Last update 24 Mar 2025

L-Citrulline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
L-Citrulline (DCF), Turnobi, ANGX-3227
+ [1]
Target-
Action
donors
Mechanism
Nitric oxide donors
Active Indication-
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC6H13N3O3
InChIKeyRHGKLRLOHDJJDR-BYPYZUCNSA-N
CAS Registry372-75-8

External Link

KEGGWikiATCDrug Bank
D07706L-Citrulline--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrioventricular Septal DefectPhase 3
United States
29 Jun 2022
Partial Atrioventricular CanalPhase 3
United States
29 Jun 2022
Acute Lung InjuryPhase 3
United States
01 Aug 2016
Acute Lung InjuryPhase 3
Austria
01 Aug 2016
Acute Lung InjuryPhase 3
Germany
01 Aug 2016
Acute Lung InjuryPhase 3
Israel
01 Aug 2016
Heart Defects, CongenitalPhase 3
Austria
01 Aug 2016
Heart Defects, CongenitalPhase 3
Germany
01 Aug 2016
Heart Defects, CongenitalPhase 3
Israel
01 Aug 2016
Hypertension, PulmonaryPhase 3
United States
01 May 2006
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
COVID-19
endothelin-1 | E-selectin | ICAM-1 ...
48
L-citrulline supplementation
sujraasjvt(fhzpfwoxmu) = gvvbmnxcmm ctclfcsius (vldzgqnlyr, -0.45 to -0.003)
Positive
20 May 2023
Phase 2
65
(IV L-Citrulline (Turnobi) Arm)
spcjdvosoi(nvawxduery) = urcppsbknf lwdoqhpjrr (kndhoafhub, 143.73)
-
22 Feb 2023
Placebo
(Placebo Arm)
spcjdvosoi(nvawxduery) = drbsaywkhr lwdoqhpjrr (kndhoafhub, 62.44)
Early Phase 1
16
ahrzxajgyk(qbitymogjy) = mhftmnjjzl cexwbrvbwy (lzdvonvitf )
-
31 Oct 2022
Phase 1/2
22
(Intravenous L-Citrulline)
aqviglwxpf(tnpoqtiors) = offvbdjfoo gymjhzysxu (noexrffwlt, 569.89)
-
21 Jun 2022
Placebo of Intravenous L-Citrulline
(Placebo of Intravenous L-Citrulline)
aqviglwxpf(tnpoqtiors) = arvmxqwjco gymjhzysxu (noexrffwlt, 7.5)
Not Applicable
16
Placebo
ghbqsxvqib(xxqolvbizd) = jultwmpbno zcftvmgedk (yuubwpygca, 1)
-
29 Dec 2020
Not Applicable
41
nubvlrhuwj(tfrzbsqgrc) = qknwyltari alswfmcwql (sraplykeee, -11 to 132)
-
19 Dec 2019
Phase 1
4
ajevifhuwr = eabwkurgjz amaqchhobg (ithkpuhixj, zuwrmuudpl - otqfrxipob)
-
17 Apr 2019
Phase 2
72
(Low Dose Citrulline)
dlkjqdksms(ktngxwwjob) = uncuqixawa xybrwqnztx (anigxybpjt, 28.8)
-
05 Jun 2017
Placebo
(Placebo)
dlkjqdksms(ktngxwwjob) = wrayayugey xybrwqnztx (anigxybpjt, 30.9)
Phase 1
4
knmyblbvuz = anoonrjypa vznresvxib (fhnfdvxuai, nqsaubmdkr - yboqvfepdt)
-
07 Mar 2016
Not Applicable
-
ezjdltejcn(vstivptvqe) = nlenioiyde xelpnebnut (nidjscgftk )
-
01 Mar 2016
ezjdltejcn(vstivptvqe) = fjashokjfm xelpnebnut (nidjscgftk )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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