This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other opioid-related problems. Yet, there are no programs at the VHA to help them find alternatives to opioids, nor evidence to inform the choice of interventions. This study will meet these needs by examining four interventions that are effective at reducing opioid use in patients with chronic musculoskeletal pain but have yet to be tested in cancer survivors on long term opioid therapy. The proposed work is relevant to the VHA Pain Office's mission to provide Veterans better pain management while limiting the risks of long-term opioid therapy and it aligns with VHA Research and Development's priority to examine clinical interventions for tapering opioids. Successful completion this project will keep VHA at the forefront of the battle against the opioid epidemic with a strategy that may be adapted to address the same needs in non-Veterans.

Start Date01 Apr 2025

Sponsor / Collaborator

VA Office of Research and Development

NCT05339256

/ Not yet recruitingPhase 2IIT

A Randomized, Controlled Trial of Sublingual Buprenorphine Through Telemedicine Vs In-Person Care As Usual in the Treatment of Opioid Use Disorder

This study will compare in-person induction and maintenance dosing of sublingual buprenorphine to induction and maintenance dosing of sublingual buprenorphine through comprehensive telehealth sessions and telehealth medication for opioid use disorder (MOUD).

Start Date01 Mar 2025

Sponsor / Collaborator

The New York State Psychiatric Institute

[+1]

NCT04454411

/ Not yet recruitingPhase 2IIT

Brain Mechanisms of Cognitive Response to Pharmacotherapy in Opioid Use Disorder

This study will investigate the mechanisms of cognitive-behavioral response to medications used for relapse prevention in opioid use disorder (opioid addiction, OUD), through investigation of the neural circuits underlying key cognition functions. The study will use previously validated cognitive probes, functional Magnetic Resonance Imaging (fMRI), and novel extended-release injectable preparations of opioid partial agonist buprenorphine and antagonist naltrexone, in OUD patients to explain the individual heterogeneity of OUD treatment response.

Start Date01 Feb 2025

Sponsor / Collaborator

University of Pennsylvania

100 Clinical Results associated with Buprenorphine

100 Translational Medicine associated with Buprenorphine

100 Patents (Medical) associated with Buprenorphine

12,171

Literatures (Medical) associated with Buprenorphine

01 Apr 2025·Journal of substance use and addiction treatment

Perceived organizational support for the treatment of opioid use disorder and its association with primary care provider treatment willingness and medication prescribing

Article

Author: Miller, William C ; Franz, Berkeley ; Go, Vivian ; Dhanani, Lindsay Y ; Simon, Janet E

INTRODUCTION:

Buprenorphine is a highly effective medication for opioid use disorder (MOUD; OUD), which can be prescribed alongside naloxone in the primary care setting as part of a harm reduction approach to OUD. Despite this potential, implementation challenges have limited adoption of MOUD. To address barriers at the organizational level, we need better tools to measure perceived organizational support for the treatment of OUD and use of MOUD in the primary care setting. In this study, we developed an OUDSUPPORT measure to assess the relationship between organizational culture and critical treatment attitudes and behaviors in primary care.

METHODS:

We conducted a statewide survey of 404 primary care-aligned health professionals (PCPs) in Ohio. We analyzed the survey data using descriptive and bivariate statistics. Additionally, three stepwise multivariable regression models assess the relationship between organizational support and three primary outcomes: willingness to treat OUD; receipt of the X-waiver, which was previously required to prescribe buprenorphine; and naloxone prescribing, independent of individual and county-level predictors.

RESULTS:

The OUDSUPPORT measure demonstrated satisfactory psychometric properties, and was associated with meaningful treatment outcomes. PCPs perceived the strongest organizational support for a shared mission of providing care to people with OUD. The least commonly endorsed form of organizational support was for prescribing buprenorphine. Perceived organizational support was associated with increased willingness to treat OUD (b = 0.26; 95 % CI: 0.17, 0.35); higher odds of having received the X-waiver (OR = 1.63; 95 % CI: 1.26, 2.12); and higher odds of naloxone prescribing (OR = 1.71; 95 % CI: 1.30, 2.25).

CONCLUSIONS:

OUDSUPPORT is a multidimensional measure of perceived organizational support for the treatment of OUD, which was associated with treatment willingness, receipt of buprenorphine prescribing training, and naloxone prescribing among PCPs. Implementation strategies to increase buprenorphine prescribing in the primary care setting must include efforts to decrease stigma, and address hesitance related to MOUD and harm reduction at the administrative level, in addition to addressing well known barriers at the individual prescriber level.

