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Last update 16 Sep 2026

Venlafaxine Hydrochloride

Last update 16 Sep 2026

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

SummaryVenlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), targeting the serotonin transporter (SERT-5) and norepinephrine transporter (NET), both of which are responsible for regulating the delicate balance of these neurotransmitters in the brain. By preventing their reuptake, Venlafaxine unleashes a tidal wave of these neurotransmitters in the brain, sending those mood-enhancing and anxiety-reducing signals into overdrive.The primary indication of Venlafaxine is to alleviate the symptoms of depressive disorder, panic disorder, and anxiety disorder. On December 28, 1993, the FDA approved Wyeth Corp's Venlafaxine . Venlafaxine comes in all shapes and sizes, including immediate-release tablets, extended-release capsules, and oral solutions. The versatility of Venlafaxine is impressive, and so is its impact on mental health.

Drug Type

Small molecule drug

Synonyms

Dobupal, Efexor XR, Effexor XR

+ [26]

Target

NET x SERT

Action

inhibitors

Mechanism

NET inhibitors(Norepinephrine transporter inhibitors), Serotonin reuptake inhibitors

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

Anxiety DisordersPanic DisorderPhobia, Social+ [3]

Inactive Indication-

Originator Organization

Pfizer Inc.

Active Organization

Upjohn US 2 LLCBGP Pharma ULCJohn Wyeth & Brother Ltd.

+ [6]

Inactive Organization

Wyeth AB

Pfizer Inc.

Jiangsu Haosen Pharmaceutical Research Institute Co., Ltd.

+ [2]

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (28 Dec 1993),

Depressive Disorder

RegulationPriority Review (China)

Structure/Sequence

Molecular FormulaC17H28ClNO2

InChIKeyQYRYFNHXARDNFZ-UHFFFAOYSA-N

CAS Registry99300-78-4

275

Clinical Trials associated with Venlafaxine Hydrochloride

NCT07698626

/ Not yet recruitingPhase 1IIT

A Multicenter, Open-label, Observer-blinded Randomized Controlled Trial Comparing the Efficacy and Safety of Venlafaxine Plus Education and Behavioral Modification Program Versus Education and Behavioral Modification Program Alone in Adults With Interstitial Cystitis/Bladder Pain Syndrome

This study aims to compare two treatment plans for adults with bladder pain syndrome (also called interstitial cystitis), a disease that causes long-lasting bladder pain, frequent urination and urgent need to pee. All participants will receive standardized patient education and behavioral training to relieve urinary discomfort. Half of the participants will only get this behavioral intervention, while the other half will take oral venlafaxine in addition to the same behavioral training for 12 weeks. We will check patients' pain levels, urination frequency, sleep quality, mood and daily life ability at 1, 2, 6 and 12 weeks of treatment. The main goal is to see whether adding venlafaxine can better ease bladder pain and urinary symptoms without obvious side effects. This research will provide safer and more effective treatment suggestions for patients with bladder pain syndrome.

Start Date31 Dec 2026

Sponsor / Collaborator

Beijing Tiantan Hospital

NCT07737158

/ Not yet recruitingNot ApplicableIIT

Efficacy and Safety of Venlafaxine in the Treatment of Non-specific Low Back Pain

Chronic non-specific low back pain is the leading cause of productivity loss and disability worldwide, constituting a major public health challenge. This study aims to systematically evaluate and compare the role of the antidepressant drug Venlafaxine in chronic non-specific low back pain, which is of critical importance for optimising clinical practice and developing precise, individualised treatment regimens.

Start Date01 Sep 2026

Sponsor / Collaborator

Beijing Tiantan Hospital

CTIS2025-522967-13-00

/ RecruitingPhase 4IIT

A multicenter randomized, controlled, single-blind, adaptive phase IV clinical trial to evaluate the efficiency and effectiveness of a pre-emptive pharmacogenetic strategy for antidepressant selection in patients with depressive disorder: The PREDICT adaptive clinical trial.

Start Date10 Aug 2026

Sponsor / Collaborator

Fundación para la Investigación Biomédica del Hospital

100 Clinical Results associated with Venlafaxine Hydrochloride

100 Translational Medicine associated with Venlafaxine Hydrochloride

100 Patents (Medical) associated with Venlafaxine Hydrochloride

6,774

Literatures (Medical) associated with Venlafaxine Hydrochloride

31 Dec 2026·Dialogues in Clinical Neuroscience

Treatment of posttraumatic stress disorder (PTSD)

Review

Author: Bandelow, Borwin

The present review summarises recommendations for the management of posttraumatic stress disorder (PTSD) based on a consensus among international experts in the field.Cognitive-behavioural therapy (CBT) has the best evidence base as a psychotherapy modality. Virtual reality exposure therapy appears to be an emerging treatment option for PTSD. Eye Movement Desensitisation and Reprocessing (EMDR) therapy and digital CBT-based interventions did not demonstrate superiority compared to controls. Controlled studies supporting the use of psychodynamic therapy are lacking. Early prophylactic psychotherapy for trauma victims is ineffective and may be harmful.First-line pharmacotherapy includes selective serotonin reuptake inhibitors (SSRIs) and the serotonin-noradrenaline reuptake inhibitor (SNRI) venlafaxine. Several second- and third-line medications are available for treatment-refractory patients. Currently, no medications can be recommended for prophylactic use in trauma victims.Although evidence is incomplete regarding combined psychotherapy and pharmacotherapy, available studies generally favour combination treatments over monotherapy. Repetitive transcranial magnetic stimulation (rTMS) showed efficacy in one study. In children and adolescents with PTSD, CBT demonstrated a medium effect size compared to active controls, while studies on SSRI treatment in this population yielded inconsistent results.

01 Dec 2026·Toxicology reports

VA-ECMO and HIET for toxic cardiogenic shock in an elderly patient following severe poly-intoxication: A case report

Article

Author: Poublon, N A ; Ouwerkerk, J J J ; Westra, A F ; Kraaijvanger, N

This case report presents the successful use of high-dose insulin euglycemic therapy (HIET) and venous arterial extracorporeal membrane oxygenation (VA-ECMO) in managing severe toxic cardiogenic shock following poly-intoxication in an elderly patient. A 67-year-old woman, with a history of depression, previous suicide attempts and chronic renal failure, overdosed on multiple cardiovascular active agents including metoprolol (β-blocker), nifedipine (calcium channel blocker), nortriptyline (tricyclic antidepressant), venlafaxine (serotonin-noradrenaline reuptake inhibitor), and temazepam (benzodiazepine) were reported. Initial treatment with vasopressors, HIET and supportive measures stabilized her condition temporarily. Despite these interventions, the patient developed catecholamine-refractory shock with progressive multiorgan failure, requiring escalation to VA-ECMO as a bridge to recovery. VA-ECMO resulted in hemodynamic stabilization, enabling vasopressor withdrawal and decannulation after three days. The patient survived the acute toxic phase without irreversible neurological injury. However, the course was complicated by vascular complications, prolonged mechanical ventilation, renal replacement therapy, severe functional decline and eventually death eight months later. This case illustrates that VA-ECMO may provide effective temporary circulatory support in severe reversible toxic cardiogenic shock, even in elderly patients with significant comorbidity. However, the substantial burden of long-term morbidity and prolonged recovery should be carefully weighed during multidisciplinary decision-making.

