Suzhou Zelgen Biopharmaceuticals Co., Ltd.

The prevalence of idiopathic pulmonary fibrosis has been rising over the past few years, which prompts the growing demand for treatment options. The increasing prevalence of idiopathic pulmonary fibrosis and the growing research and development activities to develop novel therapies to treat idiopathic pulmonary fibrosis to drive the market. The companies developing the potential therapies in the last stage of development include FibroGen, Boehringer Ingelheim, and several others. LAS VEGAS, May 25, 2023 /PRNewswire/ -- DelveInsight's ' Idiopathic Pulmonary Fibrosis Pipeline Insight – 2023 ' report provides comprehensive global coverage of pipeline idiopathic pulmonary fibrosis therapies in various stages of clinical development, major pharmaceutical companies working to advance the pipeline space, and future growth potential of the idiopathic pulmonary fibrosis pipeline domain. Key Takeaways from the Idiopathic Pulmonary Fibrosis Pipeline Report DelveInsight's idiopathic pulmonary fibrosis pipeline report depicts a robust space with 80+ active players working to develop 100+ pipeline therapies for idiopathic pulmonary fibrosis treatment. Key idiopathic pulmonary fibrosis companies such as FibroGen, United Therapeutics, Bellerophon Therapeutics, MediciNova, Novartis, Endeavor BioMedicines, Pliant Therapeutics, Nitto Denko, Kadmon Pharmaceuticals, Calliditas Therapeutics, Avalyn Pharmaceuticals, PureTech Health, Taiho Pharmaceutical, Bristol-Myers Squibb, Galecto Biotech AB, CSL Behring, Celgene Pharmaceutical, Vicore Pharma, Boehringer Ingelheim, Guangdong Raynovent, Sunshine Lake Pharma co, Suzhou Zelgen Biopharmaceuticals, Algernon Pharmaceuticals, Horizon Therapeutics, Daewoong Pharmaceutical, Metagone Biotech, AstraZeneca, Lung Therapeutics, Bridge Biotherapeutics, AstraZeneca, Kinarus AG, Insmed, Reviva Pharmaceuticals, Annapurna Bio, Guangdong Hengrui Pharmaceutical Co., Ltd, Ark Biosciences, Ocean Biomedical, and others are evaluating new idiopathic pulmonary fibrosis drugs to improve the treatment landscape. Promising idiopathic pulmonary fibrosis pipeline therapies in various stages of development include Pamrevlumab, Treprostinil, Nitric oxide inhalation - INOpulse, MN-001 (tipelukast), VAY736, ENV-101, PLN-74809, ND-L02-s0201, KD025, GKT137831, AP 01, LYT-100, TAS-115, BMS-986278, GB0139, CSL312, CC-90001, C21, BI1015550, ZSP1603, HEC585, Jaktinib Dihydrochloride Monohydrate, Ifenprodil, HZN-825, DWN12088, MG-S-2525, Saracatinib, LTI-03, BBT-877, AZD5055, KIN001-IPF, Treprostinil palmitil inhalation powder (TPIP), Brilaroxazine, ANPA 0073, SHR 1906, AK 3280, OCF 203, and others. In May 2023, Kinarus Therapeutics announced the signing of a strategic convertible loan agreement for a CHF 1.5 million investment by ChaoDian (Hangzhou) Investment Management Co., Ltd., an investment company based in Hangzhou City, China ("CDIM"). Further, this agreement forms the basis for discussions on the introduction, development and commercialization of KIN001 for the treatment of Idiopathic Pulmonary Fibrosis (IPF) in China. Great Health Companion Group Ltd (GHCG), a subsidiary of Hakim Unique Group, introduced CDIM to Kinarus. In April 2023, AGC Biologics announced it signed a service agreement with The Jikei University in Japan. Under the agreement, AGC Biologics will assume a technology transfer and feasibility study for a drug product focused on the treatment of Idiopathic pulmonary fibrosis at the CDMO's center of Cell and Gene Excellence in Milan. In February 2023, Insilico Medicine announced that the US Food and Drug Administration (FDA) had granted Orphan Drug Designation to INS018_055 for the treatment of Idiopathic Pulmonary Fibrosis (IPF). In February 2023, Arrowhead Pharmaceuticals Inc. announced that it had dosed the first subjects in a Phase I/IIa clinical trial of ARO-MMP7, the company's investigational