RESTORE TRIAL: A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)

This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of pemvidutide in subjects with ALD.
* Pemvidutide: 2.4 mg SC once weekly
* Placebo: Placebo SC once weekly

Start Date16 Jun 2025

Sponsor / Collaborator

Altimmune, Inc.

NCT06987513

/ RecruitingPhase 2

RECLAIM STUDY: A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol Use Disorder (AUD) in Subjects With Obesity or Overweight

This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of pemvidutide in the treatment of AUD in subjects with obesity or overweight. After signing the informed consent form, subjects will be screened and if eligible randomized 1:1 to 1 of the following 2 treatment arms:
* Pemvidutide: 2.4 mg SC once weekly
* Placebo: Placebo SC once weekly

Start Date15 May 2025

Sponsor / Collaborator

Altimmune, Inc.

NCT05989711

/ Active, not recruitingPhase 2

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Pemvidutide in Non-Cirrhotic Subjects With Nonalcoholic Steatohepatitis (NASH)

Purpose of this study is to assess the effects of pemvidutide on NASH resolution and NASH fibrosis.

Start Date27 Jul 2023

Sponsor / Collaborator

Altimmune, Inc.

100 Clinical Results associated with Pemvidutide

100 Translational Medicine associated with Pemvidutide

100 Patents (Medical) associated with Pemvidutide

Literatures (Medical) associated with Pemvidutide

01 May 2025·PEPTIDES

Multifunctional incretin peptides in therapies for type 2 diabetes, obesity and associated co-morbidities

Review

Author: Flatt, Peter R ; Bailey, Clifford J ; Conlon, J Michael

Recent studies with peptide-based incretin therapies have focussed mainly on the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide and the dual agonist tirzepatide that engages receptors for GLP-1 and glucose-dependent insulinotropic polypeptide (GIP). Randomised clinical trials and 'real-world' studies have confirmed the marked glucose-lowering and weight-lowering efficacy of these agents across diverse populations. These include different ethnic groups, young and elderly individuals with and without diabetes and/or overweight or obesity. Recent studies have also confirmed protections against the development and progression of cardiovascular and renal diseases that are additive to the benefits conferred by improved control of blood glucose and body weight. Emerging evidence suggests that incretin therapies could additionally ameliorate fatty liver disease, chronic inflammation, sleep apnea and possibly degenerative bone disorders and cognitive decline. New incretin-based peptide therapies in development include a long-acting glucagon receptor agonist (LY3324954), dual GLP-1/glucagon receptor agonists (survodutide, pemvidutide, mazdutide, G49), triple GLP-1/GIP/glucagon receptor agonists (retatrutide, efocipegtrutide), a combination of semaglutide with the amylin analogue cagrilintide (CagriSema), a unimolecular GLP-1/amylin receptor dual agonist (amycretin), and a GIP receptor antibody with GLP-1 receptor agonism (MariTide). The creation of multi-targeting incretin-based synthetic peptides provides opportunities for improved management of type 2 diabetes and obesity as well as new therapeutic approaches to an expanding list of associated co-morbidities. The aim of the review is to acquaint the reader with developments in the field from 2023 to the present (February 2025).

01 Feb 2025·Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego

Current priorities in research on metabolic-associated fatty liver disease based on the results of EASL – 2024

Review

Author: Khaitovych, Mykola V. ; Pinsky, Leonid L. ; Ryzhova, Irina P. ; Golubovska, Olga A.

Aim: To systematize and comprehensively analyze scientific sources and studies on metabolic-associated steatotic liver disease (MASLD) based on materials from the European Congress of the European Association for the Study of the Liver (EASL – 2024). Materials and Methods: This paper analyzes the current scientific research on the prevalence, pathogenesis, diagnostic methods, prognosis, and pharmacotherapy of MASLD presented at the EASL 2024 Congress. The following methods were used in the preparation of the work: a systematic approach and bibliosemantic analysis. Conclusions: Studies on the pathogenesis of MASLD progression confirm the significant role of insulin resistance and hyperinsulinemia in increasing hepatocyte cytolysis activity, raising the concentration of cytokeratin CK-18, HbA1c, low-density lipoproteins, triglycerides, and the severity of fibrosis (FIB-4). EASL 2024 studies evaluated the diagnostic efficiency of non-invasive methods for assessing steatosis and liver fibrosis severity in MASLD (FIB-4, FibroScan®, Enhanced Liver Fibrosis (ELF), Vibration Controlled Transient Elastography (VCTE), LiverPRO, etc.). Due to the high prevalence of steatotic liver disease, comorbidities such as chronic viral hepatitis C, autoimmune hepatitis, and alcoholic liver disease – contributing to liver fibrosis progression and hepatocellular carcinoma – are significant. Promising drugs for MASLD treatment include resmethyrom, fibroblast growth factor 21 analogs (including pegosafermin), and pemvidutide, a long-acting, balanced GLP-1/glucagon dual receptor agonist.

