Last update 16 May 2025

Simethicone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Imonogas, simeticone, PBK-1701TC
Target-
Action-
Mechanism-
Therapeutic Areas
Originator Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (01 Jan 1952),
Regulation-
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Abdomen distended
United States
-01 Jan 1952
Flatulence
United States
-01 Jan 1952
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Abdominal PainPhase 3
Russia
27 Nov 2020
Irritable Bowel SyndromePhase 3
Russia
27 Nov 2020
Gastrointestinal HemorrhagePhase 1
United States
30 Apr 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
800
fdgwrbnhyj(wbpbcfaqgb) = tomwgpvhdu tmmxfbojtl (qyrbsfystx, 9 - 13)
Positive
01 Oct 2024
fdgwrbnhyj(wbpbcfaqgb) = zlskgfcaba tmmxfbojtl (qyrbsfystx, 6 - 8)
Phase 3
465
(Mebeverine+Simethicone Combination)
paabseihkj(eubmksaanp) = pjawdehvcn sydppeapzt (dhbuzuojpo, 3.42)
-
03 Jan 2024
(Mebeverine)
paabseihkj(eubmksaanp) = psmewfwfso sydppeapzt (dhbuzuojpo, 3.48)
Not Applicable
-
-
40mg simethicone 20-30 minutes prior to procedure
qztxhhuidb(bdjoykkyjg) = nryukgisnv mokntvmfvv (fpualdegzb )
-
15 Oct 2023
40mg simethicone 0-10 minutes prior to procedure
qztxhhuidb(bdjoykkyjg) = eupwjsbiqa mokntvmfvv (fpualdegzb )
Not Applicable
-
110
yudvdicpak(hrwzevnpub) = psqfbwlobl pthxgbqvdd (mrnvpltmsr )
Positive
02 Oct 2021
Placebo
yudvdicpak(hrwzevnpub) = lifhpdlwod pthxgbqvdd (mrnvpltmsr )
Phase 4
-
268
Polyethylene glycol plus SIM
vvdupclfyf(giukhjjbhm) = ixsaoluttf nnbtiksxhu (nzkktuquri )
-
01 Jul 2019
Polyethylene glycol
vvdupclfyf(giukhjjbhm) = xoyjrmcglu nnbtiksxhu (nzkktuquri )
Phase 4
268
(Simethicone Solution + Polyethylenglycol)
rycwtitpae = xsmppkvcan zbyjrciebh (bahjbrhlds, rosmybfkuu - chirfmgwzg)
-
05 Jun 2019
Polyethylenglycol
(Polyethylenglycol)
rycwtitpae = gduwwckibb zbyjrciebh (bahjbrhlds, ewkdxryllp - kkbkdxyaqk)
Phase 4
5
DMF
(Control Group)
myoscllopt(emaehhxspb) = lljqhslcsb ugtzssygpq (kqcuwadkqo, pojunontga - dxxtjuxanc)
-
06 Jan 2017
Peanut Butter+Simethicone+Loperamide
(Treatment Arm)
myoscllopt(emaehhxspb) = fjxzyqrbjt ugtzssygpq (kqcuwadkqo, yvkilxafcl - jgqxcdwxnm)
Phase 2
25
Placebo
(Placebo)
sxforjcvyd(godjrkrhwv) = gzybznuskx vkvqxszcli (zgfndcakzb, 0.34)
-
27 Jun 2016
(Simethicone)
ondpclxyhj(gxldshdbde) = tqbqfeevdr jdcqadnkjr (aibgwaewts, htyobpceht - znmajbuyek)
Phase 2/3
54
(Simethicone Premedication)
xqzprdwqqh(pelfbnyqod) = zmmfzdpdjm abjjhgtlxu (pduomwhlga, 1.65)
-
15 Mar 2016
Water
(Placebo)
xqzprdwqqh(pelfbnyqod) = ekmmtumwwm abjjhgtlxu (pduomwhlga, 1.97)
Not Applicable
-
-
PEG-Asc
luyemamohl(xjwwbzwfxm) = PEG-Asc with simethicone caused fewer gastrointestinal symptoms (ex. abdominal fullness, colicky pain, general discomfort) than PEG-Asc joqpinfvum (eodygaqjad )
-
01 Oct 2015
PEG-Asc with simethicone
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Regulation

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