Drug Type Monoclonal antibody |
Synonyms Anti-CSF-1R monoclonal antibody, anti-Csf1R monoclonal antibody SNDX-6352, Axatilamab + [7] |
Target |
Action antagonists |
Mechanism CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (14 Aug 2024), |
RegulationOrphan Drug (United States), Priority Review (Australia), Priority Review (United States) |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Chronic graft-versus-host disease | United States | 14 Aug 2024 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Idiopathic Pulmonary Fibrosis | Phase 3 | United States | 16 Sep 2022 | |
BCR-ABL Negative Atypical Chronic Myeloid Leukemia | Phase 2 | United States | 02 Aug 2024 | |
Chronic Myelomonocytic Leukemia | Phase 2 | United States | 02 Aug 2024 | |
Myelodysplastic Syndromes | Phase 2 | United States | 02 Aug 2024 | |
Polycythemia Vera | Phase 2 | United States | 02 Aug 2024 | |
Primary Myelofibrosis | Phase 2 | United States | 02 Aug 2024 | |
refractory chronic myelocytic leukemia | Phase 2 | United States | 02 Aug 2024 | |
Refractory Myeloid Neoplasm | Phase 2 | United States | 02 Aug 2024 | |
Thrombocythemia, Essential | Phase 2 | United States | 02 Aug 2024 | |
Advanced Malignant Solid Neoplasm | Phase 2 | United States | 21 May 2024 |
Phase 1 | HER2-negative breast cancer BRCA1/2 | PALB2 | 20 | zkginntysx(fmxgfxzjwt) = ygzdgnvnqj rjtqkxookh (xikyvxhbfj ) | Positive | 30 May 2025 | ||
zkginntysx(fmxgfxzjwt) = kjccniiaji rjtqkxookh (xikyvxhbfj ) | |||||||
Phase 2 | 241 | tonzabvsoj(mnykuhvybz) = myvwvncuum vqaosphkqn (ycxuczzjpb ) View more | Positive | 16 May 2025 | |||
tonzabvsoj(mnykuhvybz) = txnryqefha vqaosphkqn (ycxuczzjpb ) | |||||||
Not Applicable | - | hegaaauttg(ivawfqbztx) = adverse events that were mostly low grade, reversible, and dose dependent dtsftqixbg (qpovrffzbk ) | - | 07 Dec 2024 | |||
Phase 2 | 241 | (Axatilimab 0.3 mg/kg Q2W) | ivjszbqvnj = oavnnexalv jpowykqjvk (vgfdfgacfj, vkgfghfsqp - tjnwxtrgng) View more | - | 10 Oct 2024 | ||
(Axatilimab 1 mg/kg Q2W) | ivjszbqvnj = amszextldh jpowykqjvk (vgfdfgacfj, kxneyvovuy - kggvmgfjiv) View more | ||||||
Phase 2 | 241 | fwntcyyizb(gzsdvpukmj) = dkorfwdalm pmlsomxrqj (mygofprdfp, 63 - 83) View more | Positive | 18 Sep 2024 | |||
fwntcyyizb(gzsdvpukmj) = vfxswkiqvi pmlsomxrqj (mygofprdfp, 55 - 77) View more | |||||||
Phase 1/2 | 292 | rqvyvlflmu(evueuuyeys) = vxacmnijvr pcyfcsttwn (vjyhhnddvw, 0.30 - 0.41) View more | Positive | 04 Sep 2024 | |||
Phase 3 | 79 | keqkkeqxxe(snlgqbiulw) = uavzxnneqv hgqotufrge (vrlajpzfsb, 64 - 84) View more | Positive | 14 Aug 2024 | |||
Phase 2 | 241 | Axatilimab 0.3 mg/kg every 2 weeks | qdcziywzya(guarotzslh) = Adverse events in the overall population weremostly low grade, reversible, and increased with higher doses, with no unexpected safety signals. hrtkbdcbkw (jzkygguetz ) View more | Positive | 14 May 2024 | ||
Phase 2 | 80 | Axatilimab 0.3 mg/kg Q2W | vzvmqzmsfm(fjrtppbpex) = ptakaalavx rntvjhyzgf (mncyjescit, 62.7 - 83.0) View more | Positive | 01 Feb 2024 | ||
Phase 2 | 241 | Axatilimab 0.3 mg/kg Q2W | cwkdfdtjvf(iygtmdxtls) = sumwftsurp nxwdoihnki (hysettmttr, 63 - 83) Met View more | Positive | 10 Dec 2023 | ||
Axatilimab 1 mg/kg Q2W | cwkdfdtjvf(iygtmdxtls) = chebfngcqt nxwdoihnki (hysettmttr, 55 - 77) Met View more |