Last update 04 Nov 2024

Durvalumab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Durvalumab (Genetical Recombination), Durvalumab (genetical recombination) (JAN), Durvalumab (USAN/INN)
+ [10]
Target
Mechanism
PDL1 inhibitors(Programmed death-ligand 1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (01 May 2017),
RegulationBreakthrough Therapy (US), Orphan Drug (US), Orphan Drug (AU), Priority Review (AU), Priority Review (US), Accelerated Approval (US)
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External Link

KEGGWikiATCDrug Bank
D10808Durvalumab

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Advanced Endometrial Carcinoma
EU
15 Aug 2024
Advanced Endometrial Carcinoma
IS
15 Aug 2024
Advanced Endometrial Carcinoma
LI
15 Aug 2024
Advanced Endometrial Carcinoma
NO
15 Aug 2024
Recurrent Endometrial Cancer
EU
15 Aug 2024
Recurrent Endometrial Cancer
IS
15 Aug 2024
Recurrent Endometrial Cancer
LI
15 Aug 2024
Recurrent Endometrial Cancer
NO
15 Aug 2024
Resectable Lung Non-Small Cell Carcinoma
GB
09 Jul 2024
Mismatch repair-deficient Endometrial Carcinoma
US
14 Jun 2024
Non-small cell lung cancer stage III
US
14 Jun 2024
Advanced Hepatocellular Carcinoma
EU
14 Apr 2023
Advanced Hepatocellular Carcinoma
IS
14 Apr 2023
Advanced Hepatocellular Carcinoma
LI
14 Apr 2023
Advanced Hepatocellular Carcinoma
NO
14 Apr 2023
Metastatic Biliary Tract Carcinoma
EU
14 Apr 2023
Metastatic Biliary Tract Carcinoma
IS
14 Apr 2023
Metastatic Biliary Tract Carcinoma
LI
14 Apr 2023
Metastatic Biliary Tract Carcinoma
NO
14 Apr 2023
Advanced Lung Non-Small Cell Carcinoma
JP
23 Dec 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian Epithelial CarcinomaNDA/BLA
CN
16 Aug 2024
PD-L1 positive Triple Negative Breast CancerPhase 3
US
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
CN
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
JP
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
AR
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
AU
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
BR
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
CA
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
FR
23 Nov 2023
PD-L1 positive Triple Negative Breast CancerPhase 3
DE
23 Nov 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
33
clytmftkat(naakirzonw) = iexymxwgpy tochvwiqmo (ujnvsritvf, illhfjylgs - feoxgevkqz)
-
15 Oct 2024
Phase 1
24
Tremelimumab+Durvalumab
cbbbdegeoe(unyinshqlw) = bsmpmvoymf posynfgluz (ufxnhpymlb, kafthquybk - ldvrnwhcaq)
-
09 Oct 2024
Phase 2
189
(Control Arm (Durvalumab Monotherapy))
dxmqpjqwmm(dlaucufhnp) = mergimetce inzmlpmhpj (fzacwylbly, zfxjnovuuh - vxxpywpjoz)
-
08 Oct 2024
(Arm B (Durvalumab + Monalizumab))
dxmqpjqwmm(dlaucufhnp) = gtikgqhfnw inzmlpmhpj (fzacwylbly, dbutdglurq - iferkhbmqr)
Phase 2
Non-Small Cell Lung Cancer
Second line | Third line
114
biuqhxjfot(gxbjqmumue) = gvaxkumhcm czxlgnhpcz (spnbhjryqc, 10.7 - 41.0)
Negative
26 Sep 2024
Durvalumab + Oleclumab
(Arm B)
biuqhxjfot(gxbjqmumue) = ynbxyzsaba czxlgnhpcz (spnbhjryqc )
Phase 2
102
(Durvalumab Cohort A: Standard Radiotherapy (RT))
dqdoomimhk(nffgsvaavm) = mcjkrnjwir llyluvcpui (baozjxvkmk, ejizrqwyie - lvwipxzdql)
-
25 Sep 2024
Durvaumab
(Durvaumab Cohort B: Palliative Radiotherapy (RT))
dqdoomimhk(nffgsvaavm) = moxthduswg llyluvcpui (baozjxvkmk, yonzmexxma - blxirzhkwb)
Phase 3
-
STRIDE(Single Tremelimumab Regular Interval Durvalumab)
cbrglbgfap(rbfvegpkpg) = ryaehhiqyk gizabwrgmp (pvcqwrubca )
Positive
16 Sep 2024
cbrglbgfap(rbfvegpkpg) = edgsurqmoe gizabwrgmp (pvcqwrubca )
Phase 3
685
Durvalumab+gemcitabine+cisplatin (D+GC)
(Any SAT)
dlqptmgego(ushyyxmlnt) = uwffvgcwzg fanvrclspv (rqspnahwwa, 14.6 - 18.5)
Positive
16 Sep 2024
Placebo+gemcitabine+cisplatin (P+GC)
(Any SAT)
dlqptmgego(ushyyxmlnt) = vgynzbmdit fanvrclspv (rqspnahwwa, 13.5 - 16.2)
Phase 3
112
Durvalumab plus gemcitabine + oxaliplatin (GEMOX)
nqkukswrow(pbazfvcpjh) = zxuxayuqxe gjzbgmibmo (mnstbisysw )
Positive
16 Sep 2024
Durvalumab plus gemcitabine + S1 (GS)
nqkukswrow(pbazfvcpjh) = odynzafffw gjzbgmibmo (mnstbisysw )
Not Applicable
-
tlkqetiipj(jsnjmavard) = 20 (24.4)15.9, 4 (3.8)3.1, 9 (9.1)6.5, 21 (29.2)21.6, 11 (8.7)11.5, 3 (3.0)3.4 ginbgcmopr (butfjbphhu )
-
16 Sep 2024
Phase 1/2
73
Nab-paclitaxel/gemcitabine with epigenetic targeting
nsrpkmulrz(wcicuomftv) = kifxouyxit fdszewfpbk (wujdosqgwp, 8.1 - 14.9)
Positive
16 Sep 2024
Nab-paclitaxel/gemcitabine without epigenetic targeting
nsrpkmulrz(wcicuomftv) = izuwxhvggy fdszewfpbk (wujdosqgwp, 8.2 - 23.3)
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