01 Apr 2025·Journal of substance use and addiction treatment

The impact of buprenorphine prescriber data on geospatial access to treatment in HEALing Communities Study communities, 2022

Article

Author: Srinivasan, Sumeeta ; Silwal, Anita ; Rock, Peter ; Shrestha, Shikhar ; Stopka, Thomas J ; Barboza-Salerno, Gia ; Harris, Daniel R ; Lewis, Olivia

INTRODUCTION:

The location of buprenorphine treatment providers in the United States is pivotal to the understanding of regional factors associated with prescription and uptake. We evaluated how distinct data sources of treatment providers and their associated locations contribute to the differences observed when measuring buprenorphine accessibility.

METHODS:

We compared buprenorphine treatment provider data from the Drug Enforcement Administration (DEA) and data from the behavioral health treatment locator from the Substance Abuse and Mental Health Services Administration (SAMHSA) for July 2022. Both DEA and SAMHSA data, while similar in spirit, vary substantially in how and why each data set is collected. DEA registration was required by law, while SAMHSA data was an opt-in registry of provider-submitted details. Analyzing the underlying semantics of the data is important for understanding the contextual factors driving observable differences in analytical outputs. We measured accessibility using enhanced two-step floating catchment area (E2SFCA) analysis in three states participating in the HEALing Communities Study (Kentucky, Ohio, Massachusetts). Within communities, we compared decile rankings of accessibility per census tract using each data source. We linked prescribing data from Kentucky's prescription drug monitoring program (PDMP) to measure accessibility using providers prescribing buprenorphine. We explored the significance of localized rank exchanges using neighbor set local indicators of mobility association (LIMA).

RESULTS:

The number and rate of providers per capita differed substantially at the community level between data sources in the three states. These differences were less impactful in the spatial context of buprenorphine accessibility, which required both supply and demand in regions smaller than our intervention communities. Shifts did occur when measuring the intercommunity decile ranking of accessibility of census tracts, but LIMA results indicated that these rank exchanges were not significant.

CONCLUSIONS:

When analyzing accessibility within a community using E2SFCA analyses, either DEA or SAMHSA data sources are acceptable; linkage to Kentucky's PDMP demonstrated that SAMHSA provider data is equally suitable to PDMP data for research studies involving spatial relationships with providers while being both significantly easier to obtain and less sensitive. When analyzing treatment provider rates per capita, results may vary substantially across these different data sources. Therefore, context must be considered when choosing an appropriate data source to use.

01 Apr 2025·Clinical Nutrition ESPEN

Pomegranate juice ameliorates craving and oxidative stress on patients under medication for opioid addiction treatment with methadone and buprenorphine: A ranzomised controlled trial

Article

Author: Metsios, George S ; Leventelis, Christonikos ; Papageorgiou, Kalliopi ; Tentolouri, Anna ; Barmpas, Petros T ; Kouretas, Demetrios ; Tekos, Fotios ; Ververi, Anastasia ; Makri, Sotiria ; Veskoukis, Aristidis S ; Mountzouridi, Evangelia ; Tasoulis, Sotiris

BACKGROUND & AIMS:

Buprenorphine and methadone are drugs used as medication for addiction treatment for patients with opioid use disorders (OUDs). However, scarce evidence indicates that they induce oxidative stress, which contributes to the deterioration of psychosocial parameters, thus complicating successful rehab. Therefore, a dietary antioxidant intervention such as pomegranate could be beneficial for that group of patients. Therefore, the aim of this study, whose protocol has been registered in the international database ClinicalTrials.gov (Identifier: NCT05861544), was to examine the putative beneficial role of consumption of natural pomegranate juice that possesses potent antioxidant properties on craving, a psychosocial parameter of utmost importance, and blood redox status of patients with OUDs.

METHODS:

The juice was administered at the following dosage: 250 ml/day, 7 days/week, 120 days. The heroine craving questionnaire was completed to assess craving and blood was collected by the volunteers at three time points, namely days 1, 60 and 120 and well-established redox biomarkers were measured in blood.

RESULTS:

Overall, craving of all patients was improved due to the nutritional treatment applied. Moreover, their blood antioxidant potential was enhanced due to pomegranate juice consumption.

CONCLUSIONS:

As a conclusion, the obtained evidence is promising, thus, it appears that pomegranate juice consumption could be considered as an auxiliary nutritional intervention in parallel with medication towards rehab of opioid-addicted patients.

