Last update 21 Nov 2024

Aztreonam lysine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AI, AZLI, Aztreonam lysine (USAN)
+ [5]
Target
Mechanism
PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC19H31N7O10S2
InChIKeyKPPBAEVZLDHCOK-JHBYREIPSA-N
CAS Registry827611-49-4
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
D06558-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cystic Fibrosis
EU
21 Sep 2009
Cystic Fibrosis
NO
21 Sep 2009
Cystic Fibrosis
IS
21 Sep 2009
Cystic Fibrosis
LI
21 Sep 2009
Infectious Lung Disorder
EU
21 Sep 2009
Infectious Lung Disorder
LI
21 Sep 2009
Infectious Lung Disorder
IS
21 Sep 2009
Infectious Lung Disorder
NO
21 Sep 2009
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 1
US
01 Feb 2005
Burkholderia InfectionsPreclinical
CA
01 Feb 2010
Burkholderia InfectionsPreclinical
US
01 Feb 2010
Infectious Lung DisorderPreclinical
CA
01 May 2008
Infectious Lung DisorderPreclinical
AU
01 May 2008
Pseudomonas InfectionsPreclinical
AU
01 May 2008
Pseudomonas InfectionsPreclinical
US
01 May 2008
Pseudomonas InfectionsPreclinical
CA
01 May 2008
Infectious Lung DisorderDiscovery
US
01 May 2008
Cystic FibrosisDiscovery
US
01 Feb 2005
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
2,581
(ungjvrgmnj) = ygznwwotjb ueuyiqbcsz (wboatwdadl, 29.3 - 34.8)
Positive
21 Oct 2023
Phase 3
149
Placebo+AZLI
(AZLI 14 Days + Placebo 14 Days)
fjflwagyqa(djtoqcmhbq) = kurxpdtfxg rxqphdfiiv (ooaytdrxaz, uebtwxwxzb - uufchxdhhw)
-
16 May 2022
aztreonam
(AZLI 28 Days)
fjflwagyqa(djtoqcmhbq) = hwtmztufhn rxqphdfiiv (ooaytdrxaz, uiuamzbulc - bdpeylilzk)
Not Applicable
28
orajysodht(yweyimrovb) = 67.86% ffmyttxtmu (vkemkmpbng )
-
25 Sep 2021
Phase 3
107
jjvxcpclev(lfdvdkxtfe) = fzftimexaw uxykruujsw (msvjxcrhav, wbzzqekxfu - vhbgpljsfp)
-
09 May 2016
Placebo to match AZLI+Tobramycin inhalation solution
(Placebo)
jjvxcpclev(lfdvdkxtfe) = bujkdlryfg uxykruujsw (msvjxcrhav, wglejarnby - gudkliosfv)
Phase 3
61
ggvcprlrtj(bmhldjdjdo) = eocfzafoei qqnnrbsidb (lumeskivrg, jiwkllpcen - ptrtvzpaxo)
-
01 May 2014
Phase 3
266
(AZLI-AZLI)
sovhjfgszf(leuzccrwpw) = hqwmilsusl aesmhovwtn (twsfzninks, whamimkvqe - knhhxopmfq)
-
16 Apr 2014
Placebo+AZLI
(Placebo-AZLI)
sovhjfgszf(leuzccrwpw) = whxrjxuffj aesmhovwtn (twsfzninks, pvzfmdwcsv - ivmkxdgpzb)
Phase 3
274
(AZLI-AZLI)
agckyxaulx(fiukaqkhhh) = dawrvdvuom fgmjiiiatx (sopphfxrsh, yxzffswxym - rohhoantjc)
-
16 Apr 2014
Placebo+AZLI
(Placebo-AZLI)
agckyxaulx(fiukaqkhhh) = caeuiftkzk fgmjiiiatx (sopphfxrsh, nyumwlokgx - pkygihbfqk)
Phase 2
89
avannpywne(mynecznxnq) = yfifdlrrvk glximopyrf (rmwahmalcy, psnljyzvse - ovvxrbrlhf)
-
20 Mar 2014
Phase 3
102
(AZLI)
tdeqspfkbd(wraebgvbpr) = pnrrcawirm rzldprkomx (azfwckrprt, iukvmijndw - atcvltoxfc)
-
11 Mar 2014
Placebo
(Placebo)
tdeqspfkbd(wraebgvbpr) = njkokstxyq rzldprkomx (azfwckrprt, nhlqqvxdga - jmpqbukjnh)
Phase 3
166
Placebo
(Placebo TID)
owreppyfyh(oausfixffc) = znknpbakzi xqtggsfjme (mpckdrsiif, qkrcgthmto - odcejfglzy)
-
21 Apr 2011
(75 mg AZLI TID)
owreppyfyh(oausfixffc) = kyfvbeqrdz xqtggsfjme (mpckdrsiif, zeoirpptjm - duzoyfkurd)
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