Delving into the Latest Updates on Pyrazinamide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-carbamylpyrazine, 2-pyrazinecarboxamide, Aldinamide

+ [16]

Target

FASN

Action

inhibitors

Mechanism

FAS inhibitors(Fatty acid synthase inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Tuberculosis

Inactive Indication-

Originator Organization

Alfresa Pharma Corp.

Active Organization

AFT Pharmaceuticals Ltd.

Alfresa Pharma Corp.

Harbin Guokang Pharmaceutical Co Ltd

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (20 Sep 1956),

Tuberculosis

RegulationOrphan Drug (Australia)

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Structure/Sequence

Molecular FormulaC5H5N3O

InChIKeyIPEHBUMCGVEMRF-UHFFFAOYSA-N

CAS Registry98-96-4

While drug-susceptible tuberculosis (TB) disease in children currently requires four to six months of treatment, most children may be able to be cured with a shorter treatment of more powerful drugs. Shorter treatment may be easier for children to tolerate and finish as well as ease caregiver strain from managing treatment side effects and supporting children over many months. The primary objective of this study is to evaluate if a 2-month regimen (including isoniazid (H), rifapentine (P), pyrazinamide (Z) and moxifloxacin (M)) is as safe and effective as a 4- to 6-month regimen (isoniazid, rifampicin (R), pyrazinamide, ethambutol (E)) in curing drug-susceptible TB disease in children under 10 years old. The study is also evaluating the safety of the HPZM in children with and without HIV.

Start Date15 Jan 2025

Sponsor / Collaborator

The Johns Hopkins University

NCT05917340

/ Not yet recruitingPhase 3IIT

Comparative Evaluation of Intensified Short Course Regimen and Standard Regimen for Adults TB Meningitis : an Open-label Randomized Controlled Trial

Tuberculous meningitis (TBM) is the most lethal form of extra pulmonary tuberculosis. This devastating disease kills almost a third of its sufferers and disables a significant proportion of the survivors. TBM poses one of the most difficult diagnostic and therapeutic challenges in modern clinical practice. High-quality robust clinical trials have made a considerable contribution to the treatment of pulmonary tuberculosis in the last four decades. However, evidence from such clinical trials is lacking in TBM and the treatment remains uncertain. There is a significant variation in the choice, dose and duration of drugs between countries, institutions and clinicians. Investigators propose a multi-centric open-label clinical trial to assess the efficacy of short-course anti-TB drugs with high dose rifampicin, and moxifloxacin along with conventional anti-TB drugs and adjuvant therapy with aspirin and corticosteroids. Controls will receive standard treatment as per national guidelines for TBM. The investigators also aim to assess the safety and tolerability of high-dose Rifampicin and Moxifloxacin and the Pharmacodynamics and Pharmacokinetics parameters of ATT (Rifampicin, INH, Moxifloxacin and Pyrazinamide) in CSF between the two groups

Start Date01 Mar 2024

Sponsor / Collaborator

Indian Council of Medical Research

[+3]

NCT05630872

/ Active, not recruitingPhase 2IIT

Pharmacokinetics and Safety of Double-dose Dolutegravir When Used With Rifapentine for HIV-associated Tuberculosis

A5406 hypothesizes that dolutegravir (DTG) 50 mg taken twice daily will provide adequate exposures to maintain viral suppression when dosed with rifapentine (RPT) 1200 mg for HIV-associated TB.

Start Date13 Feb 2024

Sponsor / Collaborator

National Institute of Allergy & Infectious Diseases

[+1]

100 Clinical Results associated with Pyrazinamide

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100 Translational Medicine associated with Pyrazinamide

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100 Patents (Medical) associated with Pyrazinamide

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8,477

Literatures (Medical) associated with Pyrazinamide

31 Dec 2025·Emerging Microbes & Infections

The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China

Article

Author: Wu, Ling ; Yang, Yu ; Li, Hua ; Hu, Jinxing ; Wei, Zeyou ; Chen, Yuanjin ; Gao, Junwen ; Meng, Fanrong ; Xie, Bei ; Liu, Zhihui ; Lai, Xiaomin ; Deng, Li ; Niu, Qun ; Wang, Qi ; Wang, Nan ; Lei, Jie ; Huang, Bo ; Gong, Lan

