Delving into the Latest Updates on Arginine Butyrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target

TK

Action

stimulants

Mechanism

thymidine kinase stimulants(Thymidine kinase stimulants)

Therapeutic Areas

Digestive System DisordersEndocrinology and Metabolic DiseaseOther Diseases

Active Indication

Short Bowel Syndrome

Inactive Indication

Anemia, Sickle CellBeta-ThalassemiaEpstein-Barr virus positive Lymphoma+ [2]

Originator Organization

Boston University

Active Organization

Baxter Healthcare Corp.

Inactive Organization

Boston UniversityHemaQuest Pharmaceuticals, Inc.

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

RegulationOrphan Drug (United States)

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Structure/Sequence

Molecular FormulaC10H22N4O4

InChIKeyHTWPXGKLFMPZHG-WCCKRBBISA-N

CAS Registry80407-72-3

OBJECTIVES: I. Determine whether arginine butyrate with or without epoetin alfa can stimulate gamma-globin chain production to a degree that decreases anemia and results in hematologic improvement in patients with thalassemia intermedia.
II. Determine whether a proportional increase in gamma-globin synthesis and mRNA and an improvement in nonalfa and alfaglobin chain imbalance by at least 10% over baseline correlate with improved hematologic response in these patients when treated with this regimen.
III. Determine whether a decrease in hemolysis, as assayed by a decrease in LDH, compared to baseline levels correlates with improved hematologic response in these patients when treated with this regimen.
IV. Determine whether any particular genotypes are more responsive than others to this therapy in these patients.
V. Determine whether baseline epoetin alfa levels, gender, and/or baseline reticulocyte counts (or percent circulating nucleated erythroblasts) correlate with improved hematologic response in these patients when treated with this regimen.

Start Date01 Mar 1999

Sponsor / Collaborator

Boston University

100 Clinical Results associated with Arginine Butyrate

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100 Translational Medicine associated with Arginine Butyrate

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100 Patents (Medical) associated with Arginine Butyrate

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112,265

Literatures (Medical) associated with Arginine Butyrate

31 Dec 2025·Journal of the International Society of Sports Nutrition

Effects of different dietary supplements on athletic performance in soccer players: a systematic review and network meta-analysis

Review

Author: Luo, Hua ; Xiang, Changqing ; Zhu, Xiaolin ; Nasharuddin, Nurul Amelina ; Tengku Kamalden, Tengku Fadilah

BACKGROUNDAs dietary supplements play a crucial role in meeting the unique nutritional needs of soccer players, a growing body of studies are exploring the effects of dietary supplements on athletic performance in soccer players. The effectiveness of certain supplements, such as caffeine and creatine, remains debated due to inconsistent results across studies. Therefore, this systematic review and Bayesian network meta-analysis was conducted to tentatively identify the most effective dietary supplements for soccer players.METHODSWe searched PubMed, Web of Science, Cochrane, Embase, and SPORTDiscus from database establishment to 5 February 2024 to identify randomized controlled trials (RCTs) evaluating the effects of different dietary supplements on athletic performance in soccer players. The risk of bias was assessed using the revised Cochrane risk-of-bias tool for randomized trials. A Bayesian network meta-analysis was performed using the R software and Stata 18.0. A subgroup analysis was conducted based on the competitive level of the athletes.RESULTSEighty RCTs were included, with 1,425 soccer players randomly receiving 31 different dietary supplements or placebo. The network meta-analysis showed that compared with placebo, carbohydrate + protein (SMD: 2.2, very large), carbohydrate + electrolyte (SMD: 1.3, large), bovine colostrum (SMD: moderate) and caffeine (SMD: 0.29, small) were associated with a significant effect on increasing the distance covered. Kaempferia parviflora (SMD: 0.46, small) was associated with a significant effect on enhancing muscular strength. Beta-alanine (SMD: 0.83, moderate), melatonin (SMD: 0.75, moderate), caffeine (SMD: 0.37, small), and creatine (SMD: 0.33, small) were associated with a significant effect on enhancing jump height. Magnesium creatine chelate (SMD: -3.0, very large), melatonin (SMD: -1.9, large), creatine + sodium bicarbonate (SMD: -1.4, large), and arginine (SMD: -1.2, moderate) were associated with a significant effect on decreasing sprint time. Creatine + sodium bicarbonate (SMD: -2.3, very large) and caffeine (SMD: -0.38, small) were associated with a significant effect on improving agility. Sodium pyruvate (SMD: 0.50, small) was associated with a significant effect on increasing peak power. Magnesium creatine chelate (SMD: 1.3, large) and sodium pyruvate (SMD: 0.56, small) were associated with a significant effect on increasing mean power. Carbohydrate + electrolyte (SMD: -0.56, small) was associated with a significant effect on improving the rating of perceived exertion.CONCLUSIONSThis study suggests that a range of dietary supplements, including caffeine, creatine, creatine + sodium bicarbonate, magnesium creatine chelate, carbohydrate + electrolyte, carbohydrate + protein, arginine, beta-alanine, bovine colostrum, Kaempferia parviflora, melatonin, and sodium pyruvate, can improve athletic performance in soccer players. This review provides evidence-based guidance for soccer coaches and nutritionists on using dietary supplements to enhance specific performance measures.

31 Dec 2025·mAbs

Analysis of how antigen mutations disrupt antibody binding interactions toward enabling rapid and reliable antibody repurposing

Article

Author: Pantazes, Robert J. ; Islam, Sumaiya ; Chauhan, Varun M.

