Last update 01 Nov 2024

TRPC6

Basic Info

Synonyms
focal segmental glomerulosclerosis 2, FSGS2, Short transient receptor potential channel 6
+ [6]
Introduction
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.

Analysis

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