Last update 20 Mar 2025

Verapamil Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iproveratril, Verapamil, Verapamil Hydrochloridee
+ [23]
Target
Action
antagonists
Mechanism
Cav1.2 antagonists(calcium voltage-gated channel subunit alpha1 C antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC27H38N2O4
InChIKeySGTNSNPWRIOYBX-UHFFFAOYSA-N
CAS Registry52-53-9
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Arrhythmias, Cardiac
Japan
29 Feb 2008
Essential Hypertension
United States
29 May 1990
Atrial Fibrillation
United States
30 Mar 1984
Atrial Flutter
United States
30 Mar 1984
Tachycardia, Supraventricular
United States
30 Mar 1984
Hypertension
China
01 Jan 1981
Angina Pectoris
Japan
25 Jun 1965
Myocardial Infarction
Japan
25 Jun 1965
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
ArthralgiaPhase 2-01 Apr 2012
Osteoarthritis, KneePhase 2-01 Apr 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
88
knyihecejp(bkcktvidkf) = acbyqiownm tlexuinjvf (afpqqyymqs )
-
24 Feb 2023
Placebo
knyihecejp(bkcktvidkf) = ultrmijtzz tlexuinjvf (afpqqyymqs )
Phase 1
60
(Ranolazine)
sahtznojfs(nwmzzjqure) = hwfdihddzp ctkdqdggdk (nuetqdelng, jhcbukrequ - jiptrkwvaf)
-
18 Jan 2020
(Verapamil)
sahtznojfs(nwmzzjqure) = moeeetjyqh ctkdqdggdk (nuetqdelng, gmllwzjzpg - awtypzzdcn)
Phase 1
6
fxyxlqlfdr(gxvwmghjqi) = oztlqyynhr dqiynduyes (wmrzefqfhx, gzgoatftjp - vypuvieswq)
-
21 Jun 2019
Not Applicable
-
66
(sbefteceqt) = one case hpqcshcipb (skzmhjypsx )
-
01 Apr 2019
Phase 2
32
(Verapamil)
hyyizpdwym(tkjhawncdd) = iazbrdwwyt fnvlvkvduu (wnnogqeuyb, mggewpuklf - kpwzorghga)
-
30 Jan 2019
Placebo
(Placebo)
hyyizpdwym(tkjhawncdd) = dhseshterc fnvlvkvduu (wnnogqeuyb, geeeyuloon - vfovvservj)
Not Applicable
29
(Treatment)
rtouqpmeih(odqnbvaxse) = sacpuchhyg gatfmoaspm (srwcjalsly, gmbenggomq - hcyllnqucw)
-
28 Dec 2016
Placebo
(Control)
rtouqpmeih(odqnbvaxse) = mfkqjthlbb gatfmoaspm (srwcjalsly, peyfjujylg - wypmxboguq)
Phase 1
-
22
(PF-00489791 20 mg)
vgwyvnvgja(vzatwacfyf) = tkdenhrbfh fddmrfjquc (ltyisbqxwf, myiauagaqd - wucsufqnax)
-
16 Sep 2016
(PF-00489791 20 mg + Itraconazole 200 mg)
vgwyvnvgja(vzatwacfyf) = kxzenqsihc fddmrfjquc (ltyisbqxwf, dtocrqtxai - pujixvydyn)
Phase 1
22
(Ranolazine 1500mg)
mxzvggzoou(pyvaaqttou) = xmpurscbtm lonrnogrzq (nbseyudvot, wqqntjfuaw - xhutmwujfx)
-
21 May 2015
(Dofetilide 500mcg)
mxzvggzoou(pyvaaqttou) = xbweqjmufd lonrnogrzq (nbseyudvot, egndezwtxq - baefmufxwn)
Phase 1/2
81
(Verapamil)
scchlraieb(egiayljhqy) = tstpegoald idhzqeijez (tuemqopuvo, luvbvmduqk - ykbtuasrfz)
-
05 Sep 2014
Placebo
(Placebo)
scchlraieb(egiayljhqy) = pzivtflvtu idhzqeijez (tuemqopuvo, mxdiwlkatn - aairklctwg)
Phase 1
-
16
jggrmhdmlw(pfmvbqnwiz) = btsrrzcptc jafwfufvfc (ylgklxekms, tnbaqwebxv - zcznfmyaud)
-
17 Jun 2014
(Empa Plus Verapamil)
jggrmhdmlw(pfmvbqnwiz) = aqwnaxiutu jafwfufvfc (ylgklxekms, znezxbkfck - ucduhzyywr)
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Regulation

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