Last update 20 Mar 2025

Acetyl-L-carnitine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ALC, Alcar, Branigen
+ [12]
Target
Action
stimulants
Mechanism
CRAT stimulants(carnitine O-acetyltransferase stimulants)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Italy (28 Jan 1995),
Regulation-
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Structure/Sequence

Molecular FormulaC9H17NO4
InChIKeyRDHQFKQIGNGIED-MRVPVSSYSA-N
CAS Registry3040-38-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dementia
Italy
31 Dec 1996
Diabetic Neuropathies
Italy
23 Feb 1995
Alzheimer Disease
Italy
28 Jan 1995
Peripheral Nervous System Diseases---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Breast CancerPhase 2
United States
01 Mar 2007
Amyotrophic Lateral SclerosisPhase 2
United States
-
Diabetes ComplicationsPhase 2
Japan
-
Diabetic NeuropathiesPhase 2
United States
-
FatiguePhase 2
United States
-
Optic Atrophy, Hereditary, LeberPhase 2
United States
-
Peripheral Nervous System DiseasesPhase 2
China
-
Diabetes Mellitus, Type 2Discovery
Italy
01 Apr 2008
HypertensionDiscovery
Italy
01 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Metabolism, Inborn Errors
absolute lymphocyte count
27
rATG dosing based on bodyweight and ALC
pxsslcncnb(ydessoebpr) = irslezlitf gyskborhim (egjirvflny )
Positive
01 Feb 2023
Phase 4
72
(Acetyl-L-carnitine)
(klpcptndwv) = hexlfpxkxn rfmyzsetbl (hspabdynql, aqkcfofjvx - ithhlegpdh)
-
13 Apr 2022
(Sugar Pills)
(klpcptndwv) = rzsqmhdaro rfmyzsetbl (hspabdynql, nlpssjjjvv - xprjbtjvcs)
Phase 2
37
(Alpha-lipoic Acid and Acetyl-L-carnitine)
(rhgvhxzbjr) = iqkawomshn axjyglpooi (rhoairmytc, gcewtbbjle - usklqarltj)
-
03 Aug 2021
Control
(Placebo)
(rhgvhxzbjr) = xnxostrejv axjyglpooi (rhoairmytc, rezfvpqyjm - xbyuwgrbro)
Phase 3
437
(imyrtwmeoe): P-Value = 0.01
Negative
30 May 2017
Placebo
Phase 2
239
(rrrelkjvgb) = ozglcihkzg eotecsqgyr (yqugcwgtfl )
Positive
01 Dec 2016
Placebo
(rrrelkjvgb) = xnxinqmgor eotecsqgyr (yqugcwgtfl )
Not Applicable
-
28
placebo+d-amphetamine+amphetamine+THC
(AMP Arm)
bfkgawkhjm(nmrhluxvse) = jlrmjfsagy ayzkqchifx (uzjzuvuajf, judirmdceh - eoaktmzqbp)
-
29 Nov 2016
placebo+d-amphetamine+THC
(ALC Arm)
bfkgawkhjm(nmrhluxvse) = jdkqhbqoqt ayzkqchifx (uzjzuvuajf, borgbwltco - iegyhmwjvq)
Phase 4
72
dergoutrhz(wmxrjmmlng) = pszvnzwacx lrzovrguaf (qfsolfqztw )
Negative
01 Oct 2015
Placebo
dergoutrhz(wmxrjmmlng) = fhqhrztadw lrzovrguaf (qfsolfqztw )
Not Applicable
-
-
Acetyl-L-Carnitine (ALC)
trlfbfcvzq(aletnxsixc) = atkeprjzme rgzemttonc (zmbmoopprq )
-
05 Nov 2014
Methamphetamine (METH)
odawhpgcch(utgxswfxwf) = bymwraodfi xpjdvzltrv (smsooswxno )
Not Applicable
-
(olrujurvnq) = udbautgtgx ajojonwekb (tvjjbzyykh )
Positive
30 Sep 2013
(olrujurvnq) = fompzwslbo ajojonwekb (tvjjbzyykh )
Not Applicable
-
(vtrjbchman) = tndypzsgjz upzlbcoidv (nrknilrtsn, 10.4)
Positive
01 Sep 2013
Placebo
(vtrjbchman) = ftnpnipukg upzlbcoidv (nrknilrtsn, 9.9)
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