RNA interference (RNAi) therapeutic designed to reduce the expression of matrix metalloproteinase 7 (MMP7) as a potential treatment for idiopathic pulmonary fibrosis (IPF). In February 2023, South Korea's Daewoong Pharmaceutical secured an exclusive licensing agreement with CS Pharmaceuticals for a first-in-class PRS inhibitor Bersiporocin in the Greater China region, including mainland China, Hong Kong, Taiwan, and Macau. Under this agreement, CSP will in-license Bersiporocin for Idiopathic Pulmonary Fibrosis (IPF) and potentially other fibrotic indications for a total consideration of up to $336 million, including up to $76 million in upfront and development milestone payments and double-digit royalties on Net Sales. In January 2023, Insilico Medicine announced the positive topline results of safety, tolerability, and pharmacokinetics (PK) from the Phase 1 clinical trial of INS018_055, a potential first-in-class drug discovered by Insilico's end-to-end AI platform for idiopathic pulmonary fibrosis (IPF). In January 2023, Pliant Therapeutics announced 12-week interim data from the 320 mg dose group of INTEGRIS-IPF, a multinational, randomized, double-blind, placebo-controlled Phase 2a clinical trial of bexotegrast (PLN-74809) in patients with idiopathic pulmonary fibrosis (IPF). In December 2022, Vallon Pharmaceuticals announced that they entered into a definitive agreement (the "Merger Agreement") pursuant to which GRI Bio will merge with a wholly-owned subsidiary of Vallon in an all-stock transaction (the "Merger"). The combined company will focus on advancing GRI Bio's innovative pipeline of NKT cell regulators for the treatment of inflammatory, fibrotic and autoimmune diseases. Following the closing of the Merger, the combined company is expected to operate under the name "GRI Bio, Inc." Request a sample and discover the recent advances in idiopathic pulmonary fibrosis drug treatment @ Idiopathic Pulmonary Fibrosis Pipeline Report The idiopathic pulmonary fibrosis pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage idiopathic pulmonary fibrosis drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the idiopathic pulmonary fibrosis clinical trial landscape. Idiopathic Pulmonary Fibrosis Overview Idiopathic pulmonary fibrosis (IPF) is a rare, chronic, progressive fibrosing interstitial pneumonia that primarily affects middle-aged and older adults. It affects lung tissue by thickening, stiffening, or persistent and progressive scarring that worsens irreversibly over time. Scarring affects the air sacs of IPF patients, decreasing the amount of oxygen that enters the circulation. With less oxygen in the blood, ordinary tasks such as walking can cause dyspnea. This set of lung illnesses is also known as 'Diffuse Parenchymal Lung Diseases,' and it is distinguished by a broader umbrella of 'Interstitial Lung Diseases (IDLs)'. The cause of IPF is uncertain; experts believe the condition is caused by a mix of hereditary and environmental factors. There is a significant chance that genetic variations enhance a person's risk of acquiring IPF and then being exposed to environmental variables that aggravate the condition. However, much remains unknown about this new field of study. Find out more about drugs for idiopathic pulmonary fibrosis @ New Idiopathic Pulmonary Fibrosis Drugs A snapshot of the Idiopathic Pulmonary Fibrosis Pipeline Drugs mentioned in the report: Learn more about the emerging idiopathic pulmonary fibrosis pipeline therapies @ Idiopathic Pulmonary Fibrosis Clinical Trials Idiopathic Pulmonary Fibrosis Therapeutics Assessment The idiopathic pulmonary fibrosis pipeline report proffers an integral view of idiopathic pulmonary fibrosis emerging novel therapies segmented by stage, product type, molecule type, mechanism of action, and route of administration. Scope of the Idiopathic Pulmonary Fibrosis Pipeline Report Coverage: Global Idiopathic