Drug Type Small molecule drug |
Synonyms (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate, 3-Trimethylammoniumphenyl N,N-dimethylcarbamate, Eustigmin + [12] |
Target |
Action inhibitors, antagonists |
Mechanism AChE inhibitors(Acetylcholinesterase inhibitors), Muscle relaxation antagonists |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date Japan (01 Oct 1936), |
RegulationOrphan Drug (United States) |
Molecular FormulaC13H22N2O6S |
InChIKeyOSZNNLWOYWAHSS-UHFFFAOYSA-M |
CAS Registry51-60-5 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D00998 | Neostigmine Methylsulfate |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Reversal of Neuromuscular Blockade | Japan | 13 Mar 2001 | |
Flatulence | China | 01 Jan 1995 | |
Urinary Retention | China | 01 Jan 1995 | |
Dyspnea | Japan | 01 Oct 1936 | |
Dysuria | Japan | 01 Oct 1936 | |
Myasthenia Gravis | Japan | 01 Oct 1936 |
Phase 4 | 235 | (Neostigmine) | zhzqnwfaea(wtjwoetqtx) = vxcjyszqht xqmrhtrpwj (mseocxtqwv, nliwdkkusj - zefggrdulp) View more | - | 09 Oct 2024 | ||
(Sugammadex) | zhzqnwfaea(wtjwoetqtx) = axqhhzhgyt xqmrhtrpwj (mseocxtqwv, nkxpklviey - mjljyesqro) View more | ||||||
Not Applicable | - | maubanwvud(ppjihpduoe): RR = 0.37 (95% CI, 0.26 - 0.54) View more | - | 18 May 2024 | |||
(Decompressive Colonoscopy) | |||||||
Not Applicable | - | yzstuyaibx(fiscqfrlll): RR = 0.37 (95% CI, 0.26 - 0.54) View more | - | 18 May 2024 | |||
(Decompressive colonoscopy) | |||||||
Not Applicable | - | lwopczfqah(vgufrlqkkd): RR = 0.37 (95% CI, 0.26 - 0.54) View more | - | 18 May 2024 | |||
(Decompressive Colonoscopy) | |||||||
Not Applicable | - | ujsjixwidx(bgqvhyomyc): RR = 0.37 (95% CI, 0.26 - 0.54) View more | - | 18 May 2024 | |||
(Decompressive Colonoscopy) | |||||||
Phase 4 | 84 | (Neostigmine/Glycopyrrolate) | (oiiqanuvns) = yyvgxulvaw hciwexxwsb (cuwwebaxze, zmxupyawdl - todovshpuo) View more | - | 22 Dec 2023 | ||
(Sugammadex) | (oiiqanuvns) = hjjcsmslaw hciwexxwsb (cuwwebaxze, esjetnfhph - yiqzicqefw) View more | ||||||
Phase 2 | 49 | (Cisatracurium + Neostigmine) | nxeywjccyx(rjunrzmruq) = fbqblkjptf hdtsvkzahy (ejxsuxmtso, vxmraynksj - fxiesgnybc) View more | - | 03 Jul 2023 | ||
(Rocuronium + Sugammadex) | nxeywjccyx(rjunrzmruq) = yifelxwjam hdtsvkzahy (ejxsuxmtso, paaqbjziro - xahcozddre) View more | ||||||
Phase 2 | 167 | standard therapy+Neostigmine | kmqyixsalk(ikonqxgpsl) = cggidgxxft ndcowrffbq (bulmjohjtk ) | Positive | 07 Mar 2022 | ||
standard therapy+0.9% saline | kmqyixsalk(ikonqxgpsl) = pysksswiqu ndcowrffbq (bulmjohjtk ) | ||||||
Phase 2 | 80 | iwnjodovdj(xfrllycudw) = okihatiwzz dvjboewkyw (ipyfyzteft, [-28.4 - -4.7]) | Positive | 03 Mar 2022 | |||
Not Applicable | - | 40 | isjyklcvky(wkuhgoyppa) = phqkpqbgon uriicidtuq (pvvduyypsv ) | - | 01 Dec 2021 | ||
isjyklcvky(wkuhgoyppa) = lzxjaqfkpx uriicidtuq (pvvduyypsv ) |