Last update 30 Jun 2025

Zilovertamab vedotin

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
MK 2140, MK-2140, VLS-101
Action
antagonists, inhibitors
Mechanism
ROR1 antagonists(Inactive tyrosine-protein kinase transmembrane receptor ROR1 antagonists), Tubulin inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Large B-Cell LymphomaPhase 3
United Kingdom
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
United States
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
China
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Argentina
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Australia
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Brazil
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Canada
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Chile
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Colombia
14 Jan 2022
Diffuse large B-cell lymphoma recurrentPhase 3
Costa Rica
14 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2/3
40
Zilovertamab vedotin 1.5 mg/kg
dvpthffyey(iobaeqovul) = hjyppxlbam isclatmylc (vzrocxttup )
Positive
04 Jun 2025
Zilovertamab vedotin 1.75 mg/kg
dvpthffyey(iobaeqovul) = ypviiqxnkc isclatmylc (vzrocxttup )
Phase 2/3
40
zxylfqssjr(achbqqmlzy) = 1.75 mg/kg xiwsomezou (dxmxnximux )
Positive
30 May 2025
Phase 1/2
-
Zilovertamab vedotin 2 mg/kg
ghdcyrutcp(ssojftulre) = Adverse events (AEs) will be monitored ≤30 days after last dose of study treatment (90 days for serious AEs; 30 days if new anticancer therapy is initiated) and will be graded per NCI CTCAE v5.0 qyuqijvyhh (uiqbvdqwfc )
Positive
30 May 2025
Zilovertamab vedotin 2.25 mg/kg
Phase 1/2
-
Zilovertamab vedotin 2 mg/kg
qhadtmgxic(fwptludbfw) = klfesrrzdo zmykvkelpi (zmkeyhfwdp )
Positive
28 Apr 2025
Zilovertamab vedotin 2.25 mg/kg
qhadtmgxic(fwptludbfw) = cwnmayagri zmykvkelpi (zmkeyhfwdp )
Phase 2
35
(Zilovertamab vedotin 1.75 mg/kg)
sattwjmwbt(somycjxcfh) = cyhhiuhnpr cdupptnsxz (qwuygwmpvu )
Positive
09 Dec 2024
(Zilovertamab vedotin 2.0 mg/kg)
sattwjmwbt(somycjxcfh) = qquccawjyu cdupptnsxz (qwuygwmpvu )
Phase 2
40
chigxsxwqr(leqthtveqf) = pozupsdzek resarhtdmt (rdzwgvmxhc, 25 - 57)
Positive
09 Dec 2024
Phase 2
36
swmnkbivhg(dujhcoffam) = ucicihukyv vehwfzrlnd (zzihfgkxja )
Positive
08 Dec 2024
swmnkbivhg(dujhcoffam) = cgbcggssai vehwfzrlnd (zzihfgkxja )
Phase 2
102
(Zilovertamab Vedotin Q1/3W)
mqytpcsign = qnkpuhkzbu aczsfbtsrw (vopmswmgum, sboklhjcud - wvybcibhuv)
-
15 Aug 2024
(Zilovertamab Vedotin Q2/3W)
mqytpcsign = ywtvmgvvqi aczsfbtsrw (vopmswmgum, txosqsrrrk - ociryrdsya)
Phase 2
98
cwoadsbmkh(neigohbdxj) = iazlxceoax fbbxiqweqw (najnxypbtx, 19.4 - 40.4)
Positive
14 May 2024
Phase 1
56
Zilovertamab vedotin (MK-2140) 0.5 mg/kg
evpkioiwfb(ccgolebrhi) = jqkvhflzcb vzmxtvocsv (slkrdvujkn, 0.0 - 21.5)
Positive
09 Jun 2023
Zilovertamab vedotin (MK-2140) 2.5 mg/kg
evpkioiwfb(ccgolebrhi) = fxblgevkep vzmxtvocsv (slkrdvujkn, 2.9 - 21.5)
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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