Pulmonary Fibrosis Therapeutic Assessment By Product Type: Mono, Combination, Mono/Combination Idiopathic Pulmonary Fibrosis Therapeutic Assessment By Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III Idiopathic Pulmonary Fibrosis Therapeutics Assessment By Route of Administration: Oral, Parenteral, Intravitreal, Subretinal, Topical Idiopathic Pulmonary Fibrosis Therapeutics Assessment By Molecule Type: Monoclonal Antibody, Peptides, Polymer, Small molecule, Gene therapy Idiopathic Pulmonary Fibrosis Therapeutics Assessment By Mechanism of Action: Connective tissue growth factor inhibitors, 5-lipoxygenase inhibitors, Leukotriene D4 receptor antagonists, Leukotriene receptor antagonists, Phospholipase C inhibitors, Thromboxane A2 receptor antagonists, Type 3 cyclic nucleotide phosphodiesterase inhibitors, Type 4 cyclic nucleotide phosphodiesterase inhibitors, Integrin alphavbeta1 inhibitors, Integrin alphaVbeta6 inhibitors, Antibody-dependent cell cytotoxicity, Interleukin 4 receptor antagonists, SMO protein inhibitors, Galectin 3 inhibitors Key Idiopathic Pulmonary Fibrosis Companies: FibroGen, United Therapeutics, Bellerophon Therapeutics, MediciNova, Novartis, Endeavor BioMedicines, Pliant Therapeutics, Nitto Denko, Kadmon Pharmaceuticals, Calliditas Therapeutics, Avalyn Pharmaceuticals, PureTech Health, Taiho Pharmaceutical, Bristol-Myers Squibb, Galecto Biotech AB, CSL Behring, Celgene Pharmaceutical, Vicore Pharma, Boehringer Ingelheim, Guangdong Raynovent, Sunshine Lake Pharma co, Suzhou Zelgen Biopharmaceuticals, Algernon Pharmaceuticals, Horizon Therapeutics, Daewoong Pharmaceutical, Metagone Biotech, AstraZeneca, Lung Therapeutics, Bridge Biotherapeutics, AstraZeneca, Kinarus AG, Insmed, Reviva Pharmaceuticals, Annapurna Bio, Guangdong Hengrui Pharmaceutical Co., Ltd, Ark Biosciences, Ocean Biomedical, and others. Key Idiopathic Pulmonary Fibrosis Pipeline Therapies: Pamrevlumab, Treprostinil, Nitric oxide inhalation - INOpulse, MN-001 (tipelukast), VAY736, ENV-101, PLN-74809, ND-L02-s0201, KD025, GKT137831, AP 01, LYT-100, TAS-115, BMS-986278, GB0139, CSL312, CC-90001, C21, BI1015550, ZSP1603, HEC585, Jaktinib Dihydrochloride Monohydrate, Ifenprodil, HZN-825, DWN12088, MG-S-2525, Saracatinib, LTI-03, BBT-877, AZD5055, KIN001-IPF, Treprostinil palmitil inhalation powder (TPIP), Brilaroxazine, ANPA 0073, SHR 1906, AK 3280, OCF 203, and others. Dive deep into rich insights for new drugs for idiopathic pulmonary fibrosis treatment; visit @ Idiopathic Pulmonary Fibrosis Medications Table of Contents For further information on the idiopathic pulmonary fibrosis pipeline therapeutics, reach out @ Idiopathic Pulmonary Fibrosis Drug Treatment Related Reports Idiopathic Pulmonary Fibrosis Market Idiopathic Pulmonary Fibrosis Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key idiopathic pulmonary fibrosis companies, including FibroGen, Hoffmann-La Roche Ltd, United Therapeutics, Boehringer Ingelheim, Pliant Therapeutics, Inc., Galecto Biotech, Horizon Therapeutics, CSL Behring, Kadmon Corporation, LLC, among others. Idiopathic Pulmonary Fibrosis Epidemiology Forecast Idiopathic Pulmonary Fibrosis Epidemiology Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, and idiopathic pulmonary fibrosis epidemiology trends. Pulmonary Fibrosis Pipeline Pulmonary Fibrosis Pipeline Insight – 2023 report provides comprehensive insights about the pipeline landscape, pipeline drug profiles, including clinical and non-clinical stage products, and the key pulmonary fibrosis companies, including Roche, Boehringer Ingelheim, Galecto Biotech, Cipla, Gilead Sciences, Fibrogen, Bristol-Myers Squibb, among others. Pulmonary Fibrosis Market Pulmonary Fibrosis Market Insights, Epidemiology, and Market Forecast – 2032 report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key pulmonary fibrosis companies, including Roche, Boehringer Ingelheim, Galecto Biotech, Cipla, Gilead Sciences, Fibrogen, Bristol-Myers Squibb, among others. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +1(919)321-6187 Logo: SOURCE DelveInsight Business Research, LLP

