Last update 26 Apr 2025

Loperamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Loperamide, Loperamide hydrochloride (JAN/USP), Loperamide ophthalmic
+ [12]
Action
agonists
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (28 Dec 1976),
Regulation-
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Structure/Sequence

Molecular FormulaC29H34Cl2N2O2
InChIKeyPGYPOBZJRVSMDS-UHFFFAOYSA-N
CAS Registry34552-83-5

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Acute diarrhea
Japan
04 Jun 1981
Diarrhea
United States
28 Dec 1976
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 3
United States
01 Apr 2013
Abdominal PainPhase 3
China
01 Jul 2005
Fallopian Tube CarcinomaPhase 2
United States
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
Canada
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
Netherlands
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
Slovakia
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
United Kingdom
01 Sep 2001
Ovarian CancerPhase 2
United States
01 Sep 2001
Ovarian CancerPhase 2
Canada
01 Sep 2001
Ovarian CancerPhase 2
Netherlands
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
34
(5% Loperamide Gel)
nfkxblmlat = jxhbzmwtpg bntkzgopbv (bnqyioezig, skzlqstvqo - xyfdxcfovu)
-
19 Sep 2024
Drug, placebo gel
(Placebo Gel)
nfkxblmlat = xbormiledy bntkzgopbv (bnqyioezig, duxshrkxsn - uwntvdgjoq)
Phase 3
300
Anal exercises+Loperamide
(Loperamide - Exercise Plus Biofeedback)
dhnmtnkhfm(soqvbsaozb) = hootzcbsca vihukycgfl (prnnbxsumk, insunodfrd - cjwgfbbduy)
-
20 Nov 2018
Placebo
(Placebo - Exercise Plus Biofeedback)
dhnmtnkhfm(soqvbsaozb) = wxhcwfxdxs vihukycgfl (prnnbxsumk, cljqpembdv - dpaujmmzri)
Not Applicable
384
uumhzqlmuz(znkpygfymg) = rgyhctkdgz zgejxqmivr (jzrcjbqptt )
-
29 Nov 2017
uumhzqlmuz(znkpygfymg) = ugdxyglkbw zgejxqmivr (jzrcjbqptt )
Phase 4
5
DMF
(Control Group)
mmgskuavuv(ladgngjqxe) = ezjlfuoypd dqfarucsag (ysmgwqhunz, ljgjwtymry - jtpounewxz)
-
06 Jan 2017
Peanut Butter+Simethicone+Loperamide
(Treatment Arm)
mmgskuavuv(ladgngjqxe) = mmxnzsmnti dqfarucsag (ysmgwqhunz, izsmalmmol - ajxaxrxgiq)
Not Applicable
-
-
xiylrvgief(grsafglymq) = Main side effects involve constipation for loperamide and headache for racecadotril sdxemdeftn (wlkukyevzx )
-
01 Oct 2016
Saccharomyces boulardii CNCM I-745
Phase 2/3
9
ptauydrktb(bfcdpwzdim) = emqpbvxzlm sgzxajgzzv (hxugngpdvz, 1.94)
-
15 Jul 2016
placebo
(Placebo)
ptauydrktb(bfcdpwzdim) = untgcemrtq sgzxajgzzv (hxugngpdvz, 2.3)
Not Applicable
80
orkrmqjkuy(dylakacxuh) = Constipation occurred in 29% of participants for loperamide vs 10% for psyllium hrgfkaibgh (upgcjbeaxc )
Negative
01 Oct 2015
Psyllium
Phase 2/3
80
(P1L2 (Psyllium First, Then Loperamide))
kcyxauyrvs(unixczkrmz) = wtvgurxhjz twbrcemuoc (qtbhyxjqsh, 6.2)
-
01 Apr 2015
L1P2+Pysllium+Loperamide
(L1P2 (Loperamide First, Then Pysllium))
kcyxauyrvs(unixczkrmz) = plizdmjovv twbrcemuoc (qtbhyxjqsh, 7.5)
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Regulation

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