This study investigates the epidemic trend of pyrazinamide (PZA)-resistant tuberculosis in Southern China over 11 years (2012-2022) and evaluates the mutation characteristics of PZA resistance-related genes (pncA, rpsA, and panD) in clinical Mycobacterium tuberculosis (M. tuberculosis) isolates. To fulfil these goals, we analyzed the phenotypic PZA resistance characteristics of 14,927 clinical isolates for which Bactec MGIT 960 PZA drug susceptibility testing (DST) results were available, revealing that 2,054 (13.76%) isolates were resistant to PZA. After evaluating the annual variation in the PZA resistance rate among tuberculosis cases in this region, it was observed that it decreased from 37.21% to 6.45% throughout the initial 7 years (2012-2018) and then increased from 8.01% to 12.12% over the subsequent 4 years (2019-2022). Sequences of pncA were obtained from 402 clinical M. tuberculosis complex isolates. For rpsA and panD, sequences were obtained from 360 clinical M. tuberculosis complex isolates. Mutations in pncA were found in 8 out of 223 PZA-sensitive isolates (3.59%) and 105 of 179 (58.66%) PZA-resistant isolates. Conversely, non-synonymous mutations in rpsA were identified in 5 of 137 (3.65%) PZA-resistant isolates, whereas the mutation ratio of rpsA among PZA-sensitive isolates was high at 14.03% (31/221). This difference in the rpsA mutation rate was statistically significant (P = 0.001, chi-square test). No panD mutations were observed in the 137 PZA-resistant isolates, whereas two PZA-sensitive isolates harboured point mutations in panD, including one nonsense mutation (C433 T) and another C-69 T mutation. These findings indicate that rpsA and panD may not significantly contribute to the development of PZA resistance in clinical M. tuberculosis isolates.

01 Jun 2025·Separation and Purification Technology

Unraveling the competitive cocrystallization behavior of natural products and impact of intermolecular interactions on their stability

Author: Xu, Li ; Gong, Zhuoshan ; Li, Detao ; Ouyang, Jinbo ; Zhou, Limin ; Heng, Jerry ; Zhao, Yan ; Shehzad, Hamza ; Ning, Zichen

Design of natural product cocrystals and its formation mechanism are of great significance importance to the development of fields such as medicine, food, cosmetics, and agriculture.In this research, alkaloids (theophylline, theobromine) and polyhydroxy natural products (quercetin, resveratrol, naringin) were selected as the research subjects.Through competitive cocrystal experiments, the study explored the stability differences among different cocrystals.Based on theor. calculations, the study determined the hydrogen bonds and π-π bonds within the crystals were identified.Combined with cocrystal structure anal., we discussed the influence of hydrogen bonding networks and π-π stacking modes on cocrystal stability.According to these results, the study correlated the cocrystal stability with void level, establishing the void formula to predict the stability between different cocrystals.Addnl., it summarized the structural unit cell model of natural product cocrystals, revealing formation mechanism of cocrystals, and intuitively demonstrating effect of intermol. interactions on stability of crystal.Finally, we proposed the stability law, establishing a close connection between intermol. interactions, void level, and cocrystal stability, providing a theor. basis for exploring relationship between cocrystal microstructure and stability.

14 Mar 2025·The Permanente Journal

Tuberculosis Osteomyelitis of the Wrist

Article

Author: Shah, Anand ; Cardona, Diana M ; Wu, Kevin A ; Lee, Kate E ; Seidelman, Jessica ; Kim, Grace ; Wahid, Lana

Wrist Mycobacterium tuberculosis (TB) complex osteomyelitis is rare, with polymicrobial TB osteomyelitis even more uncommon. The authors describe an unusual case of polymicrobial TB wrist osteomyelitis. The case patient presented with a 2.5-year history of 2 insidiously growing nodules on his wrist. He underwent debridement, and tissue cultures grew methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, and, later, TB complex. He was started on vancomycin, rifampin, isoniazid, pyrazinamide, and ethambutol with improvement in symptoms. This case emphasizes the importance of a broad differential and thorough workup for atypical presentations of osteomyelitis. Diagnosis of uncommon etiologies is essential for definitive treatment.

