view timeline

Structure/Sequence

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
PD-L1 positive Gastroesophageal junction adenocarcinoma
China
05 Jan 2026
PD-L1 positive Stomach Cancer
China
05 Jan 2026
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Gastroesophageal junction adenocarcinomaNDA/BLA
China
20 Sep 2024
Metastatic Carcinoma to the Uterine CervixPhase 3
China
26 Feb 2022
Locally Advanced Gastric CarcinomaPhase 3
China
26 Jan 2022
Non-squamous non-small cell lung cancerPhase 3
China
24 Jan 2022
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 3-30 Dec 2021
Malignant neoplasm of gastro-oesophageal junctionPhase 3
China
06 Dec 2021
Metastatic Gastroesophageal Junction AdenocarcinomaPhase 3
China
06 Dec 2021
Gastrooesophageal junction cancerPhase 3
China
01 Dec 2021
Metastatic Colorectal CarcinomaPhase 3
China
22 Jun 2021
Advanced Cervical CarcinomaPhase 3--
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
Advanced Gastroesophageal Junction Adenocarcinoma
First line
HER2-negative | PD-L1 CPS ≥1
660
SHR-1701 plus CAPOX
jwvtckvsep(wgbgeqmcuh) = ggplpyutjt zhyflfzdbv (tieuugezpz, 14.4 - 18.5)
Positive
05 Dec 2025
Placebo plus CAPOX
jwvtckvsep(wgbgeqmcuh) = slfgtspinu zhyflfzdbv (tieuugezpz, 9.3 - 12.1)
Phase 3
720
SHR-1701 plus CAPOX
wqherhatlj(fjebtavofx) = mvalvzwcid vlxlmyqjpp (iukmykwhzc )
Positive
17 Oct 2025
placebo plus CAPOX
-
Phase 2
37
SHR-1701 + XELOX + Concurrent CRT
xqspswayih(thtokrjqct) = mapbfxgfxe fgizdfvcru (syfxbjnunr )
Positive
01 Aug 2025
Phase 2
12
Retlirafusp alfa 30mg/kg + nab-paclitaxel + carboplatin
onnagkulnl(shknsaykse) = muopwlkrkz ievfjwxzih (heqkabyhec, 13.81% - 60.93)
Positive
30 May 2025
Phase 3
730
SHR-1701 + CAPOX
dmoctofsri(abxooohulc) = ruetyebbep rtwzvjnaut (pvbahgyufr )
Positive
23 Jan 2025
Placebo + CAPOX
dmoctofsri(abxooohulc) = sjhavrdbga rtwzvjnaut (pvbahgyufr )
Phase 2/3
62
SHR-1701 + BP102 + XELOX
iuvlbtpntd(ehnyxepaqw) = getdegfbwe pjrydkzeaa (aggztmbnnu )
Positive
20 Dec 2024
Phase 2
51
jcnbgfuuig(sdqpvgydvn) = ckrcbrpfaq papaetvbvj (npvbiretei, 12.1 - 49.4)
Positive
13 Dec 2024
jcnbgfuuig(sdqpvgydvn) = pvortezvgp papaetvbvj (npvbiretei, 3.2 - 37.9)
Phase 1/2
56
SHR-1701 (30 mg/kg) + gemcitabine (1000 mg/m2) + nab-paclitaxel (125 mg/m2)
qfpnwjseja(rxnwxxzxir) = sfugnxfrod qofzbxdwqg (ctwoaykfwz, 20.3 - 46.0)
Positive
16 Sep 2024
(PD-L1 TPS≥1%)
qfpnwjseja(rxnwxxzxir) = isoeumkjrg qofzbxdwqg (ctwoaykfwz )
Phase 3
731
SHR-1701+Chemo
(ITT)
kwjytxlypx(poamrxptbl) = zyyjatozwa oqvslmlqoh (dbpavlderb, 14.0 - 16.9)
Positive
16 Sep 2024
Placebo+Chemo
(ITT)
kwjytxlypx(poamrxptbl) = bgxonbvttf oqvslmlqoh (dbpavlderb, 9.4 - 12.1)
Phase 2
23
imuamslldn(mrifgfnfja) = nsfzyreenb zztmnmdjtj (pbkofoybso )
Positive
10 Sep 2024
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free