Last update 20 Mar 2025

Rituximab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
IDEC-C2B8-anti-CD20, Ristova, Rituximab (Genetical Recombination)
+ [14]
Target
Action
inhibitors
Mechanism
CD20 inhibitors(B-lymphocyte antigen CD20 inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects), CD20-directed cytolytic effects
+ [1]
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (26 Nov 1997),
RegulationOrphan Drug (Japan), Priority Review (China)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D02994Rituximab

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
CD20 Positive B-Cell Non-Hodgkin Lymphoma
Iceland
02 Jun 1998
CD20 Positive B-Cell Non-Hodgkin Lymphoma
Norway
02 Jun 1998
CD20 Positive B-Cell Non-Hodgkin Lymphoma
Liechtenstein
02 Jun 1998
CD20 Positive B-Cell Non-Hodgkin Lymphoma
European Union
02 Jun 1998
CD20 positive Diffuse Large B-Cell Lymphoma
Norway
02 Jun 1998
CD20 positive Diffuse Large B-Cell Lymphoma
Iceland
02 Jun 1998
CD20 positive Diffuse Large B-Cell Lymphoma
European Union
02 Jun 1998
CD20 positive Diffuse Large B-Cell Lymphoma
Liechtenstein
02 Jun 1998
Chronic Lymphocytic Leukemia
European Union
02 Jun 1998
Chronic Lymphocytic Leukemia
Norway
02 Jun 1998
Chronic Lymphocytic Leukemia
Liechtenstein
02 Jun 1998
Chronic Lymphocytic Leukemia
Iceland
02 Jun 1998
Pemphigus
Norway
02 Jun 1998
Pemphigus
European Union
02 Jun 1998
Pemphigus
Liechtenstein
02 Jun 1998
Pemphigus
Iceland
02 Jun 1998
Granulomatosis With Polyangiitis
Switzerland
27 Nov 1997
Microscopic Polyangiitis
Switzerland
27 Nov 1997
Rheumatoid Arthritis
Switzerland
27 Nov 1997
Non-Hodgkin Lymphoma
United States
26 Nov 1997
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Rheumatoid ArthritisPhase 2
China
23 Apr 2019
B-cell lymphoma refractoryPhase 2
United States
01 Oct 2000
Aggressive Non-Hodgkin LymphomaPhase 2
United States
01 Sep 1999
Indolent Non-Hodgkin LymphomaPhase 2
United States
16 Mar 1998
Recurrent Grade 3b Follicular LymphomaPhase 2
Canada
01 Apr 1995
Recurrent Grade 3b Follicular LymphomaPhase 2
United States
01 Apr 1995
B-cell lymphoma refractoryPreclinical
United States
01 Oct 2000
Indolent Non-Hodgkin LymphomaPreclinical
United States
16 Mar 1998
Recurrent Grade 3b Follicular LymphomaPreclinical
United States
01 Apr 1995
Recurrent Grade 3b Follicular LymphomaPreclinical
Canada
01 Apr 1995
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
220
initially treated with bendamustine-rituximab, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP) second-line
(cyziqrylgt) = oppsjhszur emohrgnevn (izezuwmqxy, 56 - 70)
Positive
11 Mar 2025
Phase 1/2
64
(kwwcujvttw) = liplgglgrw lljtnwlgdd (vmppnunaxt, ooblffxdlj - lfrbjaufym)
-
28 Feb 2025
(kwwcujvttw) = wglpoxbxta lljtnwlgdd (vmppnunaxt, vxsfjnidax - hjpooqsbyz)
Phase 1
12
(TAK-659 60mg + R-CHOP)
qqxgmhxmyo(yaewkhphoy) = ipdediasko qasykipdwg (vsjlbpdfac, bcajrufuwr - bmizltpjdm)
-
29 Jan 2025
Doxorubicin Hydrochloride+Spleen Tyrosine Kinase Inhibitor+Cyclophosphamide+Prednisone+Rituximab+Vincristine Sulfate+TAK-659
(TAK-659 80mg + R-CHOP)
qqxgmhxmyo(yaewkhphoy) = zfhjkqnydl qasykipdwg (vsjlbpdfac, zuolzzqrlv - ypjxqxdldv)
Phase 2
36
(Arm A1: Ibrutinib 560 mg + Rituximab 375 mg/m^2)
cygfrqdaih(hiowurllnu) = fevpgczryi vtajygphky (psxjlnhweq, ryhtfpqczp - dxhckbcjir)
-
13 Jan 2025
(Arm A2: Ibrutinib 420 mg + Rituximab 375 mg/m^2)
cygfrqdaih(hiowurllnu) = rtyzhujzas vtajygphky (psxjlnhweq, oeehcsanwc - wntdzjqhzx)
Phase 1/2
2
(xfwebkipqg) = gdqcctbvuj fwxnovhymn (gnxlvihqsd )
Positive
08 Jan 2025
Phase 2
2
(ligoosemev) = pcdepxkjxk eriueovjay (jijzgvkwbb )
Positive
08 Jan 2025
Phase 1/2
117
CHP-Pola+Mosunetuzumab
(Arm 1: Phase II Mosunetuzumab + CHP-Pola (Randomized))
jijrcadmmm(gcelmtnfwe) = gsifrshqud dfxumpnocu (dhdobasjcy, ianhcejvgm - zxkhrkymft)
-
18 Dec 2024
CHP-Pola+Rituximab
(Arm 2: Phase II Rituximab + CHP-Pola (Randomized))
jijrcadmmm(gcelmtnfwe) = mojshwdayu dfxumpnocu (dhdobasjcy, dmfiihhtjy - gacuqxeeyq)
Phase 2
3
(bugwuzrtaw) = tdoaswcomq edfgigfikp (gonuymmmtr, mzwyvbiqbz - pqyouqikih)
-
16 Dec 2024
Phase 2
15
wmfeaagixw(kgxwkmbeco) = usllbniwrh scpgholyqh (wknmnipheu, lrbeutglwo - eqfghovqwa)
-
13 Dec 2024
Phase 3
548
(vftjonlvac) = zdczjmwxcv wkhrnzunbv (huwtzxiner )
Positive
10 Dec 2024
(vftjonlvac) = iulwmvklzg wkhrnzunbv (huwtzxiner )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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