01 Jan 2025·JOURNAL OF HEPATOLOGY

Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study

Article

Author: Browne, Sarah K ; Harrison, Stephen A ; Gutierrez, Julio A ; Roberts, M Scot ; Suschak, John J ; Harris, M Scott ; Yang, Jay ; Tomah, Shaheen

BACKGROUND & AIMS:

This was a randomized, double-blind, placebo-controlled study to assess the effects of pemvidutide, a glucagon-like peptide-1 (GLP-1)/glucagon dual receptor agonist, on liver fat content (LFC) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD).

METHODS:

Patients with a BMI ≥28.0 kg/m² and LFC ≥10% by magnetic resonance imaging-proton density fat fraction were randomized 1:1:1:1 to pemvidutide at 1.2 mg, 1.8 mg, or 2.4 mg, or placebo administered subcutaneously once weekly for 12 weeks. Participants were stratified according to a diagnosis of type 2 diabetes mellitus. The primary efficacy endpoint was relative reduction (%) from baseline in LFC after 12 weeks of treatment.

RESULTS:

Ninety-four patients were randomized and dosed. Median baseline BMI and LFC across the study population were 36.2 kg/m² and 20.6%; 29% of patients had type 2 diabetes mellitus. At week 12, relative reductions in LFC from baseline were 46.6% (95% CI -63.7 to -29.6), 68.5% (95% CI -84.4 to -52.5), and 57.1% (95% CI -76.1 to -38.1) for the pemvidutide 1.2 mg, 1.8 mg, and 2.4 mg groups, respectively, vs. 4.4% (95% CI -20.2 to 11.3) for the placebo group (p <0.001 vs. placebo, all treatment groups), with 94.4% and 72.2% of patients achieving 30% and 50% reductions in LFC and 55.6% achieving normalization (≤5% LFC) at the 1.8 mg dose. Maximal responses for weight loss (-4.3%; p <0.001), alanine aminotransferase (-13.8 IU/L; p = 0.029), and corrected cT1 (-75.9 ms; p = 0.002) were all observed at the 1.8 mg dose. Pemvidutide was well-tolerated at all doses with no severe or serious adverse events.

CONCLUSIONS:

In patients with MASLD, weekly pemvidutide treatment yielded significant reductions in LFC, markers of hepatic inflammation, and body weight compared to placebo.

IMPACT AND IMPLICATIONS:

Metabolic dysfunction-associated steatotic liver disease, and its progressive form steatohepatitis, are strongly associated with overweight/obesity and it is believed that the excess liver fat associated with obesity is an important driver of these diseases. Glucagon-like peptide-1 receptor (GLP-1R) agonists elicit weight loss through centrally and peripherally mediated effects on appetite. Unlike GLP-1R agonists, glucagon receptor agonists act directly on the liver to stimulate fatty acid oxidation and inhibit lipogenesis, potentially providing a more potent mechanism for liver fat content reduction than weight loss alone. This study demonstrated the ability of once-weekly treatment with pemvidutide, a dual GLP-1R/glucagon receptor agonist, to significantly reduce liver fat content, hepatic inflammatory activity, and body weight, suggesting that pemvidutide may be an effective treatment for both metabolic dysfunction-associated steatohepatitis and obesity.

CLINICAL TRIAL NUMBER:

NCT05006885.

