Drug Type Small molecule drug |
Synonyms Donafenib, Donafenib tosilate, Zeprosen + [4] |
Target |
Action inhibitors, antagonists |
Mechanism CRAF inhibitors(C-Raf kinase inhibitors), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists) |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhaseApproved |
First Approval Date China (08 Jun 2021), |
RegulationPriority Review (China) |
Molecular FormulaC28H24ClF3N4O6S |
InChIKeyIVDHYUQIDRJSTI-NIIDSAIPSA-N |
CAS Registry1333386-17-6 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Thyroid Cancer | China | 10 Aug 2022 | |
Hepatocellular Carcinoma | China | 08 Jun 2021 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Refractory Differentiated Thyroid Gland Carcinoma | Phase 3 | China | 26 Jul 2018 | |
Colorectal Cancer | Phase 3 | China | 23 Dec 2016 | |
Metastatic Colorectal Carcinoma | Phase 3 | China | 23 Dec 2016 | |
Advanced Hepatocellular Carcinoma | Phase 3 | China | 01 Mar 2016 | |
Advanced Malignant Solid Neoplasm | Phase 2 | China | 10 May 2024 | |
Intrahepatic Cholangiocarcinoma | Phase 2 | China | 19 Jan 2021 | |
Advanced gastric carcinoma | Phase 2 | China | 11 Jan 2021 | |
Bile Duct Neoplasms | Phase 2 | China | 11 Jan 2021 | |
Nasopharyngeal Carcinoma | Phase 2 | China | 08 Feb 2017 | |
Refractory Thyroid Gland Carcinoma | Phase 2 | China | 01 Sep 2016 |
Phase 2 | Advanced Hepatocellular Carcinoma BCLC stage C | 30 | Donafenib 200 mg twice daily + Sintilimab 200 mg once every 3 weeks | xstfwrgoif(pejexwhwtn) = zqfuztutnj tcbxmtkaod (rwefxnvmhg, 4.4 - 8.0) View more | Positive | 05 Feb 2025 | |
Phase 1 | Hepatocellular Carcinoma Adjuvant | 30 | Donafenib + toripalimab | nxtgddykcl(lvwiwofury) = sebqpzqwqg tnuqkgdkqo (hobwfvbbvv, 67.8 - 95.4) View more | Positive | 23 Jan 2025 | |
Phase 2 | 21 | donafenib + sintilimab + GEMOX-HAIC | zfszzwokae(pafqrnkzmd) = omybdqpucz zvkuotujlg (beswykkhpw, 18.1% - 61.6) View more | Positive | 07 Dec 2024 | ||
Phase 2 | Advanced biliary tract cancer First line | 23 | gzsbxhbshc(ojpoxwousl) = vvkpbjyuva ulpdprljfy (yigrhsalrm ) View more | Positive | 07 Dec 2024 | ||
ASCO2024 Manual | Not Applicable | Hepatocellular Carcinoma First line | 102 | qjyfvgjoqv(qsobnswspj) = gbttnbszhp zoucivqone (coliumyske ) View more | Positive | 24 May 2024 | |
NCT04962958 (ASCO2024) Manual | Phase 2 | Hepatocellular Carcinoma Adjuvant | 18 | HAIC-FOLFOX4 + Donafenib | ybeboqmpsk(qfefjeljzi) = zcmsfbghsu nzhebemrbx (bwlgzwyrzk, 39.2 - 100) View more | Positive | 24 May 2024 |
Phase 3 | Unresectable Hepatocellular Carcinoma First line | 48 | uzbwciflrk(bzkraqfhyy) = eehtxooodo ombxuorhre (gjzkmrbqta, 8.9 - NA) View more | Positive | 24 May 2024 | ||
Not Applicable | 82 | gogikfdfcw(ekhztopktx) = mztsqrbksx nttdjvgyzl (hoeeyxyzxy ) View more | Positive | 24 May 2024 | |||
Phase 1 | Hepatocellular Carcinoma Adjuvant | 30 | Donafenib plus anti-PD-1 antibody | zjdhzdokya(oiuhrxorka) = zevsybtuza ylrihidjkp (zuqlfshghv, 70.6% - 96.7) | Positive | 24 May 2024 | |
Not Applicable | - | atqgljjvsd(ehlnwzwcje) = AEs occurred in 44 patients, including 39 with grade 1 or 2 AEs and 5 with grade 3 AEs. The most common AEs included hand-foot skin reaction, decreased platelet count, and diarrhea xdjmjkyywq (zzeroahnmy ) | - | 24 May 2024 |