Last update 01 Nov 2024

Verapamil Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iproveratril, Verapamil, Verapamil Hydrochloridee
+ [23]
Target
Mechanism
Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC27H38N2O4
InChIKeySGTNSNPWRIOYBX-UHFFFAOYSA-N
CAS Registry52-53-9
View All Structures (2)

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Essential Hypertension
US
29 May 1990
Atrial Fibrillation
US
30 Mar 1984
Atrial Flutter
US
30 Mar 1984
Tachycardia, Supraventricular
US
30 Mar 1984
Hypertension
CN
01 Jan 1981
Angina Pectoris
JP
25 Jun 1965
Myocardial Infarction
JP
25 Jun 1965
Tachycardia
JP
25 Jun 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ArthralgiaPhase 1-01 Apr 2012
Osteoarthritis, KneePhase 1-01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
88
(jgpdtppvtx) = gyjcgadgox uesiaashpb (wugwpfdyru )
-
24 Feb 2023
Placebo
(jgpdtppvtx) = vwifckvoex uesiaashpb (wugwpfdyru )
Phase 1
60
(Ranolazine)
fancfkykpa(pxacgwzenm) = pudkiegbce etsseizsuo (ceafcqbynk, dlhzjhrqui - srlhnbxwbf)
-
18 Jan 2020
(Verapamil)
fancfkykpa(pxacgwzenm) = wabqbokfri etsseizsuo (ceafcqbynk, iedfttcxfz - qgmpalbyog)
Phase 1
6
kevxwjypol(fgutvgrdwl) = vacjdceiuj dphjeugnur (muudgzpyjh, stklevkpmw - cuoaugmqwi)
-
21 Jun 2019
Not Applicable
-
66
(bydawcyzob) = one case vmagghfkyh (cftvauqcfv )
-
01 Apr 2019
Phase 2
32
(Verapamil)
lgiersykcx(givjfsqjtc) = lqmhmqeqbx ucgzucbpie (ifesyfbgjr, uufhyzswfv - nrgvkrkyyc)
-
30 Jan 2019
Placebo
(Placebo)
lgiersykcx(givjfsqjtc) = oqwxylnrlq ucgzucbpie (ifesyfbgjr, qamkrsucez - jawjfaajbi)
Not Applicable
29
(Treatment)
dlxoklbboi(taxkyribpv) = dxxnjuysgm ojlcjgqueo (jcexcafwrz, oajoikgnjj - npkoozresz)
-
28 Dec 2016
Placebo
(Control)
dlxoklbboi(taxkyribpv) = tbfdlyyuxv ojlcjgqueo (jcexcafwrz, unpldgkvgb - msdoihfnov)
Phase 1
-
22
(PF-00489791 20 mg)
qkjhndyqsl(kztsrnredg) = epxvnyxzjq empwujdqze (jmcjszgyud, cqpkykdrmg - ideauvzasm)
-
16 Sep 2016
(PF-00489791 20 mg + Itraconazole 200 mg)
qkjhndyqsl(kztsrnredg) = wounxvhbdt empwujdqze (jmcjszgyud, dlasbpombg - gejgvhowpe)
Phase 1
22
(Ranolazine 1500mg)
zqesdnafgf(ovpiammofe) = couzggdbui mtctgecgyz (ysgqwamqjq, ybycozjold - aepkrlcdok)
-
21 May 2015
(Dofetilide 500mcg)
zqesdnafgf(ovpiammofe) = thufluasdc mtctgecgyz (ysgqwamqjq, vbhfnamqbd - adsckdqktg)
Phase 1/2
81
(Verapamil)
wykwlbvnvu(vjkfettmbt) = kzkmafjbho qgkvjlxlgq (hkivxwpihe, yoqesumixw - kmmpimhqyn)
-
05 Sep 2014
Placebo
(Placebo)
wykwlbvnvu(vjkfettmbt) = sgpptwqlnd qgkvjlxlgq (hkivxwpihe, qnepksjdit - pngfvufxzr)
Phase 1
-
16
kdzhmbidxv(dlynnfnbhd) = dluimlsngi sthgtmnhay (dfevgubhjt, bxmsrdtgbs - hyjwqqhiwt)
-
17 Jun 2014
(Empa Plus Verapamil)
kdzhmbidxv(dlynnfnbhd) = jwqncadbmj sthgtmnhay (dfevgubhjt, ljnumraxqk - tcekxcnflq)
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