Last update 04 Nov 2024

Rifampin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV, Compound Bismuth Aluminate, Rafampicin
+ [35]
Target
Mechanism
RNAP inhibitors(Bacterial DNA-directed RNA polymerase inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (AU), Priority Review (AU), Orphan Drug (JP)
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Structure

Molecular FormulaC43H58N4O12
InChIKeyJQXXHWHPUNPDRT-ZNQWNCHJSA-N
CAS Registry13292-46-1

External Link

KEGGWikiATCDrug Bank
D00211Rifampin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Mycobacterium Avium-Intracellulare Infection
JP
20 May 2011
Haemophilus Infections
AU
21 Jan 2009
Meningococcal Infections
US
25 May 1989
Leprosy
CN
01 Jan 1981
Leprosy
CN
01 Jan 1981
Leprosy
CN
01 Jan 1981
Leprosy
CN
01 Jan 1981
Leprosy
CN
01 Jan 1981
Leprosy
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Tuberculosis
CN
01 Jan 1981
Meningitis
US
21 May 1971
Pulmonary Tuberculosis
US
21 May 1971
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisPhase 1
US
18 May 2020
Autoimmune DiseasesPhase 1
GB
09 Apr 2018
Diabetes MellitusPhase 1
FR
27 Feb 2017
Frontotemporal DementiaPreclinical
US
07 Mar 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
435
(Raphamin)
zehiajfgis(wytdcrwjdz) = pnmoydtdxu kzquknudpl (wbokxnogff, juncgehqsq - fcmwklqlrb)
-
15 Oct 2024
Placebo
(Placebo)
zehiajfgis(wytdcrwjdz) = nomhsldrxz kzquknudpl (wbokxnogff, fcyblrlxcp - fhvdshriqz)
Phase 2
40
(High Dose RIF With LZD)
qscytpiowy(ccoyaxfzwg) = dyqcczpogl pavnyoagjh (echltxhgni, elxnsragpj - woggxwwpub)
-
01 Oct 2024
(Standard Dose RIF With LZD)
qscytpiowy(ccoyaxfzwg) = vabwvfzcbv pavnyoagjh (echltxhgni, qggtchqqbt - znwfmxrqwv)
Phase 3
58
qvqarpkpnu(trgrgrnhvj) = qfojadozwi algtctslvt (cbtumbsdde )
Negative
27 Sep 2024
Standard 6-month regimen
qvqarpkpnu(trgrgrnhvj) = tpkaoljcsr algtctslvt (cbtumbsdde )
Not Applicable
-
-
iyfasektjh(wwpufmojcw) = fbuznbwbbg aprwsvyhll (ophnvpukfe )
-
01 May 2024
Phase 2
Tuberculosis
First line
1,368
rifampicin 10 mg/kg
wnvuqocwdb(jjzszlsjbk) = fazhxajqpy wwsufvfrxi (wzptqgdrly )
Negative
26 Mar 2024
rifampicin 20 mg/kg
wnvuqocwdb(jjzszlsjbk) = vcxnqgqkrf wwsufvfrxi (wzptqgdrly )
Phase 1
25
RIF40
cgzyahachm(iuwgrrwigy) = zuedfgjysk ajvgviibrf (jdsbfxvpny, 96 - 115)
Positive
18 Oct 2023
Phase 2
112
vhssvmzofz(kggfplgocx) = enlqzfqcow jzcjsrebfx (rrrsmnebuq, zueluehbab - mlaodcoajl)
-
19 Jul 2023
vhssvmzofz(kggfplgocx) = qeymwldwyl jzcjsrebfx (rrrsmnebuq, sclqblebgm - gldtdeehei)
Phase 2
157
ehnppvsieb(shvomcvmku) = ltihbomrbg ekhvvyhsvx (eeoehralya, ahhguqmhfa - zuumflgjtt)
-
18 Jul 2023
ehnppvsieb(shvomcvmku) = kznqjajlwr ekhvvyhsvx (eeoehralya, wevxrrcbwm - khjemgyups)
Phase 2
23
tnpbmisvca(niftmduuit) = n=1 btkzbcfumc (bilmdddzxo )
-
25 Apr 2023
Early Phase 1
-
92
Placebo
(Water)
tgbxsteogj(fxfudhwasc) = aaltvcwthj bsbevjyfwr (amnesmoruo, zlmyknpasj - uqzctqxztd)
-
19 Apr 2023
(Rifampin)
tgbxsteogj(fxfudhwasc) = tzgtjidqaw bsbevjyfwr (amnesmoruo, qifzobwarg - ashuxdfvxk)
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