10

News (Medical) associated with Pyrazinamide

06 Feb 2025

·www.drugs.com

Three All-Oral Shortened Regimens Noninferior for Rifampin-Resistant TB

THURSDAY, Feb. 6, 2025 -- Three all-oral shortened regimens have noninferior efficacy compared with standard therapy for fluoroquinolone-susceptible, rifampin -resistant tuberculosis , according to a study published in the Jan. 30 issue of the New England Journal of Medicine . Lorenzo Guglielmetti, M.D., Ph.D., from Médecins Sans Frontières in Paris, and colleagues conducted a phase 3, multinational, noninferiority trial to compare standard therapy for treatment of fluoroquinolone-susceptible, rifampin-resistant tuberculosis to five nine-month oral regimens, including combinations of bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C), and pyrazinamide (Z). A total of 754 participants were randomly assigned to one of five combinations or standard therapy; 699 were included in the modified intention-to-treat analysis and 562 were included in the per-protocol analysis. The primary end point was a favorable outcome at week 73, defined by two negative sputum culture results or favorable bacteriologic, clinical, and radiologic evolution. The noninferiority margin was −12 percentage points. The researchers found that 80.7 percent of the patients in the standard-therapy group had favorable outcomes in the modified intention-to-treat analysis. In the modified intention-to-treat population, the risk difference between standard therapy and each of the four new regimens was noninferior: 9.8, 8.3, 4.6, and 2.5 percentage points for BCLLfxZ, BLMZ, BDLLfxZ, and DCMZ, respectively. In the per-protocol population, the differences were similar, apart from DCMZ, which was not noninferior. Across the regimens, the proportion of participants with grade 3 or higher adverse events was similar. "The results of this trial support the noninferior efficacy of three all-oral shortened regimens for the treatment of rifampin-resistant tuberculosis," the authors write. Two authors disclosed ties to the biopharmaceutical industry. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

Phase 3Clinical Result

28 Jan 2025

·www.drugs.com

Kansas Reports Largest Tuberculosis Outbreak in U.S. History

TUESDAY, Jan. 28, 2025 -- Kansas health officials are fighting the largest tuberculosis (TB) outbreak in U.S. history, with 67 confirmed cases since new year began. The outbreak includes 60 active cases in Wyandotte County and seven in Johnson County, according to the Kansas Department of Health and Environment (KDHE). That's the most since the 1950s, when the U.S. Centers for Disease Control and Prevention (CDC) began monitoring and reporting TB cases. Health officials are testing and treating affected individuals. "While there is a very low risk of infection to the general public in these communities, KDHE is working to ensure that patients are receiving appropriate treatment, which will limit the ability to spread this disease and prevent additional cases from occurring," KDHE spokeswoman Jill Bronaugh told the University of Minnesota's CIDRAP News in an email. "This outbreak is still ongoing, which means that there could be more cases." TB is caused by a bacterium called Mycobacterium tuberculosis, according to the CDC. It spreads through the air when someone with active TB disease coughs or speaks. People who spend time in close contact with someone who has active TB are at greatest risk of infection. TB typically affects the lungs but can also harm the brain, kidneys or spine. Here are the two forms : Kansas health officials are regularly screening anyone who tests positive to determine whether they have latent TB infection or active TB. Treatment for latent TB typically involves one or more medications, such as isoniazid or rifampin , for up to nine months. Active TB typically requires a longer treatment course with combinations of drugs, including ethambutol , rifampin and pyrazinamide . Although a TB vaccine exists (Bacille Calmette-Guérin), it is not commonly used in the U.S., the CDC said. Certain groups face a higher risk of TB , including people who: Local health departments in Kansas are conducting free testing for individuals, regardless of insurance coverage. SOURCES: Kansas Department of Health and Environment (KDHE), news release, Jan. 24, 2025; University of Minnesota CIDRAP News, news release, Jan. 27, 2025, USA Today , media report, Jan. 27, 2025 If you live in Kansas, especially in Wyandotte or Johnson County, consider getting tested for TB if you are at risk or have symptoms. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

