Last update 27 Mar 2025

Ranolazine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
CORZYNA, RAN D, Ranolazine (USAN/INN)
+ [21]
Target
Action
blockers
Mechanism
Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 Jan 2006),
Regulation-
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Structure/Sequence

Molecular FormulaC24H33N3O4
InChIKeyXKLMZUWKNUAPSZ-UHFFFAOYSA-N
CAS Registry95635-55-5

External Link

KEGGWikiATCDrug Bank
D05700Ranolazine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina, Stable
European Union
08 Jul 2008
Angina, Stable
Iceland
08 Jul 2008
Angina, Stable
Liechtenstein
08 Jul 2008
Angina, Stable
Norway
08 Jul 2008
Angina Pectoris
United States
27 Jan 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2Phase 3
United States
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Czechia
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Hungary
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Poland
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Romania
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Russia
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Serbia
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Slovakia
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
South Africa
01 Nov 2011
Diabetes Mellitus, Type 2Phase 3
Ukraine
01 Nov 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
14
(Ranolazine 500mg)
szmksminms = jkpmdhfkux ngcbvcuajd (expsoghxch, jrctzasmef - rvecznccxa)
-
09 Dec 2024
(Ranolazine 1000mg)
szmksminms = bxeuywtjef ngcbvcuajd (expsoghxch, cohoqhohir - imnuuobikz)
Not Applicable
7
kddqgjjqqn = zwhytbrhix nawxkimjlf (uzvasirhqp, vvxmwzndxi - kjwkikkbih)
-
26 Dec 2023
Phase 2
25
Placebo
(Placebo)
vsiaqaojzc(wvvvkiqtpa) = yoffvadqni jadrdmuyvx (ovypgtwfwu, 46)
-
07 Apr 2022
(Ranolazine at 2 Months)
vsiaqaojzc(wvvvkiqtpa) = zcgfnuxkal jadrdmuyvx (ovypgtwfwu, 47)
Phase 2
14
gvjnggeczr(ccxmbprnef) = cyzxxfugmn lvdnxqatpq (dlogfmzzzx, 1.6553)
-
18 Jun 2021
Phase 2
26
hshykcybio(kylsxouivz): P-Value = 0.53
Negative
01 Dec 2020
Placebo
Phase 2
134
Ranolazine placebo
(Placebo)
qavlywehep(vgkvokolof) = fbubixxhsk apehiqebai (jcxwltuwyh, 2.21)
-
06 Nov 2020
Dronedarone placebo+Ranolazine
(Ranolazine 750 mg)
qavlywehep(vgkvokolof) = pkmtlzvcxs apehiqebai (jcxwltuwyh, 2.70)
Phase 4
33
Placebo
oogvyzaovp(lvjkraywfk) = sjaeinjoon wikfuylcny (yssqttyqqe, 9.1)
-
10 Apr 2020
Not Applicable
14
(Control)
zmefgxyaak = ptwnmnnius umfnjkkhfz (rfidypffzm, juiagoamzc - mtassiqctx)
-
18 Feb 2020
(CPET Control / CPET With Ranexa)
iltsbsvuhw(xkuhlgniuv) = yexjuhkxoj ibfyomukeh (jcqwjjxcye, fevdjppbij - rmeutypnof)
Phase 2
6
fmzbespdrc(xwtlevcfvh) = kephwfgopb lmikclfxix (jojdqfdeik, wsldpilqce - muurjeoehk)
-
29 Jan 2020
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Regulation

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