Last update 07 Nov 2024

Triapine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Triapine, 3-AP, NSC#663249
+ [5]
Target
Mechanism
RNR inhibitors(Ribonucleotide reductase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC7H9N5S
InChIKeyXMYKNCNAZKMVQN-UHFFFAOYSA-N
CAS Registry143621-35-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenosquamous CarcinomaPhase 3
US
10 May 2016
Adenosquamous CarcinomaPhase 3
CA
10 May 2016
Adenosquamous CarcinomaPhase 3
PR
10 May 2016
Cervical Squamous Cell CarcinomaPhase 3
US
10 May 2016
Cervical Squamous Cell CarcinomaPhase 3
CA
10 May 2016
Cervical Squamous Cell CarcinomaPhase 3
PR
10 May 2016
Squamous Cell CarcinomaPhase 3
US
10 May 2016
Squamous Cell CarcinomaPhase 3
CA
10 May 2016
Squamous Cell CarcinomaPhase 3
PR
10 May 2016
Uterine Cervix AdenocarcinomaPhase 3
US
10 May 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
21
(All Participants)
cwwhwyquuk(cwskgiibdy) = jrzxojlrgu irtnozbrje (rleyvtjuak, jblbnayziu - sqelqixqrx)
-
16 Oct 2024
(Triapine (100mg) + Chemoradiation))
jlqrpimjpm(pndfoaaqwi) = rzgoggdzby atkahrcwzd (lpwvzsbxtd, ibldxeraxo - hyfhmvpmfo)
Phase 3
450
Intensity-Modulated Radiation Therapy+Cisplatin
(Arm I (Cisplatin, IMRT or RT, Brachytherapy))
ewvtvvitbq(rzmpfptjun) = tffipieneq ykslgfwmoh (rxfkzfkduo, ydpegoawcr - fimgwtjlfk)
-
05 Jan 2024
Intensity-Modulated Radiation Therapy+Triapine+Cisplatin
(Arm II (Cisplatin, IMRT or RT, Brachytherapy, Triapine))
ewvtvvitbq(rzmpfptjun) = scjrrvrbhh ykslgfwmoh (rxfkzfkduo, dkofpezcuj - lorvcstuzr)
Phase 3
448
zvqgetnsvx(hmzgpkqdun): HR = 1.018 (95% CI, 0.634 - 1.635)
Negative
31 May 2023
Phase 1
31
snjrbfrkal(tzxqwfokqs) = One DLT in dose level 1, seven DLTs in dose level 2, and one grade 5 DLT in dose level 3 were observed. lkicptgsju (qolyqkreqv )
Positive
14 Apr 2023
Phase 1
31
zhocxtaypz(akwwkiwwaq) = bqekrvxfsy tlvzvfvmpv (wirqmiscko )
Positive
24 Jan 2023
Phase 1
29
pnqpvcejwl(cnejqzkfok) = jbhadwdkbn zbdzvobzhi (bvicgdttvb )
-
25 May 2020
Phase 2
26
cisplatin+Radiotherapy+triapine
snzouhmgbw(lrxcsyuawm) = latprjowfs qbjjlbyivn (gnogfmqnbm )
Positive
15 Oct 2019
cisplatin+Radiotherapy
snzouhmgbw(lrxcsyuawm) = zkgzxnympq qbjjlbyivn (gnogfmqnbm )
Phase 1
13
hekpurvhjt(ojrbphxbty) = triapine (80 mg/m2), cisplatin (50 mg/m2), paclitaxel (80 mg/m2) clvplcgxnb (vqpvdnhwzh )
Positive
04 Apr 2017
Phase 1
-
twoignzjob(csacwfqkxl) = qrxmqvroye vjjyyfscuv (oklrdomzmy )
-
01 Jan 2017
twoignzjob(csacwfqkxl) = arfdptjucz vjjyyfscuv (oklrdomzmy )
Phase 2
33
Gemcitabine+Triapine
(Stratum A Normal Liver Function Triapine, Gemcitabine)
hsavfsxlzk(yhievkcpdk) = kidatlrmgq butckarogp (bqqmswttzr, ljkbaxvgjg - daqifslzdn)
-
28 Sep 2015
Gemcitabine+Triapine
(Stratum B Abnormal Liver Function Triapine, Gemcitabine)
hsavfsxlzk(yhievkcpdk) = coqfanaulq butckarogp (bqqmswttzr, wzffzfkdml - zmwqlsadec)
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Regulation

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