01 Dec 2026·Current Pain and Headache Reports

Periosteal Osteosarcoma: Emerging Clinical Concepts, Evolving Treatment Options: A Narrative Review

Review

Author: Kaye, Alan D ; Bratton, Matthew B ; Shekoohi, Sahar ; Islam, Rahib K ; Abd-Elsayed, Alaa ; Pirzadah, Humza A ; Starns, Michael J

PURPOSE OF REVIEW:

Periosteal osteosarcomas are rare bone tumors that comprise less than 2% of all bone malignancies. The tumor was previously thought to affect the diaphysis of long bones solely, but Recent case reports have demonstrated its existence in the clavicle, mandible, and scapula.

RECENT FINDINGS:

Several factors, including stage, grade, and medullary invasion primarily drive survival and recurrence of periosteal osteosarcomas. Related to its rarity, little data currently exists regarding optimum treatment strategies, including limb amputation, surgical resection, and chemotherapy in the neoadjuvant/adjuvant setting. In this regard, bone pain is the most common manifestation. Pain treatment can include medications such as oral or transdermal opioids. Adjuvant drugs can reduce inflammation and neuropathic pain, including corticosteroids, gabapentinoid agents such as gabapentin or pregabalin, lidocaine patches, tricyclic antidepressants such as amitriptyline, nortriptyline, and desipramine, or selective serotonin-norepinephrine reuptake inhibitors such as duloxetine and venlafaxine. More advanced pain treatment interventions can be provided by interventional pain medicine physicians, such as radiofrequency ablation, peripheral nerve stimulation, spinal cord stimulation, or intrathecal drug delivery systems, when conventional opioids and adjuvants do not adequately provide relief. Molecular workups of case reports have shown common mutations, such as the p53 gene, which may provide utility for future molecular targets. The present investigation aims to synthesize currently available data on periosteal osteosarcomas, including common clinical, histologic, and radiographic presentations. In addition, this review aims to further examine the potential for biomarkers and provide recommendations for treatment and future research direction.

News (Medical) associated with Venlafaxine Hydrochloride

22 Apr 2026

·www.biospace.com

AtaiBeckley Announces Additional Phase 2a Results for EMP-01 (oral R-MDMA) Showing Large and Consistent Improvements in Social Anxiety Disorder

