Delving into the Latest Updates on Rimantadine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Rimantadine, Rimantadine Hydrochloride Granules, Rimantadine Hydrochloride Syrup

+ [13]

Target

M2 protein

Action

inhibitors

Mechanism

M2 protein inhibitors(Matrix protein 2 inhibitors)

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication

Influenza A virus infection

Inactive Indication-

Originator Organization

Sun Pharmaceutical Industries Ltd.

Active Organization

Apeloa Pharmaceutical Co., Ltd.

Inactive Organization

Sun Pharmaceutical Industries, Inc.Forest Laboratories, Inc.

Drug Highest PhaseApproved

First Approval Date

United States (17 Sep 1993),

Influenza A virus infection

Regulation-

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Structure/Sequence

Molecular FormulaC12H21N

InChIKeyUBCHPRBFMUDMNC-UHFFFAOYSA-N

CAS Registry13392-28-4

View All Structures (2)

Hepatitis C virus is one of the leading causes of liver failure and liver cancer worldwide. Current treatment of hepatitis C infection is only successful in about half of those who are eligible. The current treatment aims to boost the host immune system but does not directly act on the virus. Many drugs are in various stages of development that target the virus directly - their specific mode of action is confirmed by showing the virus is forced to adapt in the presence of the drug. As with many viruses, treating with only one specific drug would quickly lead to the virus adapting and becoming resistant. We therefore need to find new combinations of directly acting drugs. Rimantadine has already been shown in the laboratory to target hepatitis C directly. We have designed this study to see if it happens in real life as well. If so, we could use rimantadine to help fight hepatitis c more effectively.

Start Date01 May 2012

Sponsor / Collaborator

Leeds Teaching Hospitals NHS Trust

[+1]

NCT01172847

/ CompletedPhase 1

An Open-label, Multiple Dose, Randomized, Three-period Crossover Study in Healthy Subjects to Evaluate the Effect of Co-administration of Oseltamivir (Ro 64-0796) 75 mg Twice Daily and Rimantadine 100 mg Twice Daily on the Pharmacokinetic Properties of Oseltamivir and Rimantadine.

This open label, randomized, three-period crossover study will evaluate the effect of co-administration of Tamiflu (oseltamivir) and rimantadine on the pharmacokinetics of Tamiflu and rimantadine. Healthy volunteers will receive multiple oral doses of Tamiflu, rimantadine or Tamiflu plus rimantadine in random order, with a minimum wash-out period of 7 days between treatments. Anticipated time on study is up to 11 weeks.

Start Date01 Aug 2009

Sponsor / Collaborator

Hoffmann-La Roche, Inc.

100 Clinical Results associated with Rimantadine Hydrochloride

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100 Translational Medicine associated with Rimantadine Hydrochloride

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100 Patents (Medical) associated with Rimantadine Hydrochloride

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1,668

Literatures (Medical) associated with Rimantadine Hydrochloride

24 Mar 2025·Journal of Biomolecular Structure and Dynamics

Inhibition of respiratory syncytial virus by Daclatasvir and its derivatives: synthesis of computational derivatives as a new drug development

Article

Author: Afreen, Shagufta ; Mitra, Debanjan ; Abdalla, Mohnad ; Das Mohapatra, Pradeep K.

The most common cause of respiratory tract illness in newborns and young children is the respiratory syncytial virus (RSV). There is no approved vaccination or specific antiviral medication for RSV infections. Here, an attempt has been made to explore the potential of currently marketed drugs as well as their probable derivatives to improve the possibility of developing stronger medications against RSV. From the 100 synthetic drug compounds library, the best drug molecule was identified through drug-likeness properties, toxicity, molecular docking and molecular dynamics simulations. Molecular Mechanics Generalized Born Surface Area (MM-GBSA) was also a method that was applied in this study. Daclatasvir showed the highest binding energy and appeared as the best drug to inhibit matrix protein and a fusion protein of RSV. Based on Daclatasvir, 40 computational derivatives were made. D28, D34 and D40 showed far better results than the actual drug. Changes in lipophilicity character increase the binding energy of derivatives. Molecular dynamic simulations showed their non-deviated, non-fluctuated and stable complex formation with target proteins. The high number of amino acid contacts throughout the trajectory increases the stability and effectiveness of derivatives. The key to producing a novel medicine to eradicate RSV is provided by derivatives. Daclatasvir will be employed as a potential RSV inhibitor up until that point.Communicated by Ramaswamy H. Sarma.

