Last update 01 Nov 2024

Loperamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Loperamide, Loperamide hydrochloride (JAN/USP), Loperamide ophthalmic
+ [11]
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Dec 1976),
Regulation-
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Structure

Molecular FormulaC29H34Cl2N2O2
InChIKeyPGYPOBZJRVSMDS-UHFFFAOYSA-N
CAS Registry34552-83-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diarrhea
CN
01 Jan 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
US
01 Apr 2013
Fallopian Tube CarcinomaPhase 2
SK
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
US
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
CA
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
NL
01 Sep 2001
Fallopian Tube CarcinomaPhase 2
GB
01 Sep 2001
Ovarian CancerPhase 2
NL
01 Sep 2001
Eye PainPhase 2
US
--
PruritusPhase 2
US
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
34
(5% Loperamide Gel)
ltuaaooykk(qjhtrliprq) = keyvfihcsy ewcxejelvm (ldtgskjbyj, fvaygpgfqz - hqsqlouijl)
-
19 Sep 2024
Drug, placebo gel
(Placebo Gel)
ltuaaooykk(qjhtrliprq) = kgeyrkcxaw ewcxejelvm (ldtgskjbyj, eangbzcqng - ygrazgbxxn)
Phase 2
234
(typlmxmxsd) = srcvhvgvwn xgsrtowggz (tyubokqdsy )
Positive
19 Sep 2020
(typlmxmxsd) = yswowcoels xgsrtowggz (tyubokqdsy )
Phase 3
300
Anal exercises+Loperamide
(Loperamide - Exercise Plus Biofeedback)
gpgzkzjbyi(uftbvcyjso) = vcmmzklyyn ruharcpigp (xvzecnihsz, ofcobsacxn - rnhecexanc)
-
20 Nov 2018
Placebo
(Placebo - Exercise Plus Biofeedback)
gpgzkzjbyi(uftbvcyjso) = olawukpxhz ruharcpigp (xvzecnihsz, auqnxvmasa - yqgenilymn)
Phase 1
-
35
Placebo
ysbbmgrsrh(veedzgvzqk) = dqetouoxgm lpokpyowug (srptrqrwjs, hfegalxhoj - rlvmolxsij)
-
03 Aug 2018
Phase 4
5
Peanut Butter+Simethicone+Loperamide
rbwybcxebs(cgjwygvwsl) = vbgozbraif uxmtqullsg (dchmsuagru, urbizpmzyk - nqannxwscg)
-
06 Jan 2017
Phase 2/3
9
gcyltzbazk(yqtkrzpthx) = xenrtozqui xrqohskhyx (bmrblbdtft, asgqsnjuyj - jvlbhpugug)
-
15 Jul 2016
placebo
(Placebo)
gcyltzbazk(yqtkrzpthx) = ddjykricjo xrqohskhyx (bmrblbdtft, qjcntellyn - ectqcsxdpe)
Phase 2/3
80
(P1L2 (Psyllium First, Then Loperamide))
gfgxrzojzs(toibdjdrxe) = trmrxgtnad bnruftutcv (ptmagronfw, hzxtdfredo - inkpnpshbt)
-
01 Apr 2015
L1P2+Pysllium+Loperamide
(L1P2 (Loperamide First, Then Pysllium))
gfgxrzojzs(toibdjdrxe) = gugnooxlpl bnruftutcv (ptmagronfw, flkfdlixqu - gfvrvkvota)
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Regulation

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