EMP-01 demonstrated a large, clinically meaningful reduction in patient-reported SAD symptoms at Day 43: placebo-adjusted LSMD -11.5 points (p=0.002) on SPIN; placebo-adjusted LSMD -15.6 points (p=0.004) on SAFE - a 38% and 32% reduction, respectively Patient-perceived global improvement: 49% PGI-C responders at Day 43 compared to 12% on placebo No severe or serious adverse events NEW YORK, April 22, 2026 (GLOBE NEWSWIRE) -- AtaiBeckley Inc. (NASDAQ: ATAI) (“AtaiBeckley” or “Company”), a clinical-stage biotechnology company on a mission to transform patient outcomes by developing rapid-acting, durable and convenient mental health treatments, today announced expanded Phase 2a results for EMP-01 (oral R-MDMA) in adults with Social Anxiety Disorder (SAD) (n=70), demonstrating clinically meaningful and consistent improvements across clinician-rated symptoms, patient-reported experience, and real-world behavioral outcomes. At Day 43, EMP‑01 achieved a 38% reduction vs 15% on placebo (Hedges’ g=0.84) on the patient-reported Social Phobia Inventory (SPIN), a 32% reduction vs 14% on placebo on the Subtle Avoidance Frequency Examination (SAFE), and a previously reported −11.9-point LS mean difference (LSMD) on the Liebowitz Social Anxiety Scale (LSAS) versus placebo (g=0.45), with 49% responder rates on both Clinical Global Impression-Improvement (CGI-I) (previously reported) and Patient Global Impressions of Change (PGI-C). EMP-01 was well tolerated, with no severe or serious adverse events. Clinical Data Summary Drug EMP-01 (oral R-MDMA) Indication Social Anxiety Disorder Trial NCT06693609: Phase 2a (Randomized 1:1, N=70). Two‑dose regimen (Days 1 and 29) with no psychotherapy; last assessment Day 43. Endpoints Primary endpoints safety and tolerability; secondary endpoint change in LSAS total score at Day 43; exploratory endpoints SPIN, SAFE, CGI‑I, PGI‑C, PK/PD, 11D‑ASC Primary Result Well tolerated; no SAEs; no severe TEAEs Secondary Results LSAS placebo-adjusted LSMD: -11.9 points, moderate effect size (g=0.45) at Day 43 (previously reported) Exploratory Results At Day 43: SPIN: -18.3 points (38% reduction from baseline vs 15% on placebo), with a large between-group effect size (Hedges’ g=0.84); post hoc MMRM placebo-adjusted LSMD -11.5 points (p=0.002) SAFE: -25.9 points (-32% reduction from baseline vs 14% on placebo); post hoc MMRM placebo-adjusted LSMD -15.6 points (p=0.004) CGI‑I responders: 49% vs 15% placebo (previously reported) PGI‑C responders: 49% vs 12% placebo Efficacy Findings EMP‑01 produced consistent and clinically meaningful improvements across all major symptom domains of SAD: LSAS: EMP-01 demonstrated a clinically meaningful LSMD of −11.9‑points vs placebo (g=0.45) at Day 43 (previously reported), with both total and subscale improvements. Improvements were observed across both fear and avoidance subscales on the clinician-rated 24-item Liebowitz Social Anxiety Scale, indicating that patients experienced fewer social situations as distressing and were more able to engage in them. This degree of change is considered clinically meaningful and reflects broad symptom improvement across core features of social anxiety disorder including fear and anxiety of social situations. SPIN: EMP-01 produced a large, clinically meaningful patient-reported improvement of -18.3-points (38% reduction vs 15% on placebo), which corresponded to a large between-group standardized effect size (g=0.84), in self-reported SAD symptoms from baseline to Day 43. Additional model-based analyses further supported treatment benefits at Day 43, showing statistically significant improvements with a placebo-adjusted LSMD of -11.5 points (95% CI: -18.5, -4.6; p=0.002) at Day 43. Patients treated with EMP-01 moved from severe baseline symptom severity to substantially lower symptom burden by Day 43. These results on the 17-item SPIN are equivalent to being able to initiate conversations, attend social events, and perform at work with substantially less fear and avoidance. SAFE: EMP-01 demonstrated a large, clinically meaningful improvement of −25.9‑points (32% reduction vs 14% on placebo) in real-world behavioral avoidance at Day 43. Additional model-based analyses further supported treatment benefits at Day 43, showing statistically significant improvements with a placebo-adjusted LSMD of -15.6 points at Day 43 (95% CI: -26.0, -5.2; p=0.004). These results on the Subtle Avoidance Frequency Examination, a 32-item questionnaire that measures safety behaviors, suggest that participants were more willing to participate in everyday activities such as social interactions without engaging in avoidant coping behaviors. Clinical impression: 49% CGI‑I responders (NNT=2.95) at Day 43 compared to 15% on placebo (previously reported). This measure reflects clinicians’ overall judgment of meaningful improvement in a patient’s condition, considering symptom severity, functioning, and overall clinical presentation. Patient perception: 49% PGI‑C responders (NNT=2.72) at Day 43 compared to 12% on placebo. This result indicates that patients themselves perceived the treatment‑associated improvements as noticeable and meaningful in their daily lives, reinforcing the clinical and functional outcomes observed on other measures. Safety & Tolerability EMP‑01 was generally safe and well tolerated: No SAEs and no severe TEAEs in any participant 97% retention, with 0% study dropouts attributed to TEAEs TEAEs were expected and consistent with the class, transient, and predominantly mild‑to‑moderate Professor Murray Stein, Distinguished Professor of Psychiatry and Public Health at the University of California San Diego (UCSD) and consultant to AtaiBeckley, said: “ I was particularly struck by the consistency of the findings across clinician-rated and patient-reported outcomes. The improvement on the SAFE is especially interesting because reductions in subtle avoidance behaviors are seen as an important goal of cognitive behavioral therapies and yet are seldom measured in medication trials for social anxiety disorder. Taken together, these findings provide strong support for continued development of EMP-01.” Management Commentary Dr Srinivas Rao, Co-Founder and Chief Executive Officer at AtaiBeckley, said: “In this Phase 2a trial of 70 patients, EMP - 01 delivered a 49% clinician - rated and patient-reported responder rate alongside significant improvements across LSAS, SPIN, and real - world avoidance behavior. Unlike current standards of care, which require daily, chronic dosing, the durability observed in this study following just two administrations suggests that EMP-01 could be a differentiated treatment option that could meaningfully improve outcomes for people living with Social Anxiety Disorder.” Dr Kevin Craig, Chief Medical Officer at AtaiBeckley said: “ Social Anxiety Disorder is a chronic and highly impairing condition for which many patients do not achieve adequate benefit from currently available treatments. The consistent improvements observed across clinician-rated symptoms, patient-reported experience, and avoidance behavior—alongside a favorable tolerability pro encouraging evidence that EMP-01 may address multiple important dimensions of this disorder.” Study Design The multi-center study enrolled 71 adults with moderate-to-severe SAD across 7 clinical sites in the UK. Participants were randomized to receive two in-clinic administrations of EMP-01 (225 mg) or placebo, given 28 days apart, with no adjunctive psychotherapy. 