News (Medical) associated with Buprenorphine

19 Nov 2024

·www.indivior.com

Rapid Initiation with Once-monthly SUBLOCADE® Superior to Standard Initiation for Treating Opioid Use Disorder, Including in Fentanyl-Positive Patients, According to Data Presented at CSAM 2024

Data show rapid initiation with once-monthly SUBLOCADE significantly improves retention in opioid use disorder (OUD) patients, especially among fentanyl-positive participants. Study also administered second SUBLOCADE injection a week later vs. standard 28 days, enabling patients to achieve and maintain target medication levels more quickly. Data show rapid initiation with once-monthly SUBLOCADE significantly improves retention in opioid use disorder (OUD) patients, especially among fentanyl-positive participants. Study also administered second SUBLOCADE injection a week later vs. standard 28 days, enabling patients to achieve and maintain target medication levels more quickly. Presented at the 2024 Canadian Society of Addiction Medicine (CSAM) conference, this study highlights the potential of rapid initiation to transform the treatment of opioid use disorder. Presented at the 2024 Canadian Society of Addiction Medicine (CSAM) conference, this study highlights the potential of rapid initiation to transform the treatment of opioid use disorder. Data supporting the subcutaneous administration of SUBLOCADE to alternative injection sites including the thigh, upper arm, and buttocks vs current subcutaneous abdominal injection site, were also presented at CSAM. Data supporting the subcutaneous administration of SUBLOCADE to alternative injection sites including the thigh, upper arm, and buttocks vs current subcutaneous abdominal injection site, were also presented at CSAM. SUBLOCADE has received Priority Review designation from the U.S. Food and Drug Administration (FDA) to expand the label to include rapid initiation one hour after a single transmucosal buprenorphine dose as well as inclusion of alternative injection sites. SUBLOCADE has received Priority Review designation from the U.S. Food and Drug Administration (FDA) to expand the label to include rapid initiation one hour after a single transmucosal buprenorphine dose as well as inclusion of alternative injection sites. RICHMOND, Va., Nov. 19, 2024 -- Indivior PLC (Nasdaq/LSE: INDV) last week shared results from a randomized, open-label sub-study in opioid-dependent participants seeking treatment, (NCT04995029) that demonstrates rapid initiation (RI) with SUBLOCADE® (buprenorphine extended-release injection) for the treatment of OUD significantly improves treatment retention compared to standard initiation (SI). RI with SUBLOCADE in a single day may reduce barriers to treatment and improve patient retention especially those who frequently inject opioids or use fentanyl without increasing the risk of precipitated opioid withdrawal (POW) symptoms. The data were presented at the 2024 Canadian Society of Addiction Medicine (CSAM) conference in Hamilton, Ontario, Canada. “These findings underscore the potential for rapid initiation to transform opioid use disorder treatment,” said Dr. Christian Heidbreder, Ph.D., Chief Scientific Officer at Indivior. “Rapid initiation may improve patient retention and meet the immediate needs brought on by synthetic opioids in real-world settings, offering a practicable path to stabilization and long-lasting, meaningful recovery.” Conducted across multiple sites, this non-inferiority study included 729 participants (mean age 42, average opioid use of 15 years), stratified by fentanyl presence in urine screens, with an observed 78% fentanyl-positive rate. Patients randomized to RI received a single dose of 4 mg transmucosal buprenorphine (TM-BUP), followed by a SUBLOCADE injection within 1 hour. The primary endpoint was treatment retention at injection 2, administered 1 week after injection 1 comparing it to the current standard regimen of 28 days. Those in the SI group received daily TM-BUP doses over ≥7 days before injection, and if non-inferiority was met, superiority was assessed. Among the participants, RI was superior to SI in retention rates at injection 2, with a 12% improvement overall and 15% in the fentanyl-positive group. The shorter dose interval between BUP-XR injection 1 and 2 was designed to achieve and maintain buprenorphine plasma concentrations more quickly at target levels of 2 ng/mL. The overall Treatment Emergent Adverse Events (TEAE) profile up to Injection 2 was comparable for RI and SI. There were no unexpected safety findings. Data supporting the subcutaneous administration of SUBLOCADE to alternative injection sites including the thigh, upper arm, and buttocks were also presented at CSAM (NCT04995029). SUBLOCADE has received Priority Review designation granted