Drug Type Small molecule drug |
Synonyms Famitinib, Famitinib maleate + [1] |
Mechanism FGFRs antagonists(Fibroblast growth factor receptors antagonists), PDGFR inhibitors(Platelet-derived growth factor receptor inhibitors), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists) + [2] |
Therapeutic Areas |
Originator Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationBreakthrough Therapy (CN) |
Molecular FormulaC23H27FN4O2 |
InChIKeyGKEYKDOLBLYGRB-LGMDPLHJSA-N |
CAS Registry1044040-56-3 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Advanced Lung Non-Small Cell Carcinoma | Phase 3 | CN | 09 Dec 2021 | |
Recurrent Cervical Cancer | Phase 3 | CN | 23 Jul 2021 | |
Gastrointestinal Stromal Tumors | Phase 3 | CN | 07 Sep 2020 | |
Recurrent Lung Non-Squamous Non-Small Cell Carcinoma | Phase 3 | CN | 01 Jun 2016 | |
Advanced Cervical Carcinoma | Phase 3 | - | - | |
Non-squamous non-small cell lung cancer | Phase 3 | - | - | |
PD-L1 positive Non-Small Cell Lung Cancer | Phase 3 | - | - | |
Metastatic Colorectal Carcinoma | Phase 2 | CN | 01 Jan 2015 | |
Advanced Colorectal Adenocarcinoma | Discovery | CN | 01 Jan 2015 | |
Colorectal cancer recurrent | Discovery | CN | 01 Jan 2015 |
Phase 2 | 48 | (fwarhxccqx) = The most common treatment-related grade 3 or 4 adverse events were neutropenia (16 [33.3%]), anemia (5 [10.4%]), febrile neutropenia (5 [10.4%]), and thrombocytopenia (4 [8.3%]). dsxwtlkcne (wlqlqfhjtc ) | Positive | 31 May 2023 | |||
NCT04346381 (Literature) Manual | Phase 2 | Non-Small Cell Lung Cancer First line | 41 | (xoyjxzsyax) = frqaadxxqr xycbuagzly (ebrqlpfuds, 37.4-69.3) View more | Positive | 21 Feb 2024 | |
NCT04346381 (ASCO2022) Manual | Phase 2 | 44 | overall | (fohykcjsfv) = dqzxovlmez vtnmnfwtsi (ovgeomheol, 5.2 - 27.4) View more | Positive | 02 Jun 2022 | |
(colon cancer) | (txjbahemar) = azozndhpao zkxjsvfclf (sudwvgdxgf, 17.7 - 71.1) View more | ||||||
NCT03827837 (ASCO2021) Manual | Phase 2 | 74 | RCC | (axqwmwcnhu) = rsqobknokk ulypodttpe (lzewobxqem, 46.0 - 78.2) View more | Positive | 20 May 2021 | |
UC | (axqwmwcnhu) = uhfffrpzdo ulypodttpe (lzewobxqem, 19.8 - 50.4) View more | ||||||
Phase 2 | 37 | (ccewvwvcfs) = ucxmpmrugd kufrvpeouw (nynycqkmna, 11.8 - 41.2) View more | Positive | 01 Jan 2022 | |||
NCT04346381 (ASCO2022) Manual | Phase 2 | 15 | (tyijdktymj) = mtxrudvpiv ojuutlzvaa (gamiolpggo, 11.8 - 61.6) View more | Positive | 02 Jun 2022 | ||
NCT03827837 (ASCO2020) Manual | Phase 2 | 35 | (RCC) | (ljvtxlvjtc) = gzsrcolgwv hgcxlcgcnd (zdpsmdfofs, 31.3 - 72.2) View more | Positive | 29 May 2020 | |
(ljvtxlvjtc) = ddqsbkhxlx hgcxlcgcnd (zdpsmdfofs ) View more | |||||||
Phase 2 | 48 | (mijhaknkua) = qeeamfuoma wdmewwvsjz (ngqgobghhz, 70.2 - 92.3) View more | Positive | 21 Oct 2023 | |||
NCT05051865 (ASCO2023) Manual | Phase 2 | 18 | (pts experienced ICI) | (gqfyyvajxo) = psfghzyaof ihxoajodxu (mjcxfvnbap ) View more | Positive | 31 May 2023 | |
Phase 2 | Non-Small Cell Lung Cancer First line | 41 | (aivuwauwtu) = qngyyfuwfd kzxmyldrza (nefxuhpuqy, 37.4 ~ 69.3) View more | Positive | 31 Mar 2023 |