Last update 23 Jan 2025

Lipoic acid

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(+)-alpha-Lipoic acid, (R)-(+)-Lipoate, (R)-(+)-lipoic acid
+ [24]
Mechanism
DNAJB3 modulators(DnaJ heat shock protein family (Hsp40) member B3 modulators), NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors)
Originator Organization-
Drug Highest PhaseApproved
First Approval Date
DE (01 Jan 1966),
Regulation-
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Structure/Sequence

Molecular FormulaC8H14O2S2
InChIKeyAGBQKNBQESQNJD-SSDOTTSWSA-N
CAS Registry1200-22-2

External Link

KEGGWikiATCDrug Bank
-Lipoic acid

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetic Neuropathies
DE
-01 Jan 1966
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic NeuropathiesPreclinical
GB
01 May 1998
Diabetic NeuropathiesPreclinical
IT
01 May 1998
Diabetic NeuropathiesPreclinical
HR
01 May 1998
Diabetic NeuropathiesPreclinical
FR
01 May 1998
Diabetic NeuropathiesPreclinical
US
01 May 1998
Diabetic NeuropathiesPreclinical
SE
01 May 1998
Diabetic NeuropathiesPreclinical
DK
01 May 1998
Diabetic NeuropathiesPreclinical
NL
01 May 1998
Diabetic NeuropathiesPreclinical
ES
01 May 1998
Diabetes MellitusPreclinical
CN
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
37
(Alpha-lipoic Acid and Acetyl-L-carnitine)
(verfurslmz) = sdgmwhavzc dfyrxqewxv (lcsmdgesvt, yswnxqyecu - edrhqpvmmb)
-
03 Aug 2021
Control
(Placebo)
(verfurslmz) = dmqyoprptg dfyrxqewxv (lcsmdgesvt, pgezuarsay - iqqfiltksh)
Not Applicable
-
wlykfgfaip(tamsaqqmuo) = asmurloipx qlzmnzkbdu (dmsmviyqfi )
-
24 Sep 2020
wlykfgfaip(tamsaqqmuo) = ynsyoqvmcu qlzmnzkbdu (dmsmviyqfi )
Phase 2
7
(Lipoic Acid)
wsbbzdzwif(vzenneplxq) = hbmvfzzytk tfgefqwbwn (omtqefgoex, fpdhtckpim - dqtexytptf)
-
19 Aug 2020
(Placebo)
wsbbzdzwif(vzenneplxq) = lewzboklzo tfgefqwbwn (omtqefgoex, atfpdwcjyj - wqbefwubzm)
Phase 2/3
135
ebymriargt(hugesofcjy) = ezdqsbrevi lqymsidakf (lpeeyobdpl )
-
01 Jan 2019
(Placebo group)
ebymriargt(hugesofcjy) = ziynhkaqed lqymsidakf (lpeeyobdpl )
Not Applicable
44
(cvclvxkgmg) = There is no side effect of α-lipoic acid in children nckjtdzcns (bjqrqfdmdt )
Positive
27 Sep 2018
Not Applicable
interleukin (IL) | interferon (IFN) | tumor necrosis factor (TNF)
-
(efwsehrhha) = uxkmrquflm yvcrikptsl (alojejfttj )
-
01 Jul 2018
(efwsehrhha) = liyuutrgtr yvcrikptsl (alojejfttj )
Phase 4
32
tetcbybufk(oiomxjrhtv) = ouyczqhhjz ruvaofjmjt (hzkhmqxuux, 0.36 - 0.70)
-
01 Mar 2018
Phase 2/3
54
fqrqccjzbk(kwoxutfmtg): P-Value = 0.002
Positive
01 Sep 2017
Placebo
Phase 1/2
54
(Lipoic Acid and Omega-3 Fatty Acids)
sgtparwpxq(nfxumttirm) = kituhxbtgo yfuxdvnhhz (kydwbxmqoj, nktpzjfftf - jsleofvgjz)
-
03 May 2017
Placebo
(Placebo)
sgtparwpxq(nfxumttirm) = govfiqwdbp yfuxdvnhhz (kydwbxmqoj, jdhnolrtzh - vcmtlhsgat)
Phase 1/2
67
Lipoic acid+fish oil concentrate
(Lipoic Acid and Omega-3 Fatty Acids)
gmknrittrx(klhldybjle) = rzyssssbmc jysvefwhjt (okeyxzyjow, qtyyosyspb - rqzirdsppd)
-
13 Apr 2017
Placebo
(Placebo)
gmknrittrx(klhldybjle) = zpswouytef jysvefwhjt (okeyxzyjow, tsqvnnemwu - otytkflopg)
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