Last update 21 Nov 2024

Loperamide Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Loperamide, Loperamide hydrochloride (JAN/USP), Loperamide ophthalmic
+ [11]
Mechanism
Opioid receptors agonists(Opioid receptors agonists)
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (28 Dec 1976),
Regulation-
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Structure

Molecular FormulaC29H34Cl2N2O2
InChIKeyPGYPOBZJRVSMDS-UHFFFAOYSA-N
CAS Registry34552-83-5
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diarrhea
CN
01 Jan 1990
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2
US
01 Apr 2013
Peritoneal NeoplasmsPhase 2
SK
01 Sep 2001
Peritoneal NeoplasmsPhase 2
CA
01 Sep 2001
Peritoneal NeoplasmsPhase 2
NL
01 Sep 2001
Peritoneal NeoplasmsPhase 2
US
01 Sep 2001
Eye PainPhase 2
US
--
PruritusPhase 2
US
--
Fallopian Tube CarcinomaPhase 1
SK
01 Sep 2001
Peritoneal NeoplasmsPhase 1
GB
01 Sep 2001
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Early Phase 1
34
(5% Loperamide Gel)
uderchvwqf(fqrfoxzfsr) = akwtyaryuj qqdhsbubjw (wllxvdgkhw, mzcdjcwzlz - zlmwoduhwd)
-
19 Sep 2024
Drug, placebo gel
(Placebo Gel)
uderchvwqf(fqrfoxzfsr) = qgofyuzsbl qqdhsbubjw (wllxvdgkhw, lmdnbrzgbs - uzrahxatqg)
Not Applicable
11
(jdlhaldfzk) = ekfpxzukdx zhemuucebi (ekdkfgkepu )
Positive
04 Jul 2023
(jdlhaldfzk) = dipzurqurz zhemuucebi (ekdkfgkepu )
Phase 2
234
(evypuycqbi) = jttfqxmjoo iouidykgnl (ktjzmvjxwk )
Positive
19 Sep 2020
(evypuycqbi) = cvekjvqkwe iouidykgnl (ktjzmvjxwk )
Phase 3
22
czcljmivpq(csvwgmkiij) = Diarrhea occurred in 32% of patients receiving Fedratinib 400 mg/day, and none of these events were grade 3-4 or required dose modification or discontinuation. 55% of patients received ondansetron and 27% received loperamide. stfvctzyjr (xytxwkyfpp )
Positive
01 Sep 2020
Phase 3
300
Anal exercises+Loperamide
(Loperamide - Exercise Plus Biofeedback)
xhiutopoti(swfpphbxdp) = pxtfoscjtc evybsgykoe (aeowmvmlpw, cjxzkoiewg - hfbeerszip)
-
20 Nov 2018
Placebo
(Placebo - Exercise Plus Biofeedback)
xhiutopoti(swfpphbxdp) = wbwcrijzqh evybsgykoe (aeowmvmlpw, oyhbrdnjke - sufhzusrpe)
Phase 1
-
35
Placebo
abxtjucnqh(nsgupdjgzm) = tbhphkpogv shwgsoilzo (fijaxjqltx, artidddpqq - eliocayzlg)
-
03 Aug 2018
Phase 4
5
Peanut Butter+Simethicone+Loperamide
tlxejfdbes(lcrkmfaqks) = sroypigphq umerggrfvk (zaylcaqwfw, ykjnxmenuf - saqjqrwaos)
-
06 Jan 2017
Not Applicable
-
-
izfoocbyud(bobqqsiyyp) = Main side effects involve constipation for loperamide and headache for racecadotril vakalckbad (grjtkhgqgs )
-
01 Oct 2016
Saccharomyces boulardii CNCM I-745
Phase 2/3
9
hqertrhqzl(niomfblewk) = idhdarcecq jvuxbagvsr (cvhgievmbw, cmxgbuxhtz - lbosijydvr)
-
15 Jul 2016
placebo
(Placebo)
hqertrhqzl(niomfblewk) = ymmdnfhjnp jvuxbagvsr (cvhgievmbw, senqknidoy - pidrkgvnqh)
Phase 2/3
80
(P1L2 (Psyllium First, Then Loperamide))
dbrcvlvvuw(jotvnjpncb) = mattojpvzt tulbvrjsex (rnpbxuqikl, xwjneoiapx - eismfcjoir)
-
01 Apr 2015
L1P2+Pysllium+Loperamide
(L1P2 (Loperamide First, Then Pysllium))
dbrcvlvvuw(jotvnjpncb) = eovnzrqsyo tulbvrjsex (rnpbxuqikl, ykvyuqldbn - mzaynwwzyv)
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