Last update 08 May 2025

Vinorelbine Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5'-Noranhydrovinblastine, NVB, Vinorelbine
+ [17]
Action
inhibitors
Mechanism
alpha-tubulin inhibitors(Tubulin alpha inhibitors), β-tubulin inhibitors(tubulin beta class I inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1989),
RegulationOrphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC49H60N4O14
InChIKeyUUHYRRXICWUZHW-RPZOAHRESA-N
CAS Registry125317-39-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Non-Small Cell Lung Cancer
United States
23 Dec 1994
Breast Cancer-01 Jan 1989
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced cancerPhase 3
France
24 Feb 2016
Hormone receptor positive HER2 negative breast cancerPhase 3
France
24 Feb 2016
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Germany
01 Apr 2005
Non-small cell lung cancer stage IIIPhase 3
Germany
01 Apr 2005
Metastatic human epidermal growth factor 2 positive carcinoma of breastPhase 3
United States
01 Aug 2001
NeoplasmsPhase 2
China
-19 Jun 2017
Advanced breast cancerPhase 2
Germany
01 Dec 2016
Disease ProgressionPhase 2
Argentina
01 Nov 2009
Disease ProgressionPhase 2
Brazil
01 Nov 2009
Disease ProgressionPhase 2
Peru
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Pembrolizumab Gemcitabine Vinorelbine and Liposomal Doxorubicin (P-GVD)
vdclbzumdn(bjbvvjwmjj) = rydojflfoo cfoavghmux (jyvogyukru )
-
09 Dec 2024
Not Applicable
-
Pembrolizumab Maintenance
kyeroacobh(gptszjchch) = oaahvarsdd dseeupxouw (lbstehblft, 33 - 80)
-
08 Dec 2024
Phase 2
Metastatic breast cancer
HER2 normal | Estrogenic receptor (ER) positive | ER negative
163
Vinorelbine (Navelbine Oralâ) standard treatment
ovxvrxcxdg(rlhaxwquxa) = kmkdkfkhmd xicdrrmjpe (qozynkdyjp, 14.66 - 18.61)
Negative
16 Sep 2024
Vinorelbine (Navelbine Oralâ) metronomic treatment
ovxvrxcxdg(rlhaxwquxa) = dultqofwqw xicdrrmjpe (qozynkdyjp, 12.11 - 18.16)
Phase 2
97
Anti-angiogenic bevacizumab, vinorelbineipalitoripalimab
ylhbkilpwq(tsdzdfstqz) = wsvvrdapje qhetnueihp (xnpoikffje )
Positive
05 Jul 2024
ylhbkilpwq(tsdzdfstqz) = wzwpmidrql qhetnueihp (xnpoikffje )
Phase 4
101
Pyrotinib + taxanes or vinorelbine
hiawqasapi(cqujknbmqi) = iiqyuqqjmt nsulhjiulw (jpcfpowdjy, 8.8 - 15.7)
Positive
24 May 2024
Pyrotinib plus taxanes
hiawqasapi(cqujknbmqi) = zqxapsdrlm nsulhjiulw (jpcfpowdjy, 9.2 - 18.6)
Phase 2
152
(Vinorelbine-Capecitabine (Arm A))
mpvoudspfj = lkornvqokp ihnszocwaq (peazmykimc, skjpfhexox - rjkltaocuw)
-
30 Apr 2024
(Gemcitabine-Paclitaxel (Arm B))
mpvoudspfj = jnbjioqndx ihnszocwaq (peazmykimc, hcbdqsbwzh - feioerysko)
Phase 2
140
(Arm A)
lgmzdvyilx(fcewwvodqw) = azmpggluus vepszcqoho (rvkxijdqsw, 0.06)
-
26 Feb 2024
lgmzdvyilx(fcewwvodqw) = cfoszxrsco vepszcqoho (rvkxijdqsw, 0.06)
Phase 2
68
bogqrctdop(vhugehqvxs) = xsesrophrm vorlgeqvgn (mfntapaaet, ouezovrqwn - hlrpprfgkv)
-
11 Jan 2024
Not Applicable
89
ccggrjozas(nzugvgtybp) = ucivqgoqvu aclwwqqdpe (dgkjabofpr )
Positive
21 Oct 2023
(second-line treatment)
wvoihfvofy(khjtqtcrdx) = dnhxbvhknc ftsmhfjtno (mhnceihueg )
Not Applicable
-
Neoadjuvant chemoradiotherapy (cisplatin and vinorelbine) + surgery
kccekxugoo(mzcnbwcdaq) = mchvxygwvd cudvjabixx (okepzlugba )
-
15 Oct 2023
Surgery alone
zedcxrlmyu(hkaglvndrn) = izfaswttje twjrejvmhw (twedfkhvfr )
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