by the U.S. Food and Drug Administration (FDA) for a labeling supplement, which would expand the label to include rapid initiation one hour after a single transmucosal buprenorphine dose and also expands from the current subcutaneous abdominal injection site for induction and maintenance to alternative injection sites including the thigh, upper arm, and buttocks. With a Prescription Drug User Fee Act (PDUFA) action date set for February 7, 2025, this Prior Approval Supplement (PAS) submission, if approved, could allow healthcare providers a flexible approach to initiate treatment rapidly, supporting better retention outcomes for OUD patients, particularly those testing positive for fentanyl. A Priority Review designation means that the FDA's goal is to take action on an application within 6 months (compared to 10 months under standard review). If approved, this label change could translate into significant improvements in OUD treatment with SUBLOCADE. +++ This press release has been issued by Indivior Inc. and the content has not been approved or authorized by the Canadian Society of Addiction Medicine. +++ About SUBLOCADE® SUBLOCADE ® (buprenorphine extended-release) injection, for subcutaneous use, CIII INDICATION AND HIGHLIGHTED SAFETY INFORMATION INDICATION SUBLOCADE is indicated for the treatment of moderate to severe opioid use disorder in patients who have initiated treatment with a buprenorphine-containing product, followed by dose adjustment for a minimum of 7 days. SUBLOCADE should be used as part of a complete treatment plan that includes counseling and psychosocial support. HIGHLIGHTED SAFETY INFORMATION WARNING: RISK OF SERIOUS HARM OR DEATH WITH INTRAVENOUS ADMINISTRATION; SUBLOCADE RISK EVALUATION AND MITIGATION STRATEGY Serious harm or death could result if administered intravenously. SUBLOCADE forms a solid mass upon contact with body fluids and may cause occlusion, local tissue damage, and thrombo-embolic events, including life threatening pulmonary emboli, if administered intravenously. Serious harm or death could result if administered intravenously. SUBLOCADE forms a solid mass upon contact with body fluids and may cause occlusion, local tissue damage, and thrombo-embolic events, including life threatening pulmonary emboli, if administered intravenously. Because of the risk of serious harm or death that could result from intravenous self-administration, SUBLOCADE is only available through a restricted program called the SUBLOCADE REMS Program. Healthcare settings and pharmacies that order and dispense SUBLOCADE must be certified in this program and comply with the REMS requirements. Because of the risk of serious harm or death that could result from intravenous self-administration, SUBLOCADE is only available through a restricted program called the SUBLOCADE REMS Program. Healthcare settings and pharmacies that order and dispense SUBLOCADE must be certified in this program and comply with the REMS requirements. CONTRAINDICATIONS SUBLOCADE should not be administered to patients who have been shown to be hypersensitive to buprenorphine or any component of Indivior's proprietary buprenorphine gel depot delivery system. WARNINGS AND PRECAUTIONS Addiction, Abuse, and Misuse: SUBLOCADE contains buprenorphine, a Schedule III controlled substance that can be abused in a manner similar to other opioids. Monitor patients for conditions indicative of diversion or progression of opioid dependence and addictive behaviors. Respiratory Depression: Life threatening respiratory depression and death have occurred in association with buprenorphine. Warn patients of the potential danger of self-administration of benzodiazepines or other CNS depressants while under treatment with SUBLOCADE. Opioids can cause sleep-related breathing disorders e.g., central sleep apnea (CSA), sleep-related hypoxemia. Opioid use increases the risk of CSA in a dose-dependent fashion. Consider decreasing the opioid using best practices for opioid taper if CSA occurs. Strongly consider prescribing naloxone at SUBLOCADE initiation or renewal because patients being treated for opioid use disorder have the potential for relapse, putting them at risk for opioid overdose. Educate patients and caregivers on how to recognize respiratory depression and how to treat with naloxone if prescribed. Risk of Serious Injection Site Reactions: The most common injection site reactions are pain, erythema and pruritus with some involving abscess, ulceration, and necrosis. The likelihood of serious injection site reactions may increase with inadvertent intramuscular or intradermal administration. Neonatal Opioid Withdrawal Syndrome: Neonatal opioid withdrawal syndrome is an expected and treatable outcome of prolonged use of opioids during pregnancy. Adrenal Insufficiency: If diagnosed, treat with physiologic replacement of corticosteroids, and wean patient off the opioid. Risk of Opioid Withdrawal With Abrupt Discontinuation: If treatment with SUBLOCADE is discontinued, monitor patients for several months for withdrawal and treat appropriately. Risk of Hepatitis, Hepatic Events: Monitor liver function tests prior to and during treatment. Risk of Withdrawal in Patients Dependent on Full Agonist Opioids: Verify that patient is clinically stable on transmucosal buprenorphine before injecting SUBLOCADE. Treatment of Emergent Acute Pain: Treat pain with a non-opioid analgesic whenever possible. If opioid therapy is required, monitor patients closely because higher doses may be required for analgesic effect. ADVERSE REACTIONS Adverse reactions commonly associated with SUBLOCADE (in ≥5% of subjects) were constipation, headache, nausea, injection site pruritus, vomiting, increased hepatic enzymes, fatigue, and injection site pain. For more information about SUBLOCADE, the full Prescribing information including BOXED WARNING, and Medication Guide, visit www.sublocade.com. About Opioid Use Disorder (OUD) Opioid Use Disorder (OUD) is a chronic disease in which people develop a pattern of using opioids that can lead to negative consequences.1 OUD may affect the parts of the brain that are necessary for life-sustaining functions.1,2 Important Cautionary Note Regarding Forward-Looking Statements This press release contains certain statements that are forward-looking. Forward-looking statements include, among other things, express and implied statements regarding: Indivior PLC’s expectations regarding the timing of approval for the PAS for rapid induction and injection sites, and the potential impact on OUD treatments and Sublocade from such; and other statements containing the words "believe," "anticipate," "plan," "expect," "expectations," "intend," "estimate," "forecast," “strategy,” “target,” “guidance,” “outlook,” “potential,” "project," "priority," "may," "will," "should," "would," "could," "can," the negatives thereof, and variations thereon and similar expressions. By their nature, forward-looking statements involve risks and uncertainties as they relate to events or circumstances that may or may not occur in the future. Actual results may differ materially from those expressed or implied in these forward-looking statements due to a number of factors, including: failure or delay in obtaining approval of the PAS and the acceptance by HCPs and their patients of the perceived benefits of such PAS changes. For information about some of the risks and important factors that could affect our future results and financial condition, see "Risk Factors" in Indivior's Annual Report on Form 20-F for the fiscal year 2023 and its other filings with the U.S. Securities and Exchange Commission. We have based the forward-looking statements in this press release on our current expectations and beliefs concerning future events. Forward-looking statements contained in this press release apply only at the date of this press release and, except as required by law, we undertake no obligation to update or revise any forward-looking statement, whether due to new information, future developments, or otherwise. About Indivior Indivior is a global pharmaceutical company working to help change patients' lives by developing medicines to treat substance use disorders (SUD). Our vision is that all patients around the world will have access to evidence-based treatment for the chronic conditions and co-occurring disorders of SUD. Indivior is dedicated to transforming SUD from a global human crisis to a recognized and treated chronic disease. Building on its global portfolio of OUD treatments, Indivior has a pipeline of product candidates designed to expand on its heritage in this category. Headquartered in the United States in Richmond, VA, Indivior employs over 1,000 individuals globally and its portfolio of products is available in over 30 countries worldwide. Visit www.indivior.com to learn more. Connect with Indivior on LinkedIn by visiting www.linkedin.com/company/indivior. Media Contacts: US Media: Cassie France-Kelly VP, Communications Indivior PLC Tel: +1(804) 724-0327 References  National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Committee on Medication-Assisted Treatment for Opioid Use Disorder, Mancher, M., & Leshner, A. I. (Eds.). (2019). Medications for Opioid Use Disorder Save Lives. National Academies Press (US). Accessed October 30, 2023, from https://www-ncbi-nlm-nih-gov.libproxy1.nus.edu.sg/books/NBK538936/pdf/Bookshelf_NBK538936.pdf NIDA. 2022, March 22. Drugs and the Brain. Accessed October 30,2023, from https://nida-nih-gov.libproxy1.nus.edu.sg/publications/drugs-brains-behavior-science-addiction/drugs-brain