Antibody repurposing is the process of changing a known antibody so that it binds to a mutated antigen. One of the findings to emerge from the Coronavirus Disease 2019 (COVID-19) pandemic was that it was possible to repurpose neutralizing antibodies for Severe Acute Respiratory Syndrome, a related disease, to work for COVID-19. Thus, antibody repurposing is a possible pathway to prepare for and respond to future pandemics, as well as personalizing cancer therapies. For antibodies to be successfully repurposed, it is necessary to know both how antigen mutations disrupt their binding and how they should be mutated to recover binding, with this work describing an analysis to address the first of these topics. Every possible antigen point mutation in the interface of 246 antibody-protein complexes were analyzed using the Rosetta molecular mechanics force field. The results highlight a number of features of how antigen mutations affect antibody binding, including the effects of mutating critical hotspot residues versus other positions, how many mutations are necessary to be likely to disrupt binding, the prevalence of indirect effects of mutations on binding, and the relative importance of changing attractive versus repulsive energies. These data are expected to be useful in guiding future antibody repurposing experiments.

31 Dec 2025·Journal of the International Society of Sports Nutrition

Investigation of the effect of nitrate and L-arginine intake on aerobic, anaerobic performance, balance, agility, and recovery in elite taekwondo athletes

Article

Author: Buzdağlı, Yusuf ; Savaş, Adem ; Ozan, Murat ; Uçar, Halil ; Kavcı, Zafer

BACKGROUNDTaekwondo is a complex martial art that requires speed, balance, agility, and endurance. This study aims to examine the effects of nitrate and L-arginine supplementation on acute aerobic and anaerobic performance, balance, agility, and recovery in elite taekwondo athletes.METHODThis study was conducted as a double-blind, randomized, crossover study with the participation of 15 experienced taekwondo athletes aged 19.06 ± 0.96 years and 8.93 ± 1.27 years of training experience. Participants visited the laboratory a total of nine times, including a practice session and anthropometric measurements. These visits consisted of eight experimental sessions conducted at 72-hour intervals. The experimental sessions were conducted with nitrate, L-arginine, and a combination of both supplements (NIT*L-ARG) and placebo. Nitrate supplementation was provided by homogenizing fresh spinach (837.40 mg/kg), while L-ARG was given as a single dose of 6 g in powder form three hours before exercise.RESULTSNIT*L-ARG supplementation significantly improved the anaerobic performance of athletes in Wingate peak power and peak power (w/kg) compared to placebo and in mean power compared to NIT, L-ARG, and PLA. In addition, NIT*L-ARG supplementation significantly improved blood lactate levels and agility performance immediately after Wingate and Shuttle run tests.CONCLUSIONThe combined intake of NIT*L-ARG was found to be effective in improving aerobic, anaerobic, and agility performances as well as fatigue levels of athletes. It was determined that taking NIT and L-ARG supplements alone contributed to the improvement of improving athletes' performance in Wingate mean power values and subsequent fatigue level compared to PLA.

100 Deals associated with Arginine Butyrate

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Epstein-Barr virus positive Lymphoma	NDA/BLA	United States	HemaQuest Pharmaceuticals, Inc.	01 May 2010
Epstein-Barr Virus-Related Lymphoma	NDA/BLA	United States	HemaQuest Pharmaceuticals, Inc.	01 Sep 2008
Short Bowel Syndrome	Preclinical	United States	Baxter Healthcare Corp.	09 Mar 2023
Anemia, Sickle Cell	Preclinical	United States	Boston University	01 Sep 1997
Beta-Thalassemia	Preclinical	United States	Boston University	01 Sep 1997
Leg Ulcer	Preclinical	United States	Boston University	01 Sep 1997

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00004412 (CTgov)	Phase 2	Beta-Thalassemia \| Leg Ulcer \| Anemia, Sickle Cell	23	Standard local care dressing (Standard Local Care Dressing)	brkpdvgqqa(zxdwahtenh) = tswmsdrwxx zzeyyhdxpb (pshgwralnp, ppgnvgseyf - myakqevnpo) View more	-	31 Mar 2015
NCT00004412 (CTgov)	Phase 2	Beta-Thalassemia \| Leg Ulcer \| Anemia, Sickle Cell	23	Standard local care dressing+Arginine Butyrate (Arginine Butyrate)	brkpdvgqqa(zxdwahtenh) = zlglnlrguu zzeyyhdxpb (pshgwralnp, wljzxauztv - rtwfpvujjg) View more	-	31 Mar 2015
Pubmed \| Br J Haematol	Phase 2	Leg Ulcer	-	Arginine Butyrate (Standard local care)	ockchszdma(qhoxwdiqzm) = oxmrbrkkgk zierqarlhb (qibulktjyu )	-	01 Dec 2010
Pubmed \| Br J Haematol	Phase 2	Leg Ulcer	-	Standard care with Arginine Butyrate	ockchszdma(qhoxwdiqzm) = tbcygdnrdj zierqarlhb (qibulktjyu )	-	01 Dec 2010
Pubmed \| Blood	Phase 1/2	Epstein-Barr virus associated Neoplasms	15	Arginine butyrate	(zkvdixhgpp) = wwipuhmtnk daicfudnrk (bojjywvjpc )	-	15 Mar 2007
ASCO2006	Phase 1/2	Epstein-Barr virus associated Neoplasms	-	Arginine Butyrate	(ounoxzoyvc) = zxwusjimii mmtynpwhyu (ydrxybqtgw )	-	20 Jun 2006