Last update 21 Nov 2024

Gemcitabine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
D07001-Softgel, Gemcitabine, Gemcitabine (USAN/INN)
+ [9]
Mechanism
RNR inhibitors(Ribonucleotide reductase inhibitors), DNA synthesis inhibitors
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC9H11F2N3O4
InChIKeySDUQYLNIPVEERB-QPPQHZFASA-N
CAS Registry95058-81-4

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
metastatic non-small cell lung cancerDiscovery
IT
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
FR
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
US
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
GB
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
DE
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
NL
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
BE
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
IL
01 Mar 2010
metastatic non-small cell lung cancerDiscovery
LU
01 Mar 2010
Metastatic HER2-Negative Breast CarcinomaDiscovery
US
01 Jul 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
1
(bldrpkhide) = ijnymbgvbj jbaxixyixh (szlvyggobz, xqnblignkw - gjforwinds)
-
05 Nov 2024
Not Applicable
-
Gemcitabine and nab-paclitaxel only
(vgpwfrqkfj) = dwpdmshdpj iitqzcsbgm (iegeoemoez )
-
01 Nov 2024
(vgpwfrqkfj) = iqvxfegshj iitqzcsbgm (iegeoemoez )
Phase 2
6
(yegnipfbzd) = txgfinqhur ooadbglmrp (qzvewrvvlu )
Positive
30 Oct 2024
(imbahqrkqa) = vlvwdfieeg adxsuzqvra (hhagdkbmkl )
Phase 1/2
-
Nadunolimab in combination with gemcitabine/cisplatin
(NSCLC + first arm)
(dquotohmah) = ezkrippejy assvhngcaw (orkrvwryrs )
Positive
28 Oct 2024
Nadunolimab in combination with gemcitabine/cisplatin
(biliary tract cancer + first arm)
(dquotohmah) = imnqsyzjjr assvhngcaw (orkrvwryrs )
Phase 2
64
yyyafrabql(opvdamnhyo) = sffepcbpau afhbizjvep (inpnomwgid, dsejqguvrh - dwucuvqrst)
-
10 Oct 2024
Phase 2
50
(invqzgkqon) = plrbkouidm ucuuepjdyd (yeqxxwtlxa )
Positive
16 Sep 2024
(invqzgkqon) = tescfkeygb ucuuepjdyd (yeqxxwtlxa )
Phase 3
Advanced Bile Duct Carcinoma
First line
HER2-positive
-
(issvbimnfw) = eiyjztwuia bzuflxwhzs (xhrurbvztp )
Positive
16 Sep 2024
Not Applicable
260
(xxxumzmmxw) = ofejabmgmh yeemxzusrx (cwyophzmvw, 5.6 - 7.1)
Positive
16 Sep 2024
Not Applicable
Pancreatic Cancer
Adjuvant
lipopolysaccharide | lipoteichoic acid
342
(iivwkjpome) = wxmwaaomdb tdummhzyim (qvojzsccrz )
Positive
16 Sep 2024
(iivwkjpome) = wlgbwwuvtb tdummhzyim (qvojzsccrz )
Phase 1/2
Non-Small Cell Lung Cancer
First line | Second line
40
Nadunolimab+cisplatin/gemcitabine or carboplatin/pemetrexed
(kywrspaans) = pwqcwrmppy guqvzrlgat (nenyvtgvmc )
Positive
14 Sep 2024
Nadunolimab+cisplatin/gemcitabine or carboplatin/pemetrexed
(1L)
(kywrspaans) = upxvfteicw guqvzrlgat (nenyvtgvmc )
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Regulation

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