DUBLIN, Feb. 9, 2023 /PRNewswire/ -- The "Global KRAS Inhibitors Market, Drug Price, Sales, & Clinical Trials Insight 2029" report has been added to ResearchAndMarkets.com's offering. Report Highlights Global KRAS Inhibitors Market Opportunity > USD 4 Billion By 2029 Global KRAS Drug Market Growth In 2022 > 200% Number Of Approved Drugs: 2 Drugs Approved Drug Global & Regional Sales Insight Approved Drugs Patent, Price & Dosage Analysis Regional Analysis: USA, UK, China Europe, Japan, South Korea Number Of Drugs In Clinical Trials: > 60 Drugs Insight On All Drugs In Clinical Trials By Phase, Company, Country, Indication & Patient Segment The advancement in the field of biology has led to the discovery of several oncogenes that play a critical role in cancer development and thus presenting researchers with opportunities to target them. KRAS is one such oncogene that is the most frequently mutated and therefore, specific research and clinical activities are being carried out for the possible development of novel KRAS inhibitors. The future pipeline of this target looks flourishing as several pharmaceutical companies also plan on bringing novel drug candidates against KRAS. Researchers worldwide have known about KRAS mutations for several years; however, the available therapies against it were proven to be indefinable. But after the approval of first-ever KRAS inhibitor, Lumakras (Sotorasib) developed by Amgen in 2021 for the treatment of patients with advanced KRAS G12C mutated non-small cell lung cancer, the product market showed significant growth in terms of both commercial sale success and enhanced overall survival rates. Its sales grew more than twice in 2022 as compared to 2021 levels. The drug is the first ever targeted anti-cancer treatment drug against KRAS mutations. Furthermore, Qiagen also launched Therascreen KRAS RGQ PCR Kit after it received US regulatory approval as a companion diagnostic in aiding the diagnosis of non-small cell lung cancer. This was the first companion diagnostic kit to have received premarket approval from the US FDA. Nevertheless, additional progress has been made in the industry and FDA has further approved companion diagnosis kits. In December 2022 Agilent Resolution's ctDx FIRST was granted approval by the FDA as a companion diagnostic for patients with NSCLC. The ever-increasing cases of cancer and the ability of the tumor to develop new and frequent mutations signify an unmet need for advancement of novel therapies in the management and treatment of cancer. However, with discoveries like that of Kristen rat sarcoma viral oncogene homolog (KRAS), the future of cancer-targeted therapies is something to look forward to. It is both interesting and concerning how KRAS mutations play a significant role in the pathogenesis and proliferation of cancer. With booming research and development strategies, pharmaceutical companies are rapidly moving forward and aiming for this oncogene. Recently, VITRAC Therapeutic has initiated a phase I clinical trial with AURKA Inhibitor VIC-1911 and Sotorasib a G12C inhibitor for the treatment of KRAS G12C-mutant non-small cell lung cancer (NSCLC). This study of VIC-1911 as monotherapy and in combination with Sotorasib is being performed at Yale Cancer Centre. The preclinical studies have strongly supported the combinational use of both drugs. By using this multi-targeted approach, the study aims to provide a more effective therapeutic outcome for patients with KRAS G12C-mutated NSCLC. The market for KRAS-targeted drugs is poised with exponential growth with several factors determining its potential. The KRAS market is widely supported by the accelerating trend of preclinical and in vitro studies which has