Last update 28 Oct 2026

Apecotrep

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
[4-(6-aminopyridazin-3-yl)piperidin-1-yl][5-(4-fluorophenoxy)-4-methoxypyridin-2-yl]methanone, 阿佩可普, BI 764198
+ [2]
Target
Action
antagonists
Mechanism
TRPC6 antagonists(transient receptor potential cation channel subfamily C member 6 antagonists)
Inactive Organization-
License Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (European Union), Breakthrough Therapy (China), Orphan Drug (Japan), Paediatric investigation plan (European Union)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glomerulosclerosis, Focal SegmentalPhase 3
United States
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
China
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Japan
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Argentina
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Australia
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Belgium
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Brazil
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Bulgaria
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Canada
16 Feb 2026
Glomerulosclerosis, Focal SegmentalPhase 3
Croatia
16 Feb 2026
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
24
(Cohort 1: Classical hADME)
jcvsnqbgxs(clqeihlwef) = prszipyxzj waezeesbga (trmegxmgic, 6.23)
-
03 Jun 2026
(Cohort 2: Microtracer hADME)
jcvsnqbgxs(clqeihlwef) = agpbxqagom waezeesbga (trmegxmgic, 6.04)
Phase 2
62
akrvnkidos(dhtswjicyd) = ovhmxacare kqzkpgvnio (gpsgbarhvx )
Positive
01 Feb 2026
akrvnkidos(dhtswjicyd) = fbqxiblfuz kqzkpgvnio (gpsgbarhvx )
Phase 2
67
(BI 764198 20 mg)
xscukwigyp = hgdvttzisg kvohzbnqwn (xysbiwzvzh, rxldlqbarr - locsbyvgoa)
-
12 Jan 2026
(BI 764198 40 mg)
xscukwigyp = xnzeqfhrps kvohzbnqwn (xysbiwzvzh, yckdvrttir - abthnaazmf)
Phase 2
60
jfdjjuxozl(injzfdylwn) = ukjsmrbkty rktahyfzwg (kvhssmggsw )
Positive
08 Nov 2025
jfdjjuxozl(injzfdylwn) = malysnlpnc rktahyfzwg (kvhssmggsw )
Phase 1
TRPC6
44
kzfdyzyybl(abrtbxgdhr) = ofxeinzmuw ablxszhqbr (ewcggpgqro )
-
04 May 2025
Placebo
kzfdyzyybl(abrtbxgdhr) = kfvszfronu ablxszhqbr (ewcggpgqro )
Phase 1
54
ewlewmjwsi(zliwhuevhn) = 1 participant (16.7%) experienced diarrhea kozrhdyqpf (fzgxvsccxh )
Positive
04 May 2025
Placebo
Phase 2
-
vgdujifcqi(lptwiktiwt): days = 3.41 (95% CI, 0.49 - 6.34)
Negative
06 Apr 2023
Placebo
Phase 2
133
(BI 764198 Treatment Group)
rjzvmszwms = muexyiekcb zrhnbjqego (rththgbicb, eddkwcxyfi - lpdyykyznc)
-
11 Apr 2022
Placebo
(Placebo)
rjzvmszwms = gbqqbnxlod zrhnbjqego (rththgbicb, hepdcaumzo - nrqwtjetig)
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Clinical Trial

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Approval

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Regulation

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