Last update 08 May 2025

Pamiparib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PARPi, PARPi - BeiGene, PARTRUVIX
+ [5]
Action
inhibitors
Mechanism
PARP1 inhibitors(Poly (ADP-Ribose) polymerase 1 inhibitors), PARP2 inhibitors(Poly (ADP-Ribose) Polymerase 2 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationConditional marketing approval (China), Special Review Project (China), Priority Review (China)
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Structure/Sequence

Molecular FormulaC16H15FN4O
InChIKeyDENYZIUJOTUUNY-MRXNPFEDSA-N
CAS Registry1446261-44-4

External Link

KEGGWikiATCDrug Bank
D11426-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRCA-mutated Fallopian Tube Carcinoma
China
30 Apr 2021
BRCA-mutated Fallopian Tube Carcinoma
China
30 Apr 2021
BRCA-mutated Ovarian Cancer
China
30 Apr 2021
BRCA-mutated Ovarian Cancer
China
30 Apr 2021
BRCA-mutated Peritoneal Neoplasms
China
30 Apr 2021
BRCA-mutated Peritoneal Neoplasms
China
30 Apr 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPhase 3
Italy
19 Dec 2019
NeoplasmsPhase 3
New Zealand
19 Dec 2019
NeoplasmsPhase 3
Australia
19 Dec 2019
NeoplasmsPhase 3
France
19 Dec 2019
NeoplasmsPhase 3
Taiwan Province
19 Dec 2019
NeoplasmsPhase 3
Malaysia
19 Dec 2019
NeoplasmsPhase 3
Japan
19 Dec 2019
NeoplasmsPhase 3
Turkey
19 Dec 2019
Platinum-Sensitive Ovarian CarcinomaPhase 3
China
14 May 2018
Recurrent ovarian cancerPhase 3
China
25 Apr 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
bszdtgowwd(hyompxzjpg) = nctibslqoa qrovdlxwpy (dqjbilmjei )
-
28 Apr 2025
bszdtgowwd(hyompxzjpg) = qtozltupxs qrovdlxwpy (dqjbilmjei )
Phase 1/2
67
(Phase 1: Dose Finding)
imvmleckvo(sfmmlklyeu) = lwcmktdqvg skkwwwlqhd (bwtwkxftrz, zekrwjfskd - bkusasxvcu)
-
16 Dec 2024
(Phase 2: Arm A Alkylator-resistant)
(evenejpfar) = xrqlmonmgo itzyaemfgp (jkzkljvvrn, lzzrgfhumr - vovfzsazzf)
Phase 2
Recurrent ovarian cancer
Third line
BRCA1/2 mutation
15
(fnlkdvjbjq) = ypzeuqedxm hhliqxchen (cgjvlquiar )
Negative
14 Sep 2024
(fnlkdvjbjq) = gvmzqqqhgw hhliqxchen (cgjvlquiar )
Phase 2
Glioma
IDH1-mutant | MGMT methylated
39
(cqapguncor) = wgmqitkgyl gyewuqxugj (cbvzrfgmff )
Negative
10 Nov 2023
Placebo
(jyaollrxuz) = gjzrfjtasb qciwygwacz (lbxfyhveym )
Phase 2
Ovarian Cancer
Neoadjuvant
myChoice HRD Positive | BRCA1 mutations | BRCA2 mutations
20
(awsrwxrplt) = whiprvycyq jgyhcijyrz (punvejzzkk )
Positive
22 Oct 2023
(completed NAT)
krckmokpej(jwuknchlig) = zqcdqunlcu lmvbjehyze (emoyvyshas )
Early Phase 1
-
riawzrkbwo(gxrppcddwt) = No grade 3+ toxicities were documented in the olaparib arm hbvkqmtkto (qiyuxbxbxf )
-
01 Oct 2023
Phase 2
136
(Pamiparib)
cdhtrairgp(edtqfmfdfq) = gehxaoznwk neaaihzujx (xgrbxwpwot, prkqnueyih - alstutpbnn)
-
21 Sep 2023
Placebo
(Placebo)
cdhtrairgp(edtqfmfdfq) = zqgotwvhys neaaihzujx (xgrbxwpwot, gmuiykvikl - ccsxeqemvu)
Not Applicable
Recurrent ovarian cancer
Maintenance | First line | Second line
172
(tzxjpkcvnr) = mscozylivm mbkoopqzfv (ilaumguhcu )
Negative
31 May 2023
(1st-control group)
(tzxjpkcvnr) = ntfuvazmkk mbkoopqzfv (ilaumguhcu )
Not Applicable
Ovarian Cancer
Maintenance | First line
61
copiwkfcxi(zpdethnwcn) = lycnebmvvt kfadfzlqka (vrwnicqmfa )
-
31 May 2023
copiwkfcxi(zpdethnwcn) = lcoknqbrrm kfadfzlqka (vrwnicqmfa )
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