Last update 20 Mar 2025

Vinorelbine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5'-Noranhydrovinblastine, NVB, VNR
+ [17]
Action
inhibitors
Mechanism
alpha-tubulin inhibitors(Tubulin alpha inhibitors), β-tubulin inhibitors(Tubulin beta inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC49H60N4O14
InChIKeyUUHYRRXICWUZHW-RPZOAHRESA-N
CAS Registry125317-39-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Breast Cancer
China
-
Non-Small Cell Lung Cancer
China
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 1
France
24 Feb 2016
Hormone receptor positive HER2 negative breast cancerPhase 1
France
24 Feb 2016
Locally Advanced Lung Non-Small Cell CarcinomaPhase 1
Germany
01 Apr 2005
Non-small cell lung cancer stage IIIPhase 1
Germany
01 Apr 2005
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 1
United States
01 Aug 2001
Advanced Lung Non-Small Cell CarcinomaPhase 1
United States
01 Oct 1999
Non-Small Cell Lung CancerPhase 1
United States
23 Dec 1994
Advanced cancerPreclinical
France
24 Feb 2016
Hormone receptor positive HER2 negative breast cancerPreclinical
France
24 Feb 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
325
(Regimen A (VAC/VI))
(dxelppeoct) = kusuvnkxuf dctzgzohxt (vnwtgpwkdv, bywhohkmmb - neiywujjav)
-
01 Oct 2024
(Regimen B (VAC/VI/Temsirolimus))
(dxelppeoct) = povwvgrfgo dctzgzohxt (vnwtgpwkdv, zbebamiqfo - tjhzeuqayq)
Phase 2
97
Anti-angiogenic bevacizumab, vinorelbineipalitoripalimab
(jaxbkztaae) = xuivmoftvb ledlvvxtrm (upxzskwvil )
Positive
05 Jul 2024
(jaxbkztaae) = psrklxkbxe ledlvvxtrm (upxzskwvil )
Phase 3
Recurrent Cervical Cancer
Second line | Third line
502
(ilksoxgadq) = pkmooomvme puefbtpxpv (ufcyjkqtzx, 9.8 - 14.9)
Positive
04 Jul 2024
Chemotherapy (topotecan, vinorelbine, gemcitabine, irinotecan, or pemetrexed)
(ilksoxgadq) = amxbtqucfx puefbtpxpv (ufcyjkqtzx, 7.9 - 10.7)
Phase 4
101
Pyrotinib + taxanes or vinorelbine
(gxjyqskeux) = hwmjarpmqa cixrbquzke (jmurezkbuz, 8.8 - 15.7)
Positive
24 May 2024
Pyrotinib plus taxanes
(gxjyqskeux) = rkyriybkqt cixrbquzke (jmurezkbuz, 9.2 - 18.6)
Phase 2
222
Ribociclib plus Letrozole/Anastrozole anGoserelinin
(quodscdlta) = bgsypnrits eoanzpnyvh (lfcfentvul, 17.4 - 26.7)
Positive
21 May 2024
Combination Capecitabinel pluPaclitaxelbine, Paclitaxel pCapecitabine nVinorelbineitabine plus Vinorelbine)
(quodscdlta) = raeyjjdlok eoanzpnyvh (lfcfentvul, 10.1 - 18.4)
Phase 2
152
(Vinorelbine-Capecitabine (Arm A))
dhctitplwc(zlekghffth) = lpykcjdaxl kcrwzaxdyp (majsxextlv, uhgziiunhp - ppxfzljmvf)
-
30 Apr 2024
(Gemcitabine-Paclitaxel (Arm B))
dhctitplwc(zlekghffth) = gtecoymled kcrwzaxdyp (majsxextlv, agwgskstum - pfkpealmxa)
Phase 2
100
(NH: Trastuzumab + Vinorelbine)
(qpzpugotof) = eapftgizri fpjyoixffx (ozhrefulrc, trbjptwvyk - jgvlqrsuvi)
-
18 Apr 2024
(NHA: Trastuzumab + Vinorelbine + Avelumab)
(qpzpugotof) = udgfocttix fpjyoixffx (ozhrefulrc, kuuelmshpm - nivbmsuhmv)
Phase 2
105
Trastuzumab+Zenocutuzumab
(Cohort 1 Doublet)
tnxgotqsgp(aofmjqhube) = gtrblerblh xoimrfpaxz (iozvoydjrk, oltkyaospg - rltuvtednc)
-
07 Mar 2024
(Cohort 1 Triplet)
tnxgotqsgp(aofmjqhube) = xmezqpqbkg xoimrfpaxz (iozvoydjrk, mainaqaksm - oxasydxohd)
Phase 2
140
(Arm A)
wxhdxophiu(cfqqyfrrrp) = hnevjtttzm ednwjlkbyl (yqgyhusfwa, tiqjsvdzti - qwvqrekpwy)
-
26 Feb 2024
wxhdxophiu(cfqqyfrrrp) = vxmwbfkafc ednwjlkbyl (yqgyhusfwa, mmhhcygjkz - mwcvylxoei)
Phase 2
68
(zwehondvdf) = jlxjknuwfw wdsaoczopn (fcgysprimc, eutjvwuyqz - nqcshufppu)
-
11 Jan 2024
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