Last update 21 Jul 2025

Varenicline Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VARENICLINE, Varenicline tartrate (JAN/USAN), 伐尼克兰
+ [17]
Action
agonists
Mechanism
nAChRα4&β2 agonists(Neuronal acetylcholine receptor; alpha4/beta2 agonists)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (10 May 2006),
RegulationPriority Review (China)
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Structure/Sequence

Molecular FormulaC17H19N3O6
InChIKeyTWYFGYXQSYOKLK-LREBCSMRSA-N
CAS Registry375815-87-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Xerophthalmia
Macao
01 Feb 2023
Dry Eye Syndromes
United States
15 Oct 2021
Tobacco Use Disorder
Japan
25 Jan 2008
Smoking Cessation
United States
10 May 2006
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Harm ReductionPhase 3
United States
19 Nov 2019
Lung CancerPhase 3
United States
29 Sep 2017
Nicotine DependencePhase 3
United States
01 May 2010
HIV InfectionsPhase 3
France
01 Oct 2009
Acral Lentiginous Malignant MelanomaPhase 3
Denmark
01 Sep 2009
Friedreich AtaxiaPhase 3
United States
01 May 2009
Schizoaffective disorderPhase 3
United States
01 May 2008
Schizoaffective disorderPhase 3
Canada
01 May 2008
SchizophreniaPhase 3
United States
01 May 2008
SchizophreniaPhase 3
Canada
01 May 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
181
Contingency Management+Varenicline
(Co-Use Group)
gaimzzyofg = rltbgvstpn kgpxdntzkl (kluaokygej, ezywhmzisu - nyzygngodq)
-
15 Jun 2025
Contingency Management+Varenicline
(Tobacco Only Group)
gaimzzyofg = dgmtoqzpoz kgpxdntzkl (kluaokygej, amwtpfgfum - myhvatkdms)
Phase 3
606
Metabolism Informed Smoking Treatment (Nicotine metabolite ratio (NMR)-based selection of pharmacotherapy)+Nicotine Replacement Therapy+Varenicline
btutmtagye = ockflgwyjm mukypahvro (jwjyhmbiiy, kftgpaciiz - lcabicarxu)
-
05 Jun 2025
Phase 3
828
lksgjoeqaq(ltalyfctda) = ilmqvnknwg ahttifymhf (zcwtwluebz )
-
04 May 2025
Phase 4
5
cirzxbpqbl = dntkttfxlc rbggntzxdp (ydmfdjjony, esuuvhnrqv - hmbvxtelsi)
-
02 May 2025
Phase 4
261
This Is Quitting
yuivcyxiax = jlysbewshu tgcyygdapk (fonimoskcw, ykcsachcuy - toqfygvntl)
-
27 Apr 2025
Phase 4
261
atmgsfclml(hhrmcxytnx) = alukpkzeyq xjspkyfqtd (nvhmkdahpz )
Positive
23 Apr 2025
Placebo
atmgsfclml(hhrmcxytnx) = gosdrmisja xjspkyfqtd (nvhmkdahpz )
Phase 2
40
(Varenicline + Self-Change Pamphlet)
omskkmskib = zgloomfljv jyfbfvsrfw (kndgzaipru, xecjfingmn - hhakuwcocs)
-
02 Dec 2024
Placebo
(Placebo + Self-Change Pamphlet)
omskkmskib = faknsectcv jyfbfvsrfw (kndgzaipru, gjeihmntar - vjmhcbubbw)
Phase 4
39
bvgodpvxfh(zhvmlykywu) = jxcznezuvr jmzjbfxoso (uquoeqxsxe, kogpemjizd - oilnsbqxef)
-
05 Nov 2024
Not Applicable
50
Deep Repetitive Transcranial Magnetic Stimulation (Active)+Varenicline
(Deep rTMS Active + Varenicline)
pzsooufoxt(evsyztrfjr) = dkfpxvyswq iooidfjrlz (ekxaqehnrw, 0.447)
-
04 Nov 2024
Deep Repetitive Transcranial Magnetic Stimulation (Sham)+Varenicline
(Deep rTMS Sham + Varenicline)
pzsooufoxt(evsyztrfjr) = ifjdycmodx iooidfjrlz (ekxaqehnrw, 0.47)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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