01 Feb 2025·Journal of Chromatography A

Method development and validation for the simultaneous determination of 21 antiviral drugs by ultra-high performance liquid chromatography-tandem mass spectrometry in chicken muscle and liver

Article

Author: Castiñeira-Landeira, Ana ; Arrizabalaga-Larrañaga, Ane ; Sasse, Samantha ; Broeren, Melissa ; Sterk, Saskia S

The recent unauthorization of antiviral drugs in food-producing animals according to Commission Delegated Regulation (EU) 2022/1644 have increased the need for food control laboratories to develop analytical methods and perform official controls. In this work, a simple and fast analytical methodology was developed for the simultaneous determination of 21 antiviral drugs in chicken muscle and liver by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Chromatographic separation was achieved by an HILIC BEH amide column; followed by detection with a electrospray ionization source in positive and negative modes. Based on extraction efficiencies, critical parameters affecting sample treatment were optimized including the evaporation and clean up steps to extract the largest number of antiviral drugs and reduce interferences. The method was validated according to Commission Implementing Regulation (EU) 2021/808 in chicken muscle and liver. Most compounds showed a linearity of R²>0.9800, while decision limits were between 0.18 and 7.05 μg kg^-1 and 0.19 and 36 μg kg^-1 for chicken muscle and liver, respectively. Trueness and within-lab reproducibility were determined at three levels (n = 7) and the results showed values ranging from 81 to 133 % and 4.2-57 % for chicken muscle, and 71-136 % and 4.6-106 % for chicken liver, respectively. The applicability of the developed method was demonstrated by the analysis real samples. 20 samples from the National Residue Control Plan in the Netherlands were analyzed and although none of targeted compounds were detected it is important to continue the analysis of larger set of samples to address any possible food safety risks.

13 Dec 2024·ACS ES&T Water

Time-Dependent Intrinsic Correlation Analysis Reveals Positive Relationship between Drug Types in Wastewater: Antidepressants vs Illicit Drugs and Analgesics vs Antibiotics/Antivirals

Author: Abaya, Liezel Mari M. ; Tung, Jasmin Y. ; Halwatura, Lahiruni M. ; Witmer, Cheyanne ; Aga, Diana S. ; Tsai, Christina W.

The connection between mental health and illicit substance abuse disorder is intricate and poorly understood but may potentially be unraveled by examining residues of antidepressants and illicit drugs through wastewater-based epidemiol. (WBE).In this study, we assessed time-dependent intrinsic correlations (TDIC) between the concentrations of antidepressants and illicit drugs and their metabolites in untreated sewage samples during three sampling campaigns, from Sept. 2022 to May 2024.Notable pos. correlations (+medium in 2022; + weak in 2023; + medium in 2022) were observed between illicit drugs (e.g., methamphetamine, cocaine, and its benzoylecgonine metabolite) and bupropion (an antidepressant).For other psychoactive drugs examined (citalopram, venlafaxine, and its metabolite desvenlafaxine) + medium correlations were observed with illicit drugs in the 2023 and 2024 sampling campaigns.This is the first time WBE demonstrates the interconnection between prescription psychoactive drugs, such as antidepressants, and illicit drugs, underscoring TDICs strength in extracting information from complementary data.We applied similar data analytics using residues of antivirals and antibiotics in untreated sewage and their correlation with acetaminophen; the expected results were obtained.TDIC between acetaminophen and antibiotics showed a strong correlation during the whole sampling event, supporting the applicability of TDIC in WBE research.

100 Deals associated with Rimantadine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D00901	Rimantadine Hydrochloride	J05AC02	DB00478

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Influenza A virus infection	China	Apeloa Pharmaceutical Co., Ltd.	01 Jan 2001

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01172847 (CTgov)	Phase 1	-	24	Oseltamivir (Oseltamivir)	fyuokxoeby(qsflaexjjo) = jadlelbxwn fdiaepyzhh (dipwpxrylw, bdjpsjspua - qogbwgmhsk) View more	-	21 Mar 2016
				Oseltamivir+Rimantadine (Oseltamivir + Rimantadine)	fyuokxoeby(qsflaexjjo) = zipvybmgvs fdiaepyzhh (dipwpxrylw, bqubldzdkj - yeuhlliani) View more