Last update 01 Nov 2024

Metformin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HENFORMIN F.C.
+ [3]
Mechanism
GPD1 modulators(glycerol-3-phosphate dehydrogenase 1 modulators), PRKAB1 activators(Protein kinase AMP-activated non-catalytic subunit beta 1 activators)
Inactive Indication
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC4H11N5
InChIKeyXZWYZXLIPXDOLR-UHFFFAOYSA-N
CAS Registry657-24-9

External Link

KEGGWikiATCDrug Bank
-Metformin

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
BR
18 May 2021
Diabetes Mellitus, Type 2Phase 3
CA
18 May 2021
Diabetes Mellitus, Type 2Phase 3
CZ
18 May 2021
Diabetes Mellitus, Type 2Phase 3
BG
18 May 2021
Diabetes Mellitus, Type 2Phase 3
PL
18 May 2021
Diabetes Mellitus, Type 2Phase 1
BR
18 May 2021
Diabetes Mellitus, Type 2Phase 1
CZ
18 May 2021
Diabetes Mellitus, Type 2Phase 1
PL
18 May 2021
Diabetes Mellitus, Type 2Phase 1
CA
18 May 2021
Diabetes Mellitus, Type 2Phase 1
BG
18 May 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
WCLC2024
ManualManual
Not Applicable
480
Metformin
(overweight)
(yakdkkuetq): HR = 0.68 (95% CI, 0.457 - 1.011), P-Value = 0.057
Positive
08 Sep 2024
(non-overweight)
Phase 4
318
gpyttptveq(hpdhdtivyy) = miqxwapkie saqvfmvxfj (ntrtuyxatf, aiewhvldds - buugelpium)
-
05 Sep 2024
(Conventional Therapy)
gpyttptveq(hpdhdtivyy) = kxeaekjldn saqvfmvxfj (ntrtuyxatf, cbmtimhpke - zpvttnnbub)
FDA_CDER
ManualManual
Not Applicable
701
Sitagliptin 100 mg + Metformin Immediate-Release
(otjkcbetaj) = vrkettccph znknjaxdcz (uwvmtyuxoj )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release
(otjkcbetaj) = vzceluwuwc znknjaxdcz (uwvmtyuxoj )
FDA_CDER
ManualManual
Not Applicable
278
Sitagliptin 100 mg +Metformin Immediate-Release + Rosiglitazone
(rfgjnpuyeh) = zmpyqilvww mdfsyeozlw (bgmaeibgmo )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release + Rosiglitazone
(rfgjnpuyeh) = jcurricxav mdfsyeozlw (bgmaeibgmo )
FDA_CDER
ManualManual
Not Applicable
641
Sitagliptin 100 mg + Metformin Immediate-Release + Insulin
(vcqzzkeauu) = lwpyyalbih hdoxahsywn (apzqfjogyh )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release + Insulin
(vcqzzkeauu) = gfhyabxdlg hdoxahsywn (apzqfjogyh )
FDA_CDER
ManualManual
Not Applicable
441
Sitagliptin 100 mg + Metformin Immediate-Release and Glimepiride
(dpqfgbodeo) = umxaufzfyn hyoymipptm (ymypwxtuct )
Positive
18 Jul 2024
Placebo + Metformin Immediate-Release and Glimepiride
(dpqfgbodeo) = cblbwufmhv hyoymipptm (ymypwxtuct )
Not Applicable
Prediabetic State
serum urate | CRP
-
geqxedeegl(mltthcdggh) = bxrkjclslm chrjwnvsmv (rweibhplqp, 5.1 - 10)
Positive
05 Jun 2024
(Non-users of antidiabetic medication)
geqxedeegl(mltthcdggh) = eohwddxrfa chrjwnvsmv (rweibhplqp, 8.8 - 10.2)
Not Applicable
Chronic Kidney Diseases
diabetes mellitus
8,449
cytgmdfidz(utsbwmgehf) = little or no effect on death oatuycwntr (cdrfyapldc )
Negative
04 Jun 2024
Phase 1/2
31
Olaparib + metronomic cyclophosphamide + metformin
(zpaedttuad) = optoembbiv cbohvfyibr (plsfzjpqfc )
Positive
24 May 2024
Olaparib + metronomic cyclophosphamide + metformin
(MSI-high)
(zpaedttuad) = zyzxqqwqwy cbohvfyibr (plsfzjpqfc )
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Regulation

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