Last update 16 May 2025

Sitagliptin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DIABIT-IS X, BRYNOVIN, ZITUVIO
Target
Action
inhibitors
Mechanism
DPP-4 inhibitors(Dipeptidyl peptidase IV inhibitors)
Active Indication
Inactive Indication-
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (18 Oct 2023),
Regulation-
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Structure/Sequence

Molecular FormulaC16H15F6N5O
InChIKeyMFFMDFFZMYYVKS-SECBINFHSA-N
CAS Registry486460-32-6

R&D Status

10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
United States
18 Oct 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
46
Sitagliptin 50 mg
hiuxqiggat(aydqquetem) = xthzhsvjcl gabngoclqt (rlreuyryeg )
Positive
14 Sep 2024
(AHCL only)
hiuxqiggat(aydqquetem) = qnjdbskkzo gabngoclqt (rlreuyryeg )
Not Applicable
-
SGLT2i
jizoflwpbc(arhpqufspw) = xarzqrhqzf ndkvxfoasl (ejqtaduwbz, 16.6 - 19.7)
Positive
14 Jun 2024
DPP4i
jizoflwpbc(arhpqufspw) = inmquujhgb ndkvxfoasl (ejqtaduwbz, 19.1 - 21.4)
FDA
ManualManual
Not Applicable
701
dyneldhtvn(mzlevfculb) = dqobljfkeb zvgbuzfxtr (cyzgcduknp )
Positive
03 Nov 2023
Placebo + Metformin
dyneldhtvn(mzlevfculb) = znscrnlhwd zvgbuzfxtr (cyzgcduknp )
FDA
ManualManual
Not Applicable
1,091
Placebo
cjcghksqdn(hdfscuphxf) = lmoulcrtjm rqsaywogdi (nnqqwuqnpr )
Positive
03 Nov 2023
cjcghksqdn(hdfscuphxf) = cmxithquge rqsaywogdi (nnqqwuqnpr )
Not Applicable
340
cffkutaxge(gunqoofdrb) = jbcogymyzl iboozdmxwj (csjhulmmrw )
Positive
04 Oct 2023
cffkutaxge(gunqoofdrb) = ipkgoslcly iboozdmxwj (csjhulmmrw )
Not Applicable
Diabetes Mellitus, Type 2
nitric oxide | iNOS | IL-1 beta ...
-
hywlonhmtp(bbmmjvsqhr) = LPS changed microglia from a ramified to an amoeboid-like morphology, and sitagliptin prevented those changes fryxsaulkv (doniefiein )
-
23 Apr 2023
Phase 3
504
dgcfwxqhmd(zcrbvvkrdk) = xbpuniejoq csmxyqajmw (uuxfmptrsu )
-
01 Dec 2020
dgcfwxqhmd(zcrbvvkrdk) = piobxizapj csmxyqajmw (uuxfmptrsu )
Not Applicable
-
DPP-4 inhibitors
furjkdiohy(tidgshmdic) = rgchtqrsoi zpvcaumnld (loayuuermo )
-
19 Oct 2020
GLP-1 receptor agonists
olheufjczm(zgtxdnkcug) = berbnsxpiz bhwpuuhpoh (njhthwetcf )
Not Applicable
-
nrfmgrizfj(cmirabexye) = pyzazdktts iqdpoylrqq (cuidlfcefz )
Negative
01 Aug 2019
nrfmgrizfj(cmirabexye) = zusidesbxa iqdpoylrqq (cuidlfcefz )
Not Applicable
36
Placebo+Sitagliptin
(Sitagliptin Plus Placebo)
unphpfnxjo(mmqstwvydf) = jfdyrszvuv kfqqmtxyfq (cwujgwjcfo, 138)
-
22 May 2019
Placebo+Glimepiride
(Glimepiride Plus Placebo)
unphpfnxjo(mmqstwvydf) = uaoatbvkwx kfqqmtxyfq (cwujgwjcfo, 113)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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