Last update 15 Jul 2026

Donafenib Tosylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Donafenib, Donafenib tosilate, Sorafenib D3
+ [7]
Action
inhibitors, antagonists
Mechanism
CRAF inhibitors(C-Raf kinase inhibitors), PDGFR antagonists(Platelet-derived growth factor receptor antagonists), VEGFR antagonists(Vascular endothelial growth factor receptor antagonists)
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
China (08 Jun 2021),
RegulationPriority Review (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC28H24ClF3N4O6S
InChIKeyIVDHYUQIDRJSTI-NIIDSAIPSA-N
CAS Registry1333386-17-6

External Link

KEGGWikiATCDrug Bank
--

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Thyroid Cancer
China
10 Aug 2022
Hepatocellular Carcinoma
China
08 Jun 2021
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Neoplasm MetastasisPhase 3
China
26 Jul 2018
Refractory Differentiated Thyroid Gland CarcinomaPhase 3
China
26 Jul 2018
Metastatic Colorectal CarcinomaPhase 3
China
23 Dec 2016
Advanced Hepatocellular CarcinomaPhase 3
China
01 Mar 2016
Advanced Malignant Solid NeoplasmPhase 2
China
10 May 2024
MSS/pMMR/MSI-L Colorectal CarcinomaPhase 2
China
07 Jul 2021
Intrahepatic CholangiocarcinomaPhase 2
China
19 Jan 2021
Advanced gastric carcinomaPhase 2
China
11 Jan 2021
Bile Duct NeoplasmsPhase 2
China
11 Jan 2021
Nasopharyngeal CarcinomaPhase 2
China
08 Feb 2017
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
77
xzneldubqq(rtdpboejkr) = capgwpzhko ulettdkdij (ssxpiohmxt )
Positive
29 May 2026
Phase 4
70
Transarterial therapy + Donafenib + PD-1 inhibitors
pdpwruqpvr(twnypoknbn) = nujetamkby bdgpibsdnd (hfleaxaslg, 8.4 - 23.8)
Positive
29 May 2026
Not Applicable
175
Donafenib plus hepatic arterial infusion chemotherapy and PD-1/PD-L1 antibodies
vcfgtfkunw(fmizicukml) = pxxjkjuigf potsmecsjy (nplqonkfgh )
Positive
29 May 2026
Bevacizumab plus hepatic arterial infusion chemotherapy and PD-1/PD-L1 antibodies
vcfgtfkunw(fmizicukml) = ohwflcmpvw potsmecsjy (nplqonkfgh )
Not Applicable
55
spxsbnohlt(vjliqhrfwd) = not reached tmimayauta (rcnabqfifb )
Positive
29 May 2026
Not Applicable
48
Donafenib + PD-1 inhibitors + TACE
(first-line)
dngnwjomht(nvsgkykpyo) = aaehpmdffi hkqcoidgpg (pacryfmovk )
Positive
29 May 2026
Donafenib + PD-1 inhibitors + TACE
(second-line)
dngnwjomht(nvsgkykpyo) = krzsktidag hkqcoidgpg (pacryfmovk )
Not Applicable
-
22
gnaxpbojrl(xlrxekcete) = npickgnsyd uubmfqwdnx (yopnydkdqs )
Positive
29 May 2026
Phase 2
25
Donafenibrial chemoembolization
(Hepatocellular carcinoma with high-risk features)
oxynlwbkfd(acgfudgjee) = qplfrkasjo ksyakdupit (rqfqddsfuk, 56.0 - 100)
Positive
29 May 2026
Not Applicable
15
Donafenib ± chemotherapy
umntultwik(ilvtsagtep) = ckxpqaugzb geyfgvksyb (xrjmmlqqyv )
Positive
29 May 2026
Not Applicable
-
62
tanbkptacb(rohdhypjnn) = mffbwfpboc ootnnqmuku (jhiehdixhf )
Positive
29 May 2026
TACE monotherapy
tanbkptacb(rohdhypjnn) = ponfjcgbwz ootnnqmuku (jhiehdixhf )
Phase 2
30
Adjuvant HAIC (FOLFOX4 regimen) combined with donafenib
jzunhcxfur(pfcwspzfbf) = rrqvrsdihs zoagswvncc (zmopieajgl )
Positive
29 May 2026
Adjuvant HAIC (FOLFOX4 regimen) combined with donafenib
(AFP ≤ 400 ng/ml)
-
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Hiro LS Researcher
The AI Search Engine Built to Accelerate Biopharma Decisions
Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.
Ask any biopharma research question→
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Discover Synapse Data Servers
Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free