70 participants received at least one dose of study drug, and 69 completed the Day 43 efficacy assessments, indicating high patient acceptability and retention. All clinician-rated assessments were conducted by blinded central raters. Topline results from this study were previously reported in February 2026. Frequently Asked Questions Q1: What do the additional Phase 2a results for EMP-01 mean for patients with Social Anxiety Disorder? A1: AtaiBeckley today reported additional efficacy and safety dataset from its Phase 2a trial of EMP-01 (oral R-MDMA) in adults with Social Anxiety Disorder. The results show consistent, clinically meaningful improvements across every major symptom domain - clinician-rated anxiety (LSAS), patient-reported symptoms (SPIN), real-world avoidance behavior (SAFE), and global impression scales (CGI-I, PGI-C). Approximately 49% of EMP-01-treated patients were rated as much or very much improved by both their clinician and themselves, compared to roughly 15% and 12% on placebo, respectively. The full safety dataset also confirmed a favorable safety and tolerability pro no serious adverse events. Q2: How does EMP-01’s reduction in patient-reported social anxiety compare to standard-of-care treatments? A2: On the Social Phobia Inventory (SPIN), EMP-01 produced a placebo-adjusted LSMD of 11.5 points in a supportive post hoc MMRM analysis, with a large effect size (Hedges’ g = 0.84) and a 38% reduction from baseline after two doses over six weeks. In a cross-trial comparison, standard-of-care pharmacotherapies (venlafaxine, paroxetine) produced placebo-subtracted SPIN differences of approximately 6.7–7.8 points at comparable timepoints. On the SAFE behavioral avoidance measure, EMP-01 produced a 32% reduction (−25.9 points), exceeding the −17-point benchmark reported for cognitive behavioral therapy for SAD after 12–16 weeks. Cross-trial comparisons are inherently limited due to differences in study design, patient populations, endpoints, and duration. Q3: How does EMP-01 differ from existing pharmacotherapies for Social Anxiety Disorder? A3: Current first-line treatments for SAD - primarily SSRIs and SNRIs - require daily dosing and approximately 8–12 weeks to show meaningful effect, and roughly 50% of patients do not achieve adequate response. EMP-01 is designed as an intermittent, in-clinic oral treatment: in this trial, two administrations delivered over 28 days produced clinically meaningful improvements at Day 43, without adjunctive psychotherapy. EMP-01 is an investigational product and has not been approved by the U.S. Food and Drug Administration (FDA). Q4: What is Social Anxiety Disorder (SAD)? A4: Social Anxiety Disorder (SAD) is one of the most prevalent psychiatric conditions worldwide, affecting an estimated 400–800 million individuals with a lifetime prevalence of approximately 12%. The disorder is characterized by persistent and debilitating fear, self-consciousness, and heightened anxiety during social interactions. SAD is frequently co-morbid with major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, attention deficit/hyperactivity disorder, bipolar disorder, and substance use disorders, contributing to substantial functional impairment and reduced quality of life. In the United States alone, roughly 30 million adults are affected by SAD; however, only about 50% of affected individuals receive treatment. Even among patients who access care, treatment adequacy remains suboptimal, and around 50% of SAD patients do not achieve adequate response to first line therapies and often deal with chronic medication side effects. Q5: What does post hoc MMRM mean A5: These were supportive statistical analyses conducted after topline results using a standard repeated-measures modelling approach. The results were consistent with the primary dataset and increase confidence in the robustness of treatment effects on SPIN and SAFE. About EMP-01 (Oral R-MDMA) EMP-01 is an oral, single-enantiomer R‑MDMA candidate being developed as a potential treatment for people living with Social Anxiety Disorder (SAD). It has been designed to elicit entactogenic and psychedelic subjective effects, with reduced dopaminergic and noradrenergic activity compared with racemic MDMA in order to support safe, scalable outpatient administration for individuals with SAD, who currently have a high unmet medical treatment need. EMP-01 is an investigational product and has not been approved by the FDA. About AtaiBeckley Inc. AtaiBeckley is a clinical-stage biotechnology company on a mission to transform patient outcomes by developing rapid-acting, durable and convenient mental health treatments. AtaiBeckley’s pipeline of novel therapies includes BPL-003 (mebufotenin benzoate nasal spray) for treatment-resistant depression (TRD), VLS-01 (DMT buccal film) for TRD and EMP-01 ((R)-MDMA HCI) for social anxiety disorder. BPL-003 is in Phase 3 planning, VLS-01 and EMP-01 are in Phase 2 clinical development. The Company is also advancing a drug discovery program to identify novel, non-hallucinogenic 5-HT2AR agonists for opioid use disorder and TRD. These programs aim to create breakthroughs in mental health through transformative interventional psychiatry therapies that can integrate seamlessly into healthcare systems. For the latest updates and to learn more about the AtaiBeckley mission, visit or follow the Company on LinkedIn and on X . Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “anticipate,” “initiate,” “could,” “would,” “project,” “plan,” “potentially,” “preliminary,” “likely,” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements include express or implied statements relating to, among other things: our business strategy and plans; progress and results of our EMP-01 trials; the timing of further data on EMP-01; the therapeutic potential of EMP-01; and the potential benefits of EMP-01 for patients with SAD. Forward-looking statements are neither promises nor guarantees, but involve known and unknown risks and uncertainties that could cause actual results to differ materially from those projected, including, without limitation, the important factors described in the section titled “Risk Factors” in our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission (“SEC”), as such factors may be updated from time to time in our quarterly reports and other filings with the SEC. AtaiBeckley disclaims any obligation to update or revise any forward-looking statements contained in this press release, other than to the extent required by applicable law. Contact Information: Investors: Jason Awe, PhD VP, Investor Relations IR@ataibeckley.com Media: Charlotte Chorley Associate Director, Communications PR@ataibeckley.com

