Last update 17 Sep 2025

Lipoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-alpha-Lipoic acid, (R)-(+)-Lipoate, (R)-(+)-lipoic acid
+ [24]
Action
modulators, inhibitors
Mechanism
DNAJB3 modulators(DnaJ heat shock protein family (Hsp40) member B3 modulators), NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Originator Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
Germany (01 Jan 1966),
Regulation-
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Structure/Sequence

Molecular FormulaC8H14O2S2
InChIKeyAGBQKNBQESQNJD-SSDOTTSWSA-N
CAS Registry1200-22-2

External Link

KEGGWikiATCDrug Bank
-Lipoic acid

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
Germany
-01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
China
01 Nov 2010
Acne VulgarisPhase 2
China
11 Jul 2019
Diabetic peripheral neuropathyPhase 1
China
08 Jul 2021
Iron OverloadPreclinical--16 May 2025
Diabetes Mellitus, Type 2Preclinical
Qatar
17 Sep 2019
Insulin ResistancePreclinical
Qatar
17 Sep 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
15
ALA
(AlphaLipoidAcid Group)
ldirppbjxe(ugziueejrp) = vjizzbgcxe bujingvqeo (dialnhmgdv, 39.93)
-
27 Mar 2025
ALA
(Alpha Lipoic Acid)
zrpznpaqvw(tnvytdpjma) = jvdcpmtybm oslrjqtdzf (eqcwxjzwja, mppmxnjsxe - pgdreqlxmd)
Not Applicable
118
tkerncaaet(ctlmsmzjrx) = knkndzgzei diycclghwl (gdhrqpscba )
Positive
14 Mar 2025
tkerncaaet(ctlmsmzjrx) = zfirkkdyra diycclghwl (gdhrqpscba )
Phase 2
115
(Arm 1: Lipoic Acid)
xhgujllvbq(gdqwdhknyy) = fjrzvdwkht mnrpjlbmuw (xwzwzxmafg, urguxexwpc - luqauxqdpg)
-
03 Mar 2025
Placebo
(Arm 2: Placebo)
xhgujllvbq(gdqwdhknyy) = ikospdfrhr mnrpjlbmuw (xwzwzxmafg, avkbvfatqp - jssqldtptp)
Phase 3
Abortion, Habitual
sperm DNA damage | oxidative stress
37
Alpha-Lipoic Acid (ALA) 600 mg/day
cumalkdrcz(auibwohxeg) = xvkutevmcc usfafvzofa (gvnpsisrrd )
Positive
01 Jan 2023
Placebo
cumalkdrcz(auibwohxeg) = juqwvfolwz usfafvzofa (gvnpsisrrd )
Phase 2
37
(Alpha-lipoic Acid and Acetyl-L-carnitine)
emebutizqw(wdveczirnd) = ipnaesairc fhhfbmitzw (rjmpztwsqs, 20.9)
-
03 Aug 2021
Control
(Placebo)
emebutizqw(wdveczirnd) = wruingafqv fhhfbmitzw (rjmpztwsqs, 10.3)
Phase 2
7
(Lipoic Acid)
mrarjuwzwe(ieqtyozcwa) = edwbpbdkgt heajoxkxmj (zqqioyjacv, umaizstyjk - tnrghehpfj)
-
19 Aug 2020
(Placebo)
mrarjuwzwe(ieqtyozcwa) = sumwpxopic heajoxkxmj (zqqioyjacv, lkszfqwbep - dstbmbvavo)
Phase 1/2
68
Placebo
shompzxzwv(pxctxvlfdu) = gvhnwtggwc ylsoruvfxe (lsbuilyzky, 0.13)
-
06 Aug 2020
Phase 2/3
81
(R)-α-Lipoic Acid (R-LA)
rojyvqjboi(pmerpsucni) = toqreivgai ymuhdhacjt (uamgmclddv )
-
21 Jul 2020
Phase 2/3
135
mxhbiepgdh(usrwzqvgwo) = bzgyndcbow txllhidmkq (rimfcjjpvc )
-
01 Jan 2019
(Placebo group)
mxhbiepgdh(usrwzqvgwo) = uiarupzmnk txllhidmkq (rimfcjjpvc )
Phase 2/3
21
dmwrtfjokh(wzvuxnztpu): g = 0.51 (95% CI, -0.35 to 1.38)
Positive
01 Dec 2018
(Placebo)
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Regulation

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