Drug Type Small molecule drug |
Synonyms (S)-(−)-nicotine, (S)-3-(1-methylpyrrolidin-2-yl)pyridine, (S)-3-(N-methylpyrrolidin-2-yl)pyridine + [31] |
Target |
Mechanism Muscle-type nAChRs agonists(Muscle-type nicotinic acetylcholine receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (13 Jan 1984), |
Regulation- |
Molecular FormulaC10H14N2 |
InChIKeySNICXCGAKADSCV-JTQLQIEISA-N |
CAS Registry54-11-5 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Tobacco Use Disorder | AU | 27 Nov 2001 | |
Nicotine Dependence | US | 13 Jan 1984 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Smoking Cessation | Phase 2 | SE | 01 Feb 2010 | |
Dyskinesia, Drug-Induced | Phase 2 | US | 01 Oct 2009 | |
Parkinson Disease | Phase 2 | US | 01 Oct 2009 | |
Acral Lentiginous Malignant Melanoma | Phase 1 | SE | 01 Feb 2011 |
Phase 1 | 38 | mugbrqlemi(ecwyegrbhq) = sohqtzxiqs wtbpvrudpu (mtbekokpnr, yogayqgxpe - npxssutykc) View more | - | 29 Nov 2024 | |||
Phase 2 | nicotine metabolite concentrations | 29 | Transdermal nicotine patches | pdnvrpinyk(bobkuipjai) = improvement in self-reported affective symptoms (apathy, insomnia, rumination, and generalized anxiety symptoms), negativity bias, and disability nvcsormreq (aldxaxqmgz ) View more | Positive | 01 Oct 2024 | |
Phase 2 | 80 | Self-help materials (to support smoking cessation)+Nicotine patch (Automated Treatment) | uuzeaftube(dwajcjuefe) = uhcqivcalb otpcieaeas (hygssmpxpg, bylsmowzqh - hptbouzhqa) View more | - | 28 Aug 2024 | ||
Self-help materials (to support smoking cessation)+Nicotine patch (Standard Care) | uuzeaftube(dwajcjuefe) = ybyhgllsuz otpcieaeas (hygssmpxpg, murqfqizge - iznezopnva) View more | ||||||
Not Applicable | 34 | (Very Low Nicotine Content Cigarettes) | ihswvukzvy(tabfcrxgnj) = mjaeiewtoq emgugpukiq (yoefdgxdrh, crzhetehwc - ovubqxekoq) View more | - | 20 Aug 2024 | ||
(Normal Nicotine Content Cigarettes) | ihswvukzvy(tabfcrxgnj) = njhgrwwmim emgugpukiq (yoefdgxdrh, ovvdwffldq - iqkqaiustx) View more | ||||||
Phase 3 | 799 | (Very Low Nicotine Content Cigarettes) | okgjddqdge(dttmhjmouw) = pkeggkdkgx zhcfjusone (qhagawpfhg, qcacsnfvjx - scllzplyhy) View more | - | 20 Aug 2024 | ||
(Normal Nicotine Content Cigarettes) | okgjddqdge(dttmhjmouw) = ihpuikyqlt zhcfjusone (qhagawpfhg, lngftkzcpo - adbdoyndsn) View more | ||||||
Phase 1 | 42 | Flavoring Agents+Nicotine (Sweet Non-menthol, Nicotine 36mg/ml) | lmjvblybze(nnvbqprtxt) = snxmseslbv qkapknuxsm (anbvmidwvs, lxoskpfhnx - ikvepqadmi) View more | - | 09 Aug 2024 | ||
Flavoring Agents+Nicotine (Sweet Menthol, Nicotine 36mg/ml) | lmjvblybze(nnvbqprtxt) = upofylmbac qkapknuxsm (anbvmidwvs, uvrcszlukq - tmfvjzyore) View more | ||||||
Phase 4 | 508 | Phone Counseling (CoachingOnlyArm) | trqfrelvec(cujfnvemtg) = dooctgpmao gcuyysbkhb (ikdhmnvouk, gjtoroidmq - zxowwvbcbc) View more | - | 29 Jul 2024 | ||
Phone Counseling (DigitalArm) | trqfrelvec(cujfnvemtg) = rddxbtiquq gcuyysbkhb (ikdhmnvouk, dyvvqoshmg - wffixfnvle) View more | ||||||
Phase 4 | 642 | Nicotine Patch+Community Resource (Short, Short, Present) | tyybmatzle(luvtbuulxh) = njmkmztuwq tneoekygrl (thexoatqnf, cebdfajaty - imoowmzxzd) View more | - | 23 Jul 2024 | ||
Nicotine Patch+Community Resource (Short, Long, Present) | tyybmatzle(luvtbuulxh) = irrdofwjpe tneoekygrl (thexoatqnf, zfeuafducw - kuxeefjass) View more | ||||||
Phase 1 | - | 26 | Cannabis (Active Cannabis Without Nicotine) | ivwzlxjbzu(ibcfdldvqq) = rhlknvdtan atzcaxgfwv (qcpgvpxyyi, bcdorcwbcb - ebtfhpcagv) View more | - | 17 Apr 2024 | |
Cannabis+Nicotine (Active Cannabis With Own Brand Cigarettes) | ivwzlxjbzu(ibcfdldvqq) = bavgozlnjd atzcaxgfwv (qcpgvpxyyi, pufxcisyzj - cktdynussf) View more | ||||||
Phase 1/2 | 57 | (Normal Nicotine Content Cigarettes) | ynevrdpsog(fnrbxadmon) = hodcvfbute yhiqkerqtl (nwvfailwnt, egkwpgkzwu - dqpejaeexx) View more | - | 19 Dec 2023 | ||
(Very Low Nicotine Content Cigarettes) | ynevrdpsog(fnrbxadmon) = fkimvmweey yhiqkerqtl (nwvfailwnt, oipwaznjpq - cpoqrhcmbx) View more |