Clinical ResultPhase 2Phase 3

23 Mar 2026

·www.prnewswire.com

Viatris Advances Innovative Portfolio with Approval of Effexor® in Japan for Adults with Generalized Anxiety Disorder (GAD)

Addresses a Significant Unmet Need in Japan as First and Only Approved Treatment Option for GAD PITTSBURGH, March 23, 2026 /PRNewswire/ -- Viatris Inc. (Nasdaq: VTRS), a global healthcare company, today announced that Japan's Ministry of Health, Labour and Welfare (MHLW) has approved Effexor® SR 37.5 mg / 75 mg capsules (venlafaxine hydrochloride), a serotonin-noradrenaline reuptake inhibitor (SNRI), for the treatment of adults with generalized anxiety disorder (GAD). Following the MHLW's decision, Effexor® becomes the first and only approved treatment option in Japan for adults living with GAD, addressing a long-standing unmet medical need in mental health and enabling new access to care. Effexor® is currently approved in Japan for the indication of major depressive disorder in adults, and with this approval, is now available to patients with GAD. GAD is among the most prevalent and highly disabling mental health conditions, negatively impacting patients' quality of life and disrupting activities of daily living. A recent study reported the prevalence of probable GAD in Japan as 7.6% of the general population.1 "The approval of Effexor® in Japan for generalized anxiety disorder demonstrates the successful execution of our strategy to advance a differentiated and increasingly innovative portfolio in Japan, bringing forward value-added therapies that address a significant unmet need," said Philippe Martin, Viatris Chief R&D Officer. "This approval also reflects our ability to effectively implement an optimized lifecycle strategy for our established brands and to leverage our deep local expertise." "This approval marks the introduction of a new treatment option for adults in Japan living with GAD," said Corinne Le Goff, Viatris Chief Commercial Officer. "We look forward to leveraging our strong infrastructure and deep expertise in central nervous system therapies in Japan to bring access to this much needed treatment to patients." The approval of Effexor® for GAD is based on a Phase 3 placebo-controlled, randomized, double-blind, multicenter study of venlafaxine in patients with GAD conducted in Japan (Study B2411367), which achieved its primary objective of superiority of anxiolytic effects of venlafaxine compared to placebo at 8 weeks, based on the change in the Hamilton Anxiety Rating Scale (HAM-A) total score from baseline (two-sided p-value=0.012). All seven secondary efficacy endpoints as defined by the trial protocol were met. Effexor® was generally well tolerated with a profile consistent with its known safety profile in non-Japanese patients. In particular: Low discontinuation rates due to treatment emergent adverse events (TEAEs) were seen (7.3% vs 1.7% in placebo) with 3.9% vs 0.6% assessed as related to treatment. No serious TEAEs or TEAEs with severe intensity were observed (0% vs 1.1% and 0.6%, respectively, in placebo). These results and the results of a long-term extension study of venlafaxine in Japanese outpatients with GAD were included as part of the applications for approval. Effexor® is currently approved to treat GAD in more than 80 countries outside of Japan. About Generalized Anxiety Disorder (GAD) Generalized Anxiety Disorder (GAD) is a mental health disorder whose central symptom is chronic and uncontrollable "anxiety" or "worry" about everyday life events or activities. Other symptoms include difficulty to get enough sleep, muscle tension/stiffness, feeling restless, irritable, or finding it difficult to concentrate, which may cause impairment in social, occupational, or other areas of functioning. In Japan, the World Health Organization reports that 2.6% of the population will suffer from GAD in their lifetime. A recent study in Japan reported the prevalence of probable GAD is 7.6%1, suggesting that this condition may be significantly underdiagnosed. About Viatris' Innovative Portfolio in Japan Viatris' portfolio of innovative products in Japan includes approved products such as Spydia ® Nasal Spray (diazepam) for the treatment of status epilepticus. The company's pipeline in Japan includes investigational products such as pitolisant for the treatment of excessive daytime sleepiness associated with obstructive sleep apnea syndrome and narcolepsy, and products in pivotal Phase 3 trials which are currently ongoing, such as selatogrel in acute myocardial infarction (AMI), Nefecon in IgA nephropathy, and cenerimod in systemic lupus erythematosus (SLE). About Viatris Viatris Inc. (Nasdaq: VTRS) is a global healthcare company whose mission is to empower people worldwide to live healthier at every stage of life. We meet the needs of patients around the world by acting decisively with ingenuity and resolve. Whether we're developing new medicines, working to maintain a resilient supply of needed therapies, or pursuing bold innovation, we deliver solutions that are effective at scale and built to endure. We're purpose-built to make an impact with a dynamic portfolio that spans generics, established brands and innovative medicines that address areas of significant unmet need. We are headquartered in the U.S., with global centers in Pittsburgh, Shanghai, China, and Hyderabad, India. Learn more at viatris.com and investor.viatris.com, and connect with us on LinkedIn, Instagram, YouTube and X. References: Matsuyama S, Otsubo T, Nomoto K, Higa S, Takashio O. Prevalence of Generalized Anxiety Disorder in Japan: A General Population Survey. Neuropsychiatr Dis Treat. 2024;20:1355-1366. Forward-Looking Statements This press release includes statements that constitute "forward-looking statements." These statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements may include statements that Viatris advances innovative portfolio with approval of Effexor® in Japan for adults with GAD; addresses a significant unmet need in Japan as first and only approved treatment option for GAD; the approval of Effexor® in Japan for generalized anxiety disorder demonstrates the successful execution of our strategy to advance a differentiated and increasingly innovative portfolio in Japan, bringing forward value-added therapies that address a significant unmet need; this approval also reflects our ability to effectively implement an optimized life cycle strategy for our established brands and leverage our deep local expertise; we look forward to leveraging our strong infrastructure and deep expertise in central nervous system therapies in Japan to bring access to this much needed treatment to patients; and the outcome of clinical trials. Because forward-looking statements inherently involve risks and uncertainties, actual future results may differ materially from those expressed or implied by such forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to: the uncertainties inherent in research and development, including the outcomes of clinical trials; the ability to meet anticipated clinical endpoints; the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from clinical studies; failure to achieve the intended benefits of our strategic initiatives and priorities; goodwill or impairment charges or other losses; any changes in or difficulties with the Company's manufacturing facilities; failure to achieve expected or targeted future financial and operating performance and results; Viatris' or its partners' ability to develop, manufacture, and commercialize products; any regulatory, legal or other impediments to Viatris' ability to bring new products to market; products in development and/or that receive regulatory approval may not achieve expected levels of market acceptance, efficacy or safety; actions and decisions of healthcare and pharmaceutical regulators; changes in healthcare and pharmaceutical laws and regulations in the U.S. and abroad; the scope, timing and outcome of any ongoing legal proceedings, and the impact of any such proceedings on Viatris; any significant breach of data security or data privacy or disruptions to our IT systems; risks associated with international operations; changes in third-party relationships; the effect of any changes in Viatris' or its partners' customer and supplier relationships and customer purchasing patterns; the impacts of competition; changes in the economic and financial conditions of Viatris or its partners; uncertainties regarding future demand, pricing and reimbursement for the Company's products; uncertainties and matters beyond the control of management, including but not limited to general political and economic conditions, potential adverse impacts from future tariffs and trade restrictions, inflation rates and global exchange rates; and the other risks described in Viatris' filings with the Securities and Exchange Commission ("SEC"). Viatris routinely uses its website as a means of disclosing material information to the public in a broad, non-exclusionary manner for purposes of the SEC's Regulation Fair Disclosure (Reg FD). Viatris undertakes no obligation to update these statements for revisions or changes after the date of this press release other than as required by law. SOURCE Viatris Inc. 21% more press release views with Request a Demo

Clinical ResultPhase 3Drug Approval

19 Mar 2026

·www.prnewswire.com

Viatris to Outline its Vision for Sustained Revenue and Earnings Growth Through 2030

Growing Base Business Evolving Into More Durable Portfolio of Higher-Margin Generics, Value-Added Medicines and Established Brands Expecting Impactful Near-Term Launches, Including Fast-Acting Meloxicam and Low-Dose Estrogen Weekly Patch in the U.S., and Pitolisant and Effexor® for GAD in Japan Unlocking Long-Term Value Through Potential Blockbusters Selatogrel and Cenerimod Strong Cash Flow Generation Enabling Capital Return and Disciplined Business Development Providing Long-Term Targets for Sustained Growth Through 2030 PITTSBURGH, March 19, 2026 /PRNewswire/ -- Viatris Inc. (Nasdaq: VTRS) will host its Investor Event today, where members of the executive leadership team will outline the Company's strategic vision, key drivers and financial framework expected to deliver sustained revenue and earnings growth through 2030. Executive Commentary "Over the past several years, we have taken decisive actions to strengthen the foundation of Viatris by simplifying the portfolio, strengthening the balance sheet and stabilizing the base business," said Scott A. Smith , CEO, Viatris. "Today, we are entering the next phase of our evolution. With a growing base business, multiple anticipated near-term launches, a promising innovative pipeline and the financial flexibility to pursue disciplined accretive business development, we believe Viatris is well positioned to deliver sustained revenue and earnings growth through the end of the decade while continuing to create value for patients and shareholders." "Our diversified portfolio and strong cash flow generation provide significant financial flexibility to invest in growth while maintaining a disciplined capital allocation framework," said Doretta Mistras , CFO, Viatris. "We expect to have more than $11 billion in cash available for deployment through 2030, which would enable us to return capital to shareholders and pursue accretive business development to further strengthen our long-term growth profile." Key Elements to be Highlighted at the Investor Event During the event, the Company will highlight key elements supporting its long-term growth targets, including its: Strategic vision and priorities R&D capabilities and pipeline overview Commercial capabilities and building blocks of growth Portfolio strategy and business development Financial framework for accelerating shareholder value The Company believes these elements collectively support its framework for delivering sustained revenue and earnings growth through 2030. Long-Term Financial Targets and Capital Allocation At the event, the Company will also outline its long-term financial targets through 2030, including the capital allocation framework intended to support its future growth. For its Combined Long-Term Targets through 2030, the Company expects to deliver 5% to 6% Total Revenues CAGR, 7% to 8% Adjusted EBITDA CAGR, 9% to 10% Adjusted EPS CAGR and more than $3 billion in annual free cash flow in 2030. The Combined Long-Term Targets are comprised of the Company's Base Case Long-Term Targets and Potential Additional Drivers. For its Base Case Long-Term Targets through 2030, Viatris expects its base business, supported by anticipated upcoming launches of value-added medicines, to deliver 3% to 4% Total Revenues CAGR, 4% to 5% Adjusted EBITDA CAGR, including operating leverage from the cost savings resulting from its Enterprise-Wide Strategic Review, 6% to 7% Adjusted EPS CAGR, including the benefit from future expected share repurchases, and more than $2.7 billion in annual free cash flow in 2030. As part of its recently completed Enterprise-Wide Strategic Review, Viatris identified approximately $650 million in gross cost savings over a three-year period, with up to $250 million expected to be reinvested in the Company. Potential Additional Drivers include expected growth from accretive business development and the potential launches of selatogrel and cenerimod. The Company expects more than $11 billion in cash available for deployment through 2030 under its Base Case Long-Term Targets and has assumed that approximately 50% of the cash available for deployment through 2030 will be allocated to disciplined accretive business development. Investor Event Webcast A live webcast of the Investor Event will begin today at 10:00 a.m. ET and can be accessed on the Company's website at investor.viatris.com. Presentation materials and a replay of the webcast will also be available on the Company's website. Certain Key Terms and Presentation Matters Revenue and Earnings : Refers to Total Revenues, Adjusted EBITDA and Adjusted EPS. Key Exchange Rates Our 2026 financial guidance and long-term financial targets are based on the following budgeted exchange rates: Euro ($/EUR) 0.87, China Renminbi ($/CNY) 7.19, Japanese Yen ($/JPY) 144.35, and Indian Rupee ($/INR) 85.80. About Viatris Viatris Inc. (Nasdaq: VTRS) is a global healthcare company whose mission is to empower people worldwide to live healthier at every stage of life. We meet the needs of patients around the world by acting decisively with ingenuity and resolve. Whether we're developing new medicines, working to maintain a resilient supply of needed therapies, or pursuing bold innovation, we deliver solutions that are effective at scale and built to endure. We're purpose-built to make an impact with a dynamic portfolio that spans generics, established brands and innovative medicines that address areas of significant unmet need. We are headquartered in the U.S., with global centers in Pittsburgh, Shanghai, China, and Hyderabad, India. Learn more at viatris.com and investor.viatris.com, and connect with us on LinkedIn, Instagram, YouTube and X. Forward-Looking Statements This press release contains "forward-looking statements". These statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements may include, without limitation, statements about: long-term financial targets; vision for sustained revenue and earnings growth through 2030; growing base business evolving into more durable portfolio of higher-margin generics, value-added medicines and established brands; expecting impactful near-term launches, including fast-acting meloxicam and low-dose estrogen weekly patch in the U.S., and pitolisant and Effexor® for GAD in Japan; unlocking long-term value through potential blockbusters selatogrel and cenerimod; strong cash flow generation enabling capital return and disciplined business development; providing long-term targets for sustained growth through 2030; the Company's strategic vision, key drivers and financial framework expected to deliver sustained revenue and earnings growth through 2030; today, we are entering the next phase of our evolution; with a growing base business, multiple anticipated near-term launches, a promising innovative pipeline and the financial flexibility to pursue disciplined accretive business development, we believe Viatris is well positioned to deliver sustained revenue and earnings growth through the end of the decade while continuing to create value for patients and shareholders; our diversified portfolio and strong cash flow generation provide significant financial flexibility to invest in growth while maintaining a disciplined capital allocation framework; we expect to have more than $11 billion in cash available for deployment through 2030, which would enable us to return capital to shareholders and pursue accretive business development to further strengthen our long-term growth profile; key elements supporting long-term growth targets, including: strategic vision and priorities, R&D capabilities and pipeline overview, commercial capabilities and building blocks of growth, portfolio strategy and business development, financial framework for accelerating shareholder value; the Company believes these elements collectively support its framework for delivering sustained revenue and earnings growth through 2030; the capital allocation framework intended to support its future growth; Combined Long-Term Targets through 2030 of 5% to 6% Total Revenues CAGR, 7% to 8% Adjusted EBITDA CAGR, 9% to 10% Adjusted EPS CAGR and more than $3 billion in annual free cash flow in 2030; Combined Long-Term Targets are comprised of the Company's Base Case Long-Term Targets and Potential Additional Drivers; for Base Case Long-Term Targets through 2030, Viatris expects its base business, supported by anticipated upcoming launches of value-added medicines, to deliver 3% to 4% Total Revenues CAGR, 4% to 5% Adjusted EBITDA CAGR, including operating leverage from the cost savings resulting from its Enterprise-Wide Strategic Review, 6% to 7% Adjusted EPS CAGR, including the benefit from future expected share repurchases, and more than $2.7 billion in annual free cash flow in 2030; as part of its recently completed Enterprise-Wide Strategic Review, Viatris identified approximately $650 million in gross cost savings over a three-year period, with up to $250 million expected to be reinvested in the Company; Potential Additional Drivers include expected growth from accretive business development and the potential launches of selatogrel and cenerimod; the Company expects more than $11 billion in cash available for deployment through 2030 under its Base Case Long-Term Targets and has assumed that approximately 50% of the cash available for deployment through 2030 will be allocated to disciplined accretive business development; the goals or outlooks with respect to the Company's strategic initiatives and priorities, including but not limited to divestitures, acquisitions, strategic alliances, collaborations and partnerships, or other potential transactions; the anticipated benefits of such strategic initiatives or priorities, or restructuring activities; future opportunities for the Company and its products; regulatory submissions and decisions; the outcomes of clinical trials and research studies; R&D and new product development; launch plans; and any other statements regarding the Company's future operations, financial or operating results, capital allocation, dividend policy and payments, share repurchases, debt ratio and covenants, anticipated business levels, future earnings, planned activities, anticipated growth, market opportunities, strategies, imperatives; competitions, commitments, confidence in future results, efforts to create, enhance or otherwise unlock value, and other expectations and targets for future periods. Forward-looking statements may often be identified by the use of words such as "will", "may", "could", "should", "would", "project", "believe", "anticipate", "expect", "plan", "estimate", "forecast", "potential", "pipeline", "intend", "continue", "target", "seek" and variations of these words or comparable words. Because forward-looking statements inherently involve risks and uncertainties, actual future results may differ materially from those expressed or implied by such forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to: the possibility that the Company may not realize the intended benefits of, or achieve the intended goals or outlooks with respect to, its strategic initiatives and priorities; the possibility that the Company may be unable to achieve the intended or expected benefits of its enterprise-wide strategic review and related cost-saving and restructuring activities within the expected timeframe or at all; the possibility that the Company may be unable to achieve intended or expected benefits in connection with divestitures, acquisitions, strategic alliances, collaborations, or other transactions, or restructuring programs, within the expected timeframes or at all; goodwill or impairment charges or other losses; success of clinical trials and the Company's or its partners' ability to execute on new product opportunities and develop, manufacture and commercialize products; any changes in or difficulties with the Company's manufacturing facilities, including with respect to short- or long-term shutdowns, inspections, remediation and restructuring activities, supply chain continuity, inventory management, or the ability to meet anticipated demand; the Company's failure to achieve expected or targeted future financial and operating performance and results; the potential impact of natural or man-made disasters, public health outbreaks, fires, accidents, weather, unrest or other emergencies in regions where we or our partners or suppliers operate; actions and decisions of healthcare and pharmaceutical regulators; changes in relevant laws, regulations and policies and/or the application or implementation thereof, including but not limited to tax, healthcare and pharmaceutical laws, regulations and policies globally; the ability to attract, motivate and retain key personnel; the Company's liquidity, capital resources and ability to obtain financing; any regulatory, legal or other impediments to the Company's ability to bring new products to market; products in development that receive regulatory approval may not achieve expected levels of market acceptance, efficacy or safety; longer review, response and approval times as a result of evolving regulatory priorities and reductions in personnel at health agencies; the scope, timing and outcome of any ongoing legal proceedings, including government inquiries or investigations, and the impact of any such proceedings on the Company; any significant breach of data security or data privacy or disruptions to our IT systems; risks associated with having significant operations globally; the ability to protect intellectual property and preserve intellectual property rights; changes in third-party relationships; the effect of any changes in the Company's or its partners' customer and supplier relationships and customer purchasing patterns, including customer loss and business disruption being greater than expected following an adverse regulatory action, acquisition or divestiture; the impacts of competition, including decreases in sales or revenues as a result of the loss of market exclusivity for certain products; changes in the economic and financial conditions of the Company or its partners; uncertainties regarding future demand, pricing and reimbursement for the Company's products; uncertainties and matters beyond the control of management, including but not limited to general political and economic conditions, potential for adverse impacts from future tariffs and trade restrictions, inflation rates and global exchange rates; and inherent uncertainties involved in the estimates and judgments used in the preparation of financial statements, and the providing of estimates of financial measures, in accordance with U.S. GAAP and related standards or on an adjusted basis. For more detailed information on the risks and uncertainties associated with Viatris Inc. ("Viatris" or the "Company"), see the risks described in Part I, Item 1A of the Company's Annual Report on Form 10-K for the year ended December 31, 2025, and our other filings with the SEC. You can access Viatris' filings with the SEC through the SEC website at or through our website and Viatris strongly encourages you to do so. Viatris routinely posts information that may be important to investors on our website at investor.viatris.com, and we use this website address as a means of disclosing material information to the public in a broad, non-exclusionary manner for purposes of the SEC's Regulation Fair Disclosure (Reg FD). The contents of our website are not incorporated into this press release or our filings with the SEC. Viatris undertakes no obligation to update any statements herein for revisions or changes after the date of this press release other than as required by law. In particular, certain statements in this release relate to our "long-term financial targets", including but not limited to providing long-term targets for 2026-2030, including base case long-term target CAGR of 3-4% for Total Revenues, 4-5% for Adjusted EBITDA, 6-7% for Adjusted EPS; >$2.7B base case long-term target for free cash flow by 2030; potential additional drivers for selatogrel and cenerimod of +1% for total revenues and 0% for Adjusted EBITDA and Adjusted EPS; potential additional drivers for accretive business development of 1% for Total Revenues and 3% for Adjusted EBITDA and Adjusted EPS; combined long-term target CAGR of 5-6% for Total Revenues, 7-8% for Adjusted EBITDA and 9-10% for Adjusted EPS; >$3B combined long-term target free cash flow by 2030; and >$11 billion in cash available for deployment by 2030. Viatris believes that the assumptions used as a basis for the long-term financial targets are reasonable based on the information available to management at this time. However, this information is not fact, and you are cautioned not to place undue reliance on any such information. While certain of these statements might use language that imply a level of certainty about the likelihood that Viatris will attain its long-term financial targets, it is possible that Viatris will not attain them in the timeframe noted or at all. The long-term financial targets reflect assumptions as to key exchange rates as well as regarding certain business decisions that are subject to change. Important factors that may affect actual results and cause the long-term financial targets not to be achieved, or that may change the underlying variables and assumptions on which the long-term financial targets were based and cause the long-term financial targets to differ materially, include, but are not limited to, risks and uncertainties relating to our strategic priorities and initiatives, restructuring activities, inability to manage base business erosion, failure to bring new products to market on the expected timeframes or at all, failure to execute stock repurchases consistent with current expectations, stock price volatility, higher than anticipated SG&A, gross margins and R&D spend, industry performance, interest rate volatility, foreign exchange rates, tax rates, the regulatory environment and general business and economic conditions, as well as those set forth in the first paragraph of this "Forward Looking Statements" slide. In addition, although certain of the long-term financial targets are presented with numerical specificity, they are still forward-looking statements that involve inherent risks and uncertainties. Further, the long-term financial targets cover multiple years and such information by its nature becomes less reliable with each successive year. Accordingly, there can be no assurance that any aspect of long-term financial targets will be realized or that actual results will not differ materially. Therefore, you should construe these statements regarding the long-term financial targets only as goals, targets and objectives rather than promises of future performance or absolute statements. Non-GAAP Financial Measures This press release includes the presentation and discussion of certain financial information that differs from what is reported under accounting principles generally accepted in the United States ("U.S. GAAP"). These non-GAAP financial measures, including, but not limited to, adjusted EBITDA, free cash flow, and adjusted EPS are presented in order to supplement investors' and other readers' understanding and assessment of the financial performance of Viatris. Free cash flow refers to U.S. GAAP net cash provided by operating activities less capital expenditures. Adjusted EBITDA refers to as U.S. GAAP net earnings (loss) adjusted for income tax provision (benefit), interest expense and depreciation and amortization (to calculate EBITDA) and further adjusted for share-based compensation expense, litigation settlements and other contingencies, net, loss on divestitures of businesses, impairment of goodwill and restructuring, acquisition and divestiture related and other special items. Adjusted EPS refers to adjusted net earnings divided by the weighted average number of diluted shares of common stock outstanding. Investors and other readers should consider non-GAAP measures only as supplements to, not as substitutes for or as superior measures to, the measures of financial performance prepared in accordance with U.S. GAAP. Long-Term Financial Targets The Company is not providing forward-looking information for U.S. GAAP net (loss) earnings, EPS or U.S. GAAP net cash provided by operating activities or a quantitative reconciliation of its long-term targets for adjusted EBITDA CAGR, adjusted EPS CAGR and free cash flow to their most directly comparable U.S. GAAP measures, U.S. GAAP net earnings (loss) CAGR, EPS CAGR and U.S. GAAP net cash provided by operating activities, respectively, because it is unable to predict with reasonable certainty the ultimate outcome of certain significant items, including integration, acquisition and divestiture-related expenses, restructuring expenses, asset impairments, litigation settlements, future share repurchases, and other contingencies, such as changes to contingent consideration, acquired IPR&D and certain other gains or losses, including for the fair value accounting impact for equity investments, as well as related income tax accounting because certain of these items have not occurred, are out of the Company's control and/or cannot be reasonably predicted without unreasonable effort. These items are uncertain, depend on various factors, and could have a material impact on U.S. GAAP reported results for the relevant periods. SOURCE Viatris Inc. 21% more press release views with Request a Demo

Financial Statement

100 Deals associated with Venlafaxine Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
D00821	Venlafaxine Hydrochloride	N06AX16	DB00285

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anxiety Disorders	Canada	BGP Pharma ULC	04 Mar 1998
Panic Disorder	Canada	BGP Pharma ULC	04 Mar 1998
Phobia, Social	Canada	BGP Pharma ULC	04 Mar 1998
Generalized anxiety disorder	United States	Upjohn US 2 LLC	20 Oct 1997
Depressive Disorder, Major	United Kingdom	John Wyeth & Brother Ltd.	27 Nov 1994
Depressive Disorder	United States	Wyeth Pharmaceuticals LLC	28 Dec 1993

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02977299 (ASCERTAIN-TRD \| ASCERTAINTRD, CTgov)	Phase 4	Depressive Disorder, Treatment-Resistant	278	Aripiprazole (Aripiprazole Augmentation)	snkpgmzmwy(ifenptoibj) = uuolxbdayk swhfgcrohg (wbdwhtwyqt, 1.1) View more	-	09 Jul 2026
				Repetitive transcranial magnetic stimulation (rTMS) (rTMS Augmentation)	snkpgmzmwy(ifenptoibj) = wjenzvdcrt swhfgcrohg (wbdwhtwyqt, 1.3) View more
DDW2026	Not Applicable	-	443	Amitriptyline	uekjyfuzbq(cjppmegelw) = xeegxverpo wrvbgkkpog (echorykeae ) View more	Positive	02 May 2026
NCT03574792 (CTgov)	Phase 2	Pain \| Cutaneous Squamous Cell Carcinoma of the Head and Neck	62	Quality-of-Life Assessment+Oxycodone+Methadone+Gabapentin (Arm I (Gabapentin, Methadone, Oxycodone))	yselsqcsva(euttrtevpo) = oopqwfiwkv payeilohkf (pockapxaoe, 10) View more	-	16 Apr 2026
				Quality-of-Life Assessment+Oxycodone+Methadone+Venlafaxine+Gabapentin (Arm II (Gabapentin, Methadone, Oxycodone, Venlafaxine))	yselsqcsva(euttrtevpo) = moqiderhfd payeilohkf (pockapxaoe, 17) View more
NCT04639193 (RESCUE-Combo, Pubmed \| Ann Am Thorac Soc)	Phase 2	Sleep Apnea, Obstructive	20	Acetazolamide+eszopiclone	fxbcdwygrq(fbivhjqlhr) = ybpayasash plurrcrbdx (oshiiycqfd, -24.1 to -5.2)	Positive	08 Nov 2024
NCT05569031 (Pubmed \| Int Clin Psychopharmacol)	Phase 4	Maintenance	95	Venlafaxine 225mg/day	uqxvtjxlor(qjyalckibm) = fxjqlhsxva eymnlzdyeo (ykzaiqfora )	Positive	01 Nov 2024
				Naltrexone 50mg/day	uqxvtjxlor(qjyalckibm) = pwwtumfdzo eymnlzdyeo (ykzaiqfora )
NCT04218123 (Pubmed \| JAMA Otolaryngol Head Neck Surg)	Phase 2/3	Meniere Disease	40	Venlafaxine 37.5 mg	mvvjzwxmqk(ihwjeykbru) = aobclbbxds ekttpskojp (hfluohkqaf, 4.4)	Negative	01 Nov 2024
				Placebo	mvvjzwxmqk(ihwjeykbru) = ahdjaqedyp ekttpskojp (hfluohkqaf, 4.6)
NCT04639193 (RESCUE-Combo, CTgov)	Phase 2	Sleep Apnea, Obstructive	20	Acetazolamide+Eszopiclone (Dual-Therapy)	jnvwfqraqb(pablituqva) = uwgcwucrmq hbyaickvdu (hwepqgpypo, niynxoomzd - cudgjlyxgy) View more	-	02 May 2024
				Placebo+Acetazolamide+Eszopiclone (Placebo)	jnvwfqraqb(pablituqva) = laixhkorll hbyaickvdu (hwepqgpypo, zwtcrjnbxz - kvkrpvqofu) View more
NCT02977299 (ASCERTAIN-TRD, Pubmed \| Mol Psychiatry) Manual	Phase 4	Depressive Disorder, Treatment-Resistant	260	Aripiprazole	qrhbdbwnfv(wgftpfidec) = dvztfpqmbm zlarbmtgdx (sgugmieynv, 1.1) View more	Negative	07 Mar 2024
				Repetitive transcranial magnetic stimulation	qrhbdbwnfv(wgftpfidec) = yeylulqibm zlarbmtgdx (sgugmieynv, 1.3) View more
NCT00974155 (Pubmed \| J Clin Psychopharmacol)	Phase 4	Depressive Disorder, Major	234	Venlafaxine	raaiacxwxu(fbtgjobqfq) = The most frequent ADRs during treatment with VF were orthostatic dizziness (15.8%) kicjxvmicu (gvskhslbno ) View more	-	16 Nov 2020
NCT02714400 (Pubmed \| Chest)	Phase 4	Sleep Apnea Syndromes	20	Venlafaxine	mxgsfcehyf(vhedboszxe) = sbgbsgxmso hlqazpfheg (esdwcgsabx, -12.0 to 0.9) View more	-	01 Aug 2020
				Placebo	dxwepfuarv(gtsqjjdqko) = xkzdtxheux kgcafquqxa (hfdlesgzkr, -0.5 to 5)

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