Clinical ResultPriority ReviewPhase 3

07 Nov 2024

·www.camurus.com

Camurus’ Interim Report Third Quarter 2024

“Solid third quarter and raised full-year outlook” Summary third quarter 2024 July - September January - September Significant events after the period Financial summary third quarter 2024 Excluding one-time milestones related to the Brixadi approval by the FDA in the US in 2023 At constant exchange rate Fredrik Tiberg, President and CEO: “Camurus has had another good quarter with positive financial development and excellent performance across our businesses. Sales of Buvidal and Brixadi continued to grow, resulting in our best result to date, excluding one-time revenues. Our pipeline progressed well with positive Phase 3 results from the ACROINNOVA 2 study, confirming the long-term safety profile and efficacy of CAM2029 in patients with acromegaly. In parallel, our clinical studies of CAM2029 for the treatment of neuroendocrine tumors and polycystic liver disease advanced. In the US, the FDA continued its review of our new drug application for CAM2029 in acromegaly. After the quarter, a Complete Response Letter was received from the Agency, solely relating to a cGMP-inspection at a third-party manufacturing site and pending issuance of an inspection classification.” Audiocast Financial analysts and media are invited to attend a telephone conference and presentation of the results today at 2.00 pm (CET). The conference call can also be followed by a link on www.camurus.com or via external link: https://financialhearings.com/event/48851 For more information: Fredrik Tiberg, President and CEO Tel. +46 (0)46 286 46 92 fredrik.tiberg@camurus.com Fredrik Joabsson, Chief Business Development Officer Tel. +46 (0)70 776 17 37 ir@camurus.com About Camurus Camurus is a Swedish science-led biopharmaceutical company committed to developing and commercializing innovative and differentiated medicines for the treatment of severe and chronic conditions. New drug products with best-in-class potential are conceived based on the company’s proprietary FluidCrystal® drug delivery technologies and its extensive R&D expertise. Camurus’ clinical pipeline includes products for the treatment of dependence, pain, cancer, and endocrine disease, developed in-house and in collaboration with international pharmaceutical companies. The company’s shares are listed on Nasdaq Stockholm under the ticker CAMX. For more information, visit www.camurus.com. This information is information that Camurus AB is obliged to make public pursuant to the EU Market Abuse Regulation and to the Securities Markets Act. The information was submitted for publication, through the agency of the chief executive officer, at 07.00 am CET on 7 November, 2024.

Financial StatementClinical ResultDrug ApprovalPhase 3

31 Oct 2024

·www.businesswire.com

Anthem Blue Cross and Blue Shield Foundation Awards $600,000 Grant to Care for the Homeless

NEW YORK--( BUSINESS WIRE )--Anthem Blue Cross and Blue Shield Foundation today announced a $600,000 grant to Care For the Homeless (CFH) to expand its "Bronx Health Reach Initiative," a program addressing mental health and substance use disorders among the South Bronx homeless population. The Bronx Health Reach Initiative is a vital street-based outreach program designed to combat mental health and substance use crises, focusing on Medication-Assisted Treatment (MAT) for opioid addiction. In 2023, CFH provided trauma-informed services to over 11,000 homeless individuals in New York City, a 15% increase from the previous year. “The mental health and substance use disorder crisis affecting the homeless community deserves urgent and sustained support. This grant will enable Care For the Homeless to expand critical services and ensure access to much-needed treatment for vulnerable populations,” said Dr. Mark Levy, President and CEO of Anthem Blue Cross and Blue Shield. “At Anthem, we believe in addressing social determinants of health in a way that drives meaningful and measurable outcomes in the communities we serve.” Care For the Homeless President & CEO George Nashak added, “Recovery begins with accessible, compassionate care. This grant from Anthem allows us to deepen our impact in the South Bronx, particularly in reaching individuals who are battling both homelessness and substance use disorders. Expanding our immediate street-based initiation of Medication-Assisted Treatment (MAT) to address the opioid crisis allows us to provide timely, life-saving treatment to those who need it most.” The two-year grant will enhance outreach, staffing, and treatment resources, strengthening CFH's partnerships and increasing community engagement. With the opioid crisis continuing to impact the Bronx, this expansion is crucial for providing sustainable recovery opportunities. In addition to expanding access to care, the Bronx Health Reach Initiative will implement a comprehensive strategy to address the critical gaps in mental health and substance use disorder treatment within the South Bronx's homeless population. A key focus of the program is the immediate street-based initiation of Medication-Assisted Treatment (MAT), particularly with Buprenorphine, a proven treatment for opioid addiction. By engaging individuals directly where they are, the program aims to remove barriers to treatment and foster long-term recovery. The initiative will utilize a mixed-methods approach, conducting pre- and post-assessments to track progress and impact. Key performance metrics will include treatment engagement, housing stability, and community support. Regular checkpoints, including participant surveys and clinical data reviews, will ensure ongoing program evaluation, allowing for real-time adjustments to enhance effectiveness. CFH projects that over two years, the program will reach 3,300 people, with more than 1,250 individuals expected to participate in the full range of services, including mental health counseling, substance use treatment, and housing support. By prioritizing timely intervention and fostering strong community partnerships, the program aims to improve treatment adherence and access to care for participants by 40% while improving long-term housing stability and quality of life outcomes. The ultimate goal is to create a sustainable recovery model that addresses the immediate and ongoing needs of the South Bronx's most vulnerable populations. About Care For the Homeless Care For the Homeless (CFH) is a 501(c)(3) non-profit and is committed to providing individuals experiencing homelessness with high-quality medical, mental, and behavioral health care services. In addition, CFH actively advocates for policies to prevent and end homelessness. CFH also currently operates six housing facilities including four transitional shelters for adult men and women and two Safe Havens for street homeless men, all of which have on-site health care services, as well as twenty-three health care delivery sites across all five New York City boroughs. For more information, visit www.careforthehomeless.org . About Anthem Blue Cross and Blue Shield Foundation The Anthem Blue Cross and Blue Shield Foundation, an independent licensee of the Blue Cross and Blue Shield Association, is a philanthropic arm of the Elevance Health Foundation. The Foundation works to address health equity by focusing on improving the health of the socially vulnerable through strategic partnerships and programs in our communities with an emphasis on maternal child health; mental health; and food as medicine. Additionally, the Foundation also responds to disasters when our communities need us the most. The Foundation coordinates the company’s year-round Dollars for Dollars program which provides a 100 percent match of associates’ donations, as well as its Volunteer Time Off and Dollars for Doers community service programs. ®ANTHEM is a registered trademark of Anthem Insurance Companies, Inc. The Blue Cross names and symbol are registered marks of the Blue Cross and Blue Shield Association. To learn more about the Anthem Blue Cross and Blue Shield Foundation and the Elevance Health Foundation, please visit https://www.elevancehealth.foundation/ and its blog at www.medium.com/elevancehealthfoundation .

