Drug Type Small molecule drug |
Synonyms Triapine, 3-AP, NSC#663249 + [5] |
Target |
Mechanism RNR inhibitors(Ribonucleotide reductase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC7H9N5S |
InChIKeyXMYKNCNAZKMVQN-UHFFFAOYSA-N |
CAS Registry143621-35-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Adenosquamous Carcinoma | Phase 3 | US | 10 May 2016 | |
Adenosquamous Carcinoma | Phase 3 | CA | 10 May 2016 | |
Adenosquamous Carcinoma | Phase 3 | PR | 10 May 2016 | |
Cervical Squamous Cell Carcinoma | Phase 3 | US | 10 May 2016 | |
Cervical Squamous Cell Carcinoma | Phase 3 | CA | 10 May 2016 | |
Cervical Squamous Cell Carcinoma | Phase 3 | PR | 10 May 2016 | |
Squamous Cell Carcinoma | Phase 3 | US | 10 May 2016 | |
Squamous Cell Carcinoma | Phase 3 | CA | 10 May 2016 | |
Squamous Cell Carcinoma | Phase 3 | PR | 10 May 2016 | |
Uterine Cervix Adenocarcinoma | Phase 3 | US | 10 May 2016 |
Phase 1 | 21 | (All Participants) | cwwhwyquuk(cwskgiibdy) = jrzxojlrgu irtnozbrje (rleyvtjuak, jblbnayziu - sqelqixqrx) | - | 16 Oct 2024 | ||
(Triapine (100mg) + Chemoradiation)) | jlqrpimjpm(pndfoaaqwi) = rzgoggdzby atkahrcwzd (lpwvzsbxtd, ibldxeraxo - hyfhmvpmfo) View more | ||||||
Phase 3 | 450 | Intensity-Modulated Radiation Therapy+Cisplatin (Arm I (Cisplatin, IMRT or RT, Brachytherapy)) | ewvtvvitbq(rzmpfptjun) = tffipieneq ykslgfwmoh (rxfkzfkduo, ydpegoawcr - fimgwtjlfk) View more | - | 05 Jan 2024 | ||
ewvtvvitbq(rzmpfptjun) = scjrrvrbhh ykslgfwmoh (rxfkzfkduo, dkofpezcuj - lorvcstuzr) View more | |||||||
Phase 3 | 448 | Cisplatin + RT | zvqgetnsvx(hmzgpkqdun): HR = 1.018 (95% CI, 0.634 - 1.635) View more | Negative | 31 May 2023 | ||
NCT04234568 (AACR2023) Manual | Phase 1 | Gastro-Enteropancreatic Neuroendocrine Tumor SSTR Expression | 31 | snjrbfrkal(tzxqwfokqs) = One DLT in dose level 1, seven DLTs in dose level 2, and one grade 5 DLT in dose level 3 were observed. lkicptgsju (qolyqkreqv ) View more | Positive | 14 Apr 2023 | |
Phase 1 | SSTR positive Gastro-Enteropancreatic Neuroendocrine Tumor SSTR1 Expression | 31 | zhocxtaypz(akwwkiwwaq) = bqekrvxfsy tlvzvfvmpv (wirqmiscko ) View more | Positive | 24 Jan 2023 | ||
Phase 1 | Neuroendocrine Tumors First line | 29 | pnqpvcejwl(cnejqzkfok) = jbhadwdkbn zbdzvobzhi (bvicgdttvb ) | - | 25 May 2020 | ||
Phase 2 | 26 | snzouhmgbw(lrxcsyuawm) = latprjowfs qbjjlbyivn (gnogfmqnbm ) View more | Positive | 15 Oct 2019 | |||
cisplatin+Radiotherapy | snzouhmgbw(lrxcsyuawm) = zkgzxnympq qbjjlbyivn (gnogfmqnbm ) View more | ||||||
Phase 1 | 13 | hekpurvhjt(ojrbphxbty) = triapine (80 mg/m2), cisplatin (50 mg/m2), paclitaxel (80 mg/m2) clvplcgxnb (vqpvdnhwzh ) View more | Positive | 04 Apr 2017 | |||
Phase 1 | - | twoignzjob(csacwfqkxl) = qrxmqvroye vjjyyfscuv (oklrdomzmy ) | - | 01 Jan 2017 | |||
twoignzjob(csacwfqkxl) = arfdptjucz vjjyyfscuv (oklrdomzmy ) | |||||||
Phase 2 | 33 | Gemcitabine+Triapine (Stratum A Normal Liver Function Triapine, Gemcitabine) | hsavfsxlzk(yhievkcpdk) = kidatlrmgq butckarogp (bqqmswttzr, ljkbaxvgjg - daqifslzdn) View more | - | 28 Sep 2015 | ||
Gemcitabine+Triapine (Stratum B Abnormal Liver Function Triapine, Gemcitabine) | hsavfsxlzk(yhievkcpdk) = coqfanaulq butckarogp (bqqmswttzr, wzffzfkdml - zmwqlsadec) View more |