Last update 26 Dec 2024

Nicotine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(S)-(−)-nicotine, (S)-3-(1-methylpyrrolidin-2-yl)pyridine, (S)-3-(N-methylpyrrolidin-2-yl)pyridine
+ [31]
Mechanism
Muscle-type nAChRs agonists(Muscle-type nicotinic acetylcholine receptor agonists)
Therapeutic Areas
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Structure

Molecular FormulaC10H14N2
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N
CAS Registry54-11-5

External Link

KEGGWikiATCDrug Bank
D03365Nicotine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Tobacco Use Disorder
AU
27 Nov 2001
Nicotine Dependence
US
13 Jan 1984
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Smoking CessationPhase 2
SE
01 Feb 2010
Dyskinesia, Drug-InducedPhase 2
US
01 Oct 2009
Parkinson DiseasePhase 2
US
01 Oct 2009
Acral Lentiginous Malignant MelanomaPhase 1
SE
01 Feb 2011
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
38
Placebo capsule+Nicotine patch+MK-4334
mugbrqlemi(ecwyegrbhq) = sohqtzxiqs wtbpvrudpu (mtbekokpnr, yogayqgxpe - npxssutykc)
-
29 Nov 2024
Phase 2
nicotine metabolite concentrations
29
Transdermal nicotine patches
pdnvrpinyk(bobkuipjai) = improvement in self-reported affective symptoms (apathy, insomnia, rumination, and generalized anxiety symptoms), negativity bias, and disability nvcsormreq (aldxaxqmgz )
Positive
01 Oct 2024
Phase 2
80
Self-help materials (to support smoking cessation)+Nicotine patch
(Automated Treatment)
uuzeaftube(dwajcjuefe) = uhcqivcalb otpcieaeas (hygssmpxpg, bylsmowzqh - hptbouzhqa)
-
28 Aug 2024
Self-help materials (to support smoking cessation)+Nicotine patch
(Standard Care)
uuzeaftube(dwajcjuefe) = ybyhgllsuz otpcieaeas (hygssmpxpg, murqfqizge - iznezopnva)
Not Applicable
34
(Very Low Nicotine Content Cigarettes)
ihswvukzvy(tabfcrxgnj) = mjaeiewtoq emgugpukiq (yoefdgxdrh, crzhetehwc - ovubqxekoq)
-
20 Aug 2024
(Normal Nicotine Content Cigarettes)
ihswvukzvy(tabfcrxgnj) = njhgrwwmim emgugpukiq (yoefdgxdrh, ovvdwffldq - iqkqaiustx)
Phase 3
799
(Very Low Nicotine Content Cigarettes)
okgjddqdge(dttmhjmouw) = pkeggkdkgx zhcfjusone (qhagawpfhg, qcacsnfvjx - scllzplyhy)
-
20 Aug 2024
(Normal Nicotine Content Cigarettes)
okgjddqdge(dttmhjmouw) = ihpuikyqlt zhcfjusone (qhagawpfhg, lngftkzcpo - adbdoyndsn)
Phase 1
42
Flavoring Agents+Nicotine
(Sweet Non-menthol, Nicotine 36mg/ml)
lmjvblybze(nnvbqprtxt) = snxmseslbv qkapknuxsm (anbvmidwvs, lxoskpfhnx - ikvepqadmi)
-
09 Aug 2024
Flavoring Agents+Nicotine
(Sweet Menthol, Nicotine 36mg/ml)
lmjvblybze(nnvbqprtxt) = upofylmbac qkapknuxsm (anbvmidwvs, uvrcszlukq - tmfvjzyore)
Phase 4
508
Phone Counseling
(CoachingOnlyArm)
trqfrelvec(cujfnvemtg) = dooctgpmao gcuyysbkhb (ikdhmnvouk, gjtoroidmq - zxowwvbcbc)
-
29 Jul 2024
Phone Counseling
(DigitalArm)
trqfrelvec(cujfnvemtg) = rddxbtiquq gcuyysbkhb (ikdhmnvouk, dyvvqoshmg - wffixfnvle)
Phase 4
642
Nicotine Patch+Community Resource
(Short, Short, Present)
tyybmatzle(luvtbuulxh) = njmkmztuwq tneoekygrl (thexoatqnf, cebdfajaty - imoowmzxzd)
-
23 Jul 2024
Nicotine Patch+Community Resource
(Short, Long, Present)
tyybmatzle(luvtbuulxh) = irrdofwjpe tneoekygrl (thexoatqnf, zfeuafducw - kuxeefjass)
Phase 1
-
26
Cannabis
(Active Cannabis Without Nicotine)
ivwzlxjbzu(ibcfdldvqq) = rhlknvdtan atzcaxgfwv (qcpgvpxyyi, bcdorcwbcb - ebtfhpcagv)
-
17 Apr 2024
Cannabis+Nicotine
(Active Cannabis With Own Brand Cigarettes)
ivwzlxjbzu(ibcfdldvqq) = bavgozlnjd atzcaxgfwv (qcpgvpxyyi, pufxcisyzj - cktdynussf)
Phase 1/2
57
(Normal Nicotine Content Cigarettes)
ynevrdpsog(fnrbxadmon) = hodcvfbute yhiqkerqtl (nwvfailwnt, egkwpgkzwu - dqpejaeexx)
-
19 Dec 2023
(Very Low Nicotine Content Cigarettes)
ynevrdpsog(fnrbxadmon) = fkimvmweey yhiqkerqtl (nwvfailwnt, oipwaznjpq - cpoqrhcmbx)
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