100 Deals associated with Buprenorphine

External Link

KEGG	Wiki	ATC	Drug Bank
D07132	Buprenorphine	N07BC01	DB00921

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Opioid-Related Disorders	US	Braeburn, Inc.	23 May 2023
Opium Dependence	EU	Camurus AB	20 Nov 2018
Opium Dependence	IS	Camurus AB	20 Nov 2018
Opium Dependence	LI	Camurus AB	20 Nov 2018
Opium Dependence	NO	Camurus AB	20 Nov 2018
Opioid abuse	US	Indivior, Inc.	30 Nov 2017
Pain	US	Purdue Pharma LP	13 Oct 2017
Chronic Pain	US	Purdue Pharma LP	30 Jun 2010

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Analgesia	Phase 3	-	Purdue Pharma LP	01 Nov 2011
Pain, Postoperative	Phase 3	-	Purdue Pharma LP	01 Nov 2011
Cancer Pain	Phase 3	CN	Beijing Mengdi Pharmaceutical Co. Ltd.	01 Aug 2009
Intervertebral Disc Disease	Phase 3	CN	Beijing Mengdi Pharmaceutical Co. Ltd.	01 Aug 2009
opioid dependence methadone	Phase 3	US	Titan Pharmaceuticals, Inc.	01 Sep 2008
Osteoarthritis, Knee	Phase 3	US	Purdue Pharma LP	01 Sep 2007
Osteoarthritis	Phase 3	US	Purdue Pharma LP	01 Apr 2004
Low Back Pain	Phase 3	US	Purdue Pharma LP	01 Feb 2004
Irritable Bowel Syndrome	Phase 2	US	OrphoMed, Inc.Startup	22 Nov 2019
Depressive Disorder, Major	Preclinical	CN	Shenzhen Sciencare Medical Industries Co., Ltd.	27 Sep 2024

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03605342 (CTgov)	Phase 2	Opioid abuse \| Stress Disorders, Post-Traumatic	38	Cognitive Processing Therapy (CPT)+Buprenorphine (Buprenorphine + CPT-C)	piwypcwfjd(ebiuqhjwlp) = nqbqsmcqyp lfnfbbxqns (eevdgjgzmg, lihotbbfkr - qtnbtteehl) View more	-	19 Aug 2024
				Individual Drug Counseling (IDC)+Buprenorphine (Buprenorphine + IDC)	piwypcwfjd(ebiuqhjwlp) = ossfhzxclb lfnfbbxqns (eevdgjgzmg, ukzfyjgrqd - tktdingyqz) View more
NCT04225598 (Pubmed)	Phase 2	-	100	Extended-Release Buprenorphine (CAM2038)	wukdzbguek(ffhsuibwdn) = ttuxlfavrr wgohsrgrwi (ygbgipcpqh ) View more	Positive	08 Jul 2024
NCT02651584 (PRNewswire) Manual	Phase 3	Opioid-Related Disorders	123	BRIXADI (fentanyl-positive)	saszavddqj(mpvwinpmyd) = wqcnqtjgww phqwmsrbql (vnjxkkficq ) View more	Positive	25 Jun 2024
				buprenorphine + naloxone (fentanyl-positive)	saszavddqj(mpvwinpmyd) = dnmbnnlfeu phqwmsrbql (vnjxkkficq ) View more
NCT02651584 (Pubmed)	Phase 3	fentanyl-positive \| norfentanyl	428	Subcutaneous Buprenorphine	ksmbtdwtih(jgkzoeewep) = mprssdnkfj zarsdhcbka (fjeemmaodr )	Positive	03 Jun 2024
				Sublingual Buprenorphine-Naloxone	ksmbtdwtih(jgkzoeewep) = ekihgojhcr zarsdhcbka (fjeemmaodr )
NCT04254081 (ABCD&E, CTgov)	Phase 4	Anesthesia \| Pain, Procedural	57	Buprenorphine 0.15 MG (Buprenorphine 0.15mg + 1% Lidocaine Paracervical Block)	vwsepvucwm(nuejegzsek) = wazaviletj srjzucaioi (qpgjcaexvy, rizkkereyx - jcmdbaduak) View more	-	01 Aug 2023
				Lidocaine 1% Injectable Solution (1% Lidocaine Paracervical Block)	vwsepvucwm(nuejegzsek) = fhqnnpakts srjzucaioi (qpgjcaexvy, khvvdcjuzs - bimpplyccv) View more
NCT02611752 (FDA) Manual	Phase 2	Opioid-Related Disorders	47	BRIXADI	rsguftrzgs(pebptrlbtq) = No active intramuscular hydromorphone dose resulted in a mean drug liking VAS Emax score of 11 mm or greater when compared to placebo lznsukwbob (qpvicubahu )	Positive	23 May 2023
				Placebo
NCT02651584 (FDA) Manual	Phase 3	Opioid-Related Disorders	428	BRIXADI	tgfkileprl(sqotlfgnpa) = ilxvpgrujd xkgkjfehmu (rtefdbgdsh ) View more	Positive	23 May 2023
				buprenorphine/naloxone	tgfkileprl(sqotlfgnpa) = pwczjqlxxw xkgkjfehmu (rtefdbgdsh ) View more
NCT02187198 (CTgov)	Phase 3	Opium Dependence	9	Buprenorphine (Buprenorphine Low Dose)	kpsqbprmvr(xeulfprqmr) = sqqwrxlnwf kbumfftnsk (dwextygrjh, ifhjbznsky - tvuehzclhu) View more	-	10 Mar 2023
				Buprenorphine (Buprenorphine High Dose)	kpsqbprmvr(xeulfprqmr) = hjkhuxleoc kbumfftnsk (dwextygrjh, ihawgjdezj - ufkbwsnqij) View more
NCT02543944 (GBN, CTgov)	Phase 2/3	Unspecified drug dependence	117	Naltrexone (depot)+Buprenorphine+Clonidine+Gabapentin+Naltrexone (oral) (Gabapentin)	treemncebt(imvsajveir) = tbfmcnzdhc moszdtbayh (rxpbwdaphw, surcrctqqh - idbesppabs) View more	-	28 Jul 2022
				Placebo+Naltrexone (depot)+Buprenorphine+Clonidine+Naltrexone (oral) (Placebo)	treemncebt(imvsajveir) = slkyjsdodz moszdtbayh (rxpbwdaphw, qovvftdetr - wyvhbbrqdx) View more
NCT03232346 (CTgov)	Phase 3	Opioid-Related Disorders	11	Vivitrol (Regimen 1)	lsnjmqmmig(njrejvzzwi) = dppfcqouwj coqhjiulpz (keehoftdph, jtnwvixeux - utlagxeiiw) View more	-	21 Jun 2022
				Buprenorphine (Regimen 2)	lsnjmqmmig(njrejvzzwi) = ldzjoexnbi coqhjiulpz (keehoftdph, yycrsjjnrh - gmpwrmluvb) View more

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