130

News (Medical) associated with Pemvidutide

09 Jul 2025

·ir.altimmune.com

Altimmune Announces Initiation of RESTORE Phase 2 Trial Evaluating the Efficacy and Safety of Pemvidutide in Alcohol-Associated Liver Disease (ALD)

GAITHERSBURG, Md., July 09, 2025 (GLOBE NEWSWIRE) -- Altimmune, Inc. (Nasdaq: ALT), a late clinical-stage biopharmaceutical company developing novel peptide-based therapeutics for liver and cardiometabolic diseases, today announced that it has enrolled the first patient in the RESTORE Phase 2 trial evaluating the efficacy and safety of pemvidutide in subjects with Alcohol-Associated Liver Disease (ALD). Pemvidutide is a novel, investigational GLP-1/glucagon dual receptor agonist in development for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH), Alcohol Use Disorder (AUD), ALD and obesity. RESTORE (NCT07009860) is a randomized, placebo-controlled trial enrolling approximately 100 patients across 34 sites, with Dr. Rohit Loomba, Professor of Medicine, Chief of the Division of Gastroenterology and Hepatology, and Director of the MASLD Research Center at the University of California, San Diego, serving as the principal investigator. Patients will be randomized 1:1 to 2.4mg pemvidutide or placebo for 48 weeks. The primary endpoint of the trial is the change from baseline in liver stiffness measurement (LSM) by vibration controlled transient elastography (VCTE) at Week 24. Key secondary endpoints include the change from baseline in LSM by VCTE at Week 48, changes in Enhanced Liver Fibrosis (ELF) score at Weeks 24 and 48, and changes in alcohol consumption and body weight at the same time points. An investigational new drug (IND) application for pemvidutide in ALD was filed in December 2024 and cleared by FDA in January 2025. “Of the 28 million Americans with AUD, over 6 million have progressed to ALD, a condition for which there are no approved treatments and few in development,” said Dr. Loomba. “Alcohol-related liver mortality is highest in patients with comorbid obesity, highlighting the urgent need for a liver-directed therapy that can also drive weight loss. The robust reductions in body weight, liver fat and VCTE and the low rates of adverse event discontinuation in the recently completed IMPACT Phase 2b MASH trial support my expectation for success, and I am honored to be a part of this important clinical trial.” “We are excited to launch the RESTORE trial in ALD,” added Scott Harris, M.D., Chief Medical Officer of Altimmune. “We believe that the statistically significant reductions in VCTE, liver fat and markers of fibrosis and inflammation in the recent IMPACT trial at 24 weeks position pemvidutide for a positive efficacy readthrough in the RESTORE trial.” About Pemvidutide Pemvidutide is a novel, investigational, peptide-based 1:1 GLP-1/glucagon dual receptor agonist in development for the treatment of Metabolic Dysfunction-Associated Steatohepatitis (MASH), Alcohol Use Disorder (AUD) and Alcohol-Associated Liver Disease (ALD) and obesity. Activation of the GLP-1 and glucagon receptors is believed to mimic the complementary effects of diet and exercise on weight loss, with GLP-1 suppressing appetite and glucagon increasing energy expenditure. Glucagon is also recognized as having direct effects on hepatic fat metabolism, which is believed to lead to rapid reductions in levels of liver fat and serum lipids. In the ongoing IMPACT Phase 2b trial, at Week 24, once weekly pemvidutide demonstrated statistically significant MASH resolution without worsening of fibrosis, positive trends in liver fibrosis stage improvement without worsening of MASH, statistically significant reductions in non-invasive tests of fibrosis, weight loss, and liver fat content, and improvements in blood pressure. In a post-hoc AI-based analysis of the biopsies from the IMPACT trial, pemvidutide achieved a statistically significant reduction in liver fibrosis. In earlier trials, pemvidutide also demonstrated class-leading lean mass preservation and robust reductions in triglycerides and LDL cholesterol. Pemvidutide was well tolerated in the IMPACT trial, demonstrating potentially best-in-class tolerability among drugs in development for MASH with very low rates of discontinuation due to adverse events. The U.S. FDA granted Fast Track designation to pemvidutide for the treatment of MASH. The MOMENTUM Phase 2 obesity trial was completed in 2024 and the ongoing IMPACT Phase 2b MASH trial 48-week readout is expected in Q4 2025. In addition, RECLAIM, a Phase 2 trial in AUD and RESTORE, a Phase 2 trial in ALD, were initiated in May 2025 and July 2025, respectively. About Altimmune Altimmune is a late clinical-stage biopharmaceutical company focused on developing novel peptide-based therapeutics for liver and cardiometabolic diseases. The Company’s lead program is pemvidutide, a GLP-1/glucagon dual receptor agonist for the treatment of MASH, AUD, ALD and obesity. For more information, please visit www.altimmune.com. Follow @Altimmune, Inc. on LinkedIn Follow @AltimmuneInc on Twitter Forward-Looking Statement Any statements made in this press release related to the development or commercialization of pemvidutide, an investigational product candidate, and other business and financial matters including without limitation, clinical trial study design, status, correspondence, results and data, including the RESTORE trial and ongoing RECLAIM and IMPACT Trials, the timing of key milestones for the Company’s clinical assets, future plans or expectations for pemvidutide for the treatment of MASH, AUD, ALD and obesity, and the prospects for receiving regulatory approval or commercializing or selling any product or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words "may," "could," "should," "anticipate," "believe," "estimate," "expect," "intend," "plan," "predict" and similar expressions and their variants, as they relate to Altimmune, Inc. may identify forward-looking statements. The Company cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward looking statements or historical experience include risks and uncertainties, including risks relating to: delays in regulatory review, manufacturing and supply chain interruptions, access to clinical sites, enrollment, adverse effects on healthcare systems and disruption of the global economy; the reliability of the results of studies relating to human safety and possible adverse effects resulting from the administration of the Company's product candidates; the Company's ability to manufacture clinical trial materials on the timelines anticipated; and the success of future product advancements, including the success of future clinical trials. Further information on the factors and risks that could affect the Company's business, financial conditions and results of operations are contained in the Company's filings with the U.S. Securities and Exchange Commission, including under the heading "Risk Factors" in the Company's most recent annual report on Form 10-K, quarterly report on Form 10-Q and the Company’s other filings with the SEC, which are available at www.sec.gov. Company Contact: Greg Weaver Chief Financial Officer Phone: 240-654-1450 ir@altimmune.com Investor Contact: Lee Roth Burns McClellan Phone: 646-382-3403 lroth@burnsmc.com Media Contact: Jake Robison Inizio Evoke Comms Phone: 619-849-5383 jake.robison@inizioevoke.com Source: Altimmune, Inc