increased the number of patients that are seeking out treatment opportunities. The rising demand for this therapy has resulted in increasing acceptance of cancer management treatments. The market expects new medications to swiftly and rapidly enter the commercial sector. There are also factors that will be challenging the future potential of this market. With increased research and development activity, there also increases in the number of competitors in the market. Drug manufacturers need to develop medications that have innovation and creativity and the ability to show better outcomes than its opponents. Currently, Amgen is in the lead for KRAS targeted therapy market but with the incoming of more drugs in the future, some challenges are bound to be faced by the company if it wants to keep its position as the topmost stakeholder in the KRAS inhibitors drug market. For instance, on December 2022, the US FDA granted accelerated approval to Mirati Therapeutics' Adagrasib (Krazati) which is a RAS GTPase family inhibitor for adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer who have received at least one prior systemic therapy. This approval was based on KRYSTAL-1, a multicenter, open-label clinical trial and the indication was approved under accelerated approval based on the overall response rate and duration of response. Key Topics Covered: 1. Introduction to KRAS Inhibitors 2. Role of KRAS Inhibitors in Cancer Therapy 2.1 Lung Cancer 2.2 Pancreatic Cancer 2.3 Colorectal Cancer 2.4 Other Cancers 3. Lumakras - First Approved KRAS Inhibitor 3.1 Overview & Patent Insight 3.2 Dosage & Price Analysis 3.3 Sales Analysis 4. Krazati - Second Approved KRAS Inhibitor 4.1 Overview & Patent Insight 4.2 Dosage & Price Analysis 5. Global KRAS Inhibitor Market Outlook 5.1 Current Market Scenario 5.2 Future Market Opportunity 6. KRAS Inhibitor Market Regional Analysis 6.1 US 6.2 UK 6.3 China 6.4 Europe 6.5 Japan 6.6 South Korea 6.7 Canada 7. Global KRAS Inhibitors Clinical Pipeline Overview 7.1 By Country 7.2 By Phase 7.3 By Company 7.4 By Indication 7.5 By Patient Segment 8. Global KRAS Inhibitors Clinical Pipeline By Company, Indication & Phase 8.1 Research 8.2 Preclinical 8.3 Phase-I 8.4 Phase-I/II 8.5 Phase-II 8.6 Phase-III 9. Marketed KRAS Inhibitors Clinical Insight 9.1 Sotorasib - Amgen 9.2 Adagrasib - Mirati Therapeutics 10. Global KRAS Inhibitors Market Dynamics 10.1 Market Drivers & Opportunities for KRAS Inhibitors 10.2 Challenges for KRAS Inhibitors Market 11. Competitive Landscape 11.1 Array BioPharma 11.2 Applied Pharmaceutical Science 11.3 Amgen 11.4 AnBogen Therapeutics 11.5 Ascentage Pharma 11.6 AstraZeneca 11.7 BridgeBio Pharma 11.8 Boehringer Ingelheim 11.9 Erasca 11.10 Carmot Therapeutics 11.11 FogPharma 11.12 Frontier Medicines 11.13 Jacobio Pharmaceuticals 11.14 Jemincare 11.15 Jiangsu Hansoh Pharmaceutical 11.16 Jiangsu Hengrui Medicine Co. 11.17 Leidos Biomedical Research 11.18 Mirati Therapeutics 11.19 REVOLUTION Medicines 11.20 Roche 11.21 Shanghai Euregen Biopharma 11.22 Shanghai Yingli Pharmaceutical 11.23 Singh Biotechnology 11.24 Suzhou Genhouse Bio 11.25 Suzhou Zelgen Biopharmaceuticals For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. We provide you with the latest data on international and regional markets, key industries, the top companies, new products and the latest trends. Media Contact: Laura Wood | +353-1-481-1716 | [email protected] Logo: SOURCE Research and Markets

L’AQUILA, Italy, Dec. 12, 2022 (GLOBE NEWSWIRE) -- Genomic Biopharma Inc., a genomic medicine-based drug discovery and development company, has partnered with Associazione Poic e Dintorni APS (“POIC e dintorni APS”), a patient organization that supports the advocacy of chronic intestinal pseudo-obstruction (CIPO), to enable access to whole genome sequencing (WGS) and demonstrate the utility of genomic information to treat and cure the most severe disorders of gut motility, including: ACTG2 mediated Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) Chronic Intestinal Pseudo Obstruction (CIPO) Associazione Poic e dintorni APS is an Italian patient organization that supports the advocacy of CIPO, a rare and disabling disease characterized by a severe myogenic, neurogenic or idiopathic motility defect that affects the entire digestive tract, associated with periods of intestinal obstruction and inability to feed the patients. Through the collaboration, all members of POIC e dintorni APS and their parents will have access to whole genome sequencing. Among rare, severe and disabling intestinal diseases, Genomic Biopharma will target one of its first drug candidates, demonstrating the clinical utility of genomic information in drug discovery and development for the treatment of rare diseases. At the American Society of Human Genetics conference in October, Genomic Biopharma presented a poster that identified siRNA sequences as good candidates for the development of a new therapeutic approach in MMIHS and underscored a translational impact for future strategy to treat the underlying cause of the disease. “For those living with ultra rare diseases, in particular, the only approach is to take the broadest and most comprehensive look at the person’s genomic pro whole genome sequencing,” said Mattia Capulli, PhD, co-founder of Genomic Biopharma. “It is our mission to push genomics to new frontiers in order to develop treatments for diseases for which there are no cure or resolutive pharmacological therapies. In partnering with progressive organizations like Poic dintorni APS, we will pave the way to cure the most severe disorders of gut motility.” “As a mother of a daughter affected by CIPO since her birth and as President of a patient organization that supports the advocacy of chronic intestinal pseudo-obstruction, I am very excited about the potential that this partnership with Genomic Biopharma offers us. It clearly shows the joint-commitment to improve patients' quality of life,” said Ornella Spada, President and co-founder of Poic e dintorni APS. “Starting today, the word hope has a new and encouraging meaning for families, caregivers and patients affected by CIPO.” Another goal of the partnership is to raise awareness of MMIHS and CIPO around the world in order to bring together the world’s most knowledgeable experts from clinicians to patient advocates to truly foster the development of an international alliance of pediatric and adult patients. About Genomic Biopharma Inc. Genomic Biopharma Inc., a company created by Dante Genomics, is a drug discovery and development company building a pipeline of drug programs focused on bringing to market treatments and therapies for infectious and rare diseases. The Company develops its pipeline based on findings from Dante Genomics’ proprietary database of whole genomes. Genomic Biopharma’s core technology, the GBI AI, uses predictive algorithms and genomic data mining to support the identification of novel RNA-based therapeutics. About Associazione Poic e dintorni APS Associazione Poic e dintorni APS is an Italian patient organization that supports the advocacy of chronic intestinal pseudo-obstruction (CIPO), a rare and disabling disease characterized by a severe myogenic, neurogenic or idiopathic motility defect that affects the entire digestive tract, associated with periods of intestinal obstruction and inability to feed the patients. Its mission is to improve the quality of life of patients and to accelerate scientific research to find a cure. Poic e dintorni APS relies also on its Scientific Advisory Board leadership, made up by 18 members with different clinic-scientific background and internationally acknowledged. Learn more about CIPO here. Contact: Genomic Biopharma Inc. info@genomicbiopharma.com Associazione Poic e dintorni APS alex@poic-e-dintorni.org