VaccineClinical Study

01 Nov 2024

·www.tballiance.org

Introducing BPaL: Experiences from countries supported under the LIFT-TB project

11/2024 - PLoS One Author(s): D. F. Wares ,M. Mbenga ,V. Mirtskhulava ,M. Quelapio ,A. Slyzkyi ,I. Koppelaar ,S. N. Cho ,U. Go ,J. S. Lee ,J.-K. Jung ,D. Everitt ,S. Foraida ,M. Diachenko ,S. Juneja ,E. Burhan ,A. Totkogonova ,Z. Myint ,I. Flores ,N. A. Lytvynenko ,N. Parpieva ,N. V. Tags: BPaL, MDR-TB, Regimen Change 10/2024 Author(s): Denise Evans, Kamban Hirasen, Clive Ramushu, Lawrence Long, Edina Sinanovic, Francesca Conradie, Pauline Howell, Xavier Padanilam, Hannetjie Ferreira, Ebrahim Variaiva, Shakira Rajaram, Aastha Gupta, Sandeep Juneja, Norbert Ndjeka Tags: Bedaquiline (TMC-207), BPaL, Linezolid, Pretomanid/PA-824, TB Drug Market, TB Market 8/2024 - IJTLD Open Author(s): C. Auer, A. Gupta, C. Malbacius, A. Ghafoor, Y. Kock, O. Medvedieva, P. Hanlon, P. Steinmann, and S. Juneja Tags: BPaL, MDR-TB, TB Drug Market, TB Market 7/2024 - Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Author(s): B. Myrzaliev, M. Ahmatov, A. Duishekeeva, A. Kulzhabaeva, A. Kadyrov, A. Toktogonova, G. Abdulaeva, D.F. Wares , V. Mirtskhulava, M. Mbenga, A. Slyzkyi, S. Foraida, M. Diachenko, S. Juneja, G. Turdumambetova, A. Musaeva, A. Gebha Tags: Bedaquiline (TMC-207), BPaL, Linezolid, MDR-TB, Regimen Change, XDR-TB 6/2024 - The International Journal of Tuberculosis and Lung Disease Author(s): D. Evans, K. Hirasen, D.J. Casalme, M.T. Gler, A. Gupta, S. Juneja Tags: Bedaquiline (TMC-207), BPaL, Linezolid, Pretomanid/PA-824, Regimen Change, TB Drug Market 5/2024 - Lancet Infectious Diseases Author(s): Muge Cevik, MD Lindsay C Thompson, MPhil Caryn Upton, MD Valéria Cavalcanti Rolla Mookho Malahleha, MD Blandina Mmbaga, PhD Nosipho Ngubane, MD Zamzurina Abu Bakar, MD Mohammed Rassool, MD Ebrahim Variava, MD Rodney Dawson, MD Suzanne Staples, DPhil Umes Tags: Clinical Development, Clinical Trial Results, Global Pipeline, MDR-TB, Moxifloxacin, Pretomanid/PA-824, Pyrazinamide 5/2024 - Annals of Clinical Micobiology and Antimicrobials Author(s): Bing Zhao, Huiwen Zheng, Juliano Timm, Zexuan Song, Shaojun Pei, Ruida Xing, Yajie Guo, Ling Ma, Feina Li, Qing Li, Yan Li, Lin Huang, Chong Teng, Ni Wang, Aastha Gupta, Sandeep Juneja, Fei Huang, Yanlin Zhao, Xichao Ou Tags: Drug-Sensitivity Testing, M.tb. Biology, MDR-TB, Pretomanid/PA-824, XDR-TB 1/2024 - PLOS One Author(s): A Gupta, S Juneja, V Babawale, N R Majidovich, N Ndjeka, P T M Nguyen, P Nargiza Nusratovna, D R Omanito, T T Pakasi, Y Terleeva, A Toktogonova, Y Waheed, Z Myint, Z Yanlin, S Sahu Tags: Advocacy, Bedaquiline (TMC-207), BPaL, Linezolid, Moxifloxacin, Policy, Pretomanid/PA-824, TB Burden, TB Drug Market, TB Market 11/2023 - International Journal of Tuberculosis and Lung Disease Author(s): Taneja, R., Nahata, M. C., Scarim, J., Pande, P. G., Scarim, A., Hoddinott, G., Fourie, C. L., Jew, R. K., Schaaf, H. S., Hesseling, A. C., Garcia-Prats, A. J., Inabathina, K. Rao Tags: BENEFIT Kids, Underserved Populations 10/2023 - Clinical and Translational Science Author(s): Paloma