Phase 2Clinical ResultFast Track

27 Jun 2025

·firstwordpharma.com

Altimmune's incretin can't make good on fibrosis improvement promises

Despite touting the results of a mid-stage metabolic dysfunction-associated steatohepatitis (MASH) trial as a success, Altimmune's stock plummeted on Thursday, shaving more than 53% off its valuation. While its dual GLP-1/glucagon receptor agonist pemvidutide hit one of the study's co-primary endpoints, it fell short on the second — after reassuring investors earlier that it was on track to meet both measures.The Phase IIb IMPACT trial randomised 212 patients with biopsy-confirmed MASH and fibrosis stages F2/F3 with and without diabetes to receive either a 1.2 mg or 1.8 mg weekly subcutaneous dose of pemvidutide, or placebo After 24 weeks, 59.1% and 52.1% of those taking the low and high doses, respectively, achieved MASH resolution without worsening of fibrosis based on an intent-to-treat (ITT) analysis, which considered missing biopsies as non-responders. The results were statistically significant compared with the placebo arm, which had a 19.1% achievement rate.For the second measure, 31.8% and 34.5% of patients who received 1.2 mg and 1.8 mg pemvidutide, respectively, saw an improvement in fibrosis without worsening of MASH, which was not significant versus the 25.9% rate seen with placebo. Despite the miss, Altimmune said that when it conducted a supplemental AI-based analysis, the high dose demonstrated statistically significant reductions in fibrosis, with 30.6% of patients in that group achieving a 60% or more reduction in fibrosis compared to 8.2% for placebo.The company's AI argument didn't seem to convince investors, however, who had high expectations going into the readout. According to a note shared earlier by Jefferies, Altimmune's management had said during a fireside chat that it expected to hit statistical significance on all critical endpoints, including fibrosis and MASH improvements, and weight loss. Pemvidutide did meet the statistical significance threshold for weight loss — patients receiving the low and high doses lost 5% and 6.2% of their bodyweight, respectively, versus 1% for placebo — but the miss on fibrosis seemed to be the driving factor behind the company's stock drop. B. Riley analysts said that following a virtual non-deal roadshow with Altimmune, it "came away particularly bullish" on the IMPACT readout, predicting that pemvidutide could become a "one-stop solution for addressing the severe liver disease comorbidity associated with obesity by delivering on best-in-indication fibrosis improvement."They also noted that for Altimmune's incretin to be differentiated from other GLP-1s being evaluated for MASH, such as Novo Nordisk's semaglutide, Eli Lilly's tirzepatide, and Boehring Ingelheim's survodutide, a statistically significant fibrosis improvement at week 24 would be key. For further analysis, see Vital Signs: Tracking the MASH queue for GLP-1 agonists.Another area in which pemvidutide could stand out from the incretin crowd is tolerability. Altimmune reported that no patients receiving the low dose discontinued treatment due to adverse events (AEs), with a rate of 1.2% for those in the high dose group, compared with 2.4% for the placebo arm. There were no treatment-related serious AEs.

Clinical ResultPhase 2

27 Jun 2025

·www.biospace.com

Altimmune Nosedives on Mixed Mid-Stage MASH Data for GLP-1/Glucagon Drug

iStock, Deagreez Altimmune’s pemvidutide failed to significantly improve fibrosis in MASH patients in a Phase IIb study. The biotech crashed 53% in the aftermath of the readout. Altimmune’s dual GLP-1/glucagon agonist pemvidutide helps resolve metabolic dysfunction-associated steatohepatitis—but does not appear to have significant therapeutic benefits on fibrosis associated with the condition, according to new data from a Phase IIb trial. Writing to investors on Thursday, analysts at William Blair called this outcome “underwhelming.” Without demonstrating significant fibrosis improvement, they added, what makes pemvidutide different from other similar assets is “unclear.” “While the Phase IIb IMPACT study met the MASH [metabolic dysfunction-associated steatohepatitis] resolution endpoint, we believe investors are considerably more interested in the other primary endpoint of fibrosis improvement,” which correlates with liver failure, death and progression to cirrhosis or hepatocellular carcinoma, according to the analysts. Altimmune was trading at $3.61 at market close on Thursday, a 53% drop from its closing price the day prior. Thursday’s readout represents 24-week data from the IMPACT trial, which enrolled more than 200 patients with biopsy-confirmed MASH and with stage F2 or F3 fibrosis. Pemvidutide was dosed at either 1.2-mg or 1.8-mg subcutaneous injections and controls were given placebo. Results showed that 59.1% in the lower dose and 52.1% of patients in the higher dose pemvidutide arms achieved MASH resolution without worsening of fibrosis, compared with only 19.1% of placebo comparators. In contrast, neither treatment arm saw statistically significant improvements in fibrosis without worsening MASH in comparison with the placebo group. Altimmune also highlighted statistically significant weight loss with pemvidutide: Patients in the 1.2-mg and 1.8-mg dose groups lost 5% and 6.2% of their body weight at 24 weeks, respectively, whereas placebo counterparts only shed 1%. William Blair analysts, however, remained unimpressed, writing in their Thursday note that the magnitude of pemvidutide’s weight loss is “non-differentiating.” “Given the similarity in development phase and dual agonism mechanism of action, we believe that Eli Lilly’s Mounjaro and Boehringer Ingelheim’s survoditude” are fair comparators—and both have shown better weight loss pro the analysts added. Pemvidutide likewise met several other secondary endpoints, including reductions in liver fat and liver enzymes. Despite the decidedly negative reaction from William Blair and investors, analysts at H.C. Wainwright remained optimistic. Thursday’s data, they wrote on Tuesday, “support advancement to Phase III and strengthen the case for pemvidutide as a potential best-in-class therapy.” The sell-off in Altimmune shares, they added, “is overdone.”

Phase 2Clinical ResultPhase 3

100 Deals associated with Pemvidutide

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Nonalcoholic Steatohepatitis	Phase 3	United States	Altimmune, Inc.	-
Obesity	Phase 3	United States	Altimmune, Inc.	-
Liver Diseases, Alcoholic	Phase 2	United States	Altimmune, Inc.	16 Jun 2025
Alcohol Use Disorder	Phase 2	United States	Altimmune, Inc.	15 May 2025
Diabetes Mellitus, Type 2	Phase 1	United States	Altimmune, Inc.	30 Sep 2021

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT05989711 (IMPACT, Company_Website \| NEWS) Manual	Phase 2	Metabolic dysfunction-associated steatotic liver disease	212	Pemvidutide 1.2 mg	mzctxbezsa(eolkrvldrh) = vgwxqsnbvv rgekzqiwzm (smonxlciyd ) Met View more	Positive	26 Jun 2025
				Pemvidutide 1.8 mg	mzctxbezsa(eolkrvldrh) = bfdtfninqw rgekzqiwzm (smonxlciyd ) Met View more
NCT05292911 (GlobeNewswire) Manual	Phase 2	Obesity	67	Pemvidutide	jfiyurhbxq(mkuhvaguvo) = kfqscruljg kkezagcsyg (jucpiawtue ) View more	Positive	10 Sep 2024
NCT01625260 (CTgov)	Phase 1/2	Non-Muscle Invasive Bladder Neoplasms	12	Gemcitabine+ALT-801 (0.06 mg/kg ALT-801 With 1000 mg/m^2 Gemcitabine)	irukrdxwlr = mpuodejzom ownproasrs (gewnauplqr, exbmxogiuw - gtmhrmlyhz) View more	-	19 Jul 2024
				Gemcitabine+ALT-801 (0.08 mg/kg ALT-801 With 1000 mg/m^2 Gemcitabine)	irukrdxwlr = ayivodurtu ownproasrs (gewnauplqr, beqtuyjcbv - bakxtghdrb) View more
NCT05006885 (Pubmed \| J Hepatol) Manual	Phase 1	Metabolic dysfunction-associated steatotic liver disease type 2 diabetes mellitus (T2DM)	94	Pemvidutide 1.2 mg	iirqtdvpks(mmtywdvpke) = axxdwcmoma gubigmqixc (qnlzdspqsm, -63.7 to -29.6)	Positive	01 Jul 2024
				Pemvidutide 1.8 mg	iirqtdvpks(mmtywdvpke) = ozzftiwgss gubigmqixc (qnlzdspqsm, -84.4 to -52.5) View more
NCT05295875 (MOMENTUM, GlobeNewswire) Manual	Phase 2	Obesity	391	Pemvidutide 1.2 mgPemvidutide 1.2 mg	kftlrdgfgt(bxlnubwxyk) = bacpmpxary svgijzudav (eopinbegfs )	Positive	23 Jun 2024
				Pemvidutide 1.8 mgPemvidutide 1.8 mg	kftlrdgfgt(bxlnubwxyk) = autkzhjlmd svgijzudav (eopinbegfs )
ADA2024	Not Applicable	Overweight \| Obesity	-	Pemvidutide 1.2 mg	dozunfwsns(zzvokclzlb) = Most adverse events were mild to moderate with only 1 drug-related SAE; glycemic control (glucose, HbA1c) was maintained with minimal increases in heart rate aezmjjjwav (npuerinvwp )	-	23 Jun 2024
				Pemvidutide 1.8 mg
ADA2024	Not Applicable	Lipid Metabolism Disorders	-	Pemvidutide 1.2 mg	cxbyylvqwl(xpcmrpuewg) = Reduction in GlycA, biomarker of systemic inflammation correlated with heart failure, were also observed hwzoidzhol (ukjsqvmoeo ) View more	-	14 Jun 2024
				Pemvidutide 1.8 mg
NCT05295875 (MOMENTUM, NEWS) Manual	Phase 2	Overweight \| Obesity	391	pemvidutide 1.2mg	gpmsvarjbw(wwwxrwevzj) = izjwsuxawh inxgkuoysm (gplrwbtxgo, 1.4) View more	Positive	02 Dec 2023
				pemvidutide 1.8mg	gpmsvarjbw(wwwxrwevzj) = bpwuuelgwd inxgkuoysm (gplrwbtxgo, 1.4) View more
NCT05292911 (Corporate Publications) Manual	Phase 1	Metabolic dysfunction-associated steatotic liver disease	64	Pemvidutide 1.2mg	yvbcfdwiat(xfxdnkwdob) = ytdqwaeoao cfspegigcv (tyisancmkz ) View more	Positive	13 Nov 2023
				Pemvidutide 1.8mg	yvbcfdwiat(xfxdnkwdob) = sgshhzhshz cfspegigcv (tyisancmkz ) View more
NEWS Manual	Phase 1	Metabolic dysfunction-associated steatotic liver disease	94	placebo	mldfsynzcd(fnvaekxnrq) = bpavzadxot walbbhloty (tqgqrjghmx ) View more	Positive	25 Oct 2023
				pemvidutide 1.2 mg	mldfsynzcd(fnvaekxnrq) = cljtmircpe walbbhloty (tqgqrjghmx ) View more

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