Moraga, Paula Prieto, Almari Conradie, Majda Benhayoun, Vicki Rousell, Maria Davy, Uwe Fuhr, Rosa Antonijoan Arbos, Francisco Abad‐Santos, Antonio Portolés, Jolanda Van Duinen, Antonio J. Carcas, Alberto M. Borobia, and the ERA4TB Consortium Tags: Pharmacodynamics, Pharmacokinetics 10/2023 - Clinical Infectious Diseases Author(s): Tasnim Hasan, Ellie Medcalf, Bern-Thomas Nyang'wa, Erica Egizi, Catherine Berry, Matthew Dodd, Salah Foraida, Medea Gegia, Mengchun Li, Fuad Mirzayev, Hannah Morgan, Ilaria Motta, Linh Nguyen, Samuel Schumacher, Tim Schlub, Greg Fox Tags: Bedaquiline (TMC-207), BPaL, Linezolid, MDR-TB, Pretomanid/PA-824 10/2023 - PLOS Global Public Health Author(s): Juliano Timm, Anna Bateson, Priya Solanki, Ana Paleckyte, Adam A Witney, Sylvia A D Rofael, Stella Fabiane, Morounfolu Olugbosi, Timothy D McHugh, Eugene Sun Tags: Bedaquiline (TMC-207), BPaL, Linezolid, Pretomanid/PA-824 9/2023 - International Journal of Tuberculosis and Lung Disease Author(s): Viljoen, L., Acaba, J., Agbassi, Y. J. P., Beko, B., Goslett, C., Hoddinott, G., Kumar, B., Kumar, R. G., McKenna, L., Moses, G., Sachs, T., Seidel, S., von Delft, A. Tags: Advocacy, BENEFIT Kids, Underserved Populations 6/2023 - Indian Journal of Tuberculosis Author(s): Nibedita Rath, Chaitali Nikam, Stephanie Seidel, Anindya Sinha, Vijay Arora Tags: Advocacy, Community Engagement, TB Burden, Underserved Populations 5/2023 - Molecular Pharmaceutics Author(s): Hanh Thuy Nguyen, Tu Van Duong, Sarah Jaw-Tsai, Rebecca Bruning-Barry, Poonam Pande, Rajneesh Taneja, and Lynne S. Taylor Tags: Pretomanid/PA-824, TB Drug Market, Underserved Populations 3/2023 - International Journal of Tuberculosis and Lung Disease Author(s): R Taneja, M C Nahata, J Scarim, P G Pande, A Scarim, G Hoddinott, C L Fourie, R K Jew, H S Schaaf, A J Garcia-Prats, A C Hesseling Tags: Bedaquiline (TMC-207), BENEFIT Kids, Childhood TB, TB Burden, TB Market, Underserved Populations 3/2023 - Antimicrobial Agents and Chemotherapy Author(s): Si-Yang Li, Paul J. Converse, Fabrice Betoudji, Jin Lee, Khisimuzi Mdluli, Anna Upton, Nader Fotouhi, Eric L. Nuermberger Tags: Bedaquiline (TMC-207), BPaL, Clinical Development, Drug Discovery, Linezolid, Preclinical Data, Preclinical Models, Pretomanid/PA-824 3/2023 - International Journal of Infectious Diseases Author(s): Francesca Saluzzo, Juan Espinosa-Pereiro, Stephan Dressler, Ezio Tàvora Dos Santos Filho, Stephanie Seidel, Jesus Gonzalez Moreno, Norbert Heinrich, Adrian Sanchez-Montalva, Daniela Maria Cirillo Tags: Advocacy, Clinical Development, Community Engagement, Trial Design, Underserved Populations 2/2023 - International Journal of Tuberculosis and Lung Disease Author(s): Taneja, R., Nahata, M. C., Scarim, J., Pande, P. G., Scarim, A., Hoddinott, G., Fourie, C. L., Jew, R. K., Schaaf, H. S., Hesseling, A. C., Garcia-Prats, A. J. Tags: BENEFIT Kids, Childhood TB, Clofazamine, Underserved Populations 1/2023 - Journal of Biopharmaceutical Statistics Author(s): James Buchanana, Mengchun Lib, Barbara Hendricksonc, Parul Bhargavad, Satrajit Roychoudhury Tags: Trial Design

100 Deals associated with Pyrazinamide

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External Link

KEGG	Wiki	ATC	Drug Bank
D00144	Pyrazinamide	J04AK01	DB00339

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Tuberculosis	United States	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02619994 (MDR-END, CTgov)	Phase 2	Tuberculosis, Multidrug-Resistant	214	Locally-used WHO-approved MDR-TB regimen in Korea (Control Arm)	ojdpjkwkqx(wzcucwmicv) = blaktzimis tqlxnvnndu (brnvalftue, pnrlktfrrq - bomjqdqhxh) View more	-	03 Jan 2025
				Levofloxacin+Linezolid+Delamanid+Pyrazinamide (Experimental Arm)	ojdpjkwkqx(wzcucwmicv) = rhnamgznqv tqlxnvnndu (brnvalftue, obliqnlsgs - dmvyygkroo) View more
NCT04485156 (Pubmed \| Tuberc Respir Dis (Seoul)) Manual	Phase 3	Pulmonary Tuberculosis	58	rifampicinrisoniazid,pyrazinamideand pyrazinamide	(uimjelthju) = fykhxmumwg klxmchwfvs (suzxpjnwbp )	Negative	27 Sep 2024
				Standard 6-month regimen	(uimjelthju) = retxhelday klxmchwfvs (suzxpjnwbp )
NCT04179500 (PaSEM, CTgov)	Phase 2	Multidrug resistant pulmonary tuberculosis \| Tuberculosis, Multidrug-Resistant	26	BPaMZ (BPaMZ)	gdjhjcffnr(tfngflcqoj) = arkbvkmdwd sibcnwcodj (pfertgbfot, dgtkugrgnj - zqnqmtvoeo) View more	-	19 Sep 2024
				moxifloxacin+bedaquiline+pyrazinamide (BPaMZ Baseline)	lykflpnwbg(uhullhllig) = qdoxnpdcpq apumdbtbaj (wmlykurnqr, tzsiywwtcu - xfaenwztsp) View more
NCT03338621 (SimpliciTB, CTgov)	Phase 2/3	Multidrug resistant pulmonary tuberculosis \| Tuberculosis, Multidrug-Resistant	455	ethambutol+rifampicin+isoniazid+pyrazinamide (Drug Sensitive-TB 2HRZE/4HR)	cwvkwavjop(ydwjepqdem) = fosgdazqrt pzwhvlqavk (qpqkbqnnph, eumontdbun - mxwqjgmqai) View more	-	08 Nov 2023
				4BPaMZ (Drug Sensitive-TB 4BPaMZ)	cwvkwavjop(ydwjepqdem) = kjjfmcqtmn pzwhvlqavk (qpqkbqnnph, mtwprovxrc - rsvaiogsmd) View more
NCT03882177 (StAT-TB, CTgov)	Phase 2	Pulmonary Tuberculosis	16	Pravastatin+Vitamin B6+Rifafour (Arm 1: Pravastatin (40 mg) and Rifafour)	(adhuxuepmw) = jfofsozauf jwhroxmakq (lglysxuujr, eimfzeddri - etbywcqemp) View more	-	18 Sep 2023
				Vitamin B6+Pravastatin+Rifafour (Arm 2: Pravastatin (80 mg) and Rifafour)	(adhuxuepmw) = zwuamenqgj jwhroxmakq (lglysxuujr, hlkgxqtcal - xucsutrylc) View more
NCT02256696 (CTgov)	Phase 2	Pulmonary Tuberculosis	157	PA-824+Rifampin+Isoniazid+Pyrazinamide (Arm 1)	ecegegcogb(cjvqakdiem) = acjjmjgjrd cgnkugugvu (wxwdkylidv, mnjvcqfxqd - nvmdmgpals) View more	-	18 Jul 2023
				PA-824+Rifabutin+Isoniazid+Pyrazinamide (Arm 2)	ecegegcogb(cjvqakdiem) = nhkzmfanns cgnkugugvu (wxwdkylidv, rpfpqzbvji - akaytnacgg) View more
NCT02554318 (FSS, CTgov)	Not Applicable	PULMONARY TUBERCULOSIS ACTIVE	147	Fermented soybean+Ethambutol+Rifampicin+Isoniazid+Pyrazinamide (Intervention)	zmfjypqjxf(splxdriqzb) = jpuxwwgrko sofsgixxpj (knaoaniodx, hbqxsgrodx - wkhaqdrxgs) View more	-	21 Jun 2022
				Ethambutol+Rifampicin+Isoniazid+Pyrazinamide (Control)	zmfjypqjxf(splxdriqzb) = gtjsxgopri sofsgixxpj (knaoaniodx, mimnebdzna - gxbamtjpiu) View more
NCT02193776 (NC-005, CTgov)	Phase 2	Pulmonary Tuberculosis	240	PA-824+Bedaquiline+Pyrazinamide (DS-TB: Bedaquiline (Loading Dose/t.i.w)+ PA-824 + Pyrazinamide)	acswdzvgun(paykbydupc) = pevmwxftac kgxkcyujpl (awulkphebf, gyoyvdvqoi - qlmbjswpmy) View more	-	26 Jul 2019
				PA-824+Bedaquiline+Pyrazinamide (DS-TB: Bedaquiline (200 mg) + PA-824 + Pyrazinamide)	acswdzvgun(paykbydupc) = pyarzzgwbq kgxkcyujpl (awulkphebf, qittolujcu - gxikmoavmh) View more
NCT02342886 (STAND, CTgov)	Phase 3	Multidrug resistant pulmonary tuberculosis	284	PA-824+Moxifloxacin+Pyrazinamide (DS-TB: 4 Months Moxifloxacin + PA-824 (100 mg) + Pyrazinamide)	cghqakxcmz(wzagoompon) = bquzltrrat ebkbnyysgd (yazqaopjok, fftbfxaowd - oqwbmlehom) View more	-	26 Mar 2019
				PA-824+Moxifloxacin+Pyrazinamide (DS-TB: 4 Months Moxifloxacin + PA-824 (200 mg) + Pyrazinamide)	cghqakxcmz(wzagoompon) = qrsatggqlg ebkbnyysgd (yazqaopjok, ijvsqtlexk - flwmtaibul) View more
NCT01601626 (CTgov)	Phase 2	Tuberculosis \| HIV Infections	71	Standard-dose Lopinavir/Ritonavir+Ethambutol+Rifabutin+Pyridoxine+isoniazid+Pyrazinamide (A: Standard-dose LPV/r w/RBT)	zxjlyhtbof(zuevcnryux) = sxcorpvxqz vykwrgcaoy (yrgfuoluql, vkqffohzyx - gievqgggpx) View more	-	13 Feb 2018
				Ethambutol+Rifampin+Pyridoxine+isoniazid+Double-dose Lopinavir/Ritonavir+Pyrazinamide (B: Double-dose LPV/r w/RIF)	zxjlyhtbof(zuevcnryux) = hhoeeewllg vykwrgcaoy (yrgfuoluql